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TR199800165T1 - (R)-5-bromo-n-(1-etil-4-metil hekzahidro-1h-1,4-diazepin-6-il)-2-metoksi-6- metilamino-3-piridinkarboksamid, bunu hazirlamaya mahsus yöntem ve bu bilesigi ihtiva eden farmasötik terkip. - Google Patents

(R)-5-bromo-n-(1-etil-4-metil hekzahidro-1h-1,4-diazepin-6-il)-2-metoksi-6- metilamino-3-piridinkarboksamid, bunu hazirlamaya mahsus yöntem ve bu bilesigi ihtiva eden farmasötik terkip.

Info

Publication number
TR199800165T1
TR199800165T1 TR1998/00165T TR9800165T TR199800165T1 TR 199800165 T1 TR199800165 T1 TR 199800165T1 TR 1998/00165 T TR1998/00165 T TR 1998/00165T TR 9800165 T TR9800165 T TR 9800165T TR 199800165 T1 TR199800165 T1 TR 199800165T1
Authority
TR
Turkey
Prior art keywords
compound
pyridinecarboxamide
diazepin
methylamino
bromo
Prior art date
Application number
TR1998/00165T
Other languages
English (en)
Inventor
Kato Shiro
Hirokawa Yoshimi
Morie Toshiya
Harada Hiroshi
Yosida Naoyuki
Original Assignee
Dainippon Pharmaceutical Co.,Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co.,Ltd filed Critical Dainippon Pharmaceutical Co.,Ltd
Publication of TR199800165T1 publication Critical patent/TR199800165T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Bu bulus, asagidaki formül (I) ile ifade edilen bir bilesik: (formül) veya bunun fizyolojik açidan kabul edilebilir asit katilma tuzlarini açiklar. Talep edilen bilesik, güçlü serotonin S3 ve dopamin D2 reseptör antagonistik aktivitesine dayali olarak mükemmel kusma önleyici etkiler sergiler ve çesitli hastaliklara veya ilaç tedavilerine bagli çesitli mide-bagirsak semptomlarinin tedavisi veya önlenmesi için yararlidir.
TR1998/00165T 1995-07-28 1996-07-23 (R)-5-bromo-n-(1-etil-4-metil hekzahidro-1h-1,4-diazepin-6-il)-2-metoksi-6- metilamino-3-piridinkarboksamid, bunu hazirlamaya mahsus yöntem ve bu bilesigi ihtiva eden farmasötik terkip. TR199800165T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP07212495 1995-07-28

Publications (1)

Publication Number Publication Date
TR199800165T1 true TR199800165T1 (tr) 1998-06-22

Family

ID=16623612

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00165T TR199800165T1 (tr) 1995-07-28 1996-07-23 (R)-5-bromo-n-(1-etil-4-metil hekzahidro-1h-1,4-diazepin-6-il)-2-metoksi-6- metilamino-3-piridinkarboksamid, bunu hazirlamaya mahsus yöntem ve bu bilesigi ihtiva eden farmasötik terkip.

Country Status (24)

Country Link
US (1) US5945415A (tr)
EP (1) EP0855397B1 (tr)
KR (1) KR19990028395A (tr)
CN (1) CN1096459C (tr)
AT (1) ATE201021T1 (tr)
AU (1) AU700635B2 (tr)
BR (1) BR9609691A (tr)
CA (1) CA2228056A1 (tr)
CZ (1) CZ290442B6 (tr)
DE (1) DE69612753T2 (tr)
DK (1) DK0855397T3 (tr)
ES (1) ES2156616T3 (tr)
GR (1) GR3036089T3 (tr)
HU (1) HUP9901208A3 (tr)
IL (1) IL122753A (tr)
MX (1) MX9800620A (tr)
NO (1) NO312964B1 (tr)
NZ (1) NZ312799A (tr)
PL (1) PL184073B1 (tr)
PT (1) PT855397E (tr)
RU (1) RU2156248C2 (tr)
SK (1) SK282044B6 (tr)
TR (1) TR199800165T1 (tr)
WO (1) WO1997005129A1 (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
ITBO20020198A1 (it) * 2002-04-12 2003-10-13 Univ Bologna Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed
MXPA05007379A (es) * 2003-01-13 2006-02-10 Dynogen Pharmaceuticals Inc Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos.
AU2004204825B2 (en) * 2003-01-13 2007-07-19 Dynogen Pharmaceuticals, Inc. Method of treating functional bowel disorders
DE602004007225T2 (de) * 2003-04-04 2008-03-06 Dynogen Pharmaceuticals Inc., Waltham Methode zur behandlung von erkrankungen der unteren harnwege
WO2006105117A2 (en) * 2005-03-28 2006-10-05 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
AU2010231439A1 (en) 2009-03-31 2011-10-27 Zeria Pharmaceutical Co., Ltd. Method for manufacturing 1,5-benzodiazepine derivative
US9045460B2 (en) 2010-08-26 2015-06-02 Kowa Co., Ltd. Production method for isoquinoline derivatives and salts thereof
RU2438669C1 (ru) * 2010-10-29 2012-01-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, проявляющее свойства антагониста серотониновых 5-ht3-рецепторов
ES2713686T3 (es) * 2014-02-03 2019-05-23 Mylan Laboratories Ltd Procedimiento para la preparación de intermedios de Raltegravir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
JPH04210970A (ja) * 1990-01-26 1992-08-03 Dainippon Pharmaceut Co Ltd ベンズアミド誘導体及びその中間体
JPH03223265A (ja) * 1990-01-26 1991-10-02 Dainippon Pharmaceut Co Ltd 環状ジアミン誘導体
SU1825501A3 (ru) * 1990-10-29 1995-12-10 И.В. Комиссаров Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность
MX9206075A (es) * 1991-10-24 1993-04-01 Smithkline Beecham Plc Nuevos compuestos antagonistas del receptor 5-hidroxitriptamina y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
CA2228056A1 (en) 1997-02-13
EP0855397B1 (en) 2001-05-09
HUP9901208A2 (hu) 2000-04-28
EP0855397A1 (en) 1998-07-29
HK1018049A1 (en) 1999-12-10
IL122753A0 (en) 1998-08-16
DE69612753D1 (de) 2001-06-13
ES2156616T3 (es) 2001-07-01
PL324749A1 (en) 1998-06-08
NO312964B1 (no) 2002-07-22
PL184073B1 (pl) 2002-08-30
BR9609691A (pt) 1999-03-23
MX9800620A (es) 1998-04-30
RU2156248C2 (ru) 2000-09-20
IL122753A (en) 2000-10-31
NZ312799A (en) 1999-04-29
AU700635B2 (en) 1999-01-07
EP0855397A4 (en) 1998-12-02
SK9398A3 (en) 1998-08-05
DE69612753T2 (de) 2005-07-07
DK0855397T3 (da) 2001-06-25
KR19990028395A (ko) 1999-04-15
GR3036089T3 (en) 2001-09-28
CZ290442B6 (cs) 2002-07-17
NO980333D0 (no) 1998-01-26
PT855397E (pt) 2001-08-30
US5945415A (en) 1999-08-31
HUP9901208A3 (en) 2002-10-28
WO1997005129A1 (en) 1997-02-13
AU6471796A (en) 1997-02-26
NO980333L (no) 1998-03-23
SK282044B6 (sk) 2001-10-08
CZ23098A3 (cs) 1998-06-17
CN1096459C (zh) 2002-12-18
CN1192213A (zh) 1998-09-02
ATE201021T1 (de) 2001-05-15

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