TW200722089A - New pharmaceutical compositions for treatment of thrombosis - Google Patents

New pharmaceutical compositions for treatment of thrombosis

Info

Publication number: TW200722089A
Authority: TW; Taiwan
Prior art keywords: thrombosis; inhibitors; treatment; pharmaceutical compositions; antagonists
Prior art date: 2005-03-29

Application number

TW095110732A

Other languages

English (en)

Inventor

Paul A Reilly

James C Gilbert

Thomas H Mueller

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-29

Filing date

2006-03-28

Publication date

2007-06-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36423564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200722089(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-03-28 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2007-06-16 Publication of TW200722089A publication Critical patent/TW200722089A/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW095110732A 2005-03-29 2006-03-28 New pharmaceutical compositions for treatment of thrombosis TW200722089A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05006711		2005-03-29

Publications (1)

Publication Number	Publication Date
TW200722089A true TW200722089A (en)	2007-06-16

Family

ID=36423564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095110732A TW200722089A (en)	2005-03-29	2006-03-28	New pharmaceutical compositions for treatment of thrombosis

Country Status (19)

Country	Link
US (2)	US20060222640A1 (zh)
EP (1)	EP1885354A2 (zh)
JP (1)	JP2008534552A (zh)
KR (1)	KR20070116936A (zh)
CN (1)	CN101151030A (zh)
AR (1)	AR056291A1 (zh)
AU (1)	AU2006228600A1 (zh)
BR (1)	BRPI0608656A2 (zh)
CA (1)	CA2602563A1 (zh)
CL (1)	CL2010000395A1 (zh)
EA (1)	EA015122B1 (zh)
IL (1)	IL186267A0 (zh)
MX (1)	MX2007010664A (zh)
NO (1)	NO20074149L (zh)
NZ (1)	NZ562775A (zh)
TW (1)	TW200722089A (zh)
UA (1)	UA92603C2 (zh)
WO (1)	WO2006103206A2 (zh)
ZA (1)	ZA200706698B (zh)

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US8906894B1 (en)	2000-07-27	2014-12-09	Thomas N. Thomas	Methods for preventing and treating thrombotic disorders
US20030181488A1 (en)	2002-03-07	2003-09-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
DE10339862A1 (de) *	2003-08-29	2005-03-24	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
IL159273A0 (en) *	2003-12-09	2004-06-01	Transpharma Medical Ltd	Transdermal delivery system for sustained release of polypeptides
JP2008543359A (ja) *	2005-06-10	2008-12-04	トランスファーマメディカル，リミティド	経皮投薬用のパッチ
AR062057A1 (es) *	2006-07-17	2008-10-15	Boehringer Ingelheim Int	Uso de los inhibidores directos de la trombina
JP2010505906A (ja) *	2006-10-10	2010-02-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	３−［（２−｛［４−（ヘキシルオキシカルボニルアミノ−イミノ−メチル）−フェニルアミノ］−メチル｝−１−メチル−１ｈ−ベンゾイミダゾール−５−カルボニル）−ピリジン−２−イル−アミノ］−プロピオン酸エチルエステルの生理学的に許容される塩
DE102006051625A1 (de)	2006-11-02	2008-05-08	Bayer Materialscience Ag	Kombinationstherapie substituierter Oxazolidinone
JP5508272B2 (ja) *	2007-10-29	2014-05-28	トランスファーマメディカルリミテッド	垂直的なパッチ乾燥
US20110236405A1 (en) *	2008-07-29	2011-09-29	Tel Hashomer Medical Research Infrastructure And Services Ltd.	Coagulation factor modulation for controlling transplant organ size
CA2735983A1 (en) *	2008-09-10	2010-03-18	Transpharma Medical Ltd.	Transdermal delivery of oligosaccharides
JP2013510072A (ja) *	2008-11-11	2013-03-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	従来のワルファリン治療に対して安全性プロフィールが改善されたダビガトランエテキシレートまたはその塩を使用して血栓症を治療または予防するための方法
TW201022238A (en) *	2008-11-11	2010-06-16	Boehringer Ingelheim Int	Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved efficacy over conventional warfarin therapy
TW201031651A (en) *	2008-11-11	2010-09-01	Boehringer Ingelheim Int	Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved efficacy over conventional warfarin therapy
EP2384196B1 (en)	2008-12-30	2017-09-13	Johansson, Pär	Methods of identifying critically ill patients at increased risk of development of organ failure and compounds for the treatment hereof
DK2667878T3 (en)	2011-01-25	2016-06-27	Univ Catholique Louvain	Configurations and methods for cell transplantation
WO2013110354A1 (en) *	2012-01-25	2013-08-01	Université Catholique de Louvain	Compositions and methods for cell transplantation
CN102250099B (zh) *	2011-05-16	2013-10-16	中国药科大学	一类非肽类抗凝血酶抑制剂、其制法以及医药用途
US20130345262A1 (en)	2012-06-25	2013-12-26	Boehringer Ingelheim International Gmbh	Method for prevention of stroke
WO2014060545A1 (en) *	2012-10-19	2014-04-24	Sanovel Ilac Sanayi Ve Ticaret A.S.	Pharmaceutical compositions of dabigatran free base
WO2014060561A1 (en) *	2012-10-19	2014-04-24	Sanovel Ilac Sanayi Ve Ticaret A.S.	Oral pharmaceutical formulations comprising dabigatran
ES2759228T3 (es)	2013-07-05	2020-05-08	Univ Catholique Louvain	Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
DE102014108210A1 (de) *	2014-06-11	2015-12-17	Dietrich Gulba	Rodentizid
CN105250286A (zh) *	2015-11-13	2016-01-20	谭惠娟	一种抗血栓组合物
CN108236612A (zh) *	2016-12-27	2018-07-03	李志忠	用于冠脉介入手术中抗凝的组合产品及其用途
US12251377B2 (en)	2019-03-06	2025-03-18	University Of Rochester	Anticoagulant compositions and uses thereof
US11654036B2 (en)	2020-05-26	2023-05-23	Elixir Medical Corporation	Anticoagulant compounds and methods and devices for their use
CN115192691B (zh) *	2022-08-31	2025-03-04	晓恩医药包装材料(安庆)有限公司	一种阿加曲班注射液及预灌封注射器

