AR079059A1 - Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y uso - Google Patents
Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y usoInfo
- Publication number
- AR079059A1 AR079059A1 ARP100104251A ARP100104251A AR079059A1 AR 079059 A1 AR079059 A1 AR 079059A1 AR P100104251 A ARP100104251 A AR P100104251A AR P100104251 A ARP100104251 A AR P100104251A AR 079059 A1 AR079059 A1 AR 079059A1
- Authority
- AR
- Argentina
- Prior art keywords
- benzazepin
- oxo
- carbonyl
- amino
- acid
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000005102 attenuated total reflection Methods 0.000 abstract 1
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composicion farmacéutica y proceso de preparacion. Reivindicacion 1: Ácido {(3S)-3-[((1-[(2R)-2-carboxi-4-(1-naftil)butil]ciclopentil}-carbonil)amino]-2-oxo-2,3,4,5-tetrahidro-1H-1-benzazepin-1-il)acético cristalino, caracterizado porque es el compuesto de formula (1). Reivindicacion 2: El compuesto de acuerdo con la reivindicacion 1, caracterizado porque tiene un espectro de difraccion de rayos X de polvo que tiene reflejos característicos (expresados en grados del ángulo de difraccion 2 theta) a: 16.32, 17.05, 20.38. Reivindicacion 4: El compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 3, caracterizado porque tiene un espectro infrarrojo registrado en Reflectancia Total Atenuada que tiene bandas de absorcion características a 3426, 3267, 3060, 2936, 2876, 2598, 2456, 1736, 1639, 1597, 1512, 1487, 1459, 1441, 1424, 1391, 1315, 1232, 1191, 1137, 781, 773, 735, 713, 670 cm-1. Reivindicacion 5: El compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 4, caracterizado porque tiene un espectro 13C-NMR en estado solido con desplazamientos característicos (expresados en ppm con relacion a glicina (delta c = 176,03 para la resonancia C=O)) a: 177.0, 176.0, 174.7, 172.2, 169.7, 138.9, 136.4, 133.6, 131.5, 130.2, 127.8, 126.5, 125.3, 124.2, 123.2, 121.9, 55.1, 51.0, 41.9, 40.8, 38.5, 37.1, 28.4, 25.9, 23.1, 21.1 +- 0.1 ppm.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09178226 | 2009-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079059A1 true AR079059A1 (es) | 2011-12-21 |
Family
ID=41682516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104251A AR079059A1 (es) | 2009-12-07 | 2010-11-18 | Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y uso |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR079059A1 (es) |
| TW (1) | TW201127815A (es) |
| WO (1) | WO2011069944A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19510566A1 (de) | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19638020A1 (de) | 1996-09-18 | 1998-03-19 | Solvay Pharm Gmbh | Die gastrointestinale Durchblutung fördernde Arzneimittel |
| US7232813B2 (en) | 2004-01-12 | 2007-06-19 | Solvay Pharmaceuticals B.V. | Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders |
| PL1706121T3 (pl) | 2004-01-12 | 2009-02-27 | Turski Lechoslaw | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (HSEP) do zapobiegania i leczenia zaburzeń neurodegeneracyjnych |
| AU2005315608B2 (en) | 2004-12-15 | 2011-03-31 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors |
-
2010
- 2010-11-18 AR ARP100104251A patent/AR079059A1/es unknown
- 2010-12-06 TW TW099142340A patent/TW201127815A/zh unknown
- 2010-12-06 WO PCT/EP2010/068932 patent/WO2011069944A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| TW201127815A (en) | 2011-08-16 |
| WO2011069944A1 (en) | 2011-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |