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TW200640932A - Clopidogrel base suitable for pharmaceutical formulation and preparation thereof - Google Patents

Clopidogrel base suitable for pharmaceutical formulation and preparation thereof

Info

Publication number
TW200640932A
TW200640932A TW095106394A TW95106394A TW200640932A TW 200640932 A TW200640932 A TW 200640932A TW 095106394 A TW095106394 A TW 095106394A TW 95106394 A TW95106394 A TW 95106394A TW 200640932 A TW200640932 A TW 200640932A
Authority
TW
Taiwan
Prior art keywords
preparation
pharmaceutical formulation
base suitable
clopidogrel base
clopidogrel
Prior art date
Application number
TW095106394A
Other languages
English (en)
Inventor
Eran Turgeman
Omer Malachi
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of TW200640932A publication Critical patent/TW200640932A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW095106394A 2005-02-24 2006-02-24 Clopidogrel base suitable for pharmaceutical formulation and preparation thereof TW200640932A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65673805P 2005-02-24 2005-02-24
US65954405P 2005-03-07 2005-03-07
US66170105P 2005-03-14 2005-03-14
US67537105P 2005-04-26 2005-04-26

Publications (1)

Publication Number Publication Date
TW200640932A true TW200640932A (en) 2006-12-01

Family

ID=36928058

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095106394A TW200640932A (en) 2005-02-24 2006-02-24 Clopidogrel base suitable for pharmaceutical formulation and preparation thereof

Country Status (8)

Country Link
US (1) US20060223845A1 (zh)
EP (1) EP1851231A2 (zh)
JP (1) JP2008526896A (zh)
CA (1) CA2594763A1 (zh)
IL (1) IL184034A0 (zh)
MX (1) MX2007010267A (zh)
TW (1) TW200640932A (zh)
WO (1) WO2006091847A2 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
CA2655844A1 (en) * 2006-08-03 2008-02-14 Teva Pharmaceutical Industries Ltd. Process for preparing clopidogrel bisulphate
WO2008032995A1 (en) * 2006-09-15 2008-03-20 Boryung Pharmaceutical Co., Ltd Clopidogrel(+)-camphorsulfonate salt, method of preparing the same and a pharmaceutical composition comprising the same
CA2685331C (en) 2007-04-27 2016-07-05 Cydex Pharmaceuticals, Inc. Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
WO2008146249A1 (en) * 2007-05-30 2008-12-04 Wockhardt Research Centre Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
DK3100728T3 (da) 2009-05-13 2020-02-17 Cydex Pharmaceuticals Inc Farmaceutiske sammensætninger omfattende prasugrel og cyclodextrin-derivativ og fremgangsmåder til fremstilling og brug af samme

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664276B1 (fr) * 1990-07-04 1992-10-23 Sanofi Sa Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.
US5576328A (en) * 1994-01-31 1996-11-19 Elf Sanofi Method for the secondary prevention of ischemic events
US5872293A (en) * 1997-01-21 1999-02-16 Albemarle Corporation Separating ammonium chloride from N-hydrocarbylphosphoric triamide or N-hydrocarbylthiophosphoric triamide
FR2760456B1 (fr) * 1997-03-05 2000-05-12 Sanofi Sa Procede de preparation de derives de 2-thienyl-ethylamine
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
NZ515158A (en) * 1999-04-27 2003-06-30 Sterol Technologies Ltd Process for the purification of sterols from hydrocarbon extracts using evaporative fractionation
EP1389622A3 (en) * 1999-04-27 2004-12-15 Sterol Technologies Ltd. Process for the purification of sterols from hydrocarborn extracts using evaporative fractionation
EP1409475B1 (en) * 2001-06-27 2005-10-05 Cyclics Corporation Isolation, formulation, and shaping of macrocyclic oligoesters
US6767913B2 (en) * 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
ATE456553T1 (de) * 2002-11-27 2010-02-15 Chevron Phillips Chemical Co Herstellung von dithiodiglykol
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
EP1651646B1 (en) * 2003-08-04 2012-05-09 Wockhardt Limited A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i
GB0325603D0 (en) * 2003-11-03 2003-12-10 Sandoz Ag Organic compounds
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof

Also Published As

Publication number Publication date
CA2594763A1 (en) 2006-08-31
WO2006091847A2 (en) 2006-08-31
WO2006091847A3 (en) 2007-03-22
US20060223845A1 (en) 2006-10-05
MX2007010267A (es) 2007-09-11
EP1851231A2 (en) 2007-11-07
IL184034A0 (en) 2007-10-31
JP2008526896A (ja) 2008-07-24

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