[go: up one dir, main page]

TNSN98156A1 - Associations pharmaceutiques d'amlodipine et d'atorvastatine et procede pour leur preparation - Google Patents

Associations pharmaceutiques d'amlodipine et d'atorvastatine et procede pour leur preparation

Info

Publication number
TNSN98156A1
TNSN98156A1 TNTNSN98156A TNSN98156A TNSN98156A1 TN SN98156 A1 TNSN98156 A1 TN SN98156A1 TN TNSN98156 A TNTNSN98156 A TN TNSN98156A TN SN98156 A TNSN98156 A TN SN98156A TN SN98156 A1 TNSN98156 A1 TN SN98156A1
Authority
TN
Tunisia
Prior art keywords
amlodipine
atorvastatin
preparation
pharmaceutical combinations
treatment
Prior art date
Application number
TNTNSN98156A
Other languages
English (en)
Inventor
Buch Jan
Andrew Donald Scott Robert
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22009597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN98156(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN98156A1 publication Critical patent/TNSN98156A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'INVENTION CONCERNE DES ASSOCIATIONS PHARMACEUTIQUES D'AMLODIPINE OU D'UN DES SES SELS D'ADDITION D'ACIDES PHARMACEUTIQUEMENT ACCEPTABLES ET D'ATORVASTATINE OU DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES. ELLE CONCERNE EGALEMENT DES KITS CONTENANT CES ASSOCIATIONS AINSI Q'UN PROCEDE POUR LEUR PREPARATION . APPLICATION : UTILISATION POUR LE TRAITEMENT DE SUJETS SOUFFRANT D'ANGINE DE POITRINE, D'ATHEROSCLEROSE, D'HYPERTENSION ET D'HYPERLIPIDEMIE EN ASSOCIATION, ET POUR LE TRAITEMENT DE SUJETS PRESENTANT DES SYMPTOMES DE RISQUES CARDIAQUES.
TNTNSN98156A 1997-08-29 1998-08-26 Associations pharmaceutiques d'amlodipine et d'atorvastatine et procede pour leur preparation TNSN98156A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5727597P 1997-08-29 1997-08-29

Publications (1)

Publication Number Publication Date
TNSN98156A1 true TNSN98156A1 (fr) 2005-03-15

Family

ID=22009597

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98156A TNSN98156A1 (fr) 1997-08-29 1998-08-26 Associations pharmaceutiques d'amlodipine et d'atorvastatine et procede pour leur preparation

Country Status (49)

