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TR200001612T2 - Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler. - Google Patents

Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler.

Info

Publication number
TR200001612T2
TR200001612T2 TR2000/01612T TR200001612T TR200001612T2 TR 200001612 T2 TR200001612 T2 TR 200001612T2 TR 2000/01612 T TR2000/01612 T TR 2000/01612T TR 200001612 T TR200001612 T TR 200001612T TR 200001612 T2 TR200001612 T2 TR 200001612T2
Authority
TR
Turkey
Prior art keywords
protein
hydrophobically modified
hydrophobic
related methods
modified protein
Prior art date
Application number
TR2000/01612T
Other languages
English (en)
Inventor
R. Pepinsky Blake
P. Baker Darren
Wen Dingyi
P. Williams Kevin
A. Garber Ellen
R. Taylor Frederick
Galdes Alphonse
Porter Jeffrey
Original Assignee
Biogen, Inc
Ontogeny, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen, Inc, Ontogeny, Inc. filed Critical Biogen, Inc
Publication of TR200001612T2 publication Critical patent/TR200001612T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Graft Or Block Polymers (AREA)

Abstract

Hidrofobik olarak degisiklige ugratilmis proteinler ve bunlarin olusturulmasina yönelik yöntemler anlatilmistir. Proteinin bir yüzey amino asit artigina bir hidrofobik yari parça baglanmistir. Hidrofobik yari parça bir lipit veya bir peptit olabilir. Seçenek olarak, protein, kendisine hidrofobik bir yapi ekleyen çok çesitli kimyasal tepkimeler araciligiyla da türetilebilir. Tercih edilen protein, memeli kökenli olan bir proteindir ve Sonic, Indian ve Desert dikenli proteinlerden olusan gruptan seçilmistir. Hidrofobik yari parça, kendisine bir hücre zari, lipozom veya misel gibi bir kesecigin baglanabilecegi, uygun bir bag(lanma noktasi) olarak kullanilmistir.
TR2000/01612T 1997-12-03 1998-12-03 Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler. TR200001612T2 (tr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6742397P 1997-12-03 1997-12-03
US7893598P 1998-03-20 1998-03-20
US8968598P 1998-06-17 1998-06-17
US9980098P 1998-09-10 1998-09-10

Publications (1)

Publication Number Publication Date
TR200001612T2 true TR200001612T2 (tr) 2001-01-22

Family

ID=27490628

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01612T TR200001612T2 (tr) 1997-12-03 1998-12-03 Hidrofobik olarak değişikliğe uğratılmış protein bileşimleri ve ilgili yöntemler.

Country Status (25)

Country Link
US (1) US6444793B1 (tr)
EP (1) EP1036092B1 (tr)
JP (1) JP4289788B2 (tr)
KR (1) KR20010032753A (tr)
CN (1) CN1294595A (tr)
AT (1) ATE295372T1 (tr)
AU (1) AU757497B2 (tr)
BR (1) BR9815142A (tr)
CA (1) CA2309806A1 (tr)
CZ (1) CZ20002008A3 (tr)
DE (1) DE69830192T2 (tr)
DK (1) DK1036092T3 (tr)
EA (1) EA003739B1 (tr)
EE (1) EE200000308A (tr)
ES (1) ES2243018T3 (tr)
HU (1) HUP0100535A3 (tr)
IL (2) IL136137A0 (tr)
IS (1) IS2163B (tr)
MX (1) MXPA00005494A (tr)
NO (1) NO20002789L (tr)
NZ (1) NZ504752A (tr)
PL (1) PL197833B1 (tr)
PT (1) PT1036092E (tr)
TR (1) TR200001612T2 (tr)
WO (1) WO1999028343A2 (tr)

