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TW531406B - An intravascular photo-sonic sensor device - Google Patents

An intravascular photo-sonic sensor device Download PDF

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Publication number
TW531406B
TW531406B TW91110718A TW91110718A TW531406B TW 531406 B TW531406 B TW 531406B TW 91110718 A TW91110718 A TW 91110718A TW 91110718 A TW91110718 A TW 91110718A TW 531406 B TW531406 B TW 531406B
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Taiwan
Prior art keywords
sensing
sensing device
photoacoustic
unit
item
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TW91110718A
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Chinese (zh)
Inventor
Kan-Ping Lin
Chia-Wei Tu
Yuh-Ping Tong
Alex Hsieh
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Ind Tech Res Inst
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Publication of TW531406B publication Critical patent/TW531406B/en

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Abstract

A new intravascular photo-sonic sensor device is disclosed. The photo-sonic sensor device includes at least ultrasonic array sensors and a laser Doppler photo detector for detecting angiography and blood flow. The ultrasonic array sensors include a plurality of sensor units, a plurality of matching units, an absorptive unit, and a plurality of signal lines. The sensor units are used for receiving ultrasonic signal. In addition, the matching units are set on the sensor units. Furthermore, the absorptive unit is built in the sensor units and the signal lines locating in the absorptive unit are used for transmitting and detecting signals received by the sensor units received.

Description

531406 五、發明說明(l) -- 【本發明之領域】 本發,係關於一種侵入式光聲感測裴置,尤指一種適 用於心導管手術之心血管内微型光聲感测裝置。 【本發明之背景] 按’在進行冠狀動脈肥大 術等心導管手術時,醫師必須 金管内血流數值等生理訊息, 傳統的作法係使用侵入式 (Intravascular Ultrasound 僅能單獨掃描血管壁組織截面 並無法同時進行上述之兩種功 無法獲得即時足夠的資訊,甚 導管,造成病患的痛苦與增加 另一種作法係採用雷射都 Doppler blood fl〇w meter) 管的血流速,但對體内較深處 雷射光無法穿透到達部分則無 現血管組織之截面影像。、 發明人麦因於此,本於積 以解決上述問題之「侵入式光 驗終至完成此項嘉惠世人之發 、動脈血管栓塞、汽球擴張 獲取jk管壁組織截面影像與 以方便手術的進行。 導管超音波系統 System,IVUS ),其功能 影像或單獨量測血流流速, 能。使得醫師在手術進行中 至必須時常抽換不同功能之 手術失敗率。 普勒血流量測系統(Laser ’其係從體外量測體表微血 血管以及心臟周邊等組織, 法進行量測,且此法無法呈 極發明之精神,亟思一種可 聲感測裝置」,幾經研究實 明。531406 V. Description of the invention (l)-[Field of the invention] The present invention relates to an intrusive photoacoustic sensing device, especially a miniature photoacoustic sensing device suitable for cardiovascular applications in cardiac catheterization. [Background of the present invention] According to 'When performing cardiac catheter surgery such as coronary arterial hypertrophy, the physician must have physiological information such as the blood flow value in the golden canal. The traditional method is to use invasive (Intravascular Ultrasound can only scan the vascular wall tissue section and The inability to perform the above two functions simultaneously cannot obtain sufficient information in real time, even the catheter, causing the patient's pain and increasing the blood flow velocity of the tube using another Doppler blood floow meter. There is no cross-sectional image of the existing vascular tissue at the deeper part where the laser light cannot penetrate. In this regard, the inventor Mai Yin, this in order to solve the above-mentioned problems, "the invasive optical test is finally completed to the benefit of the world's hair, arterial vascular embolism, balloon dilation to obtain jk tube wall tissue cross-section images and to facilitate surgery Catheter ultrasound system (IVUS), its functional image or separate measurement of blood flow velocity, can enable physicians to frequently replace the failure rate of different functions during the operation. Pooler blood flow measurement system (Laser's method is to measure micro blood vessels on the surface of the body and tissues around the heart in vitro, and this method can not show the spirit of the invention. It is an urgent need to consider an acoustic sensing device. "

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【本發明之概述】[Outline of the invention]

