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TR200001903T2 - Kristalografik açıdan kararlı, şekilsiz sefalosporin bileşimleri ve bunların üretilmesine ilişkin işlem. - Google Patents

Kristalografik açıdan kararlı, şekilsiz sefalosporin bileşimleri ve bunların üretilmesine ilişkin işlem.

Info

Publication number
TR200001903T2
TR200001903T2 TR2000/01903T TR200001903T TR200001903T2 TR 200001903 T2 TR200001903 T2 TR 200001903T2 TR 2000/01903 T TR2000/01903 T TR 2000/01903T TR 200001903 T TR200001903 T TR 200001903T TR 200001903 T2 TR200001903 T2 TR 200001903T2
Authority
TR
Turkey
Prior art keywords
production
stable amorphous
crystallographically stable
water
cephalosporin compositions
Prior art date
Application number
TR2000/01903T
Other languages
English (en)
Inventor
Onodera Masahiro
Sukegawa Masamichi
Yasui Kiyoshi
Watanabe Tatsuo
Sato Toyomi
Murai Yasushi
Iinuma Katsuharu
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Publication of TR200001903T2 publication Critical patent/TR200001903T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esas itibariyla sekilsiz bir Sefditoren pivoksil maddesinin, suda çözülebilen yüksek moleküllü bir katki maddesi ile homojen bir karisimindan olusan parçaciklar ihtiva eden agizdan verilebilen, sari ve toz seklindeki bilesimlerin hazirlanmasina mahsus yöntemler sunulmaktadir. Bu bilesimler kristalli Sefditoren pivoksil maddesini ve suda çözülebilen yüksek moleküllü katki maddesini bir asitin sulu bir çözeltisi içinde eriterek, ardindan ürünü birlikte çökeltmek için ortaya çikan çözeltiyi nötrlestirerek ve bu sekilde çökeltilmis ürünü kurutarak, müteakiben de ürünü yukarida bahsedilen parçaciklar biçiminde geri kazanarak üretilebilirler.
TR2000/01903T 1998-01-07 1999-01-07 Kristalografik açıdan kararlı, şekilsiz sefalosporin bileşimleri ve bunların üretilmesine ilişkin işlem. TR200001903T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP192098 1998-01-07

Publications (1)

Publication Number Publication Date
TR200001903T2 true TR200001903T2 (tr) 2000-11-21

Family

ID=11515039

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01903T TR200001903T2 (tr) 1998-01-07 1999-01-07 Kristalografik açıdan kararlı, şekilsiz sefalosporin bileşimleri ve bunların üretilmesine ilişkin işlem.

Country Status (22)

Country Link
US (2) US6342493B1 (tr)
EP (1) EP1051978B1 (tr)
JP (1) JP3413406B2 (tr)
KR (1) KR100435315B1 (tr)
CN (1) CN1151845C (tr)
AU (1) AU736555B2 (tr)
BR (1) BRPI9907084B8 (tr)
CA (1) CA2316841C (tr)
CZ (1) CZ302082B6 (tr)
EA (1) EA002881B1 (tr)
ES (1) ES2393972T3 (tr)
HU (1) HU230295B1 (tr)
ID (1) ID25469A (tr)
IL (2) IL137004A0 (tr)
NZ (1) NZ505871A (tr)
PL (1) PL194097B1 (tr)
PT (1) PT1051978E (tr)
SK (1) SK286631B6 (tr)
TR (1) TR200001903T2 (tr)
TW (1) TW587946B (tr)
UA (1) UA70311C2 (tr)
WO (1) WO1999034832A1 (tr)

