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TNSN98090A1 - Formulations pharmaceutiques contenant du voriconazole, et procede pour leur preparation. - Google Patents

Formulations pharmaceutiques contenant du voriconazole, et procede pour leur preparation.

Info

Publication number
TNSN98090A1
TNSN98090A1 TNTNSN98090A TNSN98090A TNSN98090A1 TN SN98090 A1 TNSN98090 A1 TN SN98090A1 TN TNSN98090 A TNTNSN98090 A TN TNSN98090A TN SN98090 A TNSN98090 A TN SN98090A TN SN98090 A1 TNSN98090 A1 TN SN98090A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical formulations
formulations containing
formulation
voriconazole
Prior art date
Application number
TNTNSN98090A
Other languages
English (en)
Inventor
Denise Harding Valerie
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10814734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN98090(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN98090A1 publication Critical patent/TNSN98090A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE UNE FORMULATION PHARMACEUTIQUE COMPRENANT DU VORICONAZOLE, OU UN DE SES DERIVES PHARMACEUTIQUEMENT ACCEPTABLES, ET UN DERIVE DE CYCLODEXTRINE DE FORMULE I, DANS LAQUELLE R1a-g, R2a-g et R3a-g REPRESENTENT INDEPENDAMMENT UN GROUPE OH OU O (CH2)4SO3H, SOUS RESERVE QU'AU MOINS UN DES GROUPE R1a-g REPRESENTE UN GROUPE O (CH2)4SO3H, OU UN DES SES SELS PHARMACEUTIQUEMENT ACCEPTABLES. LA FORMULATION, A L'ETAT DE SOLUTION AQUEUSE, PEUT ETRE LYOPHILISEE. APPLICATION : UTILISATION D'UNE TELLE FORMULATION AQUEUSE, INTRAVEINEUSE OU INTRAMUSCULAIRE, AYANT UNE PLUS GRANDE DUREE DE CONSERVATION.
TNTNSN98090A 1997-06-21 1998-06-17 Formulations pharmaceutiques contenant du voriconazole, et procede pour leur preparation. TNSN98090A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9713149.4A GB9713149D0 (en) 1997-06-21 1997-06-21 Pharmaceutical formulations

Publications (1)

Publication Number Publication Date
TNSN98090A1 true TNSN98090A1 (fr) 2005-03-15

Family

ID=10814734

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98090A TNSN98090A1 (fr) 1997-06-21 1998-06-17 Formulations pharmaceutiques contenant du voriconazole, et procede pour leur preparation.

Country Status (47)

Country Link
US (1) US6632803B1 (fr)
EP (1) EP1001813B8 (fr)
JP (2) JP2000513029A (fr)
KR (1) KR100372988B1 (fr)
CN (1) CN1125653C (fr)
AP (1) AP912A (fr)
AR (1) AR015900A1 (fr)
AT (1) ATE238812T1 (fr)
AU (1) AU724799B2 (fr)
BG (1) BG64584B1 (fr)
BR (1) BRPI9809468B8 (fr)
CA (1) CA2295035C (fr)
CO (1) CO4940450A1 (fr)
CZ (1) CZ289570B6 (fr)
DE (1) DE69814091T2 (fr)
DK (1) DK1001813T3 (fr)
DZ (1) DZ2523A1 (fr)
EA (1) EA001924B1 (fr)
EG (1) EG23910A (fr)
ES (1) ES2195355T3 (fr)
GB (1) GB9713149D0 (fr)
HR (1) HRP980341B1 (fr)
HU (1) HU228338B1 (fr)
ID (1) ID22939A (fr)
IL (1) IL132918A (fr)
IS (1) IS2004B (fr)
MA (1) MA26508A1 (fr)
ME (1) ME00907B (fr)
MY (1) MY118151A (fr)
NO (1) NO313125B1 (fr)
NZ (1) NZ501066A (fr)
OA (1) OA11232A (fr)
PA (1) PA8453201A1 (fr)
PE (1) PE84899A1 (fr)
PL (1) PL191295B1 (fr)
PT (1) PT1001813E (fr)
RS (1) RS49633B (fr)
SA (1) SA98190159B1 (fr)
SI (1) SI1001813T1 (fr)
SK (1) SK282946B6 (fr)
TN (1) TNSN98090A1 (fr)
TR (1) TR199903191T2 (fr)
TW (1) TW406023B (fr)
UA (1) UA57083C2 (fr)
UY (1) UY25055A1 (fr)
WO (1) WO1998058677A1 (fr)
ZA (1) ZA985364B (fr)