Country Link
US (11) US6455574B1 (fr)
EP (3) EP1468682A1 (fr)
JP (3) JP2001514222A (fr)
KR (1) KR20010023498A (fr)
CN (2) CN101062035A (fr)
AP (1) AP1225A (fr)
AR (1) AR012269A1 (fr)
AT (2) ATE277615T1 (fr)
AU (1) AU755636B2 (fr)
BG (1) BG64665B1 (fr)
BR (1) BR9812030A (fr)
CA (1) CA2301732C (fr)
CO (1) CO4970694A1 (fr)
CY (2) CY1105108T1 (fr)
CZ (1) CZ301081B6 (fr)
DE (2) DE69835245T2 (fr)
DK (2) DK1003503T3 (fr)
DZ (1) DZ2596A1 (fr)
EA (1) EA003549B1 (fr)
ES (2) ES2227865T3 (fr)
GE (2) GEP20084338B (fr)
GT (1) GT199800127A (fr)
HN (1) HN1998000132A (fr)
HR (1) HRP980473B1 (fr)
HU (1) HUP0003656A3 (fr)
ID (1) ID23670A (fr)
IL (2) IL134303A0 (fr)
IS (1) IS2029B (fr)
LU (1) LU91253I2 (fr)
MA (1) MA26535A1 (fr)
ME (1) ME00545B (fr)
MY (1) MY123993A (fr)
NO (1) NO320267B1 (fr)
NZ (2) NZ527158A (fr)
OA (1) OA11290A (fr)
PA (1) PA8457101A1 (fr)
PE (1) PE107199A1 (fr)
PL (1) PL192360B1 (fr)
PT (2) PT1003503E (fr)
RS (1) RS50485B (fr)
SI (2) SI1491193T1 (fr)
SK (1) SK284958B6 (fr)
TN (1) TNSN98156A1 (fr)
TR (1) TR200000561T2 (fr)
TW (1) TW592696B (fr)
UA (1) UA71897C2 (fr)
UY (1) UY25157A1 (fr)
WO (1) WO1999011259A1 (fr)
ZA (1) ZA987844B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
GT199800127A (es) * 1997-08-29 2000-02-01 Combinaciones terapeuticas.
WO2000038721A1 (fr) 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs de la proteine de transfert du cholesteryle-ester et de derives de l'acide nicotinique utilisees dans le cadre de troubles cardio-vasculaires
HK1043741A1 (zh) * 1999-04-23 2002-09-27 Preston Mason R. 氨氯地平和阿托发司他汀的协作效应
US7129265B2 (en) 1999-04-23 2006-10-31 Mason R Preston Synergistic effects of amlodipine and atorvastatin metabolite as a basis for combination therapy
HN2000000050A (es) 1999-05-27 2001-02-02 Pfizer Prod Inc Sal mutua de amlodipino y atorvastatina
ES2220426T3 (es) * 1999-05-27 2004-12-16 Pfizer Products Inc. Profarmacos mutuos de amlodipino y atorvastatina.
CA2314517A1 (fr) * 1999-07-26 2001-01-26 Gust H. Bardy Systeme et methode de determination du niveau de reference de l'etat d'un patient pour utilisation dans un systeme automatise de collecte et d'analyse de donnees sur les soins aux patients
AU7547900A (en) 1999-10-11 2001-04-23 Pfizer Inc. 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)- dihydropyrazolo(4,3-d)pyrimidin-7-ones as phosphodiesterase inhibitors
US6336903B1 (en) 1999-11-16 2002-01-08 Cardiac Intelligence Corp. Automated collection and analysis patient care system and method for diagnosing and monitoring congestive heart failure and outcomes thereof
US20050119270A1 (en) * 2000-08-04 2005-06-02 Mason R. P. Synergistic effect of amlodipine and atorvastatin on aortic endothelial cell nitric oxide release
US6835742B2 (en) 2000-08-04 2004-12-28 R. Preston Mason Synergistic effect of amlodipine and atorvastatin on cholesterol crystal formation inhibition and aortic endothelial cell nitric oxide release
AU2001284413A1 (en) * 2000-08-30 2002-03-13 Sankyo Company Limited Medicinal compositions for preventing or treating heart failure
GB0027410D0 (en) * 2000-11-09 2000-12-27 Pfizer Ltd Mutual prodrug of amlodipine and atorvastatin
US6737430B2 (en) 2000-11-09 2004-05-18 Pfizer, Inc. Mutual prodrug of amlodipine and atorvastatin
US20030114497A1 (en) * 2001-07-31 2003-06-19 Laman Alani Pharmaceutical compositions of amlodipine and atorvastatin
US20030044459A1 (en) * 2001-09-04 2003-03-06 Pfizer Inc. Biomodulated multiparticulate formulations
WO2003061604A2 (fr) 2002-01-17 2003-07-31 Pharmacia Corporation Nouveaux composes d'alkyl/aryl hydroxy ou cetothiepine servant d'inhibiteurs du transport des acides biliaires de type ileal et de l'absorption de taurocholate
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US7071210B2 (en) * 2002-07-02 2006-07-04 Pfizer Inc. CETP inhibitors in combination with antihypertensive agents and uses thereof
US20040053842A1 (en) * 2002-07-02 2004-03-18 Pfizer Inc. Methods of treatment with CETP inhibitors and antihypertensive agents
US20050182106A1 (en) * 2002-07-11 2005-08-18 Sankyo Company, Limited Medicinal composition for mitigating blood lipid or lowering blood homocysteine
US20040198789A1 (en) * 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
AU2004247023A1 (en) * 2003-05-16 2004-12-23 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
WO2005097191A2 (fr) * 2004-04-04 2005-10-20 Sepracor Inc. Combinaisons comprenant de la (s)-amlodipine et un inhibiteur de la hmg-coa reductase ou un inhibiteur de l'absorption de cholesterol ou les deux a la fois et methodes permettant de reduire l'hypertension
US20080095841A1 (en) * 2004-10-06 2008-04-24 Eisai R&D Management Co., Ltd. Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition
JP2008524159A (ja) 2004-12-15 2008-07-10 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング ＮＥＰ阻害剤、内因性エンドセリン産生系の阻害剤およびＨＭＧＣｏＡレダクターゼ阻害剤を含有する医薬組成物
KR100582347B1 (ko) * 2004-12-30 2006-05-22 한미약품 주식회사 3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법
CN101415425B (zh) 2006-03-29 2014-11-26 兴和株式会社 甘油三酯降低剂和高胰岛素血症改善剂
JP2008044870A (ja) * 2006-08-11 2008-02-28 Elmed Eisai Kk 医薬組成物及びその製造方法
WO2008023869A1 (fr) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. PRÉPARATION PHARMACEUTIQUE COMBINÉE À LIBÉRATION CONTRÔLÉE COMPRENANT DES INHIBITEURS CALCIQUES À BASE DE DIHYDROPYRIDINE ET DES INHIBITEURS DE HMG-CoA RÉDUCTASE
WO2008095263A1 (fr) 2007-02-09 2008-08-14 Alphapharm Pty Ltd Forme pharmaceutique contenant deux ou davantage de principes actifs pharmaceutiques sous des formes physiques différentes
CN101742907A (zh) * 2007-05-03 2010-06-16 安塞拉制药有限公司 采用分泌型磷脂酶a2（spla2）抑制剂和spla2抑制剂组合疗法治疗心血管疾病和血脂异常
US8048880B2 (en) * 2007-05-03 2011-11-01 Anthera Pharmaceuticals, Inc. Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
CN101433539A (zh) * 2007-11-12 2009-05-20 北京瑞康医药技术有限公司 含有烟酸氨氯地平和他汀类药物的治疗组合物
CN101433538B (zh) * 2007-11-12 2012-07-25 北京瑞康医药技术有限公司 含有氨氯地平和烟酸的治疗组合物
EP2161024A1 (fr) 2008-09-05 2010-03-10 Universitätsklinikum Hamburg-Eppendorf Combinaison pour le traitement de cancer
IT1400309B1 (it) 2010-05-10 2013-05-24 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e calcio antagonisti e loro uso.
CN102755322B (zh) * 2012-07-24 2013-12-11 兆科药业（广州）有限公司 一种乐卡地平和阿托伐他汀复方制剂
CN105758967B (zh) * 2016-03-24 2017-10-27 中国药科大学 诊断区分冠状动脉粥样硬化和稳定型心绞痛的标志物群
CN110915354B (zh) * 2019-12-05 2021-11-23 重庆市农业科学院 一种马铃薯种薯自动切块机
US11452690B1 (en) 2021-01-27 2022-09-27 ECI Pharmaceuticals, LLC Oral liquid compositions comprising amlodipine besylate and methods of using the same