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US6087380A (en) *	1949-11-24	2000-07-11	Boehringer Ingelheim Pharma Kg	Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
US5510330A (en) *	1994-03-25	1996-04-23	Boehringer Mannheim Gmbh	Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
NZ286082A (en) *	1995-03-15	1998-09-24	Behringwerke Ag	Method of treating acute myocardial infarction with hirudin and acetylsalicylic acid in patients not undergoing thrombolytic treatment
FR2744918B1 (fr) *	1996-02-19	1998-05-07	Sanofi Sa	Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique
PE121699A1 (es) *	1997-02-18	1999-12-08	Boehringer Ingelheim Pharma	Heterociclos biciclicos disustituidos como inhibidores de la trombina
US6414008B1 (en) *	1997-04-29	2002-07-02	Boehringer Ingelheim Pharma Kg	Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
DE19834751A1 (de) *	1998-08-01	2000-02-03	Boehringer Ingelheim Pharma	Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
GB9930540D0 (en) *	1999-12-23	2000-02-16	Rhone Poulenc Rorer Pharma	Chemical compounds
GB0014134D0 (en) *	2000-06-10	2000-08-02	Astrazeneca Ab	Combination therapy
JP4521186B2 (ja) *	2001-09-14	2010-08-11	田辺三菱製薬株式会社	抗血栓薬とピラゾロン誘導体との組み合わせ薬剤
NZ535663A (en) *	2002-03-07	2006-06-30	Boehringer Ingelheim Pharma	Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino] propionic acid ethyl ester and the salts thereof
DE10235639A1 (de) *	2002-08-02	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel
AU2004231306A1 (en) *	2003-04-24	2004-11-04	Boehringer Ingelheim International Gmbh	Use of dipyridamole or mopidamole for treatment and prevention of thrombo-embolic diseases and disorders caused by excessive formation of thrombin and/or by elevated expression of thrombin receptors

