TN2011000161A1 - Fgf21 mutants and uses thereof - Google Patents
Fgf21 mutants and uses thereofInfo
- Publication number
- TN2011000161A1 TN2011000161A1 TN2011000161A TN2011000161A TN2011000161A1 TN 2011000161 A1 TN2011000161 A1 TN 2011000161A1 TN 2011000161 A TN2011000161 A TN 2011000161A TN 2011000161 A TN2011000161 A TN 2011000161A TN 2011000161 A1 TN2011000161 A1 TN 2011000161A1
- Authority
- TN
- Tunisia
- Prior art keywords
- fgf21 mutant
- polypeptides
- fgf21 mutants
- mutant polypeptides
- pharmaceutical compositions
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title abstract 4
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19576108P | 2008-10-10 | 2008-10-10 | |
| PCT/US2009/060045 WO2010042747A2 (fr) | 2008-10-10 | 2009-10-08 | Mutants fgf21 et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000161A1 true TN2011000161A1 (en) | 2012-12-17 |
Family
ID=41571715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000161A TN2011000161A1 (en) | 2008-10-10 | 2011-04-06 | Fgf21 mutants and uses thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9279013B2 (fr) |
| EP (1) | EP2358749B1 (fr) |
| JP (2) | JP5878757B2 (fr) |
| KR (1) | KR101651703B1 (fr) |
| CN (1) | CN102625811B (fr) |
| AU (1) | AU2009302318A1 (fr) |
| CA (1) | CA2739615C (fr) |
| CL (1) | CL2011000792A1 (fr) |
| CO (1) | CO6362020A2 (fr) |
| CR (1) | CR20110245A (fr) |
| EA (2) | EA032727B1 (fr) |
| IL (1) | IL212061A0 (fr) |
| MA (1) | MA32771B1 (fr) |
| MX (1) | MX341149B (fr) |
| NZ (1) | NZ592009A (fr) |
| PE (1) | PE20120021A1 (fr) |
| SG (1) | SG195542A1 (fr) |
| TN (1) | TN2011000161A1 (fr) |
| UA (1) | UA105016C2 (fr) |
| WO (1) | WO2010042747A2 (fr) |
| ZA (1) | ZA201103356B (fr) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| EP2068909B1 (fr) | 2007-03-30 | 2012-04-25 | Ambrx, Inc. | Polypeptides fgf-21 modifies, et leurs utilisations |
| US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| AU2009302318A1 (en) * | 2008-10-10 | 2010-04-15 | Amgen Inc. | FGF21 mutants and uses thereof |
| CN102361647B (zh) | 2009-01-23 | 2018-02-16 | 诺沃-诺迪斯克有限公司 | 具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用 |
| WO2011154349A2 (fr) * | 2010-06-08 | 2011-12-15 | Novo Nordisk A/S | Analogues et dérivés du fgf21 |
| US20110195077A1 (en) * | 2010-01-29 | 2011-08-11 | Novartis Ag | Methods and compositions using fgf23 fusion ppolypeptides |
| CN103124562A (zh) * | 2010-06-08 | 2013-05-29 | 诺沃—诺迪斯克有限公司 | Fgf21的类似物和衍生物 |
| WO2012010553A1 (fr) | 2010-07-20 | 2012-01-26 | Novo Nordisk A/S | Composés fgf21 n-terminaux modifiés |
| JP2013536233A (ja) | 2010-08-23 | 2013-09-19 | アムジエン・インコーポレーテツド | グルコキナーゼ調節タンパク質と相互作用する糖尿病治療用の化合物 |
| US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| MX2013011561A (es) | 2011-04-05 | 2014-02-28 | Amgen Inc | Compuestos de benzodioxepina y benzodioxina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes. |
| HUE033584T2 (hu) | 2011-05-16 | 2017-12-28 | Hoffmann La Roche | FGFR1 agonisták és alkalmazási eljárások |
| EP4306165A3 (fr) | 2011-07-01 | 2024-04-17 | NGM Biopharmaceuticals, Inc. | Compositions, utilisations et procédés pour le traitement de troubles métaboliques et de maladies |
| WO2013033452A2 (fr) | 2011-08-31 | 2013-03-07 | Amgen Inc. | Procédé de traitement ou d'amélioration du diabète type i employant fgf21 |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| SI2814844T1 (sl) | 2012-02-15 | 2017-10-30 | Novo Nordisk A/S | Protitelesa, ki vežejo in blokirajo sprožilni receptor, izražen na mieloidnih celicah-1 (trem-1) |
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| HRP20181817T1 (hr) | 2012-02-15 | 2018-12-28 | Novo Nordisk A/S | Anitijela koja vezuju protein 1 prepoznavanja peptidoglikana |
