ECSP18039758A - TRIESPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR THE PREVENTION OR TREATMENT OF HIV INFECTION - Google Patents
TRIESPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR THE PREVENTION OR TREATMENT OF HIV INFECTIONInfo
- Publication number
- ECSP18039758A ECSP18039758A ECIEPI201839758A ECPI201839758A ECSP18039758A EC SP18039758 A ECSP18039758 A EC SP18039758A EC IEPI201839758 A ECIEPI201839758 A EC IEPI201839758A EC PI201839758 A ECPI201839758 A EC PI201839758A EC SP18039758 A ECSP18039758 A EC SP18039758A
- Authority
- EC
- Ecuador
- Prior art keywords
- binding proteins
- trivalent
- prevention
- treatment
- triespecific
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 6
- 108091008324 binding proteins Proteins 0.000 title abstract 6
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
En la presente memoria se proporcionan que comprenden proteínas de unión triespecíficas y/o trivalentes que comprenden cuatro cadenas polipeptídicas que forman tres sitios de unión a antígeno que se unen específicamente a una o más proteínas diana del VIH o uno o más receptores de células T, en donde un primer par de polipéptidos que forman la proteína de unión posee dominios variables duales que tienen una orientación cruzada y en donde un segundo par de polipéptidos que forman la proteína de unión posee un solo dominio variable. También se proporcionan en la presente memoria métodos para preparar proteínas de unión triespecíficas y/o trivalentes y usos de tales proteínas de unión para el tratamiento y/o la prevención de VIH/SIDA.Provided herein are that they comprise trivalent and / or trivalent binding proteins comprising four polypeptide chains that form three antigen-binding sites that specifically bind to one or more HIV target proteins or one or more T cell receptors, wherein a first pair of polypeptides that make up the binding protein possesses dual variable domains that are cross-oriented and wherein a second pair of polypeptides that make up the binding protein possesses a single variable domain. Also provided herein are methods for preparing trivalent and / or trivalent binding proteins and uses of such binding proteins for the treatment and / or prevention of HIV / AIDS.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246113P | 2015-10-25 | 2015-10-25 | |
| EP16305211 | 2016-02-24 | ||
| US201662322029P | 2016-04-13 | 2016-04-13 | |
| US201662331169P | 2016-05-03 | 2016-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18039758A true ECSP18039758A (en) | 2018-10-31 |
Family
ID=69671420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201839758A ECSP18039758A (en) | 2015-10-25 | 2018-05-24 | TRIESPECIFIC AND / OR TRIVALENT BINDING PROTEINS FOR THE PREVENTION OR TREATMENT OF HIV INFECTION |
Country Status (5)
| Country | Link |
|---|---|
| DK (1) | DK3365366T3 (en) |
| EC (1) | ECSP18039758A (en) |
| LT (1) | LT3365366T (en) |
| SG (1) | SG10202003467RA (en) |
| TN (1) | TN2018000137A1 (en) |
-
2016
- 2016-10-24 TN TNP/2018/000137A patent/TN2018000137A1/en unknown
- 2016-10-24 DK DK16794472.7T patent/DK3365366T3/en active
- 2016-10-24 SG SG10202003467RA patent/SG10202003467RA/en unknown
- 2016-10-24 LT LTEPPCT/US2016/058540T patent/LT3365366T/en unknown
-
2018
- 2018-05-24 EC ECIEPI201839758A patent/ECSP18039758A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202003467RA (en) | 2020-05-28 |
| TN2018000137A1 (en) | 2019-10-04 |
| DK3365366T3 (en) | 2021-10-18 |
| LT3365366T (en) | 2021-11-25 |
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