第5頁 531406Page 5 531406

五、發明說明(2) 本發明之主要目的係在提供一種侵入式光聲感測裝 置,俾能同時獲取血管壁組織截面影像以及血管内血流數 值等生理訊息,而不需重複抽換不同功能之導管。 本發明之另一目的係在提供一種侵入式光聲感測裝 置,俾能藉由血流數值之變化確定血管栓塞之位置,以間 接減少定位用X光之照射量。 為達成上述之目的,本發明係插設於血管内部,並配 合一外部超音波源與一雷射光訊號源,本發明主要包括·· 複數感測單元,用以發射與接收超音波訊號;複數匹配單 元’係固设於极數感測早元之外圍’以匹配複數感測單元 與人體之阻抗差距;一吸收單元,其内部係為中空,且 固設於複數感測單元之内圍;複數訊號線組,係傳送複數 感測單元發射與接收超音波訊號而產生之感測訊號,複數 訊號線組係組設於吸收單元内;以及一光訊號感測單元, 係位於吸收單元内部,光訊號感測裝置包含複數光纖;其 中,雷射光訊號源經由至少一光纖作為發射光訊號之光 纖’以送至血管内,其他複數光纖作為接收光訊號之光 纖,以接收由體液所反射之光訊號,超音波感測裝置與光 訊號感測裝置係以時序控制法控制超音波與光訊 與接收順序。 、由於本發明構造新穎,能提供產業上利用,且確有增 進功效,故依法申請發明專利。 531406 五、發明說明(3) 【車父佳具體實施例之詳細說明】 有關本發明之較佳實施例,係以杯χ / ^ ^ *敬請^照第1圖顯示之立體分解圖,其主V二加以 3、吸收單元“導管5、訊號線6二ί7纖 中較佳= :早:1 二材/無限制’於本實施例 具聲3= :f配單元3之材質無限制,較佳為-種 ^ ^ M ^ ; 4具聲阻抗材料之聲阻抗值介於人體聲 衰減係數低特性的材質。二阻上'之間’並具有超音波 Technologies Gr 、 σ,、、、木用广例柯公司 deco 成成份為環氧數脂與iif:切 )等高分子材料盥三 J一 = 树月曰(Ep〇xy ms-25 吸收單元4夕从哲、fc—乳化一鋁及氧化鎢等粉末之混合物。 及收早兀4之材質無限制,於本實施較八 Ξ ΐδ尖材γ ^粉"材料所組成。封裝二為 特性。封裝體7之材Λ 減係數低與具有生物相容之 物,最佳Κ氨醋材^ 吸收ΐ 之中外圍超音^皮/測單元1為八個:且分別鑲嵌於 4間埋設有八條m t八個超音波感測單701與吸收單元 就線6,與各超音波感測單元1共用的一 第7頁 531406 五、發明說明(4) 供將各超音波感測單元1發射與接收超音波訊 丄之訊號傳送至外部顯示裝置。八個超音波感測 Γ:立Λ 別以樹脂膠合八個匹配單元3,以形成八 Γ奐能模組’且在超音波陣列換能模組外圍組 一:空之導管5,並在導管5之尖端封裝-透明之 ΓίΓ,俾供發射與#收超|波訊號,以拍頁取心血管壁 組織截面影像。 以、斑:ΐ t ί阻抗與超音波感測單元1之阻抗差距頗大, 之方式固設匹配單元3,減少超音波感測單 Λ抗,’而能順利傳導外部超音波訊號至 當然,超音波感測單元1之數量無限 在本”中係]乂八個超音波感測單元1作為說明。 吸收早兀4為一内部中漥之圓 =波二發射與接收超音波訊號後== 所產生之震動。在吸收單Hi 接收超音波訊號後 單元2,其具有一根作為傳幹部份置有光訊號感測 係連接至外部雷射發光源,就二光二21,該光額 管;光訊號感測單元2更/含體成聚光後再進入血 所反射回來之光訊號的光纖21根作為接收由血管内體液 外部顯示裝置,以顯=;2内 =該八根光賴係連接至 ^ g N血流之流速。 第3圖則顯示本發明所接 至“表示四個超音波感柯單=序控制法之示意圖,ti 早疋1發射及接收之時序,15表V. Description of the invention (2) The main purpose of the present invention is to provide an invasive photoacoustic sensing device, which can simultaneously acquire physiological information such as cross-sectional images of blood vessel wall tissues and intravascular blood flow values without the need for repeated replacements. Functional conduit. Another object of the present invention is to provide an intrusive photoacoustic sensing device, which can determine the position of a blood vessel embolism by a change in blood flow value, thereby indirectly reducing the amount of X-rays for positioning. In order to achieve the above-mentioned object, the present invention is inserted inside a blood vessel and cooperates with an external ultrasonic source and a laser light signal source. The present invention mainly includes a plurality of sensing units for transmitting and receiving ultrasonic signals; The matching unit is 'fixed on the periphery of the pole sensing early element' to match the impedance gap between the complex sensing unit and the human body; an absorption unit whose interior is hollow and fixed on the inner periphery of the complex sensing unit; The complex signal line group is a sensing signal generated by transmitting and receiving ultrasonic signals from the complex sensing unit. The complex signal line group is arranged in the absorption unit; and an optical signal sensing unit is located inside the absorption unit. The optical signal sensing device includes a plurality of optical fibers; wherein the laser light source is sent into a blood vessel through at least one optical fiber as an optical fiber for transmitting optical signals, and the other multiple optical fibers are used as optical fibers for receiving optical signals to receive light reflected by body fluids. The signal, ultrasonic sensing device and optical signal sensing device control the order of ultrasonic and optical signals and reception by a timing control method. Since the present