TW200716120A - Pyrazolo-pyrimidine derivatives as mGluR2 antagonists - Google Patents
Pyrazolo-pyrimidine derivatives as mGluR2 antagonistsInfo
- Publication number
- TW200716120A TW200716120A TW095104260A TW95104260A TW200716120A TW 200716120 A TW200716120 A TW 200716120A TW 095104260 A TW095104260 A TW 095104260A TW 95104260 A TW95104260 A TW 95104260A TW 200716120 A TW200716120 A TW 200716120A
- Authority
- TW
- Taiwan
- Prior art keywords
- pyrimidine derivatives
- pyrazolo
- mglur2 antagonists
- treating
- derivatives
- Prior art date
Links
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
- 108010038421 metabotropic glutamate receptor 2 Proteins 0.000 title 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101027 | 2005-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200716120A true TW200716120A (en) | 2007-05-01 |
Family
ID=36090752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095104260A TW200716120A (en) | 2005-02-11 | 2006-02-08 | Pyrazolo-pyrimidine derivatives as mGluR2 antagonists |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7361659B2 (zh) |
| EP (1) | EP1851225B1 (zh) |
| JP (1) | JP4708438B2 (zh) |
| KR (1) | KR100968291B1 (zh) |
| CN (1) | CN101115755B (zh) |
| AR (1) | AR052568A1 (zh) |
| AT (1) | ATE512966T1 (zh) |
| AU (1) | AU2006212457B2 (zh) |
| BR (1) | BRPI0607927A2 (zh) |
| CA (1) | CA2597608C (zh) |
| ES (1) | ES2365406T3 (zh) |
| IL (1) | IL184712A (zh) |
| MX (1) | MX2007009106A (zh) |
| NO (1) | NO20073876L (zh) |
| RU (1) | RU2402553C2 (zh) |
| TW (1) | TW200716120A (zh) |
| WO (1) | WO2006084634A1 (zh) |
| ZA (1) | ZA200706353B (zh) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2085398A1 (en) * | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| US8207181B2 (en) | 2008-03-06 | 2012-06-26 | Sanofi | Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof |
| EP2268645B1 (en) * | 2008-03-06 | 2014-11-12 | Sanofi | Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof as allosteric modulators of mglur |
| EP2604602A4 (en) | 2010-08-11 | 2013-12-18 | Taisho Pharmaceutical Co Ltd | HETEROARYL PYRAZOLE DERIVATIVE |
| US9447099B2 (en) * | 2011-10-04 | 2016-09-20 | Hoffmann-La Roche Inc. | Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine |
| ES2627347T3 (es) * | 2011-10-20 | 2017-07-27 | Glaxosmithkline Llc | Aza-heterociclos bicíclicos sustituidos y análogos como moduladores de sirtuina |
| EP2666775A1 (en) | 2012-05-21 | 2013-11-27 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| KR20150070187A (ko) | 2012-10-23 | 2015-06-24 | 에프. 호프만-라 로슈 아게 | 자폐 장애의 치료를 위한 ｍｇｌｕ２／３ 길항제 |
| CA2943877A1 (en) | 2014-04-23 | 2015-10-29 | F. Hoffmann-La Roche Ag | Mglu2/3 antagonists for the treatment of intellectual disabilities |
| JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| IL252053B2 (en) | 2014-11-06 | 2024-04-01 | Lysosomal Therapeutics Inc | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2016073889A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
| AU2015357169B2 (en) | 2014-12-03 | 2021-03-04 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2 PET ligands |
| PL236355B1 (pl) * | 2015-04-02 | 2021-01-11 | Celon Pharma Spolka Akcyjna | Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3 |
| US11045562B2 (en) | 2015-12-18 | 2021-06-29 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 PET ligands |
| PT3389727T (pt) | 2015-12-18 | 2020-10-30 | Janssen Pharmaceutica Nv | Ligantes pet de mglur2/3 radiomarcados |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| KR20180133461A (ko) * | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| US11124516B2 (en) | 2016-04-06 | 2021-09-21 | BIAL-BioTech Investments, Inc. | Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| MX389579B (es) | 2016-05-05 | 2025-03-20 | Bial R&D Invest S A | IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| WO2018127207A1 (zh) * | 2017-01-09 | 2018-07-12 | 南京明德新药研发股份有限公司 | 噻唑衍生物及其应用 |
