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TR200003844T2 - Epotilon türevleri, sentezleri ve kullanımları - Google Patents

Epotilon türevleri, sentezleri ve kullanımları

Info

Publication number
TR200003844T2
TR200003844T2 TR2000/03844T TR200003844T TR200003844T2 TR 200003844 T2 TR200003844 T2 TR 200003844T2 TR 2000/03844 T TR2000/03844 T TR 2000/03844T TR 200003844 T TR200003844 T TR 200003844T TR 200003844 T2 TR200003844 T2 TR 200003844T2
Authority
TR
Turkey
Prior art keywords
unit
units
group
single bond
present
Prior art date
Application number
TR2000/03844T
Other languages
English (en)
Inventor
Costa Nicolaou Kyriacos
Paul King Nigel
Raymond Verschoyle Finlay Maurice
He Yun
Roschangar Frank
Vourloumis Dionisios
Vallberg Hans
Bigot Antony
Original Assignee
Novartis Ag
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, The Scripps Research Institute filed Critical Novartis Ag
Publication of TR200003844T2 publication Critical patent/TR200003844T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut bulus, asagidaki formülle gösterilen bir epotilon analogu ile ilgili olup, R2 birimi bulunmayan ya da oksijen olan; ''a'' tek ya da çift bag olabilen; ''b'' birimi bulunmayan ya da bir tek bag olan; ve R2 grubunun oksijen olmasi halinde ''b'' ve ''c'' birimlerinin her ikisi bir tek bag ve ''a'' biriminin de bir tek bag olmasi; R2 grubunun mevcut olmamasi halinde ''b'' ve ''c'' birimleri de mevcut olmayan ve ''a'' biriminin bir çift bag olmasi; ve ''a'' biriminin bir çift bag olmasi halinde R2, ''b'' ve ''c'' birimlerinin mevcut olmamasi sartlari ile ''c'' birimi ya mevcut olmayan ya da bir tek bag; R3 birimi, hidrojen; düsük alkil; -CH=CH2; -C=CH; -CH2F; -CH2Cl; -CH2-OH; -CH2-O-(C1-C6-alkil); -CH2-S-(C1-C6-alkil); olusan gruptan seçilen bir radikal; R4 ve R5 birimleri birbirinden bagimsiz olarak hidrojen, metil ya da koruyucu; ve R1, sartnamede tarif edildigi gibidir veya bir tuz olusturucu grubun mevcut olmasi durumunda I formülü bilesiginin bir tuzudur (DEVAMI VAR).
TR2000/03844T 1998-06-22 1999-06-21 Epotilon türevleri, sentezleri ve kullanımları TR200003844T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/102,602 US6380394B1 (en) 1996-12-13 1998-06-22 Epothilone analogs

Publications (1)

Publication Number Publication Date
TR200003844T2 true TR200003844T2 (tr) 2001-04-20

Family

ID=22290705

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03844T TR200003844T2 (tr) 1998-06-22 1999-06-21 Epotilon türevleri, sentezleri ve kullanımları

Country Status (27)

Country Link
US (3) US6380394B1 (tr)
EP (2) EP1089998B1 (tr)
JP (1) JP4681732B2 (tr)
KR (3) KR20080045298A (tr)
CN (1) CN1192031C (tr)
AT (1) ATE343573T1 (tr)
AU (1) AU757854B2 (tr)
BR (1) BR9911420A (tr)
CA (1) CA2334342C (tr)
CY (1) CY1105863T1 (tr)
CZ (1) CZ301783B6 (tr)
DE (1) DE69933767T2 (tr)
DK (1) DK1089998T3 (tr)
ES (1) ES2273502T3 (tr)
HU (1) HUP0102711A3 (tr)
ID (1) ID28210A (tr)
IL (3) IL139784A0 (tr)
MX (1) MXPA00012443A (tr)
NO (1) NO328417B1 (tr)
NZ (1) NZ508622A (tr)
PL (1) PL197648B1 (tr)
PT (1) PT1089998E (tr)
RU (1) RU2227142C2 (tr)
SK (2) SK287864B6 (tr)
TR (1) TR200003844T2 (tr)
WO (1) WO1999067252A2 (tr)
ZA (1) ZA200007059B (tr)

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Also Published As

Publication number Publication date
SK19712000A3 (sk) 2001-09-11
AU757854B2 (en) 2003-03-06
CA2334342C (en) 2012-07-17
KR100864742B1 (ko) 2008-10-22
PL345327A1 (en) 2001-12-17
US6380394B1 (en) 2002-04-30
WO1999067252A2 (en) 1999-12-29
ATE343573T1 (de) 2006-11-15
NO20006378D0 (no) 2000-12-14
DE69933767D1 (de) 2006-12-07
SK285647B6 (sk) 2007-05-03
IL139784A0 (en) 2002-02-10
AU4774899A (en) 2000-01-10
IL182744A (en) 2010-05-17
EP1089998B1 (en) 2006-10-25
JP2002518504A (ja) 2002-06-25
ES2273502T3 (es) 2007-05-01
IL139784A (en) 2010-05-17
CZ20004769A3 (cs) 2001-07-11
JP4681732B2 (ja) 2011-05-11
PT1089998E (pt) 2007-01-31
KR20080045298A (ko) 2008-05-22
CZ301783B6 (cs) 2010-06-23
CN1306531A (zh) 2001-08-01
HUP0102711A2 (hu) 2001-12-28
ZA200007059B (en) 2002-01-30
KR20010083060A (ko) 2001-08-31
EP1089998A2 (en) 2001-04-11
ID28210A (id) 2001-05-10
SK287864B6 (sk) 2012-02-03
US6531497B1 (en) 2003-03-11
US20030203938A1 (en) 2003-10-30
DK1089998T3 (da) 2007-01-15
WO1999067252A3 (en) 2000-03-16
RU2227142C2 (ru) 2004-04-20
BR9911420A (pt) 2001-03-20
CA2334342A1 (en) 1999-12-29
NZ508622A (en) 2003-07-25
PL197648B1 (pl) 2008-04-30
EP1741715A1 (en) 2007-01-10
IL182744A0 (en) 2007-07-24
DE69933767T2 (de) 2007-09-13
KR20090066332A (ko) 2009-06-23
NO328417B1 (no) 2010-02-15
CN1192031C (zh) 2005-03-09
HK1038358A1 (en) 2002-03-15
US7579366B2 (en) 2009-08-25
HUP0102711A3 (en) 2002-09-30
MXPA00012443A (es) 2004-12-03
NO20006378L (no) 2001-02-21
CY1105863T1 (el) 2011-02-02

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