invention has a novel structure, can provide industrial use, and does have an increasing effect, it applies for an invention patent in accordance with the law. 531406 V. Description of the invention (3) [Detailed description of the specific embodiment of Che Fujia] The preferred embodiment of the present invention is a cup χ / ^ ^ * Please ^ according to the three-dimensional exploded view shown in Figure 1, which Main V 2 plus 3, absorption unit "conduit 5, signal line 6 2 ί 7 fiber is better =: early: 1 2 materials / unlimited" in this embodiment with sound 3 =: f distribution unit 3 material unlimited, It is preferably-species ^ ^ M ^; 4 materials with acoustic impedance materials whose acoustic impedance value is low in the human body's acoustic attenuation coefficient. The second resistance is 'between' and has ultrasonic technology Gr, σ ,,,, and wood Use of Guangxi Ke company's deco as the composition of epoxy resin and iif: cut) and other polymer materials JJ = Shuyue Yue (Ep〇xy ms-25 absorption unit 4 Xi Congzhe, fc-emulsified aluminum and Mixture of powders such as tungsten oxide. There is no limit to the material of the early harvest 4. In this implementation, it is made up of Ξδ 尖尖 材 γ ^ powder " material. The package 2 is a characteristic. The material Λ of the package 7 has a low reduction coefficient and With biocompatible materials, the best κ ammonia vinegar material ^ absorption ΐ mid-peripheral supersonic ^ skin / test unit 1 is eight: and embedded in 4 rooms Eight mt and eight ultrasonic sensing units 701 are connected to the absorption unit 6 and shared with each ultrasonic sensing unit 1 Page 7 531406 5. Description of the invention (4) For transmitting each ultrasonic sensing unit 1 The signals from the receiving and receiving ultrasonic signals are transmitted to the external display device. Eight ultrasonic sensors Γ: Li Λ Do not glue eight matching units 3 with resin to form eight Γ 奂 energy modules' and change energy in the ultrasonic array Module Peripheral Group 1: Empty catheter 5 and encapsulated at the tip of catheter 5-transparent ΓίΓ, 俾 for emission and # 收 超 | 波 Signal to take a page to take a cross-section image of the cardiovascular wall tissue. t ί The impedance is quite different from the impedance of the ultrasonic sensing unit 1. In this way, the matching unit 3 is fixed to reduce the impedance of the ultrasonic sensing unit, and the external ultrasonic signal can be transmitted smoothly to the ultrasonic sensing unit. The number of 1 is unlimited in this book.] Eight ultrasonic sensing units 1 are used as an illustration. Absorption early 4 is an internal circular circle = wave 2 after transmitting and receiving ultrasonic signals = = vibration generated. After absorbing a single Hi to receive the ultrasonic signal, the unit 2 has a The optical signal sensing system is connected to the external laser light source as the trunk part. It is two optical two 21, the optical frontal tube; the optical signal sensing unit 2 is more focused / contained and then enters the blood chamber to reflect back. The 21 optical fibers of the light signal are received by the external display device of the body fluids in the blood vessel to display the flow rate of the eight light sources connected to the blood flow of ^ g N. Figure 3 shows the connection to the blood flow of the present invention. "Schematic diagram showing four ultrasonic sensors and single-sequence control method, ti as early as 1 timing of transmission and reception, 15 tables

