TN2018000137A1 - Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection - Google Patents
Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infectionInfo
- Publication number
- TN2018000137A1 TN2018000137A1 TNP/2018/000137A TN2018000137A TN2018000137A1 TN 2018000137 A1 TN2018000137 A1 TN 2018000137A1 TN 2018000137 A TN2018000137 A TN 2018000137A TN 2018000137 A1 TN2018000137 A1 TN 2018000137A1
- Authority
- TN
- Tunisia
- Prior art keywords
- trispecific
- binding proteins
- prevention
- treatment
- hiv infection
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 6
- 108091008324 binding proteins Proteins 0.000 title abstract 6
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/ AIDS.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246113P | 2015-10-25 | 2015-10-25 | |
| EP16305211 | 2016-02-24 | ||
| US201662322029P | 2016-04-13 | 2016-04-13 | |
| US201662331169P | 2016-05-03 | 2016-05-03 | |
| PCT/US2016/058540 WO2017074878A1 (en) | 2015-10-25 | 2016-10-24 | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2018000137A1 true TN2018000137A1 (en) | 2019-10-04 |
Family
ID=69671420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP/2018/000137A TN2018000137A1 (en) | 2015-10-25 | 2016-10-24 | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
Country Status (5)
| Country | Link |
|---|---|
| DK (1) | DK3365366T3 (en) |
| EC (1) | ECSP18039758A (en) |
| LT (1) | LT3365366T (en) |
| SG (1) | SG10202003467RA (en) |
| TN (1) | TN2018000137A1 (en) |
-
2016
- 2016-10-24 LT LTEPPCT/US2016/058540T patent/LT3365366T/en unknown
- 2016-10-24 TN TNP/2018/000137A patent/TN2018000137A1/en unknown
- 2016-10-24 SG SG10202003467RA patent/SG10202003467RA/en unknown
- 2016-10-24 DK DK16794472.7T patent/DK3365366T3/en active
-
2018
- 2018-05-24 EC ECIEPI201839758A patent/ECSP18039758A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202003467RA (en) | 2020-05-28 |
| ECSP18039758A (en) | 2018-10-31 |
| LT3365366T (en) | 2021-11-25 |
| DK3365366T3 (en) | 2021-10-18 |
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