| ES2991283T3 (es) | 2017-11-24 | 2024-12-03 | Sumitomo Pharma Co Ltd | Derivado de 6,7-dihidropirazolo[1,5-a]pirazinona y aplicación médica del mismo |
| EP3819297B1 (en) * | 2018-07-06 | 2024-04-03 | Phaeno Therapeutics Co., Ltd. | Crystal forms of thiazole compound and application thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT880523E (pt) | 1996-02-07 | 2007-01-31 | Neurocrine Biosciences Inc | Pirazolopirimidinas com antagonistas dos receptores de crf |
| DE69804273T2 (de) | 1997-07-18 | 2002-10-31 | F. Hoffmann-La Roche Ag, Basel | 5h-Thiazolo[3,2-a]pyrimidinderivate |
| WO2000059908A2 (en) | 1999-04-06 | 2000-10-12 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
| DK1379511T3 (da) * | 2001-04-12 | 2005-11-07 | Hoffmann La Roche | Dihydro-benzo[b][1,4]diazepin-2-on-derivater som mGLuR2-antagonister II |
| JP2006523707A (ja) * | 2003-04-15 | 2006-10-19 | アストラゼネカ アクツィエボラーグ | 治療化合物 |
| US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| EP1761541B1 (en) * | 2004-06-21 | 2008-01-09 | F.Hoffmann-La Roche Ag | Pyrrazolo-pyrimidine derivatives |
-
2006
- 2006-02-03 BR BRPI0607927-0A patent/BRPI0607927A2/pt not_active IP Right Cessation
- 2006-02-03 KR KR1020077018345A patent/KR100968291B1/ko not_active Expired - Fee Related
- 2006-02-03 AT AT06706609T patent/ATE512966T1/de active
- 2006-02-03 RU RU2007128624/04A patent/RU2402553C2/ru not_active IP Right Cessation
- 2006-02-03 EP EP06706609A patent/EP1851225B1/en not_active Expired - Lifetime
- 2006-02-03 CA CA2597608A patent/CA2597608C/en not_active Expired - Fee Related
- 2006-02-03 WO PCT/EP2006/000940 patent/WO2006084634A1/en not_active Ceased
- 2006-02-03 AU AU2006212457A patent/AU2006212457B2/en not_active Ceased
- 2006-02-03 MX MX2007009106A patent/MX2007009106A/es active IP Right Grant
- 2006-02-03 ES ES06706609T patent/ES2365406T3/es not_active Expired - Lifetime
- 2006-02-03 CN CN2006800046579A patent/CN101115755B/zh not_active Expired - Fee Related
- 2006-02-03 JP JP2007554484A patent/JP4708438B2/ja not_active Expired - Fee Related
- 2006-02-06 AR ARP060100412A patent/AR052568A1/es not_active Application Discontinuation
- 2006-02-06 US US11/348,105 patent/US7361659B2/en not_active Expired - Fee Related
- 2006-02-08 TW TW095104260A patent/TW200716120A/zh unknown
-
2007
- 2007-07-19 IL IL184712A patent/IL184712A/en not_active IP Right Cessation
- 2007-07-24 NO NO20073876A patent/NO20073876L/no not_active Application Discontinuation
- 2007-07-31 ZA ZA200706353A patent/ZA200706353B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL184712A (en) | 2013-05-30 |
| JP2008530042A (ja) | 2008-08-07 |
| AU2006212457B2 (en) | 2011-04-14 |
| AR052568A1 (es) | 2007-03-21 |
| JP4708438B2 (ja) | 2011-06-22 |
| BRPI0607927A2 (pt) | 2009-10-20 |
| RU2402553C2 (ru) | 2010-10-27 |
| CN101115755B (zh) | 2013-01-16 |
| ZA200706353B (en) | 2009-09-30 |
| AU2006212457A1 (en) | 2006-08-17 |
| US20060183756A1 (en) | 2006-08-17 |
| CA2597608C (en) | 2013-12-24 |
| ES2365406T3 (es) | 2011-10-04 |
| IL184712A0 (en) | 2007-12-03 |
| US7361659B2 (en) | 2008-04-22 |
| WO2006084634A1 (en) | 2006-08-17 |
| RU2007128624A (ru) | 2009-03-20 |
| NO20073876L (no) | 2007-09-10 |
| EP1851225A1 (en) | 2007-11-07 |
| MX2007009106A (es) | 2007-09-11 |
| CN101115755A (zh) | 2008-01-30 |
| KR20070104592A (ko) | 2007-10-26 |
| ATE512966T1 (de) | 2011-07-15 |
| KR100968291B1 (ko) | 2010-07-07 |
| CA2597608A1 (en) | 2006-08-17 |
| EP1851225B1 (en) | 2011-06-15 |
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