TW201908409A - Scar removal patch and manufacturing method therefor wherein the patch is provided with excellent moisturizing and water absorbency - Google Patents
Scar removal patch and manufacturing method therefor wherein the patch is provided with excellent moisturizing and water absorbencyInfo
- Publication number
- TW201908409A TW201908409A TW106124347A TW106124347A TW201908409A TW 201908409 A TW201908409 A TW 201908409A TW 106124347 A TW106124347 A TW 106124347A TW 106124347 A TW106124347 A TW 106124347A TW 201908409 A TW201908409 A TW 201908409A
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- Prior art keywords
- mol
- polyurethane
- adhesive layer
- patch
- polyurethane adhesive
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 12
- 231100000241 scar Toxicity 0.000 title abstract 3
- 230000003020 moisturizing effect Effects 0.000 title description 9
- 239000004814 polyurethane Substances 0.000 claims abstract description 57
- 229920002635 polyurethane Polymers 0.000 claims abstract description 56
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims abstract description 41
- 229920006264 polyurethane film Polymers 0.000 claims abstract description 37
- 239000013538 functional additive Substances 0.000 claims abstract description 26
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 20
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 19
- 239000005057 Hexamethylene diisocyanate Substances 0.000 claims abstract description 15
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 15
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000004848 polyfunctional curative Substances 0.000 claims abstract description 12
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 239000012790 adhesive layer Substances 0.000 claims description 49
- 102000008186 Collagen Human genes 0.000 claims description 16
- 108010035532 Collagen Proteins 0.000 claims description 16
- 229920001436 collagen Polymers 0.000 claims description 16
- 239000003292 glue Substances 0.000 claims description 16
- 239000010410 layer Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 241000238876 Acari Species 0.000 claims description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 10
- 229920002101 Chitin Polymers 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 10
- 229960003160 hyaluronic acid Drugs 0.000 claims description 10
- 235000010413 sodium alginate Nutrition 0.000 claims description 10
- 229940005550 sodium alginate Drugs 0.000 claims description 10
- 239000000661 sodium alginate Substances 0.000 claims description 10
- 230000035699 permeability Effects 0.000 claims description 6
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000004831 Hot glue Substances 0.000 claims description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000000675 anti-caries Effects 0.000 claims 2
- 229920001971 elastomer Polymers 0.000 claims 1
- 230000002363 herbicidal effect Effects 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 7
- 229920001730 Moisture cure polyurethane Polymers 0.000 abstract 2
- 206010052428 Wound Diseases 0.000 description 13
- 208000027418 Wounds and injury Diseases 0.000 description 13
- 229920003225 polyurethane elastomer Polymers 0.000 description 8
- 206010036790 Productive cough Diseases 0.000 description 7
- 208000024794 sputum Diseases 0.000 description 7
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 230000002980 postoperative effect Effects 0.000 description 6
- 210000003802 sputum Anatomy 0.000 description 6
- 206010072170 Skin wound Diseases 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- -1 acryl Chemical group 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 239000004447 silicone coating Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
本發明涉及除疤貼片技術，特別是有關於一種利用保濕及透氣性的聚氨酯膠來製造的具有非常優良的保濕與吸水效果的手術後預防疤痕產生的貼片及其製造方法。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sputum-removing patch technology, and more particularly to a patch for preventing scarring after surgery which is produced by using a moisturizing and gas permeable polyurethane gel and having excellent moisturizing and water absorbing effects, and a method for producing the same.
