[go: up one dir, main page]

TNSN06369A1 - Derives de tetrahydronaphtyridine utiles comme ligands du recepteur d'histamine h3 - Google Patents

Derives de tetrahydronaphtyridine utiles comme ligands du recepteur d'histamine h3

Info

Publication number
TNSN06369A1
TNSN06369A1 TNP2006000369A TNSN06369A TNSN06369A1 TN SN06369 A1 TNSN06369 A1 TN SN06369A1 TN P2006000369 A TNP2006000369 A TN P2006000369A TN SN06369 A TNSN06369 A TN SN06369A TN SN06369 A1 TNSN06369 A1 TN SN06369A1
Authority
TN
Tunisia
Prior art keywords
des
ligands
dérivés
tetrahydronaphtyridine
histamine
Prior art date
Application number
TNP2006000369A
Other languages
English (en)
Inventor
John Paul Mathias
Ross Sinclair Strang
Graham Lunn
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN06369A1 publication Critical patent/TNSN06369A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne des dérivés de tétrahydronaphtyridine répondant à la formule (I) ou (I') Et des procédés pour la préparation de, les intermédiaires utilisés dans la préparation de, des compositions contenant, et les utilisations de, ces dérivés. Lesdits dérivés de tétrahydronaphtyridine sont des ligands de H3 et sont utiles dans de nombreuses maladies, de nombreux troubles et de nombreuses affections, en particulier des maladies, troubles et affections inflammatoires, allergiques et respiratoires.
TNP2006000369A 2004-05-12 2006-11-10 Derives de tetrahydronaphtyridine utiles comme ligands du recepteur d'histamine h3 TNSN06369A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04291222A EP1595881A1 (fr) 2004-05-12 2004-05-12 Dérivés de tetrahydronaphthyridine en tant que ligands de récepteur H3 d'histamine
PCT/IB2005/001267 WO2005111036A1 (fr) 2004-05-12 2005-05-06 Derives de tetrahydronaphthyridine utilises comme ligands du recepteur h3 de l'histamine

Publications (1)

Publication Number Publication Date
TNSN06369A1 true TNSN06369A1 (fr) 2008-02-22

Family

ID=34931096

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000369A TNSN06369A1 (fr) 2004-05-12 2006-11-10 Derives de tetrahydronaphtyridine utiles comme ligands du recepteur d'histamine h3

Country Status (32)