第8頁 531406 -- 發明說明(5) 示光纖21傳送光纖訊號至血管内之 根光纖接收由血管俨 夺序,t6則表示其餘八 中,每一動补 射回之光訊號之時序。其 發後:時序約20微秒,每二超音波感測單元1觸 為5微秒’整個工作週期則約為15。微秒。 控制各超音波感測單元1與傳導光纖 留5微秒大Λ /盖並在各個超音波感測單元1觸發後預 ί二導善超音波感測單元1之震盪衰減效應, 使付:V先纖21不受震盪所產生之散射雜訊干擾。 币4 i以上之說明可知,本發明係將超音波陣列减測哭盥 γ都普勒系統之雷射光源感測器共同整合於一; 血估=達到同時獲取血管壁組織截面影像以及血管内 且Γ路等生理訊息,而不需重複抽換不同功能之導管。 且本么明並能經由血流數值之變化確定血管板荚之 以間接減少定位用X光之照射量。 i ’ 綜上所陳,本發明無論就目的、手段及功效, =示其迥異於習知技術之特徵1「心導管光句 置」之一大突破,懇言奢貴審查委員明察,早日賜准= 利,俾嘉惠社會,實感德便。惟應注意的是,上述每 施例僅係為了便於說明而舉例而已,本發明所主張二只 範圍自應以中請專利範圍所述為$,而非僅限於上述= 例 ,Page 8 531406-Description of the invention (5) Shows that the optical fiber 21 transmits the optical fiber signal to the root fiber in the blood vessel and is received by the blood vessel 序, and t6 indicates the timing of the optical signal returned by each motion in the remaining eight. After it is sent out: the timing is about 20 microseconds, and every second ultrasonic sensing unit 1 touches 5 microseconds. The whole working cycle is about 15. Microseconds. Control each ultrasonic sensing unit 1 and the conducting fiber to stay 5 μs large Λ / cap and pre-tilt the vibration attenuation effect of the two-lead ultrasonic sensing unit 1 after triggering of each ultrasonic sensing unit 1, so that: V The first fiber 21 is not disturbed by the scattered noise generated by the oscillation. It can be seen from the above description that the present invention integrates the laser light source sensor of the ultrasonic array sub-measurement gamma cryppler system into one; blood estimation = to obtain the cross-sectional image of the blood vessel wall tissue and the blood vessel at the same time. And Γ and other physiological information, without the need to repeatedly exchange catheters with different functions. In addition, Benmemin can determine the vascular plate pods by indirectly reducing the amount of X-ray irradiation for positioning by changing the blood flow value. i 'In summary, the present invention, regardless of its purpose, means and efficacy, shows its characteristics that are quite different from the conventional technology. 1 A major breakthrough in the "cardiac catheter light sentence placement", sincerely urges the inspection committee members to make a clear observation and give it soon. Precise = profit, good for the society, really feel virtuous. It should be noted that each of the above embodiments is merely an example for the convenience of explanation. The two ranges claimed in the present invention should be $ as described in the patent scope, and not limited to the above.