| WO2013123444A1 (fr) | 2012-02-17 | 2013-08-22 | Amgen Inc. | Composés de sulfonyle qui interagissent avec la protéine régulatrice de la glucokinase |
| WO2013173382A1 (fr) | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophène sulfonamides et autres composés qui interagissent avec une protéine régulatrice de la glucokinase |
| CN104364261B (zh) | 2012-06-11 | 2017-04-05 | 伊莱利利公司 | 成纤维细胞生长因子21变体 |
| TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子２１蛋白質 |
| ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| US9925242B2 (en) | 2012-12-27 | 2018-03-27 | Ngm Biopharmaceuticals, Inc. | Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of nonalcoholic steatohepatitis |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2014149699A1 (fr) | 2013-03-15 | 2014-09-25 | Eli Lilly And Company | Protéine bifonctionnelle |
| MX377380B (es) | 2013-10-28 | 2025-03-10 | Ngm Biopharmaceuticals Inc | Modelos de cáncer y métodos asociados. |
| TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
| WO2015103782A1 (fr) * | 2014-01-13 | 2015-07-16 | Wenzhou Medical College Biological Pharmaceuticals And Nature Products Ltd., Co | Mutant fgf21 et son conjugué |
| US9738716B2 (en) | 2014-01-24 | 2017-08-22 | Ngm Biopharmaceuticals, Inc. | Beta klotho binding proteins and methods of use thereof |
| JP6712230B2 (ja) | 2014-03-11 | 2020-06-17 | ノバルティス アーゲー | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| EP3155005A4 (fr) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Procédés et utilisations pour la modulation de l'homéostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire |
| KR102641268B1 (ko) | 2014-07-17 | 2024-02-27 | 노보 노르디스크 에이/에스 | 점도를 감소시키기 위한 trem-1 항체의 부위 지정 돌연변이유발 |
| RU2729161C2 (ru) | 2014-10-23 | 2020-08-04 | ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. | Фармацевтические композиции, содержащие варианты пептидов, и способы их применения |
| LT3412302T (lt) | 2014-10-24 | 2021-07-26 | Bristol-Myers Squibb Company | Modifikuoti fgf-21 polipeptidai ir jų panaudojimai |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| KR20170084332A (ko) | 2014-12-04 | 2017-07-19 | 노파르티스 아게 | Klotho 변이체 폴리펩티드를 사용하는 방법 및 조성물 |
| TWI681966B (zh) * | 2014-12-23 | 2020-01-11 | 丹麥商諾佛 儂迪克股份有限公司 | Ｆｇｆ２１衍生物及其用途 |
| KR20160088656A (ko) | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| WO2016179140A1 (fr) * | 2015-05-05 | 2016-11-10 | The Regents Of The University Of California | Polymères à facteur de croissance des fibroblastes, procédés de fabrication associés et leurs applications |
| WO2016187558A2 (fr) | 2015-05-20 | 2016-11-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Procédé visant à améliorer l'issue neurologique chez des patients dont la température est modifiée à des fins thérapeutiques |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| EP3888672A1 (fr) | 2015-11-09 | 2021-10-06 | NGM Biopharmaceuticals, Inc. | Méthodes de traitement de troubles associés aux acides biliaires |
| TW201731867A (zh) | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Ｆｇｆ２１變異體 |
| WO2017220706A1 (fr) | 2016-06-22 | 2017-12-28 | Novo Nordisk A/S | Compositions pharmaceutiques de dérivés de fgf21 et leurs utilisations |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN107759694B (zh) | 2016-08-19 | 2023-01-13 | 安源医药科技（上海）有限公司 | 双特异性抗体及其制备方法与用途 |
| WO2018032638A1 (fr) | 2016-08-19 | 2018-02-22 | 安源医药科技（上海）有限公司 | Peptide de liaison pour la construction d'une protéine de fusion |
| US11370841B2 (en) | 2016-08-26 | 2022-06-28 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CA3047862A1 (fr) | 2016-12-22 | 2018-06-28 | Sanofi | Combinaisons d'agonistes du compose fgf21/agoniste du glp-1r ayant un rapport d'activite optimise |
