[go: up one dir, main page]

DE69826301D1 - Benzo[5,6]cyclohepta[1,2-b]pyridin derivate anwendbar als farnesyl protein tranferase inhibitoren - Google Patents

Benzo[5,6]cyclohepta[1,2-b]pyridin derivate anwendbar als farnesyl protein tranferase inhibitoren

Info

Publication number
DE69826301D1
DE69826301D1 DE69826301T DE69826301T DE69826301D1 DE 69826301 D1 DE69826301 D1 DE 69826301D1 DE 69826301 T DE69826301 T DE 69826301T DE 69826301 T DE69826301 T DE 69826301T DE 69826301 D1 DE69826301 D1 DE 69826301D1
Authority
DE
Germany
Prior art keywords
protein transferase
cyclohepta
benzo
farnesyl protein
pyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69826301T
Other languages
English (en)
Other versions
DE69826301T2 (de
Inventor
J Doll
Carmen Alvarez
Tarik Lalwani
Yi-Tsung Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69826301D1 publication Critical patent/DE69826301D1/de
Application granted granted Critical
Publication of DE69826301T2 publication Critical patent/DE69826301T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69826301T 1997-06-17 1998-06-15 Benzo[5,6]cyclohepta[1,2-b]pyridin derivate anwendbar als farnesyl protein tranferase inhibitoren Expired - Lifetime DE69826301T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87749897A 1997-06-17 1997-06-17
US877498 1997-06-17
PCT/US1998/011409 WO1998057968A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
DE69826301D1 true DE69826301D1 (de) 2004-10-21
DE69826301T2 DE69826301T2 (de) 2005-10-13

Family

ID=25370103

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69826301T Expired - Lifetime DE69826301T2 (de) 1997-06-17 1998-06-15 Benzo[5,6]cyclohepta[1,2-b]pyridin derivate anwendbar als farnesyl protein tranferase inhibitoren

Country Status (13)

Country Link
EP (1) EP1019398B1 (de)
JP (1) JP2002504142A (de)
KR (1) KR20010013944A (de)
CN (1) CN1267300A (de)
AT (1) ATE276250T1 (de)
AU (1) AU8253298A (de)
CA (1) CA2293368C (de)
DE (1) DE69826301T2 (de)
ES (1) ES2224413T3 (de)
HU (1) HUP0003048A2 (de)
IL (1) IL133392A0 (de)
NZ (1) NZ501612A (de)
WO (1) WO1998057968A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
WO2019142900A1 (ja) * 2018-01-19 2019-07-25 有機合成薬品工業株式会社 Ｎ－アルコキシカルボニルピペリジン誘導体の製造方法及びその中間体
AR125044A1 (es) 2021-03-09 2023-05-31 Fmc Corp Amidas bicíclicas para controlar plagas de invertebrados
CN120693061A (zh) 2023-02-13 2025-09-23 先正达农作物保护股份公司 杀有害生物活性双环化合物
WO2023097341A2 (en) 2023-03-20 2023-06-01 Fmc Corporation Bicyclic amides and esters for controlling invertebrate pests

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL128931A0 (en) * 1996-09-13 2000-02-17 Schering Corp Tricylic antitumor compounds being farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
KR20010013944A (ko) 2001-02-26
JP2002504142A (ja) 2002-02-05
EP1019398B1 (de) 2004-09-15
CA2293368A1 (en) 1998-12-23
AU8253298A (en) 1999-01-04
IL133392A0 (en) 2001-04-30
DE69826301T2 (de) 2005-10-13
ATE276250T1 (de) 2004-10-15
WO1998057968A1 (en) 1998-12-23
CA2293368C (en) 2009-01-20
CN1267300A (zh) 2000-09-20
EP1019398A1 (de) 2000-07-19
ES2224413T3 (es) 2005-03-01
NZ501612A (en) 2001-11-30
HUP0003048A2 (hu) 2001-06-28

Similar Documents

Publication Publication Date Title
ATE286046T1 (de) Trizyklische inhibitoren der farnesyl protein transferase
SE9103612D0 (sv) New peptide derivatives
BR9909961A (pt) Derivados de cadeia lateral alquila e alquenila funcionalizados de glicinamidas como inibidores de farnesil transferase
BR9807674A (pt) Inibidores bicìclicos da proteìna farnesil transferase
DK0870768T3 (da) Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler
DE69826301D1 (de) Benzo[5,6]cyclohepta[1,2-b]pyridin derivate anwendbar als farnesyl protein tranferase inhibitoren
DE69709774D1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren
NO991235D0 (no) Forbindelser anvendelige for inhibering av farnesylproteintransferase
ATE218137T1 (de) Benzo(5,6)cyclohepta(1,2-b)pyridin derivate als farnesyl protein transferase inhibitoren
ATE237611T1 (de) Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer
TR200000114T2 (tr) Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri.
DE69826281D1 (de) Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren
DE69817826D1 (de) Benzo[5,6]cyclohepta[1,2b]pyridine derivate anwendbar als farnesyl protein transferase inhibitoren
NO953557D0 (no) Antitumorpreparater og fremgangsmåte for deres fremstilling
DK369289A (da) Anvendelse af imidazopyrazolderivater som analgetica og antiinflammatoriske midler
ATE227281T1 (de) Verbindungen als farnesyl-protein transferase inhibitoren
DE69724130D1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren
DE60010344D1 (de) Diketopiperazinderivate als thrombininhibitoren
DE69731481D1 (de) Verbindungen als inhibitoren von farnesylprotein-transferase

Legal Events

Date Code Title Description
8364 No opposition during term of opposition