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TR200002893A2 - Kinolin-4-il türevleri II - Google Patents

Kinolin-4-il türevleri II

Info

Publication number
TR200002893A2
TR200002893A2 TR2000/02893A TR200002893A TR200002893A2 TR 200002893 A2 TR200002893 A2 TR 200002893A2 TR 2000/02893 A TR2000/02893 A TR 2000/02893A TR 200002893 A TR200002893 A TR 200002893A TR 200002893 A2 TR200002893 A2 TR 200002893A2
Authority
TR
Turkey
Prior art keywords
lower alkyl
amino
hydrogen
pyrrolidin
halogen
Prior art date
Application number
TR2000/02893A
Other languages
English (en)
Other versions
TR200002893A3 (tr
Inventor
Alanine Alexander
Burner Serge
Buettelmann Bernd
Heitz Neidhart Marie-Paule
Jaeschke Georg
Pinard Emmanuel
Wyler Rene
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200002893A3 publication Critical patent/TR200002893A3/tr
Publication of TR200002893A2 publication Critical patent/TR200002893A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bahsi geçen bulus içindeki genel formülün bilesimleri, R1'in hidrojen, düsük alkil, düsük alkoksi, hidroksi, amino, nitro, siyano, düsük alkil amino, di-düsük alkil-amino veya halojen; R2'nin hidrojen, düsük alkil, amino, pirolidin-3-ol, pirolidin-2-il-metanol veya-NHCH2CHROH; R3'ün hidrojen veya halojen; R'nin hidrojen, düsük alkil veya CH2OH; n'nin 1 veya 2 oldugu, ve bunun farmatiksel olarak kabul edilen asit katkili tuzlariyla ilgilidir. Bahsi geçen bulusun bilesimleri, ögrenmenin ve hafiza olusumunun oldugu kadar CNS'nin gelisiminin altindaki arabuluculuk islemlerinde sinirsel aktiviteyi ve esnekligi modüle etmekte anahtar bir görevleri olan NMDA(N-metil-D-aspartat)-alici alt tip seçici tikayicilardir.
TR2000/02893A 1999-10-08 2000-10-04 Kinolin-4-il türevleri II TR200002893A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99120131 1999-10-08

Publications (2)

Publication Number Publication Date
TR200002893A3 TR200002893A3 (tr) 2001-04-20
TR200002893A2 true TR200002893A2 (tr) 2001-04-20

Family

ID=8239160

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02893A TR200002893A2 (tr) 1999-10-08 2000-10-04 Kinolin-4-il türevleri II

Country Status (26)

Country Link
US (1) US6339093B1 (tr)
EP (1) EP1090917B1 (tr)
JP (1) JP3385318B2 (tr)
KR (1) KR100398562B1 (tr)
CN (1) CN1162424C (tr)
AR (1) AR032601A1 (tr)
AT (1) ATE313538T1 (tr)
AU (1) AU777881B2 (tr)
BR (1) BR0004709A (tr)
CA (1) CA2322309C (tr)
DE (1) DE60024947T2 (tr)
DK (1) DK1090917T3 (tr)
EG (1) EG23872A (tr)
ES (1) ES2254095T3 (tr)
HR (1) HRP20000652A2 (tr)
HU (1) HUP0003938A2 (tr)
ID (1) ID27526A (tr)
IL (1) IL138916A0 (tr)
MA (1) MA26753A1 (tr)
MX (1) MXPA00009771A (tr)
NO (1) NO20005031L (tr)
NZ (1) NZ507303A (tr)
PE (1) PE20010660A1 (tr)
PL (1) PL343057A1 (tr)
TR (1) TR200002893A2 (tr)
ZA (1) ZA200005447B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
JP2005506292A (ja) * 2001-03-08 2005-03-03 エモリー　ユニバーシティ ｐＨに依存するＮＭＤＡレセプターアンタゴニスト
US6831087B2 (en) * 2001-11-09 2004-12-14 Hoffmann-La Roche Inc. Pyridine substituted isoquinoline derivatives
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
RS52495B (sr) * 2007-06-18 2013-02-28 Richter Gedeon Nyrt. Derivati sulfonil-hinolina
AU2008272964A1 (en) 2007-06-29 2009-01-08 Emory University NMDA receptor antagonists for neuroprotection
WO2009042907A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
US9938269B2 (en) 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
SMT202000534T1 (it) 2015-12-09 2020-11-10 Cadent Therapeutics Inc Modulatori eteroaromatici del recettore nmda e loro usi
CN109415343A (zh) * 2016-05-04 2019-03-01 基因科学医药公司 用于治疗增殖性疾病的取代的2,4-二氨基-喹啉衍生物
ES2975336T3 (es) 2016-12-22 2024-07-04 Novartis Ag Moduladores del receptor NMDA y usos de los mismos
AU2019368147B2 (en) 2018-08-03 2024-05-30 Novartis Ag Heteroaromatic NMDA receptor modulators and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8409745D0 (en) * 1984-04-14 1984-05-23 Beecham Group Plc Active compounds
US4560692A (en) * 1984-07-18 1985-12-24 Hoffmann-La Roche Inc. 4-Piperidino-2-phenylquinolines
GB8716972D0 (en) * 1987-07-17 1987-08-26 Pfizer Ltd Treatment of cardiac arrhythmias
JPH0262875A (ja) 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
US4992448A (en) * 1989-10-24 1991-02-12 Hoechst-Roussel Pharmaceuticals Inc. Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders
US5304554A (en) * 1990-04-27 1994-04-19 Emory University 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
GB9203798D0 (en) * 1992-02-21 1992-04-08 Fujisawa Pharmaceutical Co Quinolylbenzofuran derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5567718A (en) * 1994-08-11 1996-10-22 Hoechst Marion Roussel Inc. 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives

Also Published As

Publication number Publication date
JP2001114777A (ja) 2001-04-24
TR200002893A3 (tr) 2001-04-20
NZ507303A (en) 2002-09-27
BR0004709A (pt) 2001-06-12
HUP0003938A2 (hu) 2002-11-28
DK1090917T3 (da) 2006-04-24
EP1090917A1 (en) 2001-04-11
NO20005031D0 (no) 2000-10-06
CN1304936A (zh) 2001-07-25
CN1162424C (zh) 2004-08-18
KR100398562B1 (ko) 2003-09-19
MXPA00009771A (es) 2002-10-23
CA2322309C (en) 2008-05-20
DE60024947T2 (de) 2006-09-21
NO20005031L (no) 2001-04-09
ID27526A (id) 2001-04-12
IL138916A0 (en) 2001-11-25
PE20010660A1 (es) 2001-06-26
HRP20000652A2 (en) 2001-12-31
HU0003938D0 (en) 2000-12-28
AU777881B2 (en) 2004-11-04
AR032601A1 (es) 2003-11-19
DE60024947D1 (de) 2006-01-26
EG23872A (en) 2007-11-27
KR20010050915A (ko) 2001-06-25
ZA200005447B (en) 2001-04-09
AU6410000A (en) 2001-04-12
ES2254095T3 (es) 2006-06-16
JP3385318B2 (ja) 2003-03-10
MA26753A1 (fr) 2004-12-20
CA2322309A1 (en) 2001-04-08
US6339093B1 (en) 2002-01-15
ATE313538T1 (de) 2006-01-15
PL343057A1 (en) 2001-04-09
EP1090917B1 (en) 2005-12-21

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