| WO2018194413A1 (fr) | 2017-04-21 | 2018-10-25 | Yuhan Corporation | Procédé de production de protéines à double fonction et ses dérivés |
| CN107056925B (zh) * | 2017-04-28 | 2022-01-14 | 中国科学院合肥物质科学研究院 | 人fgf21突变体、其制备方法及用途 |
| AU2018329850A1 (en) | 2017-09-08 | 2020-04-23 | Bristol-Myers Squibb Company | Modified fibroblast growth factor 21 (FGF-21) for use in methods for treating nonalcoholic steatohepatitis (NASH) |
| CN119386161A (zh) | 2017-12-22 | 2025-02-07 | 诺华股份有限公司 | 用fgf21变体治疗代谢障碍的方法 |
| JP7475276B2 (ja) * | 2018-02-08 | 2024-04-26 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Ｆｇｆ２１バリアント、融合タンパク質及びそれらの適用 |
| MA52190A (fr) | 2018-04-02 | 2021-02-17 | Bristol Myers Squibb Co | Anticorps anti-trem-1 et utilisations associées |
| MX2021000016A (es) | 2018-07-03 | 2021-03-09 | Bristol Myers Squibb Co | Formulaciones de factor de crecimiento de fibroblastos (fgf-21). |
| WO2021142143A1 (fr) | 2020-01-08 | 2021-07-15 | Bristol-Myers Squibb Company | Formulations de conjugués de fgf-21 |
| US11028132B1 (en) | 2020-04-07 | 2021-06-08 | Yitzhak Rosen | Half-life optimized linker composition |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| JP2023538533A (ja) | 2020-08-07 | 2023-09-08 | ブリストル－マイヤーズ スクイブ カンパニー | 線維症の処置のための、ｃｃｒ２／５拮抗剤と組み合わせたｆｇｆ２１ |
| US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
| GB2625224A (en) * | 2021-09-08 | 2024-06-12 | Leto Laboratories Co Ltd | FGF21 mutant protein and use thereof |
| WO2025164663A1 (fr) * | 2024-01-29 | 2025-08-07 | 田辺三菱製薬株式会社 | Polypeptide et son utilisation |
Family Cites Families (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| CA1310924C (fr) | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Systeme d'administration d'un medicament a l'aide de particules infectieuses |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4970154A (en) | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
| EP0315456B1 (fr) | 1987-11-05 | 1994-06-01 | Hybritech Incorporated | Immunoglobulines modifiées au moyen d'un polysaccharide présentant un potentiel immunogène réduit ou des cinétiques pharmacologiques améliorées |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| EP0401384B1 (fr) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5288855A (en) | 1989-01-23 | 1994-02-22 | Farmitalia Carlo Erba | Extracellular form of the human fibroblast growth factor receptor |
| FI920027A7 (fi) | 1989-07-06 | 1992-01-03 | Univ California | Fibroblastikasvutekijöiden reseptoreita |
| US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| EP0779362B2 (fr) | 1989-12-22 | 2012-06-13 | Laboratoires Serono SA | Constructions de type ADN pour l'activation et la modification de l'expression de gènes endogènes |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| WO1991010470A1 (fr) | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Dispositifs et procedes d'apport ameliore de facteurs actifs |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| US5672510A (en) | 1990-01-19 | 1997-09-30 | Genetic Therapy, Inc. | Retroviral vectors |
| EP0538404B1 (fr) | 1990-07-06 | 2003-06-18 | Rhone-Poulenc Rorer International (Holdings) Inc. | Recepteurs de facteur de croissance fibroblastique |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| US5217889A (en) | 1990-10-19 | 1993-06-08 | Roninson Igor B | Methods and applications for efficient genetic suppressor elements |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5229501A (en) | 1991-01-11 | 1993-07-20 | Chiron Corporation | Expression and use of human fibroblast growth factor receptor |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| IL100219A0 (en) | 1991-12-02 | 1992-09-06 | Yeda Res & Dev | Variable region within fibroblast growth factor receptors that confers ligand specificity |
