[go: up one dir, main page]

MA27624A1 - Procede pour realiser une preparation enrobee - Google Patents

Procede pour realiser une preparation enrobee

Info

Publication number
MA27624A1
MA27624A1 MA28453A MA28453A MA27624A1 MA 27624 A1 MA27624 A1 MA 27624A1 MA 28453 A MA28453 A MA 28453A MA 28453 A MA28453 A MA 28453A MA 27624 A1 MA27624 A1 MA 27624A1
Authority
MA
Morocco
Prior art keywords
making
coated preparation
preparation
pioglitazone hydrochloride
coated
Prior art date
Application number
MA28453A
Other languages
English (en)
Inventor
Kazuhiro Ohkouchi
Masahiko Koike
Hiroyoshi Koyama
Naoru Hamaguchi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32830627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27624(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA27624A1 publication Critical patent/MA27624A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention divulgue une méthode de réalisation d'une préparation enrobée de chlorhydrate de pioglitazone, qui est utile comme agent thérapeutique pour le diabète et semblables, et qui est meilleure par les caractéristiques de la préparation telles la propriété de dissolution du chlorhydrate de pioglitazone.
MA28453A 2003-01-29 2005-08-24 Procede pour realiser une preparation enrobee MA27624A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003020925 2003-01-29
JP2003276894 2003-07-18
JP2004001128 2004-01-06

Publications (1)

Publication Number Publication Date
MA27624A1 true MA27624A1 (fr) 2005-11-01

Family

ID=32830627

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28453A MA27624A1 (fr) 2003-01-29 2005-08-24 Procede pour realiser une preparation enrobee

Country Status (14)