周知，傳統除疤貼片及其製造方法之技術中，有(1)矽膠技術，(2)利用壓克力作載體的海藻酸鈉技術，傳統除疤貼片中未添加功能性添加劑。就功能性添加劑添加方式而言，傳統上是物理混合方式，傳統矽膠技術的除疤貼片不透氣，價錢貴，呈現浸潤現象，保濕效果差，不具有抗菌功能，因此待加以改善。此外，傳統利用壓克力做載體下的海藻酸鈉技術是以壓克力聚合合成，所殘存的單體具有毒性，對皮膚會產生過敏反應，傳統除疤貼片中聚氨酯膜上並未塗上點狀膠。It is known that in the techniques of the conventional mites and the manufacturing method thereof, there are (1) silicone technology, (2) sodium alginate technology using acrylic as a carrier, and no functional additive is added to the conventional mites. As far as the functional additive is added, it is traditionally a physical mixing method. The traditional silicone coating has a non-breathable patch, is expensive, exhibits a wetting phenomenon, has a poor moisturizing effect, and has no antibacterial function, so it is to be improved. In addition, the traditional sodium alginate technology using acrylic as a carrier is synthesized by acrylic polymerization, and the remaining monomer is toxic and has an allergic reaction to the skin. The conventional mites are not coated on the polyurethane film. Apply a bit of glue.
有鑑於此，本發明的主要目的在於改善傳統矽膠價錢貴，沒有透氣性，保濕效果差，傳統海藻酸鈉用壓克力當載體時，會具有毒性單體殘留及不具有抗菌功能的問題。In view of this, the main object of the present invention is to improve the cost of the traditional silicone rubber, the gas permeability is not good, and the moisturizing effect is poor. When the traditional sodium alginate is used as a carrier, it has the problem of toxic monomer residue and no antibacterial function.
為了能夠實現上述目的並解決問題，本發明主要目的是提供一種除疤貼片，包括：聚氨酯膠層，底部用於貼附至皮膚的傷口；以及聚氨酯膜，形成於該聚氨酯膠層上，且該聚氨酯膜的上方塗上若干點狀膠；其中，混合2.0~2.2莫耳%的硬化劑六亞甲基二異氰酸酯、0.6~0.8莫耳%的聚乙二醇、0.7~0.9莫耳%的聚丙二醇與0.4~0.6莫耳%的1,4-丁二醇(1,4-butanediol)，以形成主劑，其中，於加入1,4-丁二醇時加入0.05~0.35莫耳%的功能性添加劑，以製成預聚物；再將預聚物反應製成聚氨酯膠層。In order to achieve the above object and solve the problem, the main object of the present invention is to provide a mites patch comprising: a polyurethane adhesive layer, a bottom for attaching to a wound of the skin; and a polyurethane film formed on the polyurethane adhesive layer, and The polyurethane film is coated with a plurality of punctiform gels; wherein, 2.0 to 2.2 mol% of hardener hexamethylene diisocyanate, 0.6 to 0.8 mol% of polyethylene glycol, and 0.7 to 0.9 mol% are mixed. Polypropylene glycol and 0.4-0.6 mol% of 1,4-butanediol to form a main agent, wherein 0.05-0.35 mol% is added when adding 1,4-butanediol A functional additive to form a prepolymer; the prepolymer is then reacted to form a polyurethane layer.
較佳地，相對於1.0莫耳%的預聚物，主劑含有0.1莫耳%的該功能性添加劑。Preferably, the primary agent contains 0.1 mol% of the functional additive relative to 1.0 mol% of the prepolymer.
較佳地，功能性添加劑是選自玻尿酸、膠原蛋白、甲殼素、海藻酸鈉及鋅離子。Preferably, the functional additive is selected from the group consisting of hyaluronic acid, collagen, chitin, sodium alginate and zinc ions.
較佳地，聚氨酯膠層厚度是在0.5~1.0 mm之間，聚氨酯膠層水氣穿透率是每日1500克/平方公尺。Preferably, the thickness of the polyurethane adhesive layer is between 0.5 and 1.0 mm, and the water vapor permeability of the polyurethane adhesive layer is 1500 g/m 2 per day.
較佳地，聚氨酯膜的厚度是在0.01~0.04 mm之間，聚氨酯膜水氣穿透率大於每日3000克/平方公尺。Preferably, the thickness of the polyurethane film is between 0.01 and 0.04 mm, and the water vapor transmission rate of the polyurethane film is greater than 3000 g/m 2 per day.
較佳地，點狀膠是感壓膠或熱熔膠。Preferably, the dot glue is a pressure sensitive adhesive or a hot melt adhesive.
本發明另一目的是提供一種除疤貼片的製造方法，包括：混合2.0~2.2莫耳%的硬化劑六亞甲基二異氰酸酯、0.6~0.8莫耳%的聚乙二醇、0.7~0.9莫耳%的聚丙二醇與0.4~0.6莫耳%的1,4-丁二醇，以形成主劑，其中，於加入1,4-丁二醇時加入0.05~0.35莫耳%的功能性添加劑，以製成預聚物；將預聚物反應製成聚氨酯膠層；在聚氨酯膠層上形成聚氨酯膜，且聚氨酯膠層的底部用於貼附至皮膚的傷口；以及在聚氨酯膜上塗上複數個點狀膠。Another object of the present invention is to provide a method for producing a ruthenium patch comprising: mixing 2.0 to 2.2 mol% of a hardener hexamethylene diisocyanate, 0.6 to 0.8 mol% of polyethylene glycol, 0.7 to 0.9 Molar% of polypropylene glycol and 0.4-0.6 mol% of 1,4-butanediol to form a main agent, wherein 0.05-0.35 mol% of functional additive is added when adding 1,4-butanediol To prepare a prepolymer; react the prepolymer into a polyurethane adhesive layer; form a polyurethane film on the polyurethane adhesive layer, and the bottom of the polyurethane adhesive layer is used for attaching to the wound of the skin; and coating the polyurethane film with a plurality of a bit of glue.
較佳地，相對於1.0莫耳%的該預聚物，該主劑含有0.1莫耳%的該功能性添加劑。Preferably, the primary agent contains 0.1 mol% of the functional additive relative to 1.0 mol% of the prepolymer.
較佳地，功能性添加劑是選自玻尿酸、膠原蛋白、甲殼素、海藻酸鈉及鋅離子。Preferably, the functional additive is selected from the group consisting of hyaluronic acid, collagen, chitin, sodium alginate and zinc ions.
較佳地，聚氨酯膠層厚度是在0.5~1.0 mm之間，且水氣穿透率是每日1500克/平方公尺。Preferably, the thickness of the polyurethane layer is between 0.5 and 1.0 mm, and the water vapor transmission rate is 1500 g/m 2 per day.
請參閱第1圖A至B部分，揭示本發明第一實施例所提供手術後除疤貼片的解說示意圖，說明手術後除疤貼片中具有柔軟性聚氨酯膠層(polyurethane gel layer)10，聚氨酯膠層10上形成有聚氨酯膜20，聚氨酯膠層10之下貼附至皮膚31之傷口30上。聚氨酯膜20的周圍處塗上複數個點狀膠21。Referring to FIG. 1A to B, a schematic diagram of a post-operative sputum patch provided in a first embodiment of the present invention is disclosed, and a post-operative sputum patch has a flexible polyurethane gel layer 10, A polyurethane film 20 is formed on the polyurethane rubber layer 10, and the polyurethane rubber layer 10 is attached to the wound 30 of the skin 31. A plurality of dot glues 21 are applied around the polyurethane film 20.
在本發明中，聚氨酯膠層10上形成有聚氨酯膜20，聚氨酯膠層10的底部是貼附上皮膚31之傷口30上；其中，聚氨酯膠層10是先由2.0~2.2 mole%硬化劑六亞甲基二異氰酸酯(hexamethylene diisocyanate， HDI)與0.6~0.8 mole%聚乙二醇(polyethylene glycol，PEG，Mn2000)與0.7~0.9 mole%聚丙二醇(polypropylene glycol，PPG，Mn2000)與0.4~0.6 mole% 1,4-丁二醇(1,4-butanediol)形成主劑，再於加入該1,4-丁二醇時加入0.05~0.35 mole%功能性添加劑，以製成預聚物；再將預聚物反應製成聚氨酯膠層10；此外，聚氨酯膜20上塗上複數個點狀膠21。In the present invention, a polyurethane film 20 is formed on the polyurethane rubber layer 10, and the bottom of the polyurethane rubber layer 10 is a wound 30 to which the skin 31 is attached; wherein the polyurethane rubber layer 10 is firstly made of 2.0 to 2.2 mole% hardener. Hexamethylene diisocyanate (HDI) with 0.6~0.8 mole% polyethylene glycol (PEG, Mn2000) and 0.7~0.9 mole% polypropylene glycol (PPG, Mn2000) and 0.4~0.6 mole % 1,4-butanediol forms a main agent, and then adds 0.05 to 0.35 mole% of a functional additive to the 1,4-butanediol to prepare a prepolymer; The prepolymer is reacted to form a polyurethane adhesive layer 10; further, the polyurethane film 20 is coated with a plurality of dot adhesives 21.
