[go: up one dir, main page]

TW200514593A - Method and device for enhancing transdermal agent flux - Google Patents

Method and device for enhancing transdermal agent flux

Info

Publication number
TW200514593A
TW200514593A TW093123149A TW93123149A TW200514593A TW 200514593 A TW200514593 A TW 200514593A TW 093123149 A TW093123149 A TW 093123149A TW 93123149 A TW93123149 A TW 93123149A TW 200514593 A TW200514593 A TW 200514593A
Authority
TW
Taiwan
Prior art keywords
microprojections
microprojection
transdermal agent
agent flux
enhancing transdermal
Prior art date
Application number
TW093123149A
Other languages
English (en)
Inventor
Patrick S L Wong
Peter Daddona
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of TW200514593A publication Critical patent/TW200514593A/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B10/0064Devices for taking samples of body liquids for taking sweat or sebum samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B2010/0009Testing for drug or alcohol abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW093123149A 2003-08-04 2004-08-03 Method and device for enhancing transdermal agent flux TW200514593A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49261003P 2003-08-04 2003-08-04

Publications (1)

Publication Number Publication Date
TW200514593A true TW200514593A (en) 2005-05-01

Family

ID=34193137

Family Applications (2)

Application Number Title Priority Date Filing Date
TW093123149A TW200514593A (en) 2003-08-04 2004-08-03 Method and device for enhancing transdermal agent flux
TW093123148A TW200514596A (en) 2003-08-04 2004-08-03 Method and device for enhancing transdermal agent flux

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW093123148A TW200514596A (en) 2003-08-04 2004-08-03 Method and device for enhancing transdermal agent flux

Country Status (13)

