TW527187B - Compositions for reducing ocular hypertension - Google Patents

Compositions for reducing ocular hypertension Download PDF

Info

Publication number: TW527187B
Authority: TW; Taiwan
Prior art keywords: composition; concentration; weight percent; eye; surfactant
Prior art date: 1997-03-17

Application number

TW087103809A

Other languages

English (en)

Chinese (zh)

Inventor

Kenneth Warren Reed

Shau-Fong Yen

Mary Sou

Regina Flinn Peacock

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-17

Filing date

1998-03-16

Publication date

2003-04-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38729083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW527187(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-03-16 Application filed by Novartis Ag filed Critical Novartis Ag

2003-04-11 Application granted granted Critical

2003-04-11 Publication of TW527187B publication Critical patent/TW527187B/zh

Links

239000000203 mixture Substances 0.000 title claims abstract description 105
206010030043 Ocular hypertension Diseases 0.000 title claims abstract description 6
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239000002736 nonionic surfactant Substances 0.000 claims abstract description 26
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Ophthalmology & Optometry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

TW087103809A 1997-03-17 1998-03-16 Compositions for reducing ocular hypertension TW527187B (en)

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Application Number	Priority Date	Filing Date	Title
US81922197A	1997-03-17	1997-03-17

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TW527187B true TW527187B (en)	2003-04-11

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TW087103809A TW527187B (en)	1997-03-17	1998-03-16	Compositions for reducing ocular hypertension

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KR (1)	KR100555818B1 (et)
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SI (1)	SI0969846T2 (et)
TW (1)	TW527187B (et)
UA (1)	UA63938C2 (et)
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US6011062A (en) *	1994-12-22	2000-01-04	Alcon Laboratories, Inc.	Storage-stable prostaglandin compositions
AR002194A1 (es) *	1997-03-17	1998-01-07	Sanchez Reynaldo Alemany	Instrumento computarizado para el analisis del movimiento.
US6187818B1 (en)	1998-06-17	2001-02-13	Pharmacia & Upjohn Company	Prostaglandins formulation and process
JP4880808B2 (ja) *	1999-11-15	2012-02-22	久光製薬株式会社	人工涙液型点眼剤組成物
JP4000505B2 (ja) *	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
US20040097592A1 (en) *	2000-09-13	2004-05-20	Kenji Morishima	Eye drops
AU2002218527A1 (en) *	2000-12-05	2002-06-18	Sankyo Company Limited	Ocular tension-lowering compositions for topical administration
US20020198209A1 (en) *	2001-05-03	2002-12-26	Allergan Sales Inc.	Compositions having enhanced pharmacokinetic characteristics
US7074827B2 (en) *	2002-10-24	2006-07-11	Sucampo Ag (Usa) Inc.	Method for treating ocular hypertension and glaucoma
RU2266572C1 (ru) *	2004-03-17	2005-12-20	Российский государственный медицинский университет	Способ моделирования злокачественной артериальной гипертонии
TWI339659B (en) *	2004-03-18	2011-04-01	R Tech Ueno Ltd	Aqueous composition comprising thiazole derivative
US8569367B2 (en) *	2004-11-16	2013-10-29	Allergan, Inc.	Ophthalmic compositions and methods for treating eyes
GB0501192D0 (en) *	2005-01-20	2005-03-02	Resolution Chemicals Ltd	Stable prostaglandin-containing compositions
US7851504B2 (en) *	2005-03-16	2010-12-14	Allergan, Inc.	Enhanced bimatoprost ophthalmic solution
DE202005005094U1 (de) *	2005-03-31	2005-07-28	Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh	Ophthalmische Zusammensetzung
US8030349B2 (en) *	2005-08-02	2011-10-04	Santen Pharmaceutical Co., Ltd.	Method for prevention of degradation of thermally unstable medicament
JP5252787B2 (ja) *	2005-08-02	2013-07-31	参天製薬株式会社	熱的に不安定な薬物の分解抑制方法
JP2007099647A (ja) *	2005-09-30	2007-04-19	Kobayashi Pharmaceut Co Ltd	粘膜適用組成物
US8168206B1 (en)	2005-10-06	2012-05-01	Allergan, Inc.	Animal protein-free pharmaceutical compositions
CN104224704A (zh) *	2006-03-13	2014-12-24	株式会社·R-技术上野	水性组合物
BRPI0709549A2 (pt) *	2006-03-17	2011-07-19	Johnson & Johnson Vision Care	métodos para estabilizar composições instáveis oxidativamente
KR20090082401A (ko) *	2006-10-31	2009-07-30	알콘 리서치, 리미티드	안 질환 치료용 ｐａｉ－１ 결합 조절제
JPWO2008096804A1 (ja) *	2007-02-07	2010-05-27	テイカ製薬株式会社	ラタノプロスト含有点眼剤
JP2009073788A (ja) *	2007-09-21	2009-04-09	Teika Seiyaku Kk	イソプロピルウノプロストン含有眼用組成物
EA019867B1 (ru) *	2007-10-08	2014-06-30	Фовея Фармасьютикалс	Водные офтальмологические препараты
TWI544927B (zh)	2008-03-17	2016-08-11	愛爾康研究有限公司	具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
SI2254549T2 (sl) *	2008-03-17	2019-08-30	Alcon Research, Ltd.	Vodni farmacevtski sestavki, ki vsebujejo komplekse borata/poliola
EP2127638A1 (en)	2008-05-30	2009-12-02	Santen Pharmaceutical Co., Ltd	Method and composition for treating ocular hypertension and glaucoma
RU2402316C2 (ru) *	2009-01-11	2010-10-27	Пшеничников Виталий Георгиевич	Фармацевтическая антиглаукомная композиция
US8952051B2 (en) *	2009-11-05	2015-02-10	Allergan, Inc.	Ophthalmic formulations containing substituted gamma lactams and methods for use thereof
EP2696876A4 (en) *	2011-04-12	2014-09-03	R Tech Ueno Ltd	AQUEOUS OPHTHALMIC COMPOSITION
US20130029919A1 (en) *	2011-07-26	2013-01-31	Allergan, Inc.	Two part formulation system for opthalmic delivery
EP2567689A1 (en)	2011-09-12	2013-03-13	Visiotact Pharma	Ophthtalmic compositions comprising prostaglandin F2 alpha derivatives and hyaluronic acid
US8957048B2 (en)	2011-10-06	2015-02-17	Allergan, Inc.	Compositions for the treatment of dry eye
RU2014127074A (ru)	2011-12-07	2016-02-10	Аллерган, Инк.	Состав для эффективной доставки липидов в слезную пленку человека с использованием чувствительной к соли эмульсионной системы
US9907826B2 (en)	2011-12-07	2018-03-06	Allergan, Inc.	Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
EP3223794A1 (en)	2014-11-25	2017-10-04	Allergan, Inc.	Stabilized omega-3 ophthalmic compositions
JP7520851B2 (ja) *	2018-09-21	2024-07-23	アウフバウ・メディカル・イノベイションズ・リミテッド	緑内障用の組成物および方法
CA3136356A1 (en)	2019-04-12	2020-10-15	Ecolab Usa Inc.	Antimicrobial multi-purpose cleaner and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2042936C (en) *	1990-05-22	2002-04-30	Ryuji Ueno	Treatment of ocular hypertension with a synergistic combination for ophthalmic use
US5767154A (en) *	1991-02-07	1998-06-16	Allergan	5-trans-prostaglandins of the F series and their use as ocular hypotensives
WO1992013836A1 (en) *	1991-02-07	1992-08-20	Allergan, Inc.	2-decarboxyl-2-hydroxyalkyl-5-trans prostaglandin f derivatives
CA2166722A1 (en) *	1994-05-06	1995-11-16	Manoj L. Maniar	Use of vitamin e tocopheryl derivatives in ophthalmic compositions
US5631287A (en) †	1994-12-22	1997-05-20	Alcon Laboratories, Inc.	Storage-stable prostaglandin compositions
US5558876A (en) *	1995-03-29	1996-09-24	Alcon Laboratories, Inc.	Topical ophthalmic acidic drug formulations
AR002194A1 (es) *	1997-03-17	1998-01-07	Sanchez Reynaldo Alemany	Instrumento computarizado para el analisis del movimiento.