Country Link
US (1) US7976853B2 (fr)
EP (1) EP1588708A4 (fr)
KR (1) KR101114808B1 (fr)
AU (1) AU2004208606B2 (fr)
BR (1) BRPI0407074A (fr)
CA (1) CA2514539C (fr)
CR (1) CR7929A (fr)
IL (1) IL169870A (fr)
MA (1) MA27624A1 (fr)
MX (1) MXPA05007883A (fr)
NO (1) NO20053965L (fr)
NZ (1) NZ541749A (fr)
PL (1) PL377403A1 (fr)
WO (1) WO2004067001A1 (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) * 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
BRPI0414979A (pt) 2003-10-31 2006-11-21 Takeda Pharmaceutical preparação sólida
US8263121B2 (en) 2004-04-14 2012-09-11 Takeda Pharmaceutical Company Limited Solid pharmaceutical preparation
GB0423964D0 (en) * 2004-10-28 2004-12-01 Jagotec Ag Dosage form
TWI274889B (en) * 2005-10-06 2007-03-01 Elan Microelectronics Corp Resistive touch screen measurement system
JP5179363B2 (ja) * 2005-12-22 2013-04-10 武田薬品工業株式会社 固形製剤
EA016728B1 (ru) * 2006-08-10 2012-07-30 Такеда Фармасьютикал Компани Лимитед Фармацевтическая композиция
DK2107905T3 (da) * 2007-02-01 2011-01-31 Takeda Pharmaceutical Fast sammensætning omfattende alogliptin og pioglitazon
US20070172525A1 (en) * 2007-03-15 2007-07-26 Ramesh Sesha Anti-diabetic combinations
US20080064701A1 (en) * 2007-04-24 2008-03-13 Ramesh Sesha Anti-diabetic combinations
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
TW200914006A (en) * 2007-07-12 2009-04-01 Takeda Pharmaceutical Coated preparation
KR101617243B1 (ko) 2007-07-31 2016-05-02 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
WO2009070592A2 (fr) 2007-11-27 2009-06-04 Lifescan, Inc. Différentiation des cellules souches embryonnaires humaines
CA2715878C (fr) 2008-02-21 2017-06-13 Centocor Ortho Biotech Inc. Procedes, plaques a surface modifiee et compositions permettant la fixation, la culture et le detachement de cellules
US8551524B2 (en) * 2008-03-14 2013-10-08 Iycus, Llc Anti-diabetic combinations
WO2009120844A2 (fr) * 2008-03-26 2009-10-01 Teva Pharmaceutical Industries Ltd. Compositions pharmaceutiques comprenant un sensibilisateur à l’insuline et un secrétagogue d’insuline
KR20180018839A (ko) 2008-06-30 2018-02-21 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
CN102272291B (zh) 2008-10-31 2018-01-16 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
MX2011005288A (es) 2008-11-20 2011-06-01 Centocor Ortho Biotech Inc Celulas madre pluripotentes en microportadores.
ES2584053T3 (es) 2008-11-20 2016-09-23 Janssen Biotech, Inc. Métodos y composiciones para la unión de células y cultivo en sustratos planos
US10076544B2 (en) 2009-07-20 2018-09-18 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CA2784415C (fr) 2009-12-23 2019-06-18 Jean Xu Differenciation de cellules souches embryonnaires humaines
US9969981B2 (en) 2010-03-01 2018-05-15 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
KR101903562B1 (ko) 2010-05-12 2018-10-02 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
RU2627168C2 (ru) 2010-08-31 2017-08-03 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
RU2620938C2 (ru) 2010-08-31 2017-05-30 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
JP2013538807A (ja) 2010-09-01 2013-10-17 ルピン・リミテッド メトホルミンおよびピオグリタゾンを含む医薬組成物
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
CN105143446B (zh) 2011-12-22 2020-11-03 詹森生物科技公司 人胚胎干细胞分化成单一激素胰岛素阳性细胞
US9434920B2 (en) 2012-03-07 2016-09-06 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
KR102285014B1 (ko) 2012-06-08 2021-08-03 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
EP2674149B1 (fr) * 2012-06-15 2017-10-04 Shin-Etsu Chemical Co., Ltd. Procédé de préparation de granules composites comprenant de la cellulose hydroxypropyle faiblement substituée et préparation à libération rapide
RU2658488C2 (ru) 2012-12-31 2018-06-21 Янссен Байотек, Инк. Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток
EP4219683A1 (fr) 2012-12-31 2023-08-02 Janssen Biotech, Inc. Différenciation de cellules souches embryonnaires humaines en cellules endocrines pancréatiques à l'aide de régulateurs de hb9
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
KR20150103203A (ko) 2012-12-31 2015-09-09 얀센 바이오테크 인코포레이티드 췌장 내분비 세포 내로의 분화를 위한 인간 만능 세포의 현탁 및 클러스터링
BR112015030617B1 (pt) * 2013-06-17 2020-12-22 Nippon Soda Co., Ltd formulação sólida
KR101597004B1 (ko) * 2013-07-25 2016-02-23 씨제이헬스케어 주식회사 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제
EP3143127B1 (fr) 2014-05-16 2021-07-14 Janssen Biotech, Inc. Utilisation de petites molécules pour améliorer l'expression du gène mafa dans des cellules endocrines pancréatiques
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
RU2690677C1 (ru) * 2018-06-27 2019-06-05 Георгий Георгиевич Чумбуридзе Стабилизированная композиция, обладающая противовирусной, противоопухолевой, иммуномодулирующей, актопротекторной, антимутагенной и антиоксидантной активностью
CN112461947B (zh) * 2020-10-27 2022-06-28 山东省药学科学院 一种盐酸吡格列酮片溶出曲线的测定方法
CN120392688B (zh) * 2025-07-02 2025-09-16 浙江大学 一种盐酸吡格列酮和二甲双胍复方片剂及其制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5179716A (en) * 1974-12-28 1976-07-12 Shinetsu Chemical Co Kokeiiyakuseizaino seizohoho
DE3720757A1 (de) 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
ES2124794T3 (es) * 1992-10-09 1999-02-16 Kanegafuchi Chemical Ind Procedimiento para producir granulados finos.
US5651983A (en) * 1993-02-26 1997-07-29 The Procter & Gamble Company Bisacodyl dosage form for colonic delivery
DK0719140T3 (da) 1993-09-15 2008-03-03 Daiichi Sankyo Co Ltd Anvendelse af thiazolidindioner til forebyggelse eller forsinkelse af indtræden af NIDDM
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US6153632A (en) 1997-02-24 2000-11-28 Rieveley; Robert B. Method and composition for the treatment of diabetes
US6291495B1 (en) 1997-02-24 2001-09-18 Robert B. Rieveley Method and composition for the treatment of diabetes
SE9702000D0 (sv) * 1997-05-28 1997-05-28 Astra Ab New pharmaceutical formulation
CA2294582C (fr) 1997-06-18 2008-02-12 Smithkline Beecham P.L.C. Traitement du diabete a l'aide de thiazolidinedione et de metformine
US20020004515A1 (en) 1997-06-18 2002-01-10 Smith Stephen Alistair Treatment of diabetes with thiazolidinedione and metformin
CA2320900C (fr) 1998-03-19 2009-10-27 Bristol-Myers Squibb Company Systeme d'apport a liberation lente biphasique destine a des medicaments a solubilite elevee et procede associe
AU5652199A (en) * 1998-09-18 2000-04-10 Takeda Chemical Industries Ltd. Sustained release oral preparations
EP1125586A4 (fr) * 1998-10-26 2003-06-11 Tanabe Seiyaku Co Particules a liberation prolongee
DE69939485D1 (de) 1998-11-12 2008-10-16 Smithkline Beecham Plc Arzneimittel zur gesteuerten freisetzung eines insulin sensibilisators und metformin
AR023700A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Plc Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6168806B1 (en) * 1999-03-05 2001-01-02 Fang-Yu Lee Orally administrable nifedipine pellet and process for the preparation thereof
AR030920A1 (es) 1999-11-16 2003-09-03 Smithkline Beecham Plc Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones
WO2001035940A2 (fr) * 1999-11-16 2001-05-25 Smithkline Beecham P.L.C. Nouvelle composition et utilisation
CA2399463A1 (fr) * 2000-02-10 2001-08-16 Takeda Chemical Industries, Ltd. Combinaison de medicament
US6780432B1 (en) 2000-05-01 2004-08-24 Aeropharm Technology, Inc. Core formulation
US6403121B1 (en) * 2000-05-01 2002-06-11 Aeropharm Technology Incorporated Core formulation
US6524621B2 (en) 2000-05-01 2003-02-25 Aeropharm Technology Inc. Core formulation
US6610272B1 (en) * 2000-05-01 2003-08-26 Aeropharm Technology Incorporated Medicinal aerosol formulation
JP2001342185A (ja) * 2000-06-02 2001-12-11 Nichiko Pharmaceutical Co Ltd フィルムコーティングされた塩酸ラニチジン錠剤
JP4633329B2 (ja) 2001-01-12 2011-02-16 サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド スペーストドラッグデリバリーシステム
US20040092480A1 (en) * 2001-01-30 2004-05-13 Kentaro Fujinaga Medicinal composition
WO2003005995A1 (fr) 2001-07-10 2003-01-23 Aeropharm Technology Incorporated Preparation de noyau comprenant un hydrochlorure de pioglitazone et un biguanide
US20030187074A1 (en) 2002-03-04 2003-10-02 Javed Hussain Oral compositions for treatment of diabetes
AU2002356419A1 (en) 2002-06-17 2003-12-31 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
CN100367960C (zh) * 2002-07-11 2008-02-13 武田药品工业株式会社 包衣制剂的制备方法
CN100544717C (zh) * 2002-09-20 2009-09-30 华生制药公司 含有双胍和噻唑烷二酮衍生物的药物剂型
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
IN192749B (fr) * 2002-11-15 2004-05-15 Ranbaxy Lab Ltd
WO2004069229A1 (fr) 2003-02-05 2004-08-19 Ipca Laboratories Limited Medicaments antidiabetiques a double liberation et procede de production de ceux-ci

