TR200000201T2 - Ampisilinin hazırlanması için proses - Google Patents
Ampisilinin hazırlanması için prosesInfo
- Publication number
- TR200000201T2 TR200000201T2 TR2000/00201T TR200000201T TR200000201T2 TR 200000201 T2 TR200000201 T2 TR 200000201T2 TR 2000/00201 T TR2000/00201 T TR 2000/00201T TR 200000201 T TR200000201 T TR 200000201T TR 200000201 T2 TR200000201 T2 TR 200000201T2
- Authority
- TR
- Turkey
- Prior art keywords
- ampicillin
- apa
- phenylglycine
- total quantity
- phenylglycine derivative
- Prior art date
Links
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 title abstract 4
- 229960000723 ampicillin Drugs 0.000 title abstract 4
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 5
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 5
- 150000005331 phenylglycines Chemical class 0.000 abstract 3
- KIYRSYYOVDHSPG-SSDOTTSWSA-N (2r)-2-amino-2-phenylacetamide Chemical compound NC(=O)[C@H](N)C1=CC=CC=C1 KIYRSYYOVDHSPG-SSDOTTSWSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000010923 batch production Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Bulus ampisilinin hazirlanmasi için bir prosesle ilgilidir, bu proseste 6- aminopenisilanik asit (6-APA) bir fenilglisin türevi yardimiyla bir enzimatik asilasyon reaksiyonuna tabi tutulur, 6-APA'nin toplam konsantrasyonu reaksiyon karisiminda ampisilin ile birlikte 250mM' den fazladir, solüsyondaki 6-APA konsantrasyonu 300mM' den düsük tutulur ve 6-APA'ya uygulanan asilasyon ajaninin buna olan molar orani 2.5'ten düsüktür. Reaksiyon karisiminda çözülmüs halde bulunan 6-APA konsantrasyonu çesitli yöntemlerle düsük tutulabilir. 6-APA konsantrasyonunu düsük tutmanin bir yolu, baslangiçta total 6-APA miktarinin bir kisminin konulup gerisinin reaksiyon sirasinda eklenmesidir. 6-APA' nin toplam miktari tercihen reaksiyonun baslangicinda katilir. Çözülmüs 6-APA konsantrasyonunu düsük tutmanin baska bir uygun metodu da, örnegin, pH degerini reaksiyon elemanlarinin azami çözülürlügünün elde edildigi pH degerine nispeten daha düsük tutmaktir, bu örnegin, fenilglisin türevi, (DEVAMI VAR..)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1006266A NL1006266C2 (nl) | 1997-06-10 | 1997-06-10 | Werkwijze voor de bereiding van ampicilline. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000201T2 true TR200000201T2 (tr) | 2000-06-21 |
Family
ID=19765126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00201T TR200000201T2 (tr) | 1997-06-10 | 1998-05-25 | Ampisilinin hazırlanması için proses |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7029885B2 (tr) |
| EP (1) | EP0988393B1 (tr) |
| KR (1) | KR100508290B1 (tr) |
| CN (1) | CN1115417C (tr) |
| AT (1) | ATE319849T1 (tr) |
| AU (1) | AU7677798A (tr) |
| BR (1) | BR9810020A (tr) |
| ES (1) | ES2258298T3 (tr) |
| IN (1) | IN186863B (tr) |
| NL (1) | NL1006266C2 (tr) |
| TR (1) | TR200000201T2 (tr) |
| WO (1) | WO1998056946A1 (tr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6538045B1 (en) * | 1999-12-23 | 2003-03-25 | Dsm N.V. | Optical fiber coating compositions containing secondary or tertiary amino silicone-containing additive |
| WO2012175587A2 (en) | 2011-06-23 | 2012-12-27 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Novel crystalline cefoperazone intermediate |
| ES2729707T3 (es) | 2011-06-23 | 2019-11-05 | Centrient Pharmaceuticals Netherlands B V | Proceso de preparación de cefalosporinas 3'-tiosustituidas empleando una penicilina G acilasa |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2188608A5 (en) * | 1972-06-14 | 1974-01-18 | Aries Robert | Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids |
| EP0537255B1 (en) * | 1990-07-04 | 2006-02-15 | DSM IP Assets B.V. | Process for preparation of beta-lactams |
| IT1243800B (it) * | 1990-08-28 | 1994-06-28 | Sclavo Spa | Procedimento migliorato per la preparazione di cefalosporine |
| BE1007296A3 (nl) * | 1993-07-19 | 1995-05-09 | Dsm Nv | Werkwijze voor de bereiding van een beta-lactamderivaat. |
| US6048708A (en) * | 1994-07-18 | 2000-04-11 | Gist-Brocades B.V. | Process for preparation of β-lactams at constantly high concentration of reactants |
| BE1009264A3 (nl) * | 1995-03-31 | 1997-01-07 | Dsm Nv | Werkwijze voor de winning van ampicilline. |
| NL1007076C2 (nl) | 1997-09-19 | 1999-03-22 | Dsm Nv | Werkwijze voor de winning van een ß-lactam antibioticum. |
| NL1007077C2 (nl) | 1997-09-19 | 1999-03-22 | Dsm Nv | Werkwijze voor de winning van een ß-lactam antibioticum. |
| NL1007302C2 (nl) | 1997-10-17 | 1999-04-20 | Dsm Nv | Werkwijze voor de bereiding van een ß-lactam antibioticum. |
-
1997
- 1997-06-10 NL NL1006266A patent/NL1006266C2/nl not_active IP Right Cessation
-
1998
- 1998-05-25 WO PCT/NL1998/000295 patent/WO1998056946A1/en not_active Ceased
- 1998-05-25 AT AT98924672T patent/ATE319849T1/de active
- 1998-05-25 EP EP98924672A patent/EP0988393B1/en not_active Expired - Lifetime
- 1998-05-25 BR BR9810020-3A patent/BR9810020A/pt not_active Application Discontinuation
- 1998-05-25 KR KR10-1999-7011645A patent/KR100508290B1/ko not_active Expired - Fee Related
- 1998-05-25 CN CN98807876A patent/CN1115417C/zh not_active Expired - Lifetime
- 1998-05-25 ES ES98924672T patent/ES2258298T3/es not_active Expired - Lifetime
- 1998-05-25 TR TR2000/00201T patent/TR200000201T2/tr unknown
- 1998-05-25 AU AU76777/98A patent/AU7677798A/en not_active Abandoned
- 1998-06-05 IN IN1224MA1998 patent/IN186863B/en unknown
-
1999
- 1999-12-10 US US09/457,765 patent/US7029885B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1115417C (zh) | 2003-07-23 |
| KR20010013635A (ko) | 2001-02-26 |
| CN1265706A (zh) | 2000-09-06 |
| US7029885B2 (en) | 2006-04-18 |
| IN186863B (tr) | 2001-11-24 |
| WO1998056946A1 (en) | 1998-12-17 |
| AU7677798A (en) | 1998-12-30 |
| EP0988393A1 (en) | 2000-03-29 |
| ATE319849T1 (de) | 2006-03-15 |
| US20020009769A1 (en) | 2002-01-24 |
| KR100508290B1 (ko) | 2005-08-17 |
| ES2258298T3 (es) | 2006-08-16 |
| NL1006266C2 (nl) | 1998-12-14 |
| EP0988393B1 (en) | 2006-03-08 |
| BR9810020A (pt) | 2000-09-19 |
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