1996
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Also Published As

Publication number	Publication date
AU738781B2 (en)	2001-09-27
CZ325799A3 (cs)	2000-01-12
DE69820997T2 (de)	2004-12-09
HUP0002194A3 (en)	2012-08-28
EP0969846A1 (en)	2000-01-12
CA2280089C (en)	2009-03-03
DE69820997D1 (de)	2004-02-12
JP2001515502A (ja)	2001-09-18
SI0969846T2 (sl)	2010-12-31
AR011192A1 (es)	2000-08-02
NO994481D0 (no)	1999-09-16
AR002194A1 (es)	1998-01-07
EP0969846B2 (en)	2010-08-25
CZ299833B6 (cs)	2008-12-10
WO1998041208A1 (en)	1998-09-24
BR9808016A (pt)	2000-03-08
ZA982188B (en)	1998-09-17
MY122237A (en)	2006-04-29
ES2214706T5 (es)	2011-02-02
CA2280089A1 (en)	1998-09-24
IL131041A0 (en)	2001-01-28
SI0969846T1 (en)	2004-06-30
EP0969846B1 (en)	2004-01-07
HU228896B1 (en)	2013-06-28
NO994481L (no)	1999-09-16
PL335168A1 (en)	2000-04-10
CN1249687A (zh)	2000-04-05
DE69820997T3 (de)	2011-10-06
EE9900410A (et)	2000-04-17
PL197509B1 (pl)	2008-04-30
KR100555818B1 (ko)	2006-03-03
CL2009001870A1 (es)	2010-01-22
ATE257385T1 (de)	2004-01-15
BRPI9816218B1 (pt)	2016-04-12
ES2214706T3 (es)	2004-09-16
PE61899A1 (es)	1999-06-30
CN1236775C (zh)	2006-01-18
NZ337322A (en)	2001-05-25
NO327713B1 (no)	2009-09-14
KR20000076330A (ko)	2000-12-26
DK0969846T3 (da)	2004-04-13
PT969846E (pt)	2004-05-31
CO4940427A1 (es)	2000-07-24
DK0969846T4 (da)	2010-12-20
ID22389A (id)	1999-10-07
CY2526B1 (en)	2006-02-08
JP2010043110A (ja)	2010-02-25
JP4920124B2 (ja)	2012-04-18
AU7035398A (en)	1998-10-12
HK1026841A1 (en)	2000-12-29
RU2197970C2 (ru)	2003-02-10
UA63938C2 (uk)	2004-02-16
HUP0002194A2 (hu)	2000-12-28
EE04091B1 (et)	2003-08-15

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