TR200000114T2 - Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri. - Google Patents
Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri.Info
- Publication number
- TR200000114T2 TR200000114T2 TR2000/00114T TR200000114T TR200000114T2 TR 200000114 T2 TR200000114 T2 TR 200000114T2 TR 2000/00114 T TR2000/00114 T TR 2000/00114T TR 200000114 T TR200000114 T TR 200000114T TR 200000114 T2 TR200000114 T2 TR 200000114T2
- Authority
- TR
- Turkey
- Prior art keywords
- prevention
- formula
- cyclohepta
- benzo
- protein transferase
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 3
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- VVJQGUSMDLABEG-UHFFFAOYSA-N 11h-benzo[1,2]cyclohepta[3,4-b]pyridine Chemical class C1=CC2=CC=CN=C2CC2=CC=CC=C21 VVJQGUSMDLABEG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
(Formül(I), (Formül(II), Formül(III), Formül(IV), Formül(V), Formül(VI)); Formüller, (I), (II), (III), (IV), (V) ve (VI) gibi, yeni bilesikler açiklanmaktadir. Ayni zamanda açiklanan, hücrelerin anormal büyümesinin önlenmesine mahsus, farnesil protein transferazi'nin önlenmesine mahsus ve yeni bilesiklerin kullanilmasi ile kanser hastaliklarinin tedavi edilmesine mahsus yöntemlerdir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87705797A | 1997-06-17 | 1997-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000114T2 true TR200000114T2 (tr) | 2000-08-21 |
Family
ID=25369159
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00114T TR200000114T2 (tr) | 1997-06-17 | 1998-06-15 | Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri. |
| TR2000/03580T TR200003580T2 (tr) | 1997-06-17 | 1998-06-15 | Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/03580T TR200003580T2 (tr) | 1997-06-17 | 1998-06-15 | Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP0988300B1 (tr) |
| JP (1) | JP2002504148A (tr) |
| KR (1) | KR100588799B1 (tr) |
| CN (1) | CN1131228C (tr) |
| AR (1) | AR016074A1 (tr) |
| AT (1) | ATE222905T1 (tr) |
| AU (1) | AU753863B2 (tr) |
| BR (1) | BR9811470A (tr) |
| CA (1) | CA2294347C (tr) |
| CO (1) | CO4940455A1 (tr) |
| CZ (1) | CZ297450B6 (tr) |
| DE (1) | DE69807477T2 (tr) |
| DK (1) | DK0988300T3 (tr) |
| ES (1) | ES2178224T3 (tr) |
| HU (1) | HUP0003046A3 (tr) |
| ID (1) | ID30349A (tr) |
| IL (2) | IL133449A0 (tr) |
| MY (1) | MY117925A (tr) |
| NO (1) | NO318938B1 (tr) |
| NZ (1) | NZ501618A (tr) |
| PE (1) | PE83799A1 (tr) |
| PL (1) | PL191866B1 (tr) |
| PT (1) | PT988300E (tr) |
| RU (1) | RU2220139C2 (tr) |
| SK (1) | SK283820B6 (tr) |
| TR (2) | TR200000114T2 (tr) |
| TW (1) | TW544451B (tr) |
| WO (1) | WO1998057959A1 (tr) |
| ZA (1) | ZA985210B (tr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20000904A2 (en) | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| CA2429720C (en) * | 2000-11-29 | 2009-12-29 | Schering Corporation | Tricyclic compounds useful for the inhibition of farnesyl protein transferase |
| EP1896421B1 (en) * | 2005-06-23 | 2011-09-14 | Merck Sharp & Dohme Corp. | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
-
1998
- 1998-06-15 CA CA002294347A patent/CA2294347C/en not_active Expired - Fee Related
- 1998-06-15 KR KR1019997011974A patent/KR100588799B1/ko not_active Expired - Fee Related
- 1998-06-15 PL PL337481A patent/PL191866B1/pl not_active IP Right Cessation
- 1998-06-15 BR BR9811470-0A patent/BR9811470A/pt not_active Application Discontinuation
- 1998-06-15 EP EP98928888A patent/EP0988300B1/en not_active Expired - Lifetime
- 1998-06-15 CN CN98808210A patent/CN1131228C/zh not_active Expired - Fee Related
- 1998-06-15 RU RU2000101293/04A patent/RU2220139C2/ru not_active IP Right Cessation
- 1998-06-15 EP EP01120740A patent/EP1156046A1/en not_active Withdrawn
- 1998-06-15 TR TR2000/00114T patent/TR200000114T2/tr unknown
- 1998-06-15 TR TR2000/03580T patent/TR200003580T2/tr unknown
- 1998-06-15 NZ NZ501618A patent/NZ501618A/en unknown
- 1998-06-15 ZA ZA985210A patent/ZA985210B/xx unknown
- 1998-06-15 JP JP50449599A patent/JP2002504148A/ja not_active Ceased
- 1998-06-15 CZ CZ0447199A patent/CZ297450B6/cs not_active IP Right Cessation
- 1998-06-15 HU HU0003046A patent/HUP0003046A3/hu unknown
- 1998-06-15 AT AT98928888T patent/ATE222905T1/de not_active IP Right Cessation
- 1998-06-15 PE PE1998000509A patent/PE83799A1/es not_active Application Discontinuation
- 1998-06-15 ID IDW991624A patent/ID30349A/id unknown
- 1998-06-15 SK SK1824-99A patent/SK283820B6/sk not_active IP Right Cessation
- 1998-06-15 ES ES98928888T patent/ES2178224T3/es not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011500 patent/WO1998057959A1/en not_active Ceased
- 1998-06-15 DK DK98928888T patent/DK0988300T3/da active
- 1998-06-15 PT PT98928888T patent/PT988300E/pt unknown
- 1998-06-15 MY MYPI98002657A patent/MY117925A/en unknown
- 1998-06-15 AU AU80582/98A patent/AU753863B2/en not_active Ceased
- 1998-06-15 DE DE69807477T patent/DE69807477T2/de not_active Expired - Lifetime
- 1998-06-15 IL IL13344998A patent/IL133449A0/xx active IP Right Grant
- 1998-06-16 AR ARP980102864A patent/AR016074A1/es active IP Right Grant
- 1998-06-16 CO CO98034141A patent/CO4940455A1/es unknown
- 1998-06-22 TW TW087109502A patent/TW544451B/zh active
-
1999
- 1999-12-09 IL IL133449A patent/IL133449A/en not_active IP Right Cessation
- 1999-12-16 NO NO19996236A patent/NO318938B1/no not_active IP Right Cessation
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