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GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
PE20020300A1 (es) 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
CN100335047C (zh) 2002-08-20 2007-09-05 布里斯托尔-迈尔斯斯奎布公司 阿立哌唑复合制剂和方法
GB0327390D0 (en) * 2003-11-25 2003-12-31 Pfizer Ltd Pharmaceutical formulations
MXPA06006291A (es) * 2003-12-08 2006-08-23 Univ Arizona Composiciones anti-cancer sinergisticas.
EP1765336A4 (fr) 2004-06-25 2010-03-10 Univ Johns Hopkins Inhibiteurs d'angiogenese
US20100204178A1 (en) 2006-10-02 2010-08-12 James Cloyd Novel parenteral carbamazepine formulation
US20070082870A1 (en) * 2005-10-11 2007-04-12 Buchanan Charles M Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
AR061889A1 (es) 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) * 2006-09-14 2013-01-02 大道隆达（北京）医药科技发展有限公司 伏立康唑及其药用盐、中间体的一种新定向合成制备方法
BG1110U1 (bg) * 2007-06-19 2008-09-30 Рудолф ПОДЛИПСКИ Отоплителен съд за експресно локално загряване навода
EP2018866A1 (fr) * 2007-07-27 2009-01-28 Sandoz AG Compositions pharmaceutiques contenant du voriconazole
US8192721B2 (en) * 2007-12-13 2012-06-05 Verrow Pharmaceuticals, Inc. Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
WO2009137611A2 (fr) * 2008-05-06 2009-11-12 Board Of Regents, The University Of Texas System Traitement d’infection fongique pulmonaire avec du voriconazole et par inhalation
WO2010084505A2 (fr) * 2008-06-06 2010-07-29 Glenmark Pharmaceuticals Limited Formulation topique stable comprenant du voriconazole
CN101390825B (zh) * 2008-10-01 2010-12-29 山东省眼科研究所 一种伏立康唑眼内释药系统
AU2009308516B2 (en) 2008-10-21 2016-08-25 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
CN101444510B (zh) * 2008-12-31 2011-03-09 南京卡文迪许生物工程技术有限公司 含有伏立康唑的药物制剂及其制备方法
ES2573982T3 (es) 2009-08-19 2016-06-13 Ratiopharm Gmbh Proceso para la producción de coevaporados y complejos que comprenden voriconazol y ciclodextrina
WO2011064558A2 (fr) 2009-11-30 2011-06-03 Cipla Limited Composition pharmaceutique
PL3391890T3 (pl) 2010-06-29 2021-12-20 Merck Sharp & Dohme Corp. Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną
EP2409699B1 (fr) * 2010-07-23 2014-04-30 Combino Pharm, S.L. Compositions stables de voriconazole
CN102058519B (zh) * 2010-11-19 2013-01-02 苏州特瑞药业有限公司 一种伏立康唑缓释栓剂及其制备方法
WO2012171561A1 (fr) 2011-06-15 2012-12-20 Synthon Bv Composition de voriconazole stabilisée
EP2561863A1 (fr) 2011-08-22 2013-02-27 Farmaprojects, S.A.U. Compositions pharmaceutiques comportant du voriconazole
EP2874640A4 (fr) * 2012-01-05 2016-10-26 Frederick Timothy Guilford Glutathione réduite encapsulée dans un liposome pour le traitement du cancer, y compris en combinaison avec d'autres compositions pharmaceutiques
US8853248B2 (en) 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
SG10201609318UA (en) 2012-05-08 2016-12-29 Onyx Therapeutics Inc Cyclodextrin complexation methods for formulating peptide proteasome inhibitors
EP2846769A1 (fr) 2012-05-11 2015-03-18 Cipla Limited Composition pharmaceutique
EP2943224B1 (fr) 2013-01-11 2020-01-01 Xellia Pharmaceuticals ApS Complexes d'inclusion de voriconazole
CA2904670A1 (fr) 2013-03-14 2014-09-13 Fresenius Kabi Usa, Llc Formulations de voriconazole
GB201312737D0 (en) 2013-07-17 2013-08-28 Univ Greenwich Cyclodextrin
CN103690968A (zh) * 2013-11-21 2014-04-02 石药集团中奇制药技术（石家庄）有限公司 一种伏立康唑组合物及其制备方法
PT109117B (pt) * 2016-01-28 2019-02-01 Hovione Farm Sa Complexação de ingredientes ativos farmacêuticos
WO2018091668A1 (fr) 2016-11-18 2018-05-24 Aicuris Anti-Infective Cures Gmbh Nouvelles formulations de composés de la famille des bêta-lactamines substitués par une amidine, à base de cyclodextrines modifiées et d'agents acidifiants, leur préparation et leur utilisation en tant que compositions pharmaceutiques antimicrobiennes
WO2018149359A1 (fr) * 2017-02-17 2018-08-23 武汉朗来科技发展有限公司 Dérivé antibactérien de triazole, composition pharmaceutique et utilisation associées
CN113750034A (zh) * 2020-06-05 2021-12-07 中南大学湘雅三医院 耳用温敏凝胶及其制备方法
CN116570558B (zh) * 2023-06-21 2023-12-26 广州仁恒医药科技股份有限公司 一种伏立康唑眼用纳米缓释组合物及其制备方法和应用