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JP2001525341A (ja) * 1997-11-28 2001-12-11 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性ヘッジホッグタンパク質変異体、その調製方法及び医薬への適用
CA2309806A1 (en) 1997-12-03 1999-06-10 Biogen, Inc. Hydrophobically-modified protein compositions and methods
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP1557427A3 (en) * 1998-04-30 2005-10-19 Curis, Inc. Hedgehog protein conjugate
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
WO2000025725A2 (en) * 1998-11-02 2000-05-11 Biogen, Inc. Functional antagonists of hedgehog activity
DE69931390T2 (de) * 1998-12-03 2007-06-06 Curis, Inc., Cambridge Verfahren und Zusammensetzungen zur Behandlung von Krankheiten bei denen Excitotoxizität beteiligt ist
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
JP2003502292A (ja) * 1999-06-01 2003-01-21 バイオジェン インコーポレイテッド ヘッジホッグタンパク質のポリマー結合体及び利用
IL149202A0 (en) * 1999-11-05 2002-11-10 Biogen Inc Hedgehog fusion proteins and uses
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
US7052514B2 (en) * 2000-04-28 2006-05-30 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US20030235852A1 (en) * 2002-04-19 2003-12-25 Roberts Richard W. Nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues, and methods of making same using peptide modifying agents
EP1773375A1 (en) 2004-07-14 2007-04-18 University of Utah Research Foundation Netrin-related compositions and uses
US20090047282A1 (en) * 2005-03-25 2009-02-19 Hideaki Tojo Prophylactic/Therapeutic Agent for Cancer
RU2420580C2 (ru) * 2005-11-11 2011-06-10 Протеоджен Био С.Р.Л. Способ преобразования водорастворимых активных белков в гидрофобные активные белки, их применение для получения мономолекулярных слоев ориентированных активных белков и устройства, включающие водорастворимые активные белки, преобразованные в гидрофобные активные белки
WO2008057468A1 (en) 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
KR100876657B1 (ko) * 2007-10-15 2009-01-07 한국기계연구원 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법
JP5576801B2 (ja) * 2008-02-21 2014-08-20 ダーマケア・ニューロサイエンス・インスティテュート Ｍｎｔｆペプチドの美容および皮膚科用製剤
WO2009108868A2 (en) * 2008-02-27 2009-09-03 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
CN103665095A (zh) * 2012-09-11 2014-03-26 中国人民解放军军事医学科学院卫生学环境医学研究所 一种疏水性多肽修饰抗体的合成方法
CN106924754B (zh) * 2015-12-30 2021-11-09 北京大学 聚氨基酸偶联物
CN108147990B (zh) * 2016-12-02 2023-01-24 上海中医药大学 一种膜锚定元件及其应用
CA3079423A1 (en) 2017-10-25 2019-05-02 Janssen Pharmaceuticals, Inc. Compositions of phosphorylated tau peptides and uses thereof
JOP20210211A1 (ar) 2019-02-08 2023-01-30 Janssen Pharmaceuticals Inc طريقة إعطاء دواء آمنة للقاح ببتيد تاو المفسفر
JP2023136614A (ja) * 2022-03-17 2023-09-29 三菱ケミカル株式会社 植物を用いたヘッジホッグタンパク質の製造方法
CN116983461B (zh) * 2023-03-14 2025-07-22 中国石油大学(华东) 基于脂质体修饰的止血海绵体系
CN116549713B (zh) * 2023-05-09 2025-06-13 浙江大学 一种兼具组织粘合和防粘连的手术贴片和其制备方法

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US5399347A (en) 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
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CA2309806A1 (en) 1997-12-03 1999-06-10 Biogen, Inc. Hydrophobically-modified protein compositions and methods

Also Published As

Publication number Publication date
PT1036092E (pt) 2005-09-30
IL136137A (en) 2009-09-22
NO20002789L (no) 2000-08-02
BR9815142A (pt) 2000-10-10
DE69830192D1 (de) 2005-06-16
JP4289788B2 (ja) 2009-07-01
DE69830192T2 (de) 2006-01-12
NO20002789D0 (no) 2000-05-31
IS5499A (is) 2000-05-15
HUP0100535A3 (en) 2003-09-29
EP1036092A2 (en) 2000-09-20
KR20010032753A (ko) 2001-04-25
CZ20002008A3 (cs) 2001-11-14
HUP0100535A2 (hu) 2001-06-28
IL136137A0 (en) 2001-05-20
EE200000308A (et) 2001-10-15
ES2243018T3 (es) 2005-11-16
AU757497B2 (en) 2003-02-20
MXPA00005494A (es) 2003-05-19
JP2001525336A (ja) 2001-12-11
HK1030953A1 (en) 2001-05-25
AU1996699A (en) 1999-06-16
DK1036092T3 (da) 2005-08-15
EA003739B1 (ru) 2003-08-28
WO1999028343A3 (en) 1999-08-12
IS2163B (is) 2006-11-15
ATE295372T1 (de) 2005-05-15
EA200000605A1 (ru) 2000-12-25
WO1999028343A2 (en) 1999-06-10
EP1036092B1 (en) 2005-05-11
NZ504752A (en) 2002-10-25
PL341430A1 (en) 2001-04-09
CA2309806A1 (en) 1999-06-10
PL197833B1 (pl) 2008-04-30
WO1999028343A9 (en) 1999-10-14
CN1294595A (zh) 2001-05-09
US6444793B1 (en) 2002-09-03

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