Country Link
US (2) US20050031676A1 (zh)
EP (2) EP1656178A1 (zh)
JP (2) JP2007501071A (zh)
KR (2) KR20060115716A (zh)
CN (2) CN1863572A (zh)
AR (2) AR045205A1 (zh)
AU (2) AU2004264320A1 (zh)
BR (2) BRPI0413354A (zh)
CA (2) CA2534823A1 (zh)
MX (2) MXPA06001414A (zh)
SG (2) SG130191A1 (zh)
TW (2) TW200514593A (zh)
WO (2) WO2005016440A1 (zh)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
KR101323980B1 (ko) 2002-07-19 2013-10-30 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
JP2007501071A (ja) * 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置
AU2004268616B2 (en) * 2003-08-25 2010-10-07 3M Innovative Properties Company Delivery of immune response modifier compounds
JP2007523771A (ja) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの成形方法
JP5007427B2 (ja) * 2004-05-13 2012-08-22 アルザ コーポレイション 副甲状腺ホルモン剤の経皮送達のための装置および方法
TW200616660A (en) * 2004-08-11 2006-06-01 Alza Corp Apparatus and method for transdermal delivery of natriuretic peptides
EP1814574A4 (en) 2004-10-27 2009-08-05 Univ Denver ANALOGUE OF ADRENOCORTICOTROPEN HORMON AND CORRESPONDING METHODS
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2005306426B2 (en) * 2004-11-18 2011-04-28 3M Innovative Properties Company Masking method for coating a microneedle array
WO2006055844A2 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
AU2006230308A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
WO2007002523A2 (en) * 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
US20090130127A1 (en) 2005-08-01 2009-05-21 Seiji Tokumoto Adjuvant or Pharmaceutical Preparation for Transdermal or Transmucousal Administration
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
ATE532553T1 (de) 2006-02-10 2011-11-15 Hisamitsu Pharmaceutical Co Transdermales arzneiverabreichungsgerät mit mikronadeln
US20090099502A1 (en) * 2006-04-07 2009-04-16 Hisamitsu Pharmaceutical Co., Inc. Microneedle Device And Transdermal Administration Device Provided With Microneedles
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
JP5275047B2 (ja) 2007-01-31 2013-08-28 久光製薬株式会社 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤
AU2008241470B2 (en) * 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
KR101522747B1 (ko) * 2007-08-06 2015-05-26 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
WO2010006186A1 (en) * 2008-07-09 2010-01-14 Grantadler Corporation Needle for subcutaneous port
JP5902390B2 (ja) 2008-12-26 2016-04-13 久光製薬株式会社 マイクロニードルデバイス
ES2634667T3 (es) * 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
JP5785559B2 (ja) * 2009-12-16 2015-09-30 クロンテック ファーマ アーベー 注射針および注射装置
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
CN101961508A (zh) * 2010-09-30 2011-02-02 浙江大学 一种聚电解质复合涂层的制备方法
EP2665504A4 (en) * 2011-01-18 2017-01-25 Massachusetts Institute of Technology Deployable barbed microneedle array and uses thereof
EP2679242B1 (en) 2011-02-25 2020-09-09 Hisamitsu Pharmaceutical Co., Inc. Adjuvant for transdermal or transmucosal administration and pharmaceutical preparation containing same
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
CN112933391A (zh) * 2012-05-01 2021-06-11 高等教育联邦系统-匹兹堡大学 用于经皮插入的尖端负载的微针阵列
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP3021930B1 (en) * 2013-07-16 2020-10-07 3M Innovative Properties Company Hollow microneedle with beveled tip
CN105407957A (zh) * 2013-07-16 2016-03-16 3M创新有限公司 一种包括微针的制品
SG11201600331YA (en) * 2013-07-16 2016-02-26 3M Innovative Properties Co Hollow microneedle with bevel opening
CN105517621B (zh) * 2013-09-06 2019-01-01 久光制药株式会社 微型针片材
EP3064218B1 (en) 2013-10-31 2019-06-19 Hisamitsu Pharmaceutical Co., Inc. Adjuvant composition
EP2905047A1 (de) * 2014-02-10 2015-08-12 LTS LOHMANN Therapie-Systeme AG Mikronadelsystem und Verfahren seiner Herstellung
JP6325082B2 (ja) * 2014-02-27 2018-05-16 久光製薬株式会社 マイクロニードル・シート
US9138191B1 (en) * 2014-07-09 2015-09-22 Qualcomm Incorporated Integrated circuit module with lead frame micro-needles
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016088886A1 (ja) 2014-12-05 2016-06-09 久光製薬株式会社 マイクロニードルデバイスシステム
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP2015192879A (ja) * 2015-06-19 2015-11-05 ニプロ株式会社 ワクチン接種針
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
CN108778365B (zh) * 2016-01-11 2021-05-25 沃达瑞公司 微针组合物及其使用方法
WO2017135060A1 (ja) * 2016-02-04 2017-08-10 凸版印刷株式会社 マイクロニードル
JP2019513070A (ja) 2016-03-01 2019-05-23 キトテック メディカル, インコーポレイテッド 創傷閉鎖のための微細構造に基づくシステム、装置および方法
JP6717638B2 (ja) * 2016-03-31 2020-07-01 花王株式会社 開孔部を有する微細中空突起具の製造方法
WO2017176069A2 (ko) * 2016-04-07 2017-10-12 랩앤피플주식회사 생체흡수성 금속을 이용한 마이크로 니들
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
CN108403617A (zh) * 2018-02-24 2018-08-17 中山大学 曲安奈德可溶性微针及其制备方法
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
ES2964349T3 (es) * 2018-06-26 2024-04-05 Hisamitsu Pharmaceutical Co Dispositivo de microagujas y método para la fabricación del mismo
AU2020315774A1 (en) * 2019-07-22 2022-02-10 The Trustees Of Indiana University Technologies for needles with microchannels
CN110664439B (zh) * 2019-09-05 2021-07-27 华中科技大学 一种可提取皮肤组织液的微针及其制备方法
US11986613B2 (en) 2020-02-19 2024-05-21 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
CN116723879A (zh) * 2020-12-30 2023-09-08 佐治亚科技研究公司 用于诱导汗液以进行医学诊断的方法和装置
WO2023159181A1 (en) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
FR3162613A1 (fr) * 2024-06-04 2025-12-05 Anatox Système de recueil de biomatériau et/ou de dépôt de particules sur une cible et procédé associé

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
USRE25637E (en) * 1964-09-08 Means for vaccinating
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US6559123B1 (en) * 1985-04-19 2003-05-06 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
SE8501990D0 (sv) * 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5205023A (en) * 1990-04-18 1993-04-27 Hunter Robert M Child-resistant buckle and buckle guard combination
US6586006B2 (en) * 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6033582A (en) * 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
DE69719761T2 (de) * 1996-06-18 2003-12-18 Alza Corp., Palo Alto Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
KR100572539B1 (ko) * 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
KR100557261B1 (ko) * 1997-12-11 2006-03-07 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
WO1999029365A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
WO2000012173A1 (en) * 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
EP1187653B1 (en) * 1999-06-04 2010-03-31 Georgia Tech Research Corporation Devices for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
CZ20031035A3 (cs) * 2000-10-13 2004-02-18 Alza Corporation Nárazový aplikátor opatřený množinou mikročepelek
KR20030068136A (ko) * 2000-10-13 2003-08-19 알자 코포레이션 미세 돌기부로 피부를 천공하기 위한 장치 및 방법
MXPA03003303A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Retenedor del miembro de microprotrusion para aplicador de impacto.
WO2002094368A1 (en) * 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
EP1485317A2 (en) * 2001-11-30 2004-12-15 Alza Corporation Methods and apparatuses for forming microprojection arrays
RU2314760C2 (ru) * 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
EP1499890B1 (en) * 2002-05-07 2010-04-28 The Research Foundation of State University of New York High throughput method to identify biomolecule delivery formulations
KR20050054483A (ko) * 2002-06-28 2005-06-10 알자 코포레이션 코팅된 미세돌출부를 갖는 경피용 약물 전달 장치
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
JP2007501071A (ja) * 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置