| US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| US5234784A (en) | 1992-04-01 | 1993-08-10 | Eastman Kodak Company | Method of making a projection viewable transparency comprising an electrostatographic toner image |
| US5364791A (en) | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
| ATE141958T1 (de) | 1992-06-18 | 1996-09-15 | Whittier Inst Diabetes & Endoc | Verfahren zur detektion neoplastischer erkrankungen |
| JPH07509137A (ja) | 1992-07-24 | 1995-10-12 | セル ジェネシス，インク． | 異種抗体の生産 |
| US5474914A (en) | 1992-07-29 | 1995-12-12 | Chiron Corporation | Method of producing secreted CMV glycoprotein H |
| US5489743A (en) | 1993-01-19 | 1996-02-06 | Amgen Inc. | Transgenic animal models for thrombocytopenia |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| CA2162275A1 (fr) | 1993-05-07 | 1994-11-24 | Robert George Flynn | Lait et produits laitiers a lactose hydrolyse, au gout ameliore et a sucrosite reduite |
| US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
| US5654168A (en) | 1994-07-01 | 1997-08-05 | Basf Aktiengesellschaft | Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units |
| AU684524B2 (en) | 1993-06-14 | 1997-12-18 | Tet Systems Holding Gmbh & Co. Kg | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5589362A (en) | 1993-06-14 | 1996-12-31 | Basf Aktiengesellschaft | Tetracycline regulated transcriptional modulators with altered DNA binding specificities |
| US5484720A (en) | 1994-09-08 | 1996-01-16 | Genentech, Inc. | Methods for calcium phosphate transfection |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| TR200003861T2 (tr) | 1995-05-26 | 2001-04-20 | Zeneca Limited | Bir ekdison reseptörünü içeren bir gen anahtarı. |
| WO1996041865A1 (fr) | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Regulation d'evenements biologiques fondee sur la rapamycine |
| WO1996040958A1 (fr) | 1995-06-07 | 1996-12-19 | Baylor College Of Medicine | Transporteurs d'acide nucleique servant a introduire des acides nucleiques dans une cellule |
| CA2244363C (fr) | 1996-02-28 | 2006-11-14 | Ariad Gene Therapeutics, Inc. | Derives synthetiques de rapamycine utilises comme agents de multimerisation de proteines chimeres a domaines derives de l'immunophiline |
| US5679559A (en) | 1996-07-03 | 1997-10-21 | University Of Utah Research Foundation | Cationic polymer and lipoprotein-containing system for gene delivery |
| US6214795B1 (en) | 1996-11-12 | 2001-04-10 | Praecis Pharmaceuticals, Inc. | Peptide compounds useful for modulating FGF receptor activity |
| ES2281112T3 (es) | 1996-12-26 | 2007-09-16 | Kyowa Hakko Kogyo Co., Ltd. | Proteina que presenta una actividad de supresion del envejecimiento. |
| US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| US6150098A (en) | 1998-02-20 | 2000-11-21 | Amgen Inc. | Methods for identifying novel secreted mammalian polypeptides |
| ZA200007412B (en) | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| US6548634B1 (en) | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
| WO2000027885A1 (fr) | 1998-11-05 | 2000-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Nouveau popypeptide chimerique |
| WO2000046380A2 (fr) | 1999-02-08 | 2000-08-10 | Chiron Corporation | Fusion du recepteur du facteur de croissance des fibroblastes avec une immunoglobuline |