為了使柔軟性聚氨酯膠層10能保濕保水氣，功能性添加劑可選擇地加入於聚氨酯膠層10內，功能性添加劑是選自玻尿酸(hyaluronic acid)膠原蛋白(collagen)、甲殼素(chitin/chitosan)、海藻酸鈉(sodium alginate)及鋅離子。玻尿酸與膠原蛋白對於傷口具有保濕的功能，聚乙二醇與聚丙二醇對於傷口具有吸水的功能，而甲殼素對於傷口具有抑菌的功能。該聚氨酯膠層10及該聚氨酯膜20都具有透氣性且防水。In order to make the flexible polyurethane adhesive layer 10 moisturizing and retaining moisture, a functional additive is optionally added to the polyurethane adhesive layer 10, and the functional additive is selected from the group consisting of hyaluronic acid collagen (collagen) and chitin (chitin/chitosan). ), sodium alginate and zinc ions. Hyaluronic acid and collagen have a moisturizing function for wounds, and polyethylene glycol and polypropylene glycol have a function of absorbing water for wounds, and chitin has a bacteriostatic function for wounds. Both the urethane layer 10 and the urethane film 20 are breathable and waterproof.
根據本發明，因六亞甲基二異氰酸酯與PEG及PPG還有玻尿酸與膠原蛋白內-OH基作反應且六亞甲基二異氰酸酯與甲殼素的-NH2進行化學交聯。這些化學交聯的聚氨酯膠層10會附在聚氨酯膜上，與傳統的添加物之添加上去是物理混合作用實屬大不同。According to the present invention, hexamethylene diisocyanate is reacted with PEG and PPG and hyaluronic acid in the collagen-OH group, and hexamethylene diisocyanate is chemically crosslinked with chitin-NH2. These chemically crosslinked polyurethane rubber layers 10 are attached to the polyurethane film, which is quite different from the physical addition of the conventional additives.
根據本發明，聚氨酯膠層10厚度在0.5~1.0 mm之間，以0.75 mm為較佳，聚氨酯膠層10水氣穿透率MVTR等於1500 g/m2 .day。根據本發明，所製成的聚氨酯膠層10是很柔軟的，其肖氏硬度A(Shore A)在30~50之間，其延展性(elogation)是在200-800%之間，其抗拉強度(tensile)是10 MPa。According to the present invention, the thickness of the polyurethane rubber layer 10 is between 0.5 and 1.0 mm, preferably 0.75 mm, and the moisture permeability of the polyurethane rubber layer 10 is 1500 g/m 2 .day. According to the present invention, the polyurethane adhesive layer 10 is very soft, and its Shore A is between 30 and 50, and its elongation is between 200 and 800%. The tensile strength is 10 MPa.
根據本發明，聚氨酯膜20的厚度在0.01~0.04 mm之間，以0.025 mm為較佳，聚氨酯膜水氣穿透率MVTR大於3000 g/m2 .day。聚氨酯膜20的功能是阻隔外部細菌感染，防水，抗菌且當做載體。According to the present invention, the thickness of the polyurethane film 20 is between 0.01 and 0.04 mm, preferably 0.025 mm, and the water vapor transmission rate MVTR of the polyurethane film is greater than 3000 g/m 2 .day. The function of the polyurethane film 20 is to block external bacterial infection, waterproof, antibacterial and as a carrier.