Country Link
US (2) US7557121B2 (fr)
EP (2) EP1595881A1 (fr)
JP (1) JP4084410B2 (fr)
KR (1) KR100908155B1 (fr)
CN (2) CN101798305A (fr)
AP (1) AP2006003786A0 (fr)
AR (1) AR049092A1 (fr)
AT (1) ATE491707T1 (fr)
AU (1) AU2005243403B2 (fr)
BR (1) BRPI0510762A (fr)
CA (1) CA2564201C (fr)
CR (1) CR8747A (fr)
DE (1) DE602005025345D1 (fr)
DK (1) DK1756104T3 (fr)
EA (1) EA010487B1 (fr)
EC (1) ECSP066984A (fr)
ES (1) ES2355572T3 (fr)
GE (1) GEP20084552B (fr)
GT (1) GT200500112A (fr)
IL (1) IL178882A (fr)
MA (1) MA28579B1 (fr)
MX (1) MXPA06013113A (fr)
NL (1) NL1029016C2 (fr)
NO (1) NO20064577L (fr)
PA (1) PA8632801A1 (fr)
PE (1) PE20060312A1 (fr)
SV (1) SV2005002112A (fr)
TN (1) TNSN06369A1 (fr)
TW (1) TW200607506A (fr)
UY (1) UY28895A1 (fr)
WO (1) WO2005111036A1 (fr)
ZA (1) ZA200609111B (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468306B1 (en) 1998-05-29 2002-10-22 Advanced Medical Optics, Inc IOL for inhibiting cell growth and reducing glare
BRPI0417503B1 (pt) 2003-12-09 2015-07-21 Abbott Medical Optics Inc Lente intra-ocular dobrável
DK1899334T3 (da) * 2005-06-17 2008-11-24 Janssen Pharmaceutica Nv Naphthyridinforbindelser
US8158673B2 (en) * 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
JP2009514846A (ja) * 2005-11-04 2009-04-09 ファイザー・リミテッド テトラヒドロナフチリジン誘導体
WO2007099423A1 (fr) * 2006-03-02 2007-09-07 Pfizer Products Inc. Dérivés de 1-pyrrolidine indane en tant qu'antagonistes du récepteur d'histamine 3
JP2009531314A (ja) 2006-03-10 2009-09-03 ニューロジェン・コーポレーション ピペラジニルオキソアルキルテトラヒドロイソキノリン類および関連類似物
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
BRPI0712823A2 (pt) 2006-06-23 2012-07-24 Abbott Lab derivados de ciclopropil amina como moduladores de receptor de histamina h3
JP5520051B2 (ja) * 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
WO2009082698A1 (fr) * 2007-12-21 2009-07-02 Abbott Laboratories Compositions pour le traitement de troubles cognitifs
CN102007126A (zh) * 2008-02-22 2011-04-06 Irm责任有限公司 作为gpr119活性调控剂的化合物和组合物
US20110046130A1 (en) * 2008-03-31 2011-02-24 Evotec Ag Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists
WO2010026113A1 (fr) * 2008-09-03 2010-03-11 Evotec Neurosciences Gmbh Acyl- et sufonyl-tétrahydronaphtyridines et dérivés aza de celles-ci en tant qu’antagonistes de récepteur d’histamine h3
WO2010052222A1 (fr) * 2008-11-07 2010-05-14 Evotec Neurosciences Gmbh Dérivés (dihydro)naphthyridinone comme antagonistes du récepteur h3 de l’histamine
WO2010122064A1 (fr) * 2009-04-21 2010-10-28 Neurosearch A/S Dérivés de naphtyridine substitués et leur utilisation médicale
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8711772B2 (en) * 2009-05-22 2014-04-29 Qualcomm Incorporated Paging of a user equipment (UE) within a wireless communications system
WO2011005636A1 (fr) * 2009-07-09 2011-01-13 Merck Sharp & Dohme Corp. Antagonistes des récepteurs à l'orexine à base de tétrahydronaphtyridine
WO2012037258A1 (fr) 2010-09-16 2012-03-22 Abbott Laboratories Procédés de préparation de dérivés cyclopropyliques substitués en 1,2
CN102093356B (zh) * 2011-03-16 2012-12-19 无锡美克赛医药科技有限公司 一种2-氯-5,6,7,8-四氢-1,6-萘啶盐酸盐的制备方法
JP5767393B2 (ja) 2011-03-31 2015-08-19 ファイザー・インク 新規二環式ピリジノン
WO2012172449A1 (fr) 2011-06-13 2012-12-20 Pfizer Inc. Lactames convenant comme inhibiteurs des bêta-sécrétases
JP6043355B2 (ja) 2011-08-31 2016-12-14 ファイザー・インク ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
EP2852597B1 (fr) 2012-05-04 2016-06-08 Pfizer Inc Composés d'hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par des hétérocycliques à titre d'inhibiteurs d'app, bace1 et bace2
BR112014032913A2 (pt) 2012-06-29 2017-06-27 Pfizer novas 4-(amino-substituídas)-7h-pirrolo[2,3-d]pirimidinas como inibidores de lrrk2
US9260455B2 (en) 2012-09-20 2016-02-16 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
EP2931731A1 (fr) 2012-12-11 2015-10-21 Pfizer Inc. Composés d'hexahydropyrano [3,4-d][1,3]thiazin-2-amine en tant qu'inhibiteurs de bace1
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2956458B1 (fr) 2013-02-13 2017-08-09 Pfizer Inc Composés hexahydropyrano[3,4-d][1,3]thiazin-2-amine substitués par un hétéroaryle
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CN105121439A (zh) 2013-02-19 2015-12-02 辉瑞公司 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
JP6263606B2 (ja) 2013-05-02 2018-01-17 ファイザー・インク Ｐｄｅ１０阻害剤としてのイミダゾ−トリアジン誘導体
ES2742078T3 (es) 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
EP3083618B1 (fr) 2013-12-17 2018-02-21 Pfizer Inc Nouvelles 1h-pyrrolo[2,3- b]pyridines 3,4-disubstituées et 7h-pyrrolo[2,3-c]pyridazines 4,5-disubstituées en tant qu'inhibiteurs de la lrrk2
DK3126361T3 (da) 2014-04-01 2020-01-02 Pfizer Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer
CR20160455A (es) 2014-04-10 2016-12-16 Pfizer 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4-d][1,3]TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILA
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
KR102061952B1 (ko) 2014-08-06 2020-01-02 화이자 인코포레이티드 이미다조피리다진 화합물
TN2017000342A1 (en) 2015-02-03 2019-01-16 Pfizer Novel cyclopropabenzofuranyl pyridopyrazinediones
MX378963B (es) * 2015-05-28 2025-03-10 Theravance Biopharma R&D Ip Llc Compuestos de naftiridina como inhibidores de quinasa jak.
CR20170572A (es) 2015-06-17 2018-03-20 Pfizer Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
EP3350178B1 (fr) 2015-09-14 2021-10-20 Pfizer Inc. Nouveaux dérivés imidazo [4,5-c]quinoline et imidazo [4,5-c][1,5]naphthyridine utilisés comme inhibiteurs de lrrk2
WO2017051276A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(2-amino-6,6-disubstitués-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl)-1,3-thiazol-4-yl]amides
WO2017051294A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-diméthyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides utiles comme inhibiteurs de bace
WO2017051303A1 (fr) 2015-09-24 2017-03-30 Pfizer Inc. Dérivés de tétrahydropyrano[3,4-d] [1,3]oxazine et leur utilisation en tant qu'inhibiteurs de bace
SG11201806383TA (en) 2016-02-23 2018-09-27 Pfizer 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
PT3478679T (pt) 2016-07-01 2021-06-30 Pfizer Derivados de 5,7-dihidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas
CA3056027A1 (fr) 2017-03-10 2018-09-13 Pfizer Inc. Derives d'imidazo [4,5-c] quinoleine substitues cycliques
CN111051304B (zh) 2017-03-10 2022-12-27 辉瑞大药厂 作为LRRK2抑制剂的咪唑并[4,5-c]喹啉衍生物
CN110997693A (zh) 2017-06-07 2020-04-10 阿德克斯公司 τ聚集抑制剂
HUE060914T2 (hu) 2017-06-22 2023-04-28 Pfizer Dihidro-pirrolo-piridin származékok
EP3668886A2 (fr) 2017-08-18 2020-06-24 Adrx, Inc. Inhibiteurs peptidiques d'agrégation de tau
EP4219464A1 (fr) 2018-03-23 2023-08-02 Pfizer Inc. Pipérazine azaspiro derivaves
WO2022182658A1 (fr) 2021-02-23 2022-09-01 Hoth Therapeutics, Inc. Utilisation d'aprépitant pour le traitement de la maladie d'alzheimer
BR112023023866A2 (pt) * 2021-05-21 2024-02-06 Chengdu Baiyu Pharmaceutical Co Ltd Derivado de piperazina e seu uso na medicina
WO2025145091A1 (fr) 2023-12-29 2025-07-03 Pfizer Inc. Formes cristallines d'un modulateur muscarinique m4 du récepteur et méthodes de traitement de maladies