| AU3755900A (en) | 1999-03-15 | 2000-10-04 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| CA2311201A1 (fr) | 1999-08-05 | 2001-02-05 | Genset S.A. | Sequences marqueurs exprimees et proteines humaines codees |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| US7408047B1 (en) | 1999-09-07 | 2008-08-05 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| WO2001018209A1 (fr) | 1999-09-10 | 2001-03-15 | Curagen Corporation | Polypeptides du facteur de croissance du fibroblaste et acides nucleiques les codant |
| WO2001032678A1 (fr) | 1999-11-05 | 2001-05-10 | Smithkline Beecham Corporation | sbgFGF-19a |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| AU1922101A (en) | 1999-11-18 | 2001-05-30 | Chiron Corporation | Human fgf-21 gene and gene expression products |
| AU1628101A (en) | 1999-11-22 | 2001-06-04 | Millennium Pharmaceuticals, Inc. | Jaffa, a novel fibroblast growth factor family member and uses therefor |
| US7108984B2 (en) | 2000-01-12 | 2006-09-19 | Mount Sinai School Of Medicine | Methods of identifying modulators of the FGF receptor |
| US20020081663A1 (en) | 2000-01-05 | 2002-06-27 | Conklin Darrell C. | Novel FGF homolog ZFGF11 |
| WO2001049849A1 (fr) | 2000-01-05 | 2001-07-12 | Zymogenetics, Inc. | Zfgf11 : nouvel homologue de fgf |
| US20020001825A1 (en) | 2000-03-31 | 2002-01-03 | Nobuyuki Itoh | Fibroblast growth factor-like molecules and uses thereof |
| JP2002112772A (ja) | 2000-07-10 | 2002-04-16 | Takeda Chem Ind Ltd | 新規ポリペプチドおよびそのｄｎａ |
| IL139380A0 (en) | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| US20060223114A1 (en) | 2001-04-26 | 2006-10-05 | Avidia Research Institute | Protein scaffolds and uses thereof |
| US20040018499A1 (en) | 2001-06-06 | 2004-01-29 | Lal Preeti G | Extracellular messengers |
| AU2002329540A1 (en) | 2001-06-20 | 2003-01-02 | Morphosys Ag | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| EP1425304B9 (fr) | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | Conjugues de g-csf |
| US20040259780A1 (en) | 2001-07-30 | 2004-12-23 | Glasebrook Andrew Lawrence | Method for treating diabetes and obesity |
| US20050187150A1 (en) | 2001-10-31 | 2005-08-25 | New York University | Structure-based design and synthesis of FGF inhibitors and FGF modulator compounds |
| WO2003059270A2 (fr) | 2002-01-15 | 2003-07-24 | Eli Lilly And Company | Methode de diminution de la morbidite et de la mortalite chez des patients gravement malades |
| ATE502646T1 (de) | 2002-01-31 | 2011-04-15 | Max Planck Gesellschaft | Fgfr agoniste |
| EP1332761A1 (fr) | 2002-01-31 | 2003-08-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Agonistes des récepteurs du facteur de croissance des fibroblastes |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| JP2003334088A (ja) | 2002-05-22 | 2003-11-25 | Pharma Design Inc | ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子 |
| AU2003265057A1 (en) | 2002-09-04 | 2004-03-29 | Abtech | Anti-idiotypic antibodies as vegf or fgf agonists for bone therapy |
| WO2004041170A2 (fr) | 2002-11-01 | 2004-05-21 | Genentech, Inc. | Compositions et methodes pour le traitement de maladies liees au systeme immunitaire |
| JP2007524566A (ja) | 2002-12-20 | 2007-08-30 | エンカム ファーマシューティカルズ アクティーゼルスカブ | レセプターとリガンドの間の相互作用の調節の方法 |
| WO2004083381A2 (fr) | 2003-03-13 | 2004-09-30 | Indiana University Advanced Research & Technology Institute | Polynucleotides, polypeptides et mutants des recepteurs 1 du facteur de croissance des fibroblastes |
| JP2006240990A (ja) | 2003-05-15 | 2006-09-14 | Kirin Brewery Co Ltd | ｋｌｏｔｈｏタンパク質および抗ｋｌｏｔｈｏタンパク質抗体ならびにそれらの用途 |
| DK1641483T3 (da) | 2003-06-12 | 2008-06-02 | Lilly Co Eli | Fusionsproteiner |
| US7452966B2 (en) | 2003-06-12 | 2008-11-18 | Eli Lilly And Company | GLP-1 analog fusion proteins |