本發明與傳統的技術的差異在於：(1)本發明多添加功能性添加劑，功能性添加劑是選自玻尿酸、膠原蛋白、海藻酸鈉及甲殼素，傳統技術並未添加功能性添加劑。(2)就添加方式而言，傳統上是物理混合方式，本發明手術後除疤貼片之添加方式是藉化學交聯作用。本發明的手術後除疤貼片的優點具有非常優良的保濕與吸水效果及具有柔軟性，吸水效果是來自於主劑的PEG及混合物中的PEG2000與PPG2000。玻尿酸與膠原蛋白對於傷口具有保濕的功能，而甲殼素對於傷口具有抑菌的功能，而依據所預計設計手術後除疤貼片的目的，玻尿酸)、膠原蛋白、海藻酸鈉)及甲殼素中可任意選一者或任意選二者或任意選三者。(3)傳統的載體是用不織布，本發明是使用點塗的點狀膠21，因為點狀膠21具有不透氣性，點狀膠21以點狀分佈在聚氨酯膜20上可保持聚氨酯膜20具有透氣性。(4)本發明的手術後除疤貼片內不會有傳統壓克力聚合反應後殘留的毒性單體。The difference between the present invention and the conventional technology is that: (1) The present invention additionally adds a functional additive selected from the group consisting of hyaluronic acid, collagen, sodium alginate and chitin, and the conventional technology does not add a functional additive. (2) In terms of the manner of addition, it is conventionally a physical mixing mode, and the method of adding the post-operative sputum patch of the present invention is by chemical crosslinking. The post-operative sputum patch of the present invention has the advantages of very good moisturizing and water absorbing effects and softness, and the water absorbing effect is derived from PEG 2000 and PPG 2000 in the main agent PEG and the mixture. Hyaluronic acid and collagen have a moisturizing function on the wound, and chitin has a bacteriostatic function on the wound, and is designed according to the intended purpose of designing the post-operative sputum patch, hyaluronic acid), collagen, sodium alginate and chitin. You can choose one or you can choose either or whatever. (3) The conventional carrier is a non-woven fabric, and the present invention uses a dot-coated glue 21 because the dot-like glue 21 has gas impermeability, and the dot-like glue 21 is distributed in a dot shape on the polyurethane film 20 to maintain the polyurethane film 20. It is breathable. (4) The post-operative sputum patch of the present invention does not have residual toxic monomers remaining after the conventional acryl polymerization.
實例AExample A
形成聚氨酯膠層，其中，聚氨酯膠層上形成有聚氨酯膜，聚氨酯膠層下是貼附至皮膚之傷口上；其中，聚氨酯膠層是先由2.2 mole%硬化劑六亞甲基二異氰酸酯與0.8 mole%聚乙二醇PEG2000(polyethylene glycol，PEG，Mn2000)與0.7 mole%聚丙二醇PPG2000(polypropylene glycol，PPG，Mn2000)與0.5 mole% 1,4-丁二醇形成主劑，於加入1,4-丁二醇時不加入功能性添加劑膠原蛋白，以製成預聚物；再反應製成聚氨酯膠層；及在聚氨酯膜上塗上複數個點狀膠。Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the skin wound; wherein the polyurethane adhesive layer is firstly composed of 2.2 mole% hardener hexamethylene diisocyanate and 0.8 Mole% polyethylene glycol PEG2000 (polyethylene glycol, PEG, Mn2000) and 0.7 mole% polypropylene glycol PPG2000 (polypropylene glycol, PPG, Mn2000) and 0.5 mole% 1,4-butanediol form the main agent, add 1,4 - Butanediol is not added with functional additive collagen to form a prepolymer; it is then reacted to form a polyurethane adhesive layer; and a plurality of dot glues are applied to the polyurethane film.