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
RU2182904C2 (ru) 1996-02-09 2002-05-27 Джеймс Блэк Фаундейшн Лимитед Сульфонамиды и способы их получения
WO2000035296A1 (fr) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Liberation amelioree d'agents medicamenteux actifs par un enrobage de chewing-gum
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
GB9803536D0 (en) * 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
EP0982300A3 (fr) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique
TWI298068B (en) * 2000-06-21 2008-06-21 Dainippon Sumitomo Pharma Co Pharmaceutical composition for schizophrenia
MXPA02012851A (es) 2000-07-13 2003-09-05 Abbott Lab Pirrolidinas 1,3-disustituidas y 1,3,3-trisustituidas como ligandos del receptor de histamina-3 y sus aplicaciones terapeuticas.
DK1313721T3 (da) * 2000-08-08 2006-06-26 Ortho Mcneil Pharm Inc Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander
PT1311482E (pt) 2000-08-08 2007-04-30 Ortho Mcneil Pharm Inc Ariloxipiperidinas não imidazólicas como ligandos do receptor h3
EP1379493A2 (fr) 2001-03-23 2004-01-14 Eli Lilly and Company Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques
GB0206033D0 (en) * 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy
WO2005009976A1 (fr) * 2003-07-29 2005-02-03 Novo Nordisk A/S Pyridazinyl-piperazines et leur utilisation en tant que ligands du recepteur histaminique h3
JP2009514846A (ja) * 2005-11-04 2009-04-09 ファイザー・リミテッド テトラヒドロナフチリジン誘導体

