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TR200002158T2 - Prostaglandin E1'i ulaştırmak için topik terkipler - Google Patents

Prostaglandin E1'i ulaştırmak için topik terkipler

Info

Publication number
TR200002158T2
TR200002158T2 TR2000/02158T TR200002158T TR200002158T2 TR 200002158 T2 TR200002158 T2 TR 200002158T2 TR 2000/02158 T TR2000/02158 T TR 2000/02158T TR 200002158 T TR200002158 T TR 200002158T TR 200002158 T2 TR200002158 T2 TR 200002158T2
Authority
TR
Turkey
Prior art keywords
prostaglandin
deliver
topical compositions
aliphatic
mixture
Prior art date
Application number
TR2000/02158T
Other languages
English (en)
Inventor
B�Y�Kt�Mk�N Servet
B�Y�Kt�Mk�N Nad�R
L. Yeager James
Original Assignee
Nexmed Holdings, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings, Inc. filed Critical Nexmed Holdings, Inc.
Publication of TR200002158T2 publication Critical patent/TR200002158T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Prostaglandin E1 in deriden geçirilerek tatbik edilmesi için uygun olan yari kati kivaminda bir topik terkip saglanmstir. Bu terkip, prostaglandin E1, bir penetrasyon artirici madde, polisakkarid sakizi, bir lipofilik bilesik ve asidik bir tampon sistemi ihtiva eder. Penetrasyon artirici, bir alkil-2(N,N-disübstitüe amino)-alkanoat esteri, bir (N,N-disübstitüe amino)-alkanol alkanoat veya bunlarin bir karisimidir. Lipofillik bilesik, bir alifatik C1-C8 alkol, bir alifatik C8-C30 ester veya bunlarin bir karisimidir. Terkip yaklasik 3 ile yaklasik 7.4 arasinda bir tamponlasmis pH degeri saglayabilme yetenegine sahip bir tampon sistemi ihtiva eder.
TR2000/02158T 1997-11-05 1998-11-05 Prostaglandin E1'i ulaştırmak için topik terkipler TR200002158T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/964,509 US6046244A (en) 1997-11-05 1997-11-05 Topical compositions for prostaglandin E1 delivery

Publications (1)

Publication Number Publication Date
TR200002158T2 true TR200002158T2 (tr) 2000-11-21

Family

ID=25508632

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/02158T TR200002158T2 (tr) 1997-11-05 1998-11-05 Prostaglandin E1'i ulaştırmak için topik terkipler
TR2002/00146T TR200200146T2 (tr) 1997-11-05 1999-05-13 Prostaglandin E1 dağıtımı için topikal bileşimler

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2002/00146T TR200200146T2 (tr) 1997-11-05 1999-05-13 Prostaglandin E1 dağıtımı için topikal bileşimler

Country Status (20)

Country Link
US (1) US6046244A (tr)
EP (2) EP1028708B1 (tr)
JP (2) JP4491560B2 (tr)
KR (2) KR100576986B1 (tr)
CN (2) CN1191060C (tr)
AT (2) ATE455535T1 (tr)
AU (1) AU757086B2 (tr)
BR (2) BR9813945A (tr)
CA (2) CA2309165A1 (tr)
DE (2) DE69841463D1 (tr)
DK (2) DK1028708T3 (tr)
ES (2) ES2338389T3 (tr)
HK (1) HK1044289B (tr)
HU (1) HU230300B1 (tr)
IL (3) IL135914A0 (tr)
MX (1) MXPA01011560A (tr)
PT (1) PT1178833E (tr)
TR (2) TR200002158T2 (tr)
TW (1) TW443933B (tr)
WO (2) WO1999022714A1 (tr)

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Also Published As

Publication number Publication date
BR9813945A (pt) 2002-01-22
JP2002544240A (ja) 2002-12-24
JP2001521886A (ja) 2001-11-13
JP4491560B2 (ja) 2010-06-30
CA2373821A1 (en) 2000-11-23
ATE273714T1 (de) 2004-09-15
HK1044289A1 (en) 2002-10-18
DE69841463D1 (de) 2010-03-11
PT1178833E (pt) 2004-11-30
CN1195523C (zh) 2005-04-06
EP1028708A4 (en) 2006-01-18
HU230300B1 (hu) 2015-12-28
IL146470A (en) 2010-12-30
HUP0201145A2 (hu) 2002-12-28
EP1028708B1 (en) 2010-01-20
CA2309165A1 (en) 1999-05-14
TW443933B (en) 2001-07-01
DK1178833T3 (da) 2004-11-22
CN1284862A (zh) 2001-02-21
HUP0201145A3 (en) 2004-05-28
CN1191060C (zh) 2005-03-02
BR9917299A (pt) 2002-07-09
KR100576986B1 (ko) 2006-05-10
TR200200146T2 (tr) 2002-06-21
HK1044289B (en) 2005-01-07
HK1034678A1 (en) 2001-11-02
CA2373821C (en) 2003-10-07
CN1354677A (zh) 2002-06-19
AU3989199A (en) 2000-12-05
DK1028708T3 (da) 2010-05-03
US6046244A (en) 2000-04-04
DE69919594D1 (de) 2004-09-23
AU757086B2 (en) 2003-01-30
IL146470A0 (en) 2002-07-25
DE69919594T2 (de) 2005-09-15
WO2000069469A1 (en) 2000-11-23
EP1028708A1 (en) 2000-08-23
KR20020012218A (ko) 2002-02-15
WO1999022714A1 (en) 1999-05-14
ES2338389T3 (es) 2010-05-06
EP1178833A1 (en) 2002-02-13
KR20010031836A (ko) 2001-04-16
KR100462442B1 (ko) 2004-12-17
MXPA01011560A (es) 2002-06-04
EP1178833B1 (en) 2004-08-18
ES2224661T3 (es) 2005-03-01
IL135914A0 (en) 2001-05-20
ATE455535T1 (de) 2010-02-15

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