TWI281396B - Compounds useful for the treatment of diseases - Google Patents

Info

Publication number

TWI281396B

TWI281396B TW094107960A TW94107960A TWI281396B TW I281396 B TWI281396 B TW I281396B TW 094107960 A TW094107960 A TW 094107960A TW 94107960 A TW94107960 A TW 94107960A TW I281396 B TWI281396 B TW I281396B

Authority

TW

Taiwan

Prior art keywords

phenyl

ethyl

hydroxy

amino

hydroxymethyl

Prior art date

2004-03-17

Links

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• 238000000034 method Methods 0.000 claims abstract description 151
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 525
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 511
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• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 163
• -1 〇CF3 Chemical group 0.000 claims description 158
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 87
• 239000011734 sodium Substances 0.000 claims description 81
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• METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims description 55
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 55
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• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
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• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
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