Also Published As

Publication number Publication date
UY28895A1 (es) 2005-12-30
ATE491707T1 (de) 2011-01-15
ZA200609111B (en) 2008-08-27
CN101798305A (zh) 2010-08-11
EP1756104B1 (fr) 2010-12-15
WO2005111036A1 (fr) 2005-11-24
DK1756104T3 (da) 2011-02-21
AR049092A1 (es) 2006-06-28
GT200500112A (es) 2005-12-12
US7557121B2 (en) 2009-07-07
SV2005002112A (es) 2005-12-13
IL178882A0 (en) 2007-03-08
KR100908155B1 (ko) 2009-07-16
AP2006003786A0 (en) 2006-10-31
KR20070014174A (ko) 2007-01-31
CA2564201A1 (fr) 2005-11-24
JP4084410B2 (ja) 2008-04-30
TW200607506A (en) 2006-03-01
IL178882A (en) 2011-03-31
BRPI0510762A (pt) 2007-11-20
MA28579B1 (fr) 2007-05-02
MXPA06013113A (es) 2007-02-28
EA200601897A1 (ru) 2007-02-27
NL1029016C2 (nl) 2006-05-30
JP2007536374A (ja) 2007-12-13
GEP20084552B (en) 2008-11-25
ECSP066984A (es) 2006-12-29
EA010487B1 (ru) 2008-10-30
CA2564201C (fr) 2011-01-18
CR8747A (es) 2006-12-05
AU2005243403B2 (en) 2010-10-07
CN1950371B (zh) 2011-01-12
PA8632801A1 (es) 2006-06-02
PE20060312A1 (es) 2006-05-03
US20090258861A1 (en) 2009-10-15
EP1595881A1 (fr) 2005-11-16
DE602005025345D1 (de) 2011-01-27
CN1950371A (zh) 2007-04-18
ES2355572T3 (es) 2011-03-29
US20050256135A1 (en) 2005-11-17
NL1029016A1 (nl) 2005-11-15
AU2005243403A1 (en) 2005-11-24
EP1756104A1 (fr) 2007-02-28
NO20064577L (no) 2006-11-06

Similar Documents

Publication Publication Date Title
TNSN06369A1 (fr) Derives de tetrahydronaphtyridine utiles comme ligands du recepteur d'histamine h3
TNSN08359A1 (fr) Derives d'amines
MA27452A1 (fr) Derives d'indole servant d'agonistes beta-2
TN2009000112A1 (fr) Derives de sulfonamides servant d'agonistes adrenergiques et d'antagonistes muscariniques
TNSN06188A1 (fr) Derives de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de recepteurs de chimiokines
MA29160B1 (fr) Derives de triazole substitues, servant d'antagonistes d'ocytocine
MA29839B1 (fr) Derives de carboxamides servant d'antagonistes des recepteurs muscariniques
TNSN04151A1 (fr) Derives de nicotinamide utiles comme inhibiteurs de pde4
MA27624A1 (fr) Procede pour realiser une preparation enrobee
MA31949B1 (fr) Dérivés d'aminotriazole comme agonistes d'alx
TNSN08196A1 (fr) Derives de pyrazine
MA28747B1 (fr) Dérivés de pyridine
MA29170B1 (fr) Derives puriniques agissant comme des agonistes du recepteur a2a
WO2008056259A3 (fr) Dérivés d'oxazole utilisés en tant que modulateurs allostériques positifs des récepteurs métabotropiques du glutamate
MA30911B1 (fr) Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine
TNSN06360A1 (fr) 4-phenylamino-quinazoline-6-yl-amides
TNSN06051A1 (fr) Derives de piperazine pour le traitement d'infections par le hiv
MA31521B1 (fr) Dérivés de 2,3-dihydrobenzo[1,4] dioxin-2-ylméthyle utilisés en tant qu'antagonistes des alpha2c pour traiter des maladies des systèmes nerveux périphérique et central
MA29377B1 (fr) Derives de la pyrimidine pour traitement de troubles a caractere hyperproliferatif
MA30696B1 (fr) Derives de l'acide (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetique
DK1551803T3 (da) Azabicycloderivater som muskarine receptorantagonister
MA28269A1 (fr) Arylpyrazoles substitués servant d'agents parasiticides
MA29411B1 (fr) 1h-quinazoline -2,4-diones et leur utilisation en tant que ligands du recepteur ampa
MA27840A1 (fr) Derives de (2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propylphenyle servant d'agonistes beta2
TNSN04225A1 (fr) Derives de benzoxazine en tant que modulateurs de 5-ht6 et utilisations de ceux-ci