實例BInstance B
形成聚氨酯膠層，其中，聚氨酯膠層上形成有聚氨酯膜，聚氨酯膠層下是貼附至皮膚之傷口上；其中，聚氨酯膠層是先由2.2 mole%硬化劑六亞甲基二異氰酸酯與0.7 mole%聚乙二醇PEG2000與0.8 mole%聚丙二醇PPG2000與0.4~0.6 mole% 1,4-丁二醇形成主劑，於加入1,4-丁二醇時不加入功能性添加劑膠原蛋白，以製成預聚物；再反應製成聚氨酯膠層；及在聚氨酯膜上塗上複數個點狀膠。Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mole% hardener hexamethylene diisocyanate and 0.7 The mole% polyethylene glycol PEG2000 and 0.8 mole% polypropylene glycol PPG2000 and 0.4~0.6 mole% 1,4-butanediol form the main agent, and the functional additive collagen is not added when adding 1,4-butanediol. Forming a prepolymer; reacting to form a polyurethane adhesive layer; and applying a plurality of dot glues on the polyurethane film.
實例CExample C
形成聚氨酯膠層，其中，聚氨酯膠層上形成有聚氨酯膜，聚氨酯膠層下是貼附至皮膚之傷口上；其中，聚氨酯膠層是先由2.2 mole%硬化劑六亞甲基二異氰酸酯與0.6 mole%聚乙二醇PEG2000與0.9 mole%聚丙二醇PPG2000與0.4~0.6 mole% 1,4-丁二醇形成主劑，於加入1,4-丁二醇時不加入功能性添加劑膠原蛋白，以製成預聚物；再反應製成聚氨酯膠層；及在聚氨酯膜上塗上複數個點狀膠。Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mole% hardener hexamethylene diisocyanate and 0.6 The mole% polyethylene glycol PEG2000 and 0.9 mole% polypropylene glycol PPG2000 and 0.4~0.6 mole% 1,4-butanediol form the main agent, and the functional additive collagen is not added when adding 1,4-butanediol. Forming a prepolymer; reacting to form a polyurethane adhesive layer; and applying a plurality of dot glues on the polyurethane film.
實例DExample D
形成聚氨酯膠層，其中，聚氨酯膠層上形成有聚氨酯膜，聚氨酯膠層下是貼附至皮膚之傷口上；其中，聚氨酯膠層是先由2.2 mole%硬化劑六亞甲基二異氰酸酯與0.8 mole%聚乙二醇PEG2000與0.7 mole%聚丙二醇PPG2000與0.4~0.6 mole% 1,4-丁二醇形成主劑，再於加入1,4-丁二醇時加入0.1 mole%功能性添加劑膠原蛋白，以製成預聚物；再反應製成聚氨酯膠層；及在聚氨酯膜上塗上複數個點狀膠。Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the skin wound; wherein the polyurethane adhesive layer is firstly composed of 2.2 mole% hardener hexamethylene diisocyanate and 0.8 Mole% polyethylene glycol PEG2000 and 0.7 mole% polypropylene glycol PPG2000 and 0.4~0.6 mole% 1,4-butanediol form the main agent, and then add 0.1 mole% functional additive collagen when adding 1,4-butanediol The protein is made into a prepolymer; the reaction is made into a polyurethane adhesive layer; and a plurality of dot glues are coated on the polyurethane film.
實例EExample E
形成聚氨酯膠層，其中，聚氨酯膠層上形成有聚氨酯膜，聚氨酯膠層下是貼附至皮膚之傷口上；其中，聚氨酯膠層是先由2.2 mole%硬化劑六亞甲基二異氰酸酯與0.8 mole%聚乙二醇PEG2000與0.7 mole%聚丙二醇PPG2000)與0.4~0.6 mole% 1,4-丁二醇形成主劑，再於加入1,4-丁二醇時加入0.2 mole%功能性添加劑膠原蛋白，以製成預聚物；再反應製成聚氨酯膠層；及在聚氨酯膜上塗上複數個點狀膠。Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the skin wound; wherein the polyurethane adhesive layer is firstly composed of 2.2 mole% hardener hexamethylene diisocyanate and 0.8 Mole% polyethylene glycol PEG2000 and 0.7 mole% polypropylene glycol PPG2000) and 0.4~0.6 mole% 1,4-butanediol form the main agent, and then add 0.2 mole% functional additive when adding 1,4-butanediol Collagen to form a prepolymer; reacted to form a polyurethane adhesive layer; and apply a plurality of dot glues to the polyurethane film.
實例FExample F
形成聚氨酯膠層，其中，聚氨酯膠層上形成有聚氨酯膜，聚氨酯膠層底部是貼附至皮膚之傷口上；其中，聚氨酯膠層是先由2.2 mole%硬化劑六亞甲基二異氰酸酯與0.8 mole%聚乙二醇PEG2000與0.7 mole%聚丙二醇PPG2000與0.4~0.6 mole% 1,4-丁二醇形成主劑，再於加入1,4-丁二醇時加入0.3 mole%功能性添加劑膠原蛋白，以製成預聚物；再反應製成聚氨酯膠層；及在聚氨酯膜上塗上複數個點狀膠。Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the bottom of the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mole% hardener hexamethylene diisocyanate and 0.8 Mole% polyethylene glycol PEG2000 and 0.7 mole% polypropylene glycol PPG2000 and 0.4~0.6 mole% 1,4-butanediol form the main agent, and then add 0.3 mole% functional additive collagen when adding 1,4-butanediol The protein is made into a prepolymer; the reaction is made into a polyurethane adhesive layer; and a plurality of dot glues are coated on the polyurethane film.
聚氨酯膠層的性質
以上實施例僅為表達了本發明的較佳具體實施方式，但並不能因此而理解為對本發明申請專利範圍的限制。應當指出的是，對於本技術領域中的一般技術人員而言，在不脫離本發明構思的前提下，還可做出各種變形和改進，並皆屬於本發明的保護範圍。The above embodiments are merely illustrative of preferred embodiments of the invention, but are not to be construed as limiting the scope of the invention. It should be noted that various modifications and improvements can be made by those skilled in the art without departing from the spirit and scope of the invention.
10‧‧‧聚氨酯膠層10‧‧‧Polyurethane layer
20‧‧‧聚氨酯膜20‧‧‧ Polyurethane film
21‧‧‧點狀膠21‧‧‧ Point glue
30‧‧‧傷口30‧‧‧ wounds
31‧‧‧皮膚31‧‧‧ skin
第1圖A部分是本發明的除疤貼片的截面解說示意圖；B部分是本發明的除疤貼片的上視圖。Fig. 1A is a schematic cross-sectional view of a mites patch of the present invention; and Part B is a top view of the mites patch of the present invention.
Claims (10)
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| TW106124347A TWI638006B (en) | 2017-07-20 | 2017-07-20 | 疤 疤 patch and its manufacturing method |
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| TW106124347A TWI638006B (en) | 2017-07-20 | 2017-07-20 | 疤 疤 patch and its manufacturing method |
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| TWI638006B TWI638006B (en) | 2018-10-11 |
| TW201908409A true TW201908409A (en) | 2019-03-01 |
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| TWI823499B (en) * | 2022-07-27 | 2023-11-21 | 仿生生醫有限公司 | Thin-type hydrophobic sheet and manufacturing method thereof |
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| CN1231192C (en) * | 2002-07-30 | 2005-12-14 | 株式会社发裕瀑 | Multilayer polyporous foam dressing material and its producing method |
| PL1923077T3 (en) * | 2006-11-07 | 2011-06-30 | Hartmann Paul Ag | Multilayer, absorbent wound dressing with a hydophilic wound contact layer |
| KR100777908B1 (en) * | 2006-12-19 | 2007-11-28 | 주식회사 바이오폴 | Polyurethane foam dressing with improved repair rate |
| EP2165718A1 (en) * | 2008-09-19 | 2010-03-24 | Bayer MaterialScience AG | Wound dressing with a polyurethane foam layer and a covering layer made from thermoplastic polymer |
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| TWI823499B (en) * | 2022-07-27 | 2023-11-21 | 仿生生醫有限公司 | Thin-type hydrophobic sheet and manufacturing method thereof |
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