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (fr) 1974-06-07 1981-03-18
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
US4448784A (en) 1982-04-12 1984-05-15 Hoechst-Roussel Pharmaceuticals, Inc. 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
US5208225A (en) * 1986-02-27 1993-05-04 Warner-Lambert Company Compositions containing fixed combinations
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
DE3807895A1 (de) 1988-03-10 1989-09-21 Knoll Ag Erzeugnisse, enthaltend einen calciumantagonisten und einen lipidsenker
US4804770A (en) 1988-04-29 1989-02-14 E. R. Squibb & Sons, Inc. Process for preparing a keto-phosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
US5273985A (en) * 1988-07-04 1993-12-28 Eisai Co., Ltd. Glycerin derivative and its pharmacological use
WO1990003962A1 (fr) 1988-10-13 1990-04-19 Sandoz Ag Procede de preparation d'acides hept-6 enoiques et heptanoiques substitues en position 7 et de derives et intermediaires de ces acides
US4920123A (en) 1988-10-21 1990-04-24 Beyer Jr Karl H Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5622985A (en) 1990-06-11 1997-04-22 Bristol-Myers Squibb Company Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
US5155120A (en) * 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
US5208037A (en) * 1991-04-22 1993-05-04 Alza Corporation Dosage forms comprising polymers comprising different molecular weights
DE4309553A1 (de) 1993-03-24 1994-09-29 Bayer Ag Verfahren zur Herstellung von 3R,5S-(+)-Natrium-erythro-(E)-7-(4-(4-flurophenyl)-2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl)-3,5-dihydroxy-hept-6-enoat
IN176897B (fr) 1993-10-29 1996-09-28 Cadila Lab Ltd
US5385929A (en) 1994-05-04 1995-01-31 Warner-Lambert Company [(Hydroxyphenylamino) carbonyl] pyrroles
US5447922A (en) 1994-08-24 1995-09-05 Bristol-Myers Squibb Company α-phosphonosulfinic squalene synthetase inhibitors
EP0738510A3 (fr) 1995-04-20 2005-12-21 L'oreal Utilisation d'un inhibiteur d'HMG-coenzyme A-reductase pour lutter contre le vieillissement de la peau et pour traiter l'acné. Composition comprenant au moins un inhibiteur HMG-coenzyme A reductase et au moins un actif possédant des propriétes desquamantes
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
DE19539363A1 (de) 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von festen Arzneiformen
EA000514B1 (ru) * 1995-11-02 1999-10-28 Варнер-Ламберт Компани Способ нормализации липопротеидного профиля плазмы крови у млекопитающего и фармацевтическая композиция для его осуществления
US6180660B1 (en) * 1997-08-26 2001-01-30 Merck & Co., Inc. Cholesterol-lowering therapy
GT199800126A (es) * 1997-08-29 2000-01-29 Terapia de combinacion.
GT199800127A (es) * 1997-08-29 2000-02-01 Combinaciones terapeuticas.
ES2220426T3 (es) * 1999-05-27 2004-12-16 Pfizer Products Inc. Profarmacos mutuos de amlodipino y atorvastatina.
HN2000000050A (es) * 1999-05-27 2001-02-02 Pfizer Prod Inc Sal mutua de amlodipino y atorvastatina
US20030092745A1 (en) * 2000-02-25 2003-05-15 Pfizer Inc. Combination therapy
US7925624B2 (en) * 2006-03-31 2011-04-12 Amazon Technologies, Inc. System and method for providing high availability data