2006
- 2006-03-26 US US11/277,503 patent/US20060222640A1/en not_active Abandoned
- 2006-03-27 BR BRPI0608656-0A patent/BRPI0608656A2/pt not_active IP Right Cessation
- 2006-03-27 JP JP2008503489A patent/JP2008534552A/ja active Pending
- 2006-03-27 CA CA002602563A patent/CA2602563A1/en not_active Abandoned
- 2006-03-27 EP EP06725316A patent/EP1885354A2/en not_active Withdrawn
- 2006-03-27 NZ NZ562775A patent/NZ562775A/en unknown
- 2006-03-27 UA UAA200711762A patent/UA92603C2/ru unknown
- 2006-03-27 WO PCT/EP2006/061046 patent/WO2006103206A2/en not_active Ceased
- 2006-03-27 MX MX2007010664A patent/MX2007010664A/es not_active Application Discontinuation
- 2006-03-27 CN CNA2006800108359A patent/CN101151030A/zh active Pending
- 2006-03-27 AU AU2006228600A patent/AU2006228600A1/en not_active Abandoned
- 2006-03-27 KR KR1020077024953A patent/KR20070116936A/ko not_active Ceased
- 2006-03-27 EA EA200701841A patent/EA015122B1/ru not_active IP Right Cessation
- 2006-03-28 TW TW095110732A patent/TW200722089A/zh unknown
- 2006-03-29 AR ARP060101205A patent/AR056291A1/es unknown
2007
- 2007-08-10 NO NO20074149A patent/NO20074149L/no not_active Application Discontinuation
- 2007-08-13 ZA ZA200706698A patent/ZA200706698B/xx unknown
- 2007-09-25 IL IL186267A patent/IL186267A0/en unknown
2010
- 2010-03-19 US US12/727,933 patent/US20100184729A1/en not_active Abandoned
- 2010-04-21 CL CL2010000395A patent/CL2010000395A1/es unknown

Also Published As

Publication number	Publication date
IL186267A0 (en)	2008-01-20
EA200701841A1 (ru)	2008-02-28
US20100184729A1 (en)	2010-07-22
CA2602563A1 (en)	2006-10-05
NZ562775A (en)	2011-03-31
AU2006228600A1 (en)	2006-10-05
WO2006103206A2 (en)	2006-10-05
ZA200706698B (en)	2008-12-31
AR056291A1 (es)	2007-10-03
MX2007010664A (es)	2007-12-12
KR20070116936A (ko)	2007-12-11
CN101151030A (zh)	2008-03-26
UA92603C2 (ru)	2010-11-25
WO2006103206A3 (en)	2007-01-11
NO20074149L (no)	2007-12-11
US20060222640A1 (en)	2006-10-05
JP2008534552A (ja)	2008-08-28
CL2010000395A1 (es)	2010-08-20
BRPI0608656A2 (pt)	2010-01-19
EA015122B1 (ru)	2011-06-30
EP1885354A2 (en)	2008-02-13

Publication	Publication Date	Title
TW200722089A (en)	2007-06-16	New pharmaceutical compositions for treatment of thrombosis
IS8502A (is)	2006-06-08	Azatvíhringja heteróhringir sem kannabínóíð-viðtakastillar
MX2009005604A (es)	2009-06-08	Inhibidores espiro cetona de acetil-coa carboxilasa.
WO2007148185A3 (en)	2008-03-13	Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
DE60324544D1 (de)	2008-12-18	Muskarin antagonisten
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
ATE362932T1 (de)	2007-06-15	Azaindolverbindungen als kinaseinhibitoren
WO2009144555A8 (en)	2010-12-16	Pyrazolospiroketone acetyl-coa carboxylase inhibitors
MXPA05012025A (es)	2006-02-03	Imidazo y tiazolopiridinas como inhibidores de cinasa jak3.
BR0210507A (pt)	2004-06-15	Azaindóis
SE0302760D0 (sv)	2003-10-20	New compounds
EA200970585A1 (ru)	2009-10-30	Бензамидные производные как агонисты ер-рецепторов
DK1881967T3 (da)	2010-08-16	Substituerede benzo (D) isoaxol-3-yl-amin-forbindelser som analgetika
WO2009065922A3 (de)	2009-10-01	Organische verbindungen
MX2009004746A (es)	2009-05-22	Derivados de 1,2,4-triazol como inhibidores del receptor sigma.
EA201000329A1 (ru)	2010-08-30	Циклические депсипептиды
NO20085212L (no)	2009-01-12	Nye pyridinanaloger
MX2010003849A (es)	2010-04-27	Antagonistas de cgrp.
TW200722081A (en)	2007-06-16	New therapeutic combinations for the treatment or prevention of depression
TW200745062A (en)	2007-12-16	Macrocyclic factor VIIA inhibitors useful as anticoagulants
ATE538124T1 (de)	2012-01-15	Imidazokondensierte tricyclische verbindungen auf thiazoloä4,5-büpyridin-basis und pharmazeutische zusammensetzungen damit
MY147188A (en)	2012-11-14	Substituted imidazole compounds as ksp inhibitors
MX2009003758A (es)	2009-04-22	Antagonistas del receptor de trombina basados en la unidad triciclica modificada de himbacina.
AP1543A (en)	2006-01-11	Phenyl heterocyclyl ethers.
WO2007017728A3 (en)	2008-04-03	Novel heterocyclic compounds