| WO2005019258A2 (fr) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions et methodes de traitement de maladies relatives au systeme immunitaire |
| PL1680140T3 (pl) | 2003-10-16 | 2011-11-30 | Imclone Llc | Inhibitory receptora-1 czynnika wzrostu fibroblastów i związane z nim sposoby leczenia |
| AU2004303783A1 (en) | 2003-12-10 | 2005-07-07 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| WO2005066211A2 (fr) | 2003-12-19 | 2005-07-21 | Five Prime Therapeutics, Inc. | Utilisation des recepteurs 1, 2, 3 et 4 du facteur de croissance des fibroblastes comme cibles pour une intervention therapeutique |
| US20090111742A1 (en) | 2004-01-26 | 2009-04-30 | Alexei Kharitonenkov | Use of fgf-21 and thiazolidinedione for treating type 2 diabetes |
| JP2007531715A (ja) * | 2004-03-17 | 2007-11-08 | イーライ リリー アンド カンパニー | グリコール結合ｆｇｆ−２１化合物 |
| JP4505631B2 (ja) | 2004-03-31 | 2010-07-21 | 独立行政法人産業技術総合研究所 | ヘパラン硫酸糖鎖を付加したヘパリン結合性タンパク質、その製造方法及びそれを含有する医薬組成物 |
| ATE444306T1 (de) | 2004-05-13 | 2009-10-15 | Lilly Co Eli | Fgf-21-fusionsproteine |
| EP1789443A1 (fr) | 2004-09-02 | 2007-05-30 | Eli Lilly And Company | Muteines du facteur de croissance 21 du fibroblaste |
| BRPI0514790A (pt) | 2004-09-02 | 2008-06-24 | Lilly Co Eli | muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano |
| SI2586456T1 (sl) * | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Preoblikovanje in glikopegliacija fibroblastnega rastnega faktorja (FGF) |
| US7655627B2 (en) | 2004-12-14 | 2010-02-02 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| JP2008528487A (ja) | 2005-01-21 | 2008-07-31 | イーライ リリー アンド カンパニー | 心臓血管疾患を治療する方法 |
| JP2006246823A (ja) | 2005-03-11 | 2006-09-21 | Kyoto Univ | 造血因子としてのＦｇｆ２１の使用 |
| WO2006130527A2 (fr) | 2005-05-31 | 2006-12-07 | Novartis Ag | Mutations et polymorphismes de recepteur du facteur de croissance 1 des fibroblastes |
| CA2614039C (fr) | 2005-07-22 | 2015-10-13 | Five Prime Therapeutics, Inc. | Compositions et procedes de traitement de maladies a l'aide de proteines de fusion fgfr |
| US7931902B2 (en) | 2005-08-15 | 2011-04-26 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
| US8043833B2 (en) | 2005-10-31 | 2011-10-25 | Novo Nordisk A/S | Expression of soluble therapeutic proteins |
| WO2007100695A2 (fr) | 2006-02-28 | 2007-09-07 | Trustees Of Boston University | Régulateurs métaboliques et leurs utilisations |
| US8101721B2 (en) | 2006-06-15 | 2012-01-24 | Fibron Ltd. | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof |
| US20080242607A1 (en) | 2006-07-21 | 2008-10-02 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
| EP2094850B1 (fr) | 2006-12-01 | 2013-06-12 | Agency for Science, Technology And Research | Protéine kinases liées au cancer |
| EP2068909B1 (fr) | 2007-03-30 | 2012-04-25 | Ambrx, Inc. | Polypeptides fgf-21 modifies, et leurs utilisations |
| TWI577387B (zh) | 2007-04-02 | 2017-04-11 | 建南德克公司 | 克羅梭（ｋｌｏｔｈｏ）ｂｅｔａ之用途 |
| JP5187837B2 (ja) | 2007-04-06 | 2013-04-24 | 独立行政法人産業技術総合研究所 | 補助因子による受容体の活性化方法並びにリガンド活性の利用方法 |
| US7537903B2 (en) | 2007-04-23 | 2009-05-26 | Board Of Regents, The University Of Texas System | FGF21 upregulates expression of GLUT-1 in a βklotho-dependent manner |
| US20100330062A1 (en) | 2007-05-08 | 2010-12-30 | Koeffler H Phillip | Klotho protein and related compounds for the treatment and diagnosis of cancer |
| BRPI0812384A2 (pt) | 2007-05-22 | 2014-12-02 | Novartis Ag | Métodos de tratamento, diagnóstico e detecção de distúrbios associados a fgf21 |
| WO2008149521A1 (fr) | 2007-05-29 | 2008-12-11 | Immuno-Biological Labolatories Co., Ltd | Agent thérapeutique contre le cancer et procédé de traitement du cancer |
| JP2010531135A (ja) | 2007-06-04 | 2010-09-24 | ノボ ノルディスク アクティーゼルスカブ | Ｎ−アセチルグルコサミニルトランスフェラーゼを使用したｏ結合型グリコシル化 |