Also Published As

Publication number Publication date
BRPI0413354A (pt) 2006-10-10
SG130190A1 (en) 2007-03-20
MXPA06001409A (es) 2006-08-25
SG130191A1 (en) 2007-03-20
EP1654030A1 (en) 2006-05-10
EP1656178A1 (en) 2006-05-17
WO2005016440A1 (en) 2005-02-24
WO2005016441A1 (en) 2005-02-24
KR20060115717A (ko) 2006-11-09
CN1863571A (zh) 2006-11-15
JP2007501071A (ja) 2007-01-25
KR20060115716A (ko) 2006-11-09
AR045205A1 (es) 2005-10-19
AR045206A1 (es) 2005-10-19
AU2004264319A1 (en) 2005-02-24
US20050049549A1 (en) 2005-03-03
BRPI0413360A (pt) 2006-10-10
JP2007501070A (ja) 2007-01-25
MXPA06001414A (es) 2006-08-25
CA2534821A1 (en) 2005-02-24
US20050031676A1 (en) 2005-02-10
CA2534823A1 (en) 2005-02-24
AU2004264320A1 (en) 2005-02-24
CN1863572A (zh) 2006-11-15
TW200514596A (en) 2005-05-01

Similar Documents

Publication Publication Date Title
TW200514593A (en) Method and device for enhancing transdermal agent flux
WO2007008700A3 (en) Method and apparatus for the treatment of tissue
WO2007120363A3 (en) Medical device insertion
AU2003264354A1 (en) Medical treatment system, endoscope system, endoscope insert operation program, and endoscope device
BR0113196B1 (pt) folha de topo para contacto com o tecido do corpo para um artigo absorvente, dispositivo e artigo absorvente inserÍvel no espaÇo interlabial de uma usuÁria feminina, tampço que compreende a folha de topo e processo para capturar descargas provenientes de uma fonte de descargas no corpo de uma usuÁria.
CY1109972T1 (el) Χρηση τοξινης αλλαντιασης για τη θεραπευτικη αγωγη του πονου της νεραλγιας
WO2005048942A3 (en) Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent
WO2007027788A3 (en) Analyte sensor introducer and methods of use
AU2003280756A1 (en) Lancet and needle insertion device
CR8012A (es) Clavo endomedular destinado al tratamiento de fracturas de femur proximal
WO2005107730A3 (en) Cysteamines for treating complications of hypercholesterolemia and diabetes
AU2003244890A1 (en) An infusion device for medical use.
AU2003238427A1 (en) Method and device for determining blood volume during an extracorporeal blood treatment
IT1318370B1 (it) Metodo e dispositivo per la diagnosi e la terapia dello scompensocardiaco cronico.
PL1835950T4 (pl) Urządzenie i sposób wykrywania komplikacji podczas pozaustrojowej obróbki krwi
WO2009024947A3 (en) Device for dialysis and stimulation of a patient and method
EP2289574A3 (en) Medical devices and methods of making medical devices
WO2006086442A3 (en) Method of detecting abnormal tissue
IL165052A0 (en) Medium for contrast enhancement or convenience forultrasonic, endoscopic and other medical examinat ions
CY1110182T1 (el) Ιδεβενονη για τη θεραπεια των μυϊκων δυστροφιων
AU2003246537A1 (en) Device for needle-free injection of a medium into the tissue of a human or an animal, device for needle free production of an injection channel and method for the needle free injection of a medium in the tissue
WO2004079329A3 (en) Identification of therapeutic compounds
WO2008079355A3 (en) Method and system for enhancing self-treatment of onychomycosis
WO2004080477A8 (en) Aplidine for multiple myeloma treatment
ZA200502307B (en) Method for treating patients with massive blood loss