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DE3346123A1 (de) 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
DE3347421A1 (de) 1983-12-29 1985-07-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von fluorarmen alkaliphosphatloesungen
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
US5278175A (en) * 1990-02-02 1994-01-11 Pfizer Inc. Triazole antifungal agents
GB9512961D0 (en) 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
PL337692A1 (en) 2000-08-28
EA199900937A1 (ru) 2000-08-28
NZ501066A (en) 2001-01-26
CO4940450A1 (es) 2000-07-24
JP5089004B2 (ja) 2012-12-05
PA8453201A1 (es) 2000-05-24
HRP980341A2 (en) 1999-02-28
DZ2523A1 (fr) 2003-02-01
HUP0003323A2 (hu) 2001-06-28
HUP0003323A3 (en) 2002-01-28
TW406023B (en) 2000-09-21
IS5248A (is) 1999-11-15
AR015900A1 (es) 2001-05-30
EP1001813A1 (fr) 2000-05-24
BRPI9809468B8 (pt) 2022-01-18
EA001924B1 (ru) 2001-10-22
CN1125653C (zh) 2003-10-29
IL132918A (en) 2001-09-13
RS49633B (sr) 2007-08-03
BG103882A (en) 2000-07-31
EP1001813B1 (fr) 2003-05-02
AU8110498A (en) 1999-01-04
DK1001813T3 (da) 2003-07-28
HK1027966A1 (en) 2001-02-02
BR9809468B1 (pt) 2013-11-12
CZ289570B6 (cs) 2002-02-13
SI1001813T1 (en) 2004-02-29
MA26508A1 (fr) 2004-12-20
TR199903191T2 (xx) 2000-09-21
NO995565L (no) 1999-11-30
WO1998058677A1 (fr) 1998-12-30
DE69814091D1 (de) 2003-06-05
ZA985364B (en) 1999-12-20
EG23910A (en) 2007-12-30
UA57083C2 (uk) 2003-06-16
HRP980341B1 (en) 2001-12-31
PT1001813E (pt) 2003-07-31
CZ409699A3 (cs) 2000-02-16
PE84899A1 (es) 1999-09-17
YU68199A (sh) 2002-06-19
SA98190159B1 (ar) 2005-12-21
JP2002332234A (ja) 2002-11-22
KR100372988B1 (ko) 2003-02-25
IL132918A0 (en) 2001-03-19
EP1001813B8 (fr) 2014-02-12
UY25055A1 (es) 2000-12-29
PL191295B1 (pl) 2006-04-28
GB9713149D0 (en) 1997-08-27
MY118151A (en) 2004-09-30
US6632803B1 (en) 2003-10-14
OA11232A (en) 2003-05-26
ATE238812T1 (de) 2003-05-15
NO313125B1 (no) 2002-08-19
ME00907B (me) 2007-08-03
CA2295035A1 (fr) 1998-12-30
AU724799B2 (en) 2000-09-28
SK282946B6 (sk) 2003-01-09
HU228338B1 (en) 2013-03-28
IS2004B (is) 2005-04-15
AP912A (en) 2001-12-08
SK159399A3 (en) 2000-06-12
AP9801268A0 (en) 1998-06-30
CA2295035C (fr) 2005-04-19
DE69814091T2 (de) 2004-01-22
CN1261287A (zh) 2000-07-26
ES2195355T3 (es) 2003-12-01
BR9809468A (pt) 2000-06-20
BG64584B1 (bg) 2005-08-31
KR20010014006A (ko) 2001-02-26
NO995565D0 (no) 1999-11-12
JP2000513029A (ja) 2000-10-03
ID22939A (id) 1999-12-16

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