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NZ517706A (en) 1999-10-08 2004-01-30 Affinium Pharm Inc Fab I inhibitors
DE60230934D1 (de) 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
JPWO2002087588A1 (ja) 2001-04-26 2004-08-12 明治製菓株式会社 非晶質セフジトレンピボキシル組成物およびその製造方法
US8648065B2 (en) * 2002-10-02 2014-02-11 Meiji Seika Pharma Co., Ltd. Antibacterial medicinal composition of enhanced oral absorptivity
ES2518316T3 (es) 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
ATE409485T1 (de) * 2003-03-17 2008-10-15 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
US20070053973A1 (en) * 2003-10-08 2007-03-08 Shigeru Chikase Amorphous antibiotic composition comprising cefditoren pivoxil
JP2007510709A (ja) * 2003-11-07 2007-04-26 ランバクシー ラボラトリーズ リミテッド 高純度３−（２−置換ビニル）セファロスポリンの製法
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WO2012010938A2 (en) * 2010-07-23 2012-01-26 Lupin Limited Pharmaceutical compositions of cefditoren pivoxil
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ES2561878T3 (es) 2010-09-30 2016-03-01 Toyama Chemical Co., Ltd. Sal de meglumina de 6-fluoro-3-hidroxi-2-pirazinacarboxamida
RS58898B1 (sr) 2012-06-19 2019-08-30 Debiopharm Int Sa Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
EP3039011A1 (en) * 2013-08-29 2016-07-06 Cadila Healthcare Limited Polymorphic form of pyrrole derivative and intermediate thereof
WO2016114727A1 (en) 2015-01-16 2016-07-21 Öğün Yusuf Toktamiş Cefditoren pivoxil compositions with improved stability and production methods thereof
PT3419628T (pt) 2016-02-26 2021-01-05 Debiopharm Int Sa Medicamento para o tratamento de infeções do pé diabético
CN109053768A (zh) * 2018-08-07 2018-12-21 中国医药集团总公司四川抗菌素工业研究所 一种无定型头孢妥仑酯的制备方法
CA3129508A1 (en) 2019-02-14 2020-08-20 Debiopharm International S.A. Solid formulations of afabicin with histidine
CN113939306B (zh) 2019-06-14 2024-07-19 德彪药业国际股份公司 用于治疗涉及生物膜的细菌感染的药物及其用途
CN110251467A (zh) * 2019-06-26 2019-09-20 北京济美堂医药研究有限公司 一种无定形态头孢妥仑匹酯组合物的制备方法
CN112190539B (zh) * 2020-11-10 2021-11-02 深圳立健药业有限公司 一种头孢妥仑匹酯组合物及其应用
CN120732800B (zh) * 2025-08-19 2025-12-02 湖南恒昌医药集团股份有限公司 头孢托仑匹酯缓释片及其制备方法

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IL137004A0 (en) * 1998-01-07 2001-06-14 Meiji Seika Kaisha Crystallographically stable amorphous cephalosporin compositions and process for producing the same

Also Published As

Publication number Publication date
KR100435315B1 (ko) 2004-06-10
SK286631B6 (sk) 2009-02-05
IL137004A (en) 2008-11-03
JP3413406B2 (ja) 2003-06-03
CN1151845C (zh) 2004-06-02
WO1999034832A8 (en) 1999-10-28
HUP0101272A3 (en) 2002-07-29
ES2393972T8 (es) 2013-02-25
HK1035148A1 (en) 2001-11-16
AU736555B2 (en) 2001-08-02
AU1784599A (en) 1999-07-26
PT1051978E (pt) 2012-11-20
US6486149B2 (en) 2002-11-26
NZ505871A (en) 2002-10-25
BRPI9907084B8 (pt) 2021-05-25
IL137004A0 (en) 2001-06-14
EA002881B1 (ru) 2002-10-31
US6342493B1 (en) 2002-01-29
PL341589A1 (en) 2001-04-23
WO1999034832A1 (en) 1999-07-15
SK10262000A3 (sk) 2001-01-18
TW587946B (en) 2004-05-21
ID25469A (id) 2000-10-05
EA200000742A1 (ru) 2001-02-26
BR9907084A (pt) 2000-10-17
EP1051978B1 (en) 2012-08-22
EP1051978A1 (en) 2000-11-15
PL194097B1 (pl) 2007-04-30
HU230295B1 (hu) 2015-12-28
ES2393972T3 (es) 2013-01-03
CA2316841C (en) 2007-11-20
CN1290177A (zh) 2001-04-04
UA70311C2 (uk) 2004-10-15
HUP0101272A2 (hu) 2001-12-28
KR20010033961A (ko) 2001-04-25
CZ302082B6 (cs) 2010-09-29
US20020037322A1 (en) 2002-03-28
CZ20002542A3 (cs) 2000-12-13
CA2316841A1 (en) 1999-07-15
BRPI9907084B1 (pt) 2017-04-25
EP1051978A4 (en) 2007-05-02

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