Also Published As

Publication number Publication date
KR20050096958A (ko) 2005-10-06
WO2004067001A1 (fr) 2004-08-12
NO20053965L (no) 2005-08-25
AU2004208606B2 (en) 2009-09-24
CA2514539C (fr) 2012-03-06
AU2004208606A1 (en) 2004-08-12
EP1588708A1 (fr) 2005-10-26
IL169870A (en) 2012-07-31
PL377403A1 (pl) 2006-02-06
BRPI0407074A (pt) 2006-01-24
US7976853B2 (en) 2011-07-12
NZ541749A (en) 2009-06-26
EP1588708A4 (fr) 2006-03-01
MXPA05007883A (es) 2005-09-21
KR101114808B1 (ko) 2012-02-15
CR7929A (es) 2005-11-28
CA2514539A1 (fr) 2004-08-12
US20060141128A1 (en) 2006-06-29

Similar Documents

Publication Publication Date Title
MA27624A1 (fr) Procede pour realiser une preparation enrobee
BR0214164A (pt) Ligantes do receptor canabinóide
TNSN06369A1 (fr) Derives de tetrahydronaphtyridine utiles comme ligands du recepteur d'histamine h3
SE0202483D0 (sv) Chemical compounds
CA2506016A1 (fr) Derives de 3-amino-piperadine et leurs procedes de preparation
EA200602196A1 (ru) Производные пиразола, композиции, содержащие эти соединения, и способы применения
NO20043611L (no) Fremgangsmate for fremstilling av HMG-COA reduktaseinhibitorer
EP1678162A4 (fr) Inhibiteur de glycoproteine p, son procede de preparation et composition pharmaceutique comportant un tel inhibiteur
NO20014101L (no) Stabilisert oral farmasöytisk blanding inneholdende iodid og iodat og fremgangsmåte
EA200400467A1 (ru) Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
SE0200919D0 (sv) Chemical compounds
AU2003250471A1 (en) Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
AP1766A (en) Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation.
MXPA04006041A (es) Antivirales de piridoquinoxalina.
MY138826A (en) 2,7-substituted indoles
AU2003300385A1 (en) Anticancer compounds
SE0003476D0 (sv) Compounds
EA200000322A1 (ru) Способ синтеза производных хинолина
DE60225694D1 (de) Fexofenadine hydrochlorid polymorph
RU95107655A (ru) Глюкопиранозидбензотиофены, способ получения, фармацевтическая композиция
WO2003080631A8 (fr) Inhibiteurs de plasma carboxypeptidase b
EP1734037A3 (fr) Procédé pour la préparation du (R)-G(A)-(2,3-dimethoxyphenyle)-1-[2-(4-fluorophenyle)ethyle]-4-piperidinemethanol
EA200300850A1 (ru) Применение антагонистов рецептора gal3 при лечении депрессии и/или тревоги и соединения, полезные в таких способах
WO2003076426A3 (fr) Composes therapeutiques