TN2015000167A1 - Composés hétéroaromatiques utilisés comme ligands de dopamine d1 - Google Patents
Composés hétéroaromatiques utilisés comme ligands de dopamine d1Info
- Publication number
- TN2015000167A1 TN2015000167A1 TNP2015000167A TN2015000167A TN2015000167A1 TN 2015000167 A1 TN2015000167 A1 TN 2015000167A1 TN P2015000167 A TNP2015000167 A TN P2015000167A TN 2015000167 A TN2015000167 A TN 2015000167A TN 2015000167 A1 TN2015000167 A1 TN 2015000167A1
- Authority
- TN
- Tunisia
- Prior art keywords
- cognitive impairment
- disease
- cognitive
- disorder
- compounds
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 150000002390 heteroarenes Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 abstract 5
- 208000028698 Cognitive impairment Diseases 0.000 abstract 4
- 208000018737 Parkinson disease Diseases 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 208000005793 Restless legs syndrome Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024714 major depressive disease Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000000980 schizophrenia Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000001613 Gambling Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010020710 Hyperphagia Diseases 0.000 abstract 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000029560 autism spectrum disease Diseases 0.000 abstract 1
- 230000006999 cognitive decline Effects 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
Abstract
La présente invention propose en partie les composés de formule I et leurs sels pharmaceutiquement acceptables ainse que ls N-oxydes des entités précitées ; des procédés pour la préparation , les intermédiaires utitlisés dans la préparation , et des compositions contenant de tels composés , sels ou N-oxydes ainsi que leurs utilisations pour le traitement de troubles à médiation par D1 (ou associés à D1) comprenant par exemple la schizophrénie (par exemple ses symptômes cognitifs ou négatifs ; l'altération cognitive (par exemple l'altération cognitive associée à la schizophrénie, à la maladie d'Alzheimer (AD), à la maladie de Parkinson (PD) ou la thérapie de type pharmaco-thérapeutigue), le trouble d'hyperactivité avec déficit d'attention (ADHD), l'impulsivité , le jeu compulsif, l 'hyperphagie, un trouble du spectre de l'autisme , l'altération cognitive bénigne (MCI), le déclin cognitif dû a l'âge, la démence, le syndrome des jambes sans repos (RLS), la maladie de Parkinson, la chorée de Huntington, l'anxiété, la dépression, le trouble dépressif majeur (MDD), la dépression résistant au traitement (TRD) et un trouble bipolaire.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723995P | 2012-11-08 | 2012-11-08 | |
| PCT/IB2013/059768 WO2014072882A1 (fr) | 2012-11-08 | 2013-10-30 | Composés hétéroaromatiques utilisés comme ligands de la dopamine d1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2015000167A1 true TN2015000167A1 (fr) | 2016-10-03 |
Family
ID=49955424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2015000167A TN2015000167A1 (fr) | 2012-11-08 | 2015-04-30 | Composés hétéroaromatiques utilisés comme ligands de dopamine d1 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8822494B2 (fr) |
| EP (1) | EP2917216B1 (fr) |
| JP (1) | JP5823657B1 (fr) |
| KR (1) | KR101660664B1 (fr) |
| CN (1) | CN104837839A (fr) |
| AP (1) | AP3861A (fr) |
| AR (1) | AR095359A1 (fr) |
| AU (1) | AU2013343105B2 (fr) |
| BR (1) | BR112015010412A2 (fr) |
| CA (1) | CA2889572C (fr) |
| CL (1) | CL2015001233A1 (fr) |
| CO (1) | CO7350619A2 (fr) |
| CR (1) | CR20150237A (fr) |
| EA (1) | EA201500402A1 (fr) |
| ES (1) | ES2652514T3 (fr) |
| GE (1) | GEP201606598B (fr) |
| HK (1) | HK1213256A1 (fr) |
| IL (1) | IL238712A0 (fr) |
| MA (1) | MA38069A1 (fr) |
| MD (1) | MD20150037A2 (fr) |
| MX (1) | MX2015005506A (fr) |
| NI (1) | NI201500066A (fr) |
| PE (1) | PE20150966A1 (fr) |
| PH (1) | PH12015500883A1 (fr) |
| SG (1) | SG11201502884TA (fr) |
| TN (1) | TN2015000167A1 (fr) |
| TW (1) | TWI577678B (fr) |
| UA (1) | UA111687C2 (fr) |
| UY (1) | UY35129A (fr) |
| WO (1) | WO2014072882A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5857168B2 (ja) | 2012-11-08 | 2016-02-10 | ファイザー・インク | ドーパミンｄ１リガンドとしての複素芳香族化合物およびその使用 |
| EA201500402A1 (ru) * | 2012-11-08 | 2016-05-31 | Пфайзер Инк. | Гетероароматические соединения в качестве лигандов допамина d1 |
| TN2015000547A1 (fr) | 2013-06-27 | 2017-04-06 | Pfizer | Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1 |
| WO2015162518A1 (fr) * | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Composes hetero-aromatiques et leur utilisation comme ligands d1 de la dopamine |
| CA2946475A1 (fr) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Composes heteroaromatiques et leur utilisation comme ligands de la dopamine d1 |
| CN106232118A (zh) * | 2014-04-25 | 2016-12-14 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
| US9856263B2 (en) | 2014-04-28 | 2018-01-02 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
| EP3137469B1 (fr) | 2014-04-28 | 2019-10-09 | Pfizer Inc | Composés hétérocycliques et leur utilisation comme ligands des récepteurs d1 de la dopamine |
| CN103992319B (zh) * | 2014-05-27 | 2015-09-16 | 天津市斯芬克司药物研发有限公司 | 一种吡啶羧酸类化合物的制备方法 |
| CN111182898B (zh) * | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| MA49524A (fr) | 2017-06-30 | 2021-05-26 | Chase Therapeutics Corp | Compositions d'antagoniste de nk-1 et méthodes destinées à être utilisées dans le traitement de la dépression |
| WO2020087031A1 (fr) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combinaison d'un inhibiteur de réabsorption spécifique de la sérotonine et d'un agoniste partiel du récepteur de la sérotonine 1a pour réduire la dyskinésie induite par l-dopa |
| MX2022016455A (es) | 2020-06-22 | 2023-02-01 | Hoffmann La Roche | Derivados de sulfona. |
| CN115340500A (zh) * | 2021-05-14 | 2022-11-15 | 广东东阳光药业有限公司 | 一种含硫化合物的制备方法 |
| US20250145588A1 (en) * | 2022-01-29 | 2025-05-08 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of tavapadon, and preparation method therefor and use thereof |
| CN114751855B (zh) * | 2022-05-23 | 2024-05-07 | 上海皓鸿生物医药科技有限公司 | 一种2-溴-4-氨基-5-甲基吡啶的制备方法 |
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|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US6395733B1 (en) | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (fr) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Liberation amelioree d'agents medicamenteux actifs par un enrobage de chewing-gum |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| SE0201980D0 (sv) | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
| SE0301906D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | New compounds |
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