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TR200003577T2 - Enterik kaplı farmasötik tablet ve üretim metodu - Google Patents

Enterik kaplı farmasötik tablet ve üretim metodu

Info

Publication number
TR200003577T2
TR200003577T2 TR2000/03577T TR200003577T TR200003577T2 TR 200003577 T2 TR200003577 T2 TR 200003577T2 TR 2000/03577 T TR2000/03577 T TR 2000/03577T TR 200003577 T TR200003577 T TR 200003577T TR 200003577 T2 TR200003577 T2 TR 200003577T2
Authority
TR
Turkey
Prior art keywords
tablets
coated pharmaceutical
production method
enteric coated
pharmaceutical tablet
Prior art date
Application number
TR2000/03577T
Other languages
English (en)
Inventor
Ullah Ismat
J. Willey Gary
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of TR200003577T2 publication Critical patent/TR200003577T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ddI gibi, 3'ten daha az olan, düsük bir pH ortamina duyarli olan bir ilaçtan olusan ve tablet formundaki bir özü içeren, metakrilik asit kopolimerinden ve bir plastiklestiriciden olusan enterik kaplamaya sahip olan, yüksek ilaç yüklemeli, enterik kapli bir farmasötik kompozisyon saglanmaktadir. Bahsedilen tabletler; degisen boyutlarda olabilmekte, bireysel olarak, oral yolla mideye gönderilebilmekte veya istenen bir dozaja ulasmaya yetecek kadar olan tabletlerin bir toplulugu, çözünebilen kapsül içinde kapsüllenebilmektedir. Söz konusu tabletler; 3'ten düsük pH'de, ayrilmaya (disentegrasyona) karsi mükemmel dirence sahiptir, ancak, 4.5'ten daha büyük pH'de ise, mükemmel ilaç salinim özelliklerine sahiptirler. Bunun yaninda, bahsedilen farmasötik kompozisyonu yapmanin yeni bir metodu da bildirilmektedir.
TR2000/03577T 1998-07-17 1998-08-06 Enterik kaplı farmasötik tablet ve üretim metodu TR200003577T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11841898A 1998-07-17 1998-07-17

Publications (1)

Publication Number Publication Date
TR200003577T2 true TR200003577T2 (tr) 2001-06-21

Family

ID=22378467

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03577T TR200003577T2 (tr) 1998-07-17 1998-08-06 Enterik kaplı farmasötik tablet ve üretim metodu

Country Status (35)

Country Link
US (2) US6331316B1 (tr)
EP (1) EP1098635B1 (tr)
JP (1) JP2002520350A (tr)
KR (1) KR100535954B1 (tr)
CN (1) CN1195499C (tr)
AR (1) AR019934A1 (tr)
AT (1) ATE268165T1 (tr)
AU (1) AU750388B2 (tr)
BG (1) BG65443B1 (tr)
BR (1) BR9815948A (tr)
CA (1) CA2337885C (tr)
CO (1) CO5090840A1 (tr)
CZ (1) CZ301557B6 (tr)
DE (1) DE69824319T2 (tr)
DK (1) DK1098635T3 (tr)
EE (1) EE05021B1 (tr)
EG (1) EG23944A (tr)
ES (1) ES2221188T3 (tr)
GE (1) GEP20032912B (tr)
HU (1) HU226492B1 (tr)
ID (1) ID27019A (tr)
IL (1) IL139701A0 (tr)
LT (1) LT4844B (tr)
LV (1) LV12638B (tr)
NO (1) NO330554B1 (tr)
NZ (1) NZ508298A (tr)
PL (1) PL195587B1 (tr)
PT (1) PT1098635E (tr)
RO (1) RO121082B1 (tr)
RU (1) RU2201217C2 (tr)
SK (1) SK285152B6 (tr)
TR (1) TR200003577T2 (tr)
UA (1) UA73092C2 (tr)
WO (1) WO2000003696A1 (tr)
ZA (1) ZA993446B (tr)

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