TN2011000259A1 - Substituted pyrimidines for the treatment of diseases such as cancer - Google Patents

Substituted pyrimidines for the treatment of diseases such as cancer

Info

Publication number: TN2011000259A1
Authority: TN; Tunisia
Prior art keywords: treatment; diseases; cancer; substituted pyrimidines; medicament
Prior art date: 2008-11-24

Application number

TN2011000259A

Other languages

English (en)

Inventor

Hein Stadtmueller

Ioannis Sapountzis

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-24

Filing date

2011-05-20

Publication date

2012-12-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42115425&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2011000259(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-05-20 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2012-12-17 Publication of TN2011000259A1 publication Critical patent/TN2011000259A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TN2011000259A 2008-11-24 2011-05-20 Substituted pyrimidines for the treatment of diseases such as cancer TN2011000259A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08169807		2008-11-24
EP09169654		2009-09-07
PCT/EP2009/065768 WO2010058032A2 (fr)	2008-11-24	2009-11-24	Nouveaux composés

Publications (1)

Publication Number	Publication Date
TN2011000259A1 true TN2011000259A1 (en)	2012-12-17

Family

ID=42115425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2011000259A TN2011000259A1 (en)	2008-11-24	2011-05-20	Substituted pyrimidines for the treatment of diseases such as cancer

Country Status (26)

Country	Link
US (4)	US8846689B2 (fr)
EP (1)	EP2367800B9 (fr)
JP (1)	JP5622740B2 (fr)
KR (1)	KR101710058B1 (fr)
CN (2)	CN102292322B (fr)
AP (1)	AP2960A (fr)
AR (1)	AR074210A1 (fr)
AU (1)	AU2009317170B2 (fr)
BR (1)	BRPI0922801B1 (fr)
CA (1)	CA2744351C (fr)
CL (1)	CL2011001215A1 (fr)
CO (1)	CO6511283A2 (fr)
EA (1)	EA021997B1 (fr)
EC (1)	ECSP11011079A (fr)
ES (1)	ES2664499T3 (fr)
GE (1)	GEP20146072B (fr)
IL (1)	IL212814B (fr)
MA (1)	MA32811B1 (fr)
MX (1)	MX337116B (fr)
MY (1)	MY176944A (fr)
NZ (1)	NZ592925A (fr)
PE (1)	PE20120034A1 (fr)
TN (1)	TN2011000259A1 (fr)
TW (1)	TWI491605B (fr)
UY (1)	UY32259A (fr)
WO (1)	WO2010058032A2 (fr)

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US8729265B2 (en)	2009-08-14	2014-05-20	Boehringer Ingelheim International Gmbh	Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US20120244141A1 (en)	2010-09-28	2012-09-27	Boehringer Ingelheim International Gmbh	Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
EP2675793B1 (fr)	2011-02-17	2018-08-08	Cancer Therapeutics Crc Pty Limited	Inhibiteurs de fak
DK2675794T3 (da)	2011-02-17	2019-05-06	Cancer Therapeutics Crc Pty Ltd	Selektive fak-inhibitorer
WO2013146963A1 (fr) *	2012-03-28	2013-10-03	武田薬品工業株式会社	Composé hétérocyclique
HUE052080T2 (hu)	2013-09-09	2021-04-28	Peloton Therapeutics Inc	Ariléterek és azok felhasználásai
US10807948B2 (en)	2015-03-11	2020-10-20	Peloton Therapeutics, Inc.	Aromatic compounds and uses thereof
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US10155726B2 (en)	2015-03-11	2018-12-18	Peloton Therapeutics, Inc.	Substituted pyridines and uses thereof
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US20170066778A1 (en) *	2015-09-04	2017-03-09	Aunova Medchem LLC	Solubility for target compounds
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TW202313044A (zh)	2021-08-16	2023-04-01	大陸商應世生物科技（南京）有限公司	Ｉｎ１００１８與ｐｌｄ的聯用
WO2023107705A1 (fr)	2021-12-10	2023-06-15	Incyte Corporation	Amines bicycliques utilisées comme inhibiteurs de cdk12
CN118369120A (zh)	2021-12-10	2024-07-19	应世生物科技(南京)有限公司	治疗肿瘤的药物组合及用途
CA3238851A1 (fr)	2021-12-21	2023-06-29	Yuli Xie	Compose utilise comme inhibiteur de fak et son utilisation
AU2023224815A1 (en) *	2022-02-28	2024-09-26	Wigen Biomedicine Technology (shanghai) Co., Ltd.	Compound as fak inhibitor and use thereof
EP4545080A1 (fr) *	2022-06-24	2025-04-30	Inxmed (Nanjing) Co., Ltd.	Combinaison pharmaceutique pour le traitement de tumeurs et son utilisation
CN117462553A (zh) *	2022-07-20	2024-01-30	益方生物科技(上海)股份有限公司	药物组合产品以及组合疗法
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CN118580221A (zh) *	2023-03-02	2024-09-03	应世生物科技(南京)有限公司	化合物的固体形式

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GB0619343D0 (en)	2006-09-30	2006-11-08	Vernalis R&D Ltd	New chemical compounds
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ES2550152T3 (es)	2006-12-13	2015-11-04	F. Hoffmann-La Roche Ag	Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
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JP5539734B2 (ja)	2007-01-31	2014-07-02	ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド	チオピリミジンベースの化合物およびその使用
PT2154967E (pt) *	2007-04-16	2014-06-05	Hutchison Medipharma Entpr Ltd	Derivados de pirimidina
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TWI491605B (zh)	2008-11-24	2015-07-11	Boehringer Ingelheim Int	新穎化合物
TW201024281A (en)	2008-11-24	2010-07-01	Boehringer Ingelheim Int	New compounds
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2009
- 2009-11-23 TW TW098139766A patent/TWI491605B/zh active
- 2009-11-23 AR ARP090104511A patent/AR074210A1/es not_active Application Discontinuation
- 2009-11-24 JP JP2011536901A patent/JP5622740B2/ja active Active
- 2009-11-24 MY MYPI2011002290A patent/MY176944A/en unknown
- 2009-11-24 US US13/130,669 patent/US8846689B2/en active Active
- 2009-11-24 KR KR1020117014264A patent/KR101710058B1/ko active Active
- 2009-11-24 NZ NZ592925A patent/NZ592925A/xx unknown
- 2009-11-24 GE GEAP200912270A patent/GEP20146072B/en unknown
- 2009-11-24 WO PCT/EP2009/065768 patent/WO2010058032A2/fr not_active Ceased
- 2009-11-24 AP AP2011005706A patent/AP2960A/xx active
- 2009-11-24 EP EP09756513.9A patent/EP2367800B9/fr active Active
- 2009-11-24 CN CN200980155031.1A patent/CN102292322B/zh active Active
- 2009-11-24 MX MX2011005420A patent/MX337116B/es active IP Right Grant
- 2009-11-24 ES ES09756513.9T patent/ES2664499T3/es active Active
- 2009-11-24 CA CA2744351A patent/CA2744351C/fr active Active
- 2009-11-24 AU AU2009317170A patent/AU2009317170B2/en active Active
- 2009-11-24 EA EA201100794A patent/EA021997B1/ru not_active IP Right Cessation
- 2009-11-24 PE PE2011001080A patent/PE20120034A1/es active IP Right Grant
- 2009-11-24 BR BRPI0922801-2A patent/BRPI0922801B1/pt active IP Right Grant
- 2009-11-24 UY UY0001032259A patent/UY32259A/es not_active Application Discontinuation
- 2009-11-24 CN CN201410635154.8A patent/CN104478865B/zh active Active
2011
- 2011-05-11 IL IL212814A patent/IL212814B/en active IP Right Grant
- 2011-05-20 MA MA33866A patent/MA32811B1/fr unknown
- 2011-05-20 TN TN2011000259A patent/TN2011000259A1/fr unknown
- 2011-05-24 EC EC2011011079A patent/ECSP11011079A/es unknown
- 2011-05-24 CO CO11063881A patent/CO6511283A2/es not_active Application Discontinuation
- 2011-05-24 CL CL2011001215A patent/CL2011001215A1/es unknown
2014
- 2014-08-29 US US14/472,627 patent/US20140371205A1/en not_active Abandoned
2015
- 2015-09-04 US US14/845,529 patent/US20150376141A1/en not_active Abandoned
2016
- 2016-08-24 US US15/245,854 patent/US9676762B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2012509864A (ja)	2012-04-26
MX2011005420A (es)	2011-06-16
EA201100794A1 (ru)	2012-01-30
US20110288071A1 (en)	2011-11-24
CN102292322A (zh)	2011-12-21
ES2664499T3 (es)	2018-04-19
US20150376141A1 (en)	2015-12-31
US20160362404A1 (en)	2016-12-15
IL212814A0 (en)	2011-07-31
CA2744351C (fr)	2017-07-04
UY32259A (es)	2010-06-30
GEP20146072B (en)	2014-04-10
IL212814B (en)	2018-05-31
JP5622740B2 (ja)	2014-11-12
WO2010058032A2 (fr)	2010-05-27
CO6511283A2 (es)	2012-08-31
CN104478865B (zh)	2017-09-22
EA021997B1 (ru)	2015-10-30
BRPI0922801A2 (pt)	2020-08-04
AP2960A (en)	2014-08-31
BRPI0922801B1 (pt)	2021-12-21
MY176944A (en)	2020-08-27
CN104478865A (zh)	2015-04-01
US9676762B2 (en)	2017-06-13
MA32811B1 (fr)	2011-11-01
TWI491605B (zh)	2015-07-11
US20140371205A1 (en)	2014-12-18
PE20120034A1 (es)	2012-02-19
ECSP11011079A (es)	2011-06-30
KR101710058B1 (ko)	2017-02-24
HK1160841A1 (zh)	2012-08-17
EP2367800B9 (fr)	2021-10-20
US8846689B2 (en)	2014-09-30
CN102292322B (zh)	2015-11-25
EP2367800B1 (fr)	2018-02-28
ES2664499T9 (es)	2022-01-03
AU2009317170A1 (en)	2010-05-27
KR20110084551A (ko)	2011-07-25
MX337116B (es)	2016-02-12
WO2010058032A3 (fr)	2010-07-15
AU2009317170B2 (en)	2015-05-28
AR074210A1 (es)	2010-12-29
EP2367800A2 (fr)	2011-09-28
TW201026682A (en)	2010-07-16
CA2744351A1 (fr)	2010-05-27
NZ592925A (en)	2013-04-26
AP2011005706A0 (en)	2011-06-30
CL2011001215A1 (es)	2011-09-30

Publication	Publication Date	Title
MY176944A (en)	2020-08-27	Substituted pyrimidines for the treatment of diseases such as cancer
TN2012000369A1 (en)	2014-01-30	5-alkynyl-pyrimidines
MX2009013935A (es)	2010-01-28	Compuestos quimicos.
MX2011009780A (es)	2011-09-30	Pirimidinas sustituidas para el tratamiento del cancer.
WO2009000832A3 (fr)	2009-04-16	Nouveaux composés chimiques
TW200726753A (en)	2007-07-16	2,4-diamino-pyrimidines as aurora inhibitors
PH12013500152A1 (en)	2013-02-18	New aminopyrazoloquinazolines
UA94944C2 (ru)	2011-06-25	2,4-диаминопиримидины как ингибиторы киназ, которые принимают участие в регуляции клеточного цикла
WO2010007116A3 (fr)	2010-06-17	Nouveaux composés chimiques
MX2011011661A (es)	2011-11-18	Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750.
MX2011012643A (es)	2011-12-14	2,4-diaminopiridinas para el tratamiento de enfermedades caracterizadas por la proliferacion celular excesiva o anormal.
IN2012DN02714A (fr)	2015-09-11
MX2012013274A (es)	2013-05-28	Novedosos derivados de la pirimidina.
MX2012001413A (es)	2012-03-21	Compuestos azaheterociclicos novedosos.
MX2013010898A (es)	2013-12-06	Novedoso derivados de la pirimidina.
MA32505B1 (fr)	2011-07-03	5-alcynyl-pyrimidines
TW200630374A (en)	2006-09-01	Thiazolyldihydroindazoles
MX2010009837A (es)	2010-09-28	Tiazolil-dihidro-indazoles.
WO2010012745A3 (fr)	2010-07-22	Benzimidazoles
TN2011000531A1 (en)	2013-05-24	5- alkynyl - pyridines
GB2469980A (en)	2010-11-03	Novel napthalimide-benzimidazole hybrids as potential antitumour agents and process for the preparation thereof
TN2012000370A1 (en)	2014-01-30	5-alkynyl pyrimidines and their use as kinase inhibitors
NZ609924A (en)	2015-02-27	Porphyrin treatment of neurodegenerative diseases
TN2011000530A1 (en)	2013-05-24	Thia-triaza-cyclopentazulenes as pi3-kinases inhibitors for the treatment of cancer
TN2011000049A1 (en)	2012-09-05	5-alkynyl-pyrimidines