Also Published As

Publication number Publication date
CN1268052A (zh) 2000-09-27
IL134303A0 (en) 2001-04-30
MY123993A (en) 2006-06-30
CZ2000511A3 (cs) 2000-06-14
OA11290A (en) 2003-08-25
CZ301081B6 (cs) 2009-10-29
CO4970694A1 (es) 2000-11-07
YU2100A (sh) 2002-11-15
CN101062035A (zh) 2007-10-31
CY2007003I1 (el) 2009-11-04
UY25157A1 (es) 2000-12-29
PL339092A1 (en) 2000-12-04
JP2004210797A (ja) 2004-07-29
EP1491193B1 (fr) 2006-07-12
NZ537880A (en) 2007-04-27
SI1491193T1 (sl) 2006-10-31
CA2301732C (fr) 2005-03-29
US20060223865A1 (en) 2006-10-05
DE69835245D1 (de) 2006-08-24
JP2001514222A (ja) 2001-09-11
GEP20104874B (en) 2010-01-11
IS2029B (is) 2005-08-15
US20090297598A1 (en) 2009-12-03
ES2227865T3 (es) 2005-04-01
BR9812030A (pt) 2000-09-26
EP1468682A1 (fr) 2004-10-20
EA200000164A1 (ru) 2000-10-30
ME00545B (me) 2011-10-10
US20140039017A1 (en) 2014-02-06
TR200000561T2 (tr) 2000-07-21
EP1003503B1 (fr) 2004-09-29
CA2301732A1 (fr) 1999-03-11
ATE332689T1 (de) 2006-08-15
LU91253I2 (fr) 2006-08-21
AU8554898A (en) 1999-03-22
CY1105108T1 (el) 2010-03-03
US6455574B1 (en) 2002-09-24
US20040048906A1 (en) 2004-03-11
ATE277615T1 (de) 2004-10-15
PT1003503E (pt) 2004-12-31
UA71897C2 (uk) 2005-01-17
SI1003503T1 (en) 2004-12-31
US20030008904A1 (en) 2003-01-09
GEP20084338B (fr) 2008-03-25
CY2007003I2 (el) 2009-11-04
HN1998000132A (es) 1999-02-09
ZA987844B (en) 2000-02-28
DK1003503T3 (da) 2005-01-10
JP2010111693A (ja) 2010-05-20
IL134303A (en) 2006-10-05
AU755636B2 (en) 2002-12-19
WO1999011259A1 (fr) 1999-03-11
HUP0003656A3 (en) 2002-10-28
ID23670A (id) 2000-05-11
GT199800127A (es) 2000-02-01
NO20000998D0 (no) 2000-02-28
PT1491193E (pt) 2006-10-31
NZ527158A (en) 2005-03-24
US20110201654A1 (en) 2011-08-18
AP9801334A0 (en) 1998-09-30
KR20010023498A (ko) 2001-03-26
AR012269A1 (es) 2000-09-27
NO20000998L (no) 2000-02-28
PA8457101A1 (es) 2000-05-24
BG104177A (en) 2000-12-29
AP1225A (en) 2003-11-20
BG64665B1 (bg) 2005-11-30
SK2042000A3 (en) 2000-12-11
RS50485B (sr) 2010-03-02
HUP0003656A2 (en) 2001-03-28
EP1003503A1 (fr) 2000-05-31
DZ2596A1 (fr) 2003-02-22
NO320267B1 (no) 2005-11-14
SK284958B6 (sk) 2006-03-02
US20130131125A1 (en) 2013-05-23
DE69835245T2 (de) 2007-07-19
HRP980473B1 (en) 2005-10-31
HRP980473A2 (en) 1999-06-30
EP1491193A1 (fr) 2004-12-29
DE69826683D1 (de) 2004-11-04
ES2266961T3 (es) 2007-03-01
DK1491193T3 (da) 2006-10-16
TW592696B (en) 2004-06-21
PE107199A1 (es) 1999-11-06
EA003549B1 (ru) 2003-06-26
DE69826683T2 (de) 2005-10-20
US20100168187A1 (en) 2010-07-01
US20060270717A1 (en) 2006-11-30
PL192360B1 (pl) 2006-10-31
IS5343A (is) 2000-01-14
MA26535A1 (fr) 2004-12-20
US20120208854A1 (en) 2012-08-16

