TW201127815A - Crystalline {(3s)-3-[({1-[(2r)-2-carboxy-4-(1-naphthyl)butyl]cyclopentyl}-carbonyl)amino]-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl}acetic acid, its preparation and use - Google Patents

Crystalline {(3s)-3-[({1-[(2r)-2-carboxy-4-(1-naphthyl)butyl]cyclopentyl}-carbonyl)amino]-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl}acetic acid, its preparation and use Download PDF

Info

Publication number: TW201127815A
Authority: TW; Taiwan
Prior art keywords: compound; formula; mixture; preparation; brain damage
Prior art date: 2009-12-07

Application number

TW099142340A

Other languages

English (en)

Chinese (zh)

Inventor

Touria Elhamdaoui-Achterberg

Nicolaas Buizer

Gerrit Klein

Rheenen Jeroen Van

Dasselaar Eric Eibert Van

Guido Dirk Batema

Jong Paulus Petrus Gerardus De

Original Assignee

Abbott Healthcare Products Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-07

Filing date

2010-12-06

Publication date

2011-08-16

2010-12-06 Application filed by Abbott Healthcare Products Bv filed Critical Abbott Healthcare Products Bv

2011-08-16 Publication of TW201127815A publication Critical patent/TW201127815A/zh

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238000002360 preparation method Methods 0.000 title claims abstract description 17
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235000017550 sodium carbonate Nutrition 0.000 description 1
229940005573 sodium fumarate Drugs 0.000 description 1
235000019294 sodium fumarate Nutrition 0.000 description 1
239000008259 solid foam Substances 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
210000003802 sputum Anatomy 0.000 description 1
208000024794 sputum Diseases 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW099142340A 2009-12-07 2010-12-06 Crystalline {(3s)-3-[({1-[(2r)-2-carboxy-4-(1-naphthyl)butyl]cyclopentyl}-carbonyl)amino]-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl}acetic acid, its preparation and use TW201127815A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP09178226		2009-12-07

Publications (1)

Publication Number	Publication Date
TW201127815A true TW201127815A (en)	2011-08-16

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ID=41682516

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Application Number	Title	Priority Date	Filing Date
TW099142340A TW201127815A (en)	2009-12-07	2010-12-06	Crystalline {(3s)-3-[({1-[(2r)-2-carboxy-4-(1-naphthyl)butyl]cyclopentyl}-carbonyl)amino]-2-oxo-2,3,4,5-tetrahydro-1h-1-benzazepin-1-yl}acetic acid, its preparation and use

Country Status (3)

Country	Link
AR (1)	AR079059A1 (es)
TW (1)	TW201127815A (es)
WO (1)	WO2011069944A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19510566A1 (de)	1995-03-23	1996-09-26	Kali Chemie Pharma Gmbh	Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de)	1996-09-18	1998-03-19	Solvay Pharm Gmbh	Die gastrointestinale Durchblutung fördernde Arzneimittel
US7232813B2 (en)	2004-01-12	2007-06-19	Solvay Pharmaceuticals B.V.	Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders
PL1706121T3 (pl)	2004-01-12	2009-02-27	Turski Lechoslaw	Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (HSEP) do zapobiegania i leczenia zaburzeń neurodegeneracyjnych
AU2005315608B2 (en)	2004-12-15	2011-03-31	Solvay Pharmaceuticals Gmbh	Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors

2010
- 2010-11-18 AR ARP100104251A patent/AR079059A1/es unknown
- 2010-12-06 TW TW099142340A patent/TW201127815A/zh unknown
- 2010-12-06 WO PCT/EP2010/068932 patent/WO2011069944A1/en not_active Ceased

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Publication number	Publication date
AR079059A1 (es)	2011-12-21
WO2011069944A1 (en)	2011-06-16

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