第9頁 531406 圖式簡單說明 【圖式簡單說明】 第1圖係本發明之立體分解圖。 第2圖係本發明之示意圖。 第3圖係本發明超音波與光訊號之發射與接收之時序控制 圖0 【圖號說明】 超音波感測單元1 光纖21 吸收單元4 訊號線6 光訊號感測單元2 匹配單元3 導管5 封裝體7Page 9 531406 Brief description of the drawings [Simplified description of the drawings] Figure 1 is an exploded perspective view of the present invention. Figure 2 is a schematic diagram of the present invention. Figure 3 is the timing control diagram of the transmission and reception of ultrasonic and optical signals according to the present invention. 0 [Illustration of the drawing number] Ultrasonic sensing unit 1 Optical fiber 21 Absorption unit 4 Signal line 6 Optical signal sensing unit 2 Matching unit 3 Conduit 5 Package 7

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Claims (1)

531406 六、申請專利範圍 1. 一種侵入式光聲感測裝置,係插設於血管内部,並 配合一雷射光訊號源,該光聲感測裝置主要包括: 複數感測單元,用以發射與接收超音波訊號; 複數匹配單元’係固設於該複數感測單元之外圍,以 匹配該複數感測單元與人體之阻抗差距; 一吸收單元’係固設於該複數感測單元之内圍,以吸 收該複數感測單元產生之散射雜訊,該吸收單元内部係 中空; … 複數訊號線組,係傳送該複數感測單元發射與接收該 超音波訊號而產生之感測訊號,該複數訊號線組係組設= 該吸收單元内;以及 一光訊 號感測裝置 其中,該雷 光纖,以送 光纖,以接 與該光訊號 光訊號之發 2 ·如申 該作為接收 3 ·如申 管光聲感測 係套設於該 該封裝體。 號感測 包含複 射光訊 至該血 收由體 感測裝 射與接 請專利 光訊號 請專利 裝置尚 複數感 單元, 數光纖 號源經管内, 液所反 置係以 收順序 範圍第 之其他 範圍第 包括一 測單元 係位於該吸收單元内部,該光訊 由至少一光纖作為發射光訊號之 其他複數光纖作為接收光訊號之 射之光訊號,該超音波感測裝置 時序控制法控制該超音波源與該 〇 ' 1項所述之光聲感測裝置,其中 光纖數為三至八根。 1、項,述之光聲感測裝置,該血 導管與一封裝體;該導管之一端 之外圍’並於該導管之一端裝設531406 6. Scope of patent application 1. An intrusive photoacoustic sensing device is inserted inside a blood vessel and cooperates with a laser light signal source. The photoacoustic sensing device mainly includes: a plurality of sensing units for transmitting and Receiving ultrasonic signals; the complex matching unit is fixedly arranged on the periphery of the complex sensing unit to match the impedance gap between the complex sensing unit and the human body; an absorption unit is fixedly arranged on the inner periphery of the complex sensing unit To absorb the scattered noise generated by the complex sensing unit, which is hollow inside; the complex signal line group is used to transmit the sensing signal generated by the complex sensing unit transmitting and receiving the ultrasonic signal, the complex number The signal line group is set up in the absorption unit; and an optical signal sensing device, in which the thunder optical fiber is used to send the optical fiber to connect with the optical signal and the optical signal is transmitted. The tube photoacoustic sensing system is sleeved on the package. No. sensing includes re-transmitting optical signals to the blood receiver, body sensing, loading and receiving patented optical signals, patented devices, and multiple-number sensing units. The number of optical fiber signal sources passes through the tube. The first range includes a measurement unit located inside the absorption unit. The optical signal uses at least one optical fiber as the transmitting optical signal and other plural optical fibers as the receiving optical signal. The ultrasonic sensing device timing control method controls the ultrasonic signal. The sound wave source and the photoacoustic sensing device described in the above item 0, wherein the number of optical fibers is three to eight. Item 1. The photoacoustic sensing device described above, the blood tube and a package body; the periphery of one end of the tube 'is installed at one end of the tube 531406 六 '申請專_圍 ' -/" ' "' 兮封4 ·如申睛專利範圍第3項所述之光聲感測裝置,其中 ^右$體之聲阻抗係介於人體卩旦抗與生理食鹽水之間,並 ’、知1音波衰減係數低與具有生物相容之特性。 ^ & ·如申凊專利範圍第4項所述之光聲感測裝置,其中 該封裴體係採用聚氨酯(PU )。 ^ 6 ·如申睛專利範圍第4項所述之光聲感測裝置,其中 鑪封裝體之頭端係呈一稜鏡狀,以增加所發射之光訊號的 聚光作用。 7 ·如申睛專利範圍第1項所述之光聲感測裝置,其中 該複數匹配單元係以濺鍍或膠合於該複數感測單元之外 圍。 8·如申,專利範圍第1項所述之光聲感測裝置,其中 該複數感測單元係為壓電陶曼材料。 9 · ^申請專利範圍第1項所述之光聲感測裝置,其中 該吸收單元之主要成分係包括:高分子材料、樹脂、以 金屬粉末。 - 10·如申請專利範圍第丨項所述之光聲感測裝置,i 該複數感測單元之數量係為八個。 11 ·如申請專利範圍第i項所述之光聲感測裝置, 該複數匹配單元之聲阻抗係介於人體阻抗與該 =、 單元之間,並具有超音波衰減係數低的特性。 感測531406 Six 'Applications for Special Purposes'-/ " '"' xifeng 4 · The photoacoustic sensing device described in item 3 of the patent scope of Shenyan, where the acoustic impedance of the right body is between the human body and the body. Once it is resistant to physiological saline, it has low acoustic attenuation coefficient and has biocompatible characteristics. ^ & The photoacoustic sensing device described in item 4 of the patent application, wherein the sealing system uses polyurethane (PU). ^ 6 The photoacoustic sensing device as described in item 4 of Shenjing's patent scope, wherein the head end of the furnace package is shaped like a cymbal to increase the light condensing effect of the emitted light signal. 7 · The photoacoustic sensing device according to item 1 of the Shenjing patent scope, wherein the plurality of matching units are sputtered or glued outside the plurality of sensing units. 8. As claimed, the photoacoustic sensing device described in item 1 of the patent scope, wherein the plurality of sensing units are piezoelectric talman materials. 9. The photoacoustic sensing device described in item 1 of the scope of the patent application, wherein the main components of the absorption unit include: polymer materials, resins, and metal powders. -10 · According to the photoacoustic sensing device described in item 丨 of the scope of patent application, i, the number of the plurality of sensing units is eight. 11 · According to the photoacoustic sensing device described in item i of the scope of patent application, the acoustic impedance of the complex matching unit is between the impedance of the human body and the unit, and has a characteristic of low ultrasonic attenuation coefficient. Sensing
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