Similar Documents

Publication Publication Date Title
TNSN98156A1 (fr) Associations pharmaceutiques d'amlodipine et d'atorvastatine et procede pour leur preparation
TNSN98155A1 (fr) Associations de compositions pharmaceutiques d'atorvastatine et d'agents antihypertensifs, et procede pour leur preparation
TNSN98158A1 (fr) Associations pharmaceutiques d'amlodipine et d'une statine, et procede pour leur preparation
TNSN00110A1 (fr) Sel mutuel d'amlodipine et d'atorvastatine, procede pour sa preparation et compositions pharmaceutiques le contenant
TNSN01125A1 (fr) Compositions pharmaceutiques comprenant un inhibiteur de cetp et de l'atorvastatine
CA2206837A1 (fr) Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
TNSN97193A1 (fr) Amides inhibiteurs de secretion de apo b/mtp, procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN98017A1 (fr) Derives de sulfonyluree, procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN98025A1 (fr) Derives d'acide arylsulfonylhydroxamique, procede pour leur preparation et compositions les contenant.
TNSN97087A1 (fr) 4(3h)-quinazolinones 2,3-disubstituees nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN00113A1 (fr) Precurseurs medicamenteux mutuels d'amlodipine et d'atorvastatine, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN99214A1 (fr) Azalides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN96153A1 (fr) Procedes et intermediaires pour la preparation de 1-benzyl-4 ((5,6 -dimethoxy-1-indanone)-2- yl) methylpiperidine.
MA24704A1 (fr) Formulations nouvelles de paroxetine et procede pour leur preparation
MA24682A1 (fr) Formes polymorphes nouvelles de cipamfylline, procede pour leur preparation et compositions les contenant
TNSN00142A1 (fr) Complexe d'eletriptan et d'une sulfobutylether- betacyclodextrine, procede pour sa preparation et compositions pharmaceutiques les contenant.
RU96102110A (ru) Способ профилактики и лечения изъязвлений роговицы
BR0012121A (pt) Derivado de aminotetralina para terapia de doenças cardiovasculares
TNSN97042A1 (fr) Derives de quinoxaline utiles en therapeutique, procede pour leur preparation et formulations pharmaceutiques les contenant.
TNSN00085A1 (fr) Composition pharmaceutique comprenant de l'amlodipine et de l'atorvastatine ou un de ses metabolites
TNSN96110A1 (fr) Precurseur medicamenteux de trovafloxacine, procede pour sa preparation et compositions le contenant.
CA2390787A1 (fr) Association de riluzole et de gabapentine et son utilisation comme medicament
TNSN01081A1 (fr) Compositions de s-methyl-dihydro-ziprasidone