| EP3260129A1 (fr) | 2007-08-03 | 2017-12-27 | Eli Lilly and Company | Un composé du fgf-21 et d'un composé du glp-1 pour son utilisation dans le traitement des diabètes |
| US8426396B2 (en) | 2008-01-08 | 2013-04-23 | Shriners Hospitals For Children | Treatment for achondroplasia |
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| US20110015345A1 (en) | 2008-03-19 | 2011-01-20 | Ambrx, Inc. | Modified FGF-23 Polypeptides and Their Uses |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| WO2010006214A1 (fr) | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Anticorps de neutralisation de fgf-21 et leurs utilisations |
| US8338569B2 (en) | 2008-08-04 | 2012-12-25 | Five Prime Therapeutics, Inc. | FGFR extracellular domain acidic region muteins |
| AU2009302318A1 (en) * | 2008-10-10 | 2010-04-15 | Amgen Inc. | FGF21 mutants and uses thereof |
| WO2010129600A2 (fr) | 2009-05-05 | 2010-11-11 | Amgen Inc. | Mutants de fgf21 et leurs utilisations |
| TWI436776B (zh) | 2009-05-05 | 2014-05-11 | Amgen Inc | Ｆｇｆ２１突變體及其用途 |
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- 2009-10-08 CN CN200980150308.1A patent/CN102625811B/zh active Active
- 2009-10-08 PE PE2011000856A patent/PE20120021A1/es not_active Application Discontinuation
- 2009-10-08 WO PCT/US2009/060045 patent/WO2010042747A2/fr not_active Ceased
- 2009-10-08 EP EP09748878.7A patent/EP2358749B1/fr active Active
- 2009-10-08 KR KR1020117010559A patent/KR101651703B1/ko active Active
- 2009-10-08 SG SG2013075916A patent/SG195542A1/en unknown
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- 2009-10-08 US US13/123,205 patent/US9279013B2/en active Active
- 2009-10-08 NZ NZ592009A patent/NZ592009A/xx unknown
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- 2009-10-08 CA CA2739615A patent/CA2739615C/fr active Active
- 2009-10-08 EA EA201990619A patent/EA201990619A1/ru unknown
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- 2009-10-08 JP JP2011531178A patent/JP5878757B2/ja active Active
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2011
- 2011-03-31 IL IL212061A patent/IL212061A0/en unknown
- 2011-04-06 TN TN2011000161A patent/TN2011000161A1/fr unknown
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- 2011-04-08 CL CL2011000792A patent/CL2011000792A1/es unknown
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- 2011-05-09 ZA ZA2011/03356A patent/ZA201103356B/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2358749B1 (fr) | 2018-07-18 |
| UA105016C2 (uk) | 2014-04-10 |
| EP2358749A2 (fr) | 2011-08-24 |
| AU2009302318A1 (en) | 2010-04-15 |
| NZ592009A (en) | 2012-11-30 |
| MX341149B (es) | 2016-08-09 |
| US20110195895A1 (en) | 2011-08-11 |
| CL2011000792A1 (es) | 2011-08-26 |
| ZA201103356B (en) | 2012-02-29 |
| US9279013B2 (en) | 2016-03-08 |
| JP2015165801A (ja) | 2015-09-24 |
| JP5878757B2 (ja) | 2016-03-08 |
| WO2010042747A2 (fr) | 2010-04-15 |
| JP2012504965A (ja) | 2012-03-01 |
| SG195542A1 (en) | 2013-12-30 |
| PE20120021A1 (es) | 2012-02-10 |
| MX2011003788A (es) | 2011-08-03 |
| WO2010042747A3 (fr) | 2010-06-17 |
| CN102625811B (zh) | 2016-09-21 |
| KR20110093790A (ko) | 2011-08-18 |
| CA2739615A1 (fr) | 2010-04-15 |
| MA32771B1 (fr) | 2011-11-01 |
| CR20110245A (es) | 2011-08-29 |
| US20160244497A1 (en) | 2016-08-25 |
| CA2739615C (fr) | 2017-12-05 |
| EA032727B1 (ru) | 2019-07-31 |
| CO6362020A2 (es) | 2012-01-20 |
| IL212061A0 (en) | 2011-06-30 |
| CN102625811A (zh) | 2012-08-01 |
| EA201100516A1 (ru) | 2011-10-31 |
| EA201990619A1 (ru) | 2019-07-31 |
| KR101651703B1 (ko) | 2016-08-26 |
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