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AU2732388A - A process for the enzymatic hydrolysis of alpha- aminoadipinyl-monoamino compounds - Google Patents

A process for the enzymatic hydrolysis of alpha- aminoadipinyl-monoamino compounds

Info

Publication number
AU2732388A
AU2732388A AU27323/88A AU2732388A AU2732388A AU 2732388 A AU2732388 A AU 2732388A AU 27323/88 A AU27323/88 A AU 27323/88A AU 2732388 A AU2732388 A AU 2732388A AU 2732388 A AU2732388 A AU 2732388A
Authority
AU
Australia
Prior art keywords
aminoadipinyl
alpha
enzymatic hydrolysis
monoamino compounds
monoamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU27323/88A
Other versions
AU616450B2 (en
Inventor
Werner Aretz
Klaus Sauber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU2732388A publication Critical patent/AU2732388A/en
Application granted granted Critical
Publication of AU616450B2 publication Critical patent/AU616450B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

gamma -Glutamyltranspeptidase, which can be prepared by fermentation, can be used to hydrolyse alpha -aminoadipinyl-monoamino compounds, especially D-( delta )- alpha -aminoadipinyl-7-aminocephalosporanic acid.
AU27323/88A 1987-12-21 1988-12-20 A process for the enzymatic hydrolysis of alpha- aminoadipinyl-monoamino compounds Ceased AU616450B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873743323 DE3743323A1 (en) 1987-12-21 1987-12-21 PROCESS FOR ENZYMATIC HYDROLYSIS OF (ALPHA) -AMINOADIPINYL-MONOAMINO COMPOUNDS
DE3743323 1987-12-21

Publications (2)

Publication Number Publication Date
AU2732388A true AU2732388A (en) 1989-06-22
AU616450B2 AU616450B2 (en) 1991-10-31

Family

ID=6343136

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27323/88A Ceased AU616450B2 (en) 1987-12-21 1988-12-20 A process for the enzymatic hydrolysis of alpha- aminoadipinyl-monoamino compounds

Country Status (14)

Country Link
EP (1) EP0321849B1 (en)
JP (1) JP2816167B2 (en)
KR (1) KR0149656B1 (en)
AT (1) ATE91711T1 (en)
AU (1) AU616450B2 (en)
CA (1) CA1317246C (en)
CZ (1) CZ283529B6 (en)
DE (2) DE3743323A1 (en)
DK (1) DK710588A (en)
ES (1) ES2058224T3 (en)
HU (1) HU202917B (en)
IE (1) IE62566B1 (en)
PT (1) PT89282B (en)
ZA (1) ZA889442B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU611406B2 (en) * 1987-01-17 1991-06-13 Hoechst Aktiengesellschaft Gamma-glutamyltranspeptidase, its preparation and its use
US5153120A (en) * 1990-02-07 1992-10-06 Kyowa Hakko Kogyo Co., Ltd. Process for the production of γ-glutamyl transpeptidase

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme
US5229274A (en) * 1989-06-27 1993-07-20 Merck & Co., Inc. Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
JPH04281787A (en) * 1991-03-04 1992-10-07 Yoshihiro Asada Method for producing γ-glutamyl transpeptidase
RO116648B1 (en) * 1991-10-15 2001-04-30 Merck & Co Inc Bioprocess for preparing 7-amino-3-deacetylcephalosporanic acid and 7-amino-cephalosporanic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6121097A (en) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd Preparation of 7-aminocephalosporanic acid and derivative thereof
DE3881531D1 (en) * 1987-01-17 1993-07-15 Hoechst Ag USE OF GAMMA GLUTAMYL TRANSPEPTIDASE.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU611406B2 (en) * 1987-01-17 1991-06-13 Hoechst Aktiengesellschaft Gamma-glutamyltranspeptidase, its preparation and its use
US5153120A (en) * 1990-02-07 1992-10-06 Kyowa Hakko Kogyo Co., Ltd. Process for the production of γ-glutamyl transpeptidase

Also Published As

Publication number Publication date
PT89282B (en) 1993-07-30
JPH01199576A (en) 1989-08-10
DK710588A (en) 1989-06-22
HUT49168A (en) 1989-08-28
ZA889442B (en) 1989-08-30
DK710588D0 (en) 1988-12-20
CZ283529B6 (en) 1998-04-15
KR0149656B1 (en) 1998-08-17
DE3743323A1 (en) 1989-06-29
IE883807L (en) 1989-06-21
CZ847388A3 (en) 1997-12-17
ES2058224T3 (en) 1994-11-01
EP0321849B1 (en) 1993-07-21
EP0321849A2 (en) 1989-06-28
HU202917B (en) 1991-04-29
KR890010211A (en) 1989-08-07
PT89282A (en) 1989-12-29
JP2816167B2 (en) 1998-10-27
EP0321849A3 (en) 1990-09-12
AU616450B2 (en) 1991-10-31
ATE91711T1 (en) 1993-08-15
IE62566B1 (en) 1995-02-08
DE3882503D1 (en) 1993-08-26
CA1317246C (en) 1993-05-04

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired