[go: up one dir, main page]

TN2010000305A1 - Pyrrolopyrimidines and pyrrolopyridines - Google Patents

Pyrrolopyrimidines and pyrrolopyridines

Info

Publication number
TN2010000305A1
TN2010000305A1 TN2010000305A TN2010000305A TN2010000305A1 TN 2010000305 A1 TN2010000305 A1 TN 2010000305A1 TN 2010000305 A TN2010000305 A TN 2010000305A TN 2010000305 A TN2010000305 A TN 2010000305A TN 2010000305 A1 TN2010000305 A1 TN 2010000305A1
Authority
TN
Tunisia
Prior art keywords
compounds
pyrrolopyridines
pyrrolopyrimidines
alk
meanings
Prior art date
Application number
TN2010000305A
Other languages
English (en)
Inventor
Catherine Leblanc
Robert Alexander Pulz
Nikolaus Johannes Stiefl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2010000305A1 publication Critical patent/TN2010000305A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TN2010000305A 2008-01-11 2010-06-30 Pyrrolopyrimidines and pyrrolopyridines TN2010000305A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150182 2008-01-11
PCT/EP2009/050225 WO2009087225A2 (fr) 2008-01-11 2009-01-09 Pyrrolopyrimidines et pyrrolopyridines

Publications (1)

Publication Number Publication Date
TN2010000305A1 true TN2010000305A1 (en) 2011-11-11

Family

ID=39445770

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2010000305A TN2010000305A1 (en) 2008-01-11 2010-06-30 Pyrrolopyrimidines and pyrrolopyridines

Country Status (22)

Country Link
US (1) US8314112B2 (fr)
EP (1) EP2242756A2 (fr)
JP (1) JP5643110B2 (fr)
KR (1) KR20100116606A (fr)
CN (1) CN101970435B (fr)
AR (1) AR070127A1 (fr)
AU (1) AU2009203694B2 (fr)
BR (1) BRPI0907231A2 (fr)
CA (1) CA2711845A1 (fr)
CL (1) CL2009000028A1 (fr)
CO (1) CO6331340A2 (fr)
CR (1) CR11554A (fr)
EA (1) EA201001126A1 (fr)
EC (1) ECSP10010335A (fr)
IL (1) IL206819A0 (fr)
MA (1) MA31952B1 (fr)
MX (1) MX2010007605A (fr)
PE (1) PE20091306A1 (fr)
TN (1) TN2010000305A1 (fr)
TW (1) TW200934781A (fr)
WO (1) WO2009087225A2 (fr)
ZA (1) ZA201004602B (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2099796E (pt) * 2006-11-30 2011-09-06 Genentech Inc Compostos azaindolilo e métodos de utilização
KR20100095020A (ko) 2007-12-19 2010-08-27 암젠 인크 세포 주기 억제제로서의 융합된 피리딘, 피리미딘 및 트리아진 화합물
AU2009233951B2 (en) 2008-04-07 2014-02-27 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
EA029131B1 (ru) 2008-05-21 2018-02-28 Ариад Фармасьютикалз, Инк. Фосфорсодержащие производные в качестве ингибиторов киназы
CA2676946A1 (fr) * 2009-08-28 2011-02-28 Lucie Peduto Inhibiteurs de l'enzyme adam12 et leur utilisation contre la fibrose induite par l'inflammation
EP2475666A2 (fr) 2009-09-11 2012-07-18 Trius Therapeutics, Inc. Inhibiteurs de gyrase
EP2531500B1 (fr) 2010-02-05 2018-01-24 Merck Patent GmbH Dérivés d'hétaryl-[1,8]naphtyridine
ES2528441T3 (es) 2010-02-22 2015-02-10 Merck Patent Gmbh Hetarilaminonaftiridinas
EP2539338A1 (fr) * 2010-02-24 2013-01-02 Syngenta Participations AG Nouveaux microbicides
WO2012002577A1 (fr) 2010-06-30 2012-01-05 富士フイルム株式会社 Nouveaux dérivés de nicotinamide et leurs sels
CN103124496B (zh) 2010-10-06 2016-03-30 葛兰素史密丝克莱恩有限责任公司 作为pi3激酶抑制剂的苯并咪唑衍生物
MY161199A (en) 2011-03-23 2017-04-14 Amgen Inc Fused tricyclic dual inhibitors of cdk 4/6 and flt3
EA201391626A1 (ru) 2011-05-04 2014-03-31 Ариад Фармасьютикалз, Инк. Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
EA030465B1 (ru) 2011-07-01 2018-08-31 Новартис Аг Комбинированная терапия, включающая ингибитор cdk4/6 и ингибитор pi3k для применения в лечении рака
EP2573086A1 (fr) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG Monohydrate de mesylate acétamide N-[5-(Aminosulfonyl)-4-méthyl-1,3-thiazol-2-yl]-N-méthyl-2-[4-(2-pyridinyl)phényl]
EP2573085A1 (fr) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG Monohydrate de mesylate acétamide N-[5-(aminosulfonyl)-4méthyl-1,3-thiazol-2-yl]-N-méthyl-2-[4-(2-pyridinyl)phényl] disposant d'une gamme de distribution de taille de particules spécifiques et portée de surface spécifique
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
MX2014014832A (es) * 2012-06-07 2015-02-12 Hoffmann La Roche Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa.
SG11201408816QA (en) * 2012-07-03 2015-03-30 Aurigene Discovery Tech Ltd 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS
US9682983B2 (en) 2013-03-14 2017-06-20 The Brigham And Women's Hospital, Inc. BMP inhibitors and methods of use thereof
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
CA2914100A1 (fr) 2013-06-04 2014-12-11 Bayer Pharma Aktiengesellschaft Imidazo[1,2-a]pyridines a substitution 3-aryle et leur utilisation
US9688699B2 (en) 2014-02-19 2017-06-27 Bayer Pharma Aktiengesellschaft 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines
EP3122355A4 (fr) * 2014-03-26 2017-08-09 The Brigham and Women's Hospital, Inc. Compositions et procédés d'inhibition de la bmp
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
US10513521B2 (en) 2014-07-15 2019-12-24 The Brigham And Women's Hospital, Inc. Compositions and methods for inhibiting BMP
MX2017003930A (es) 2014-09-26 2017-06-30 Gilead Sciences Inc Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank.
CA2969268A1 (fr) 2014-12-02 2016-06-09 Bayer Pharma Aktiengesellschaft Imidazo[1,2-a]pyridines a substitution heteroaryle et leur utilisation
WO2016172496A1 (fr) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Inhibiteurs de lsd1 et leurs utilisations
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
US9708333B2 (en) 2015-08-12 2017-07-18 Incyte Corporation Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors
WO2017035366A1 (fr) 2015-08-26 2017-03-02 Incyte Corporation Dérivés de type pyrrolo-pyrimidine utilisés comme inhibiteurs des tam
FR3041640B1 (fr) 2015-09-30 2019-05-17 Les Laboratoires Servier NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
EA201891024A1 (ru) 2015-12-17 2018-12-28 Джилид Сайэнс, Инк. Соединения-ингибиторы tank-связывающей киназы
CN109311868B (zh) 2015-12-22 2022-04-01 尚医治疗有限责任公司 用于治疗癌症和炎性疾病的化合物
SMT202300480T1 (it) 2016-03-28 2024-01-10 Incyte Corp Composti di pirrolotriazina come inibitori di tam
CA3020870C (fr) 2016-04-15 2024-04-30 Blueprint Medicines Corporation Inhibiteurs du recepteur alk ( activin receptor-like kinase )
SI3532459T1 (sl) 2016-10-26 2024-03-29 Constellation Pharmaceuticals, Inc. Zaviralci LSD1 in njihove medicinske uporabe
EA201992780A1 (ru) 2017-06-21 2020-06-02 ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания
CN109384782A (zh) * 2017-08-04 2019-02-26 厦门大学 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途
TWI821200B (zh) 2017-09-27 2023-11-11 美商英塞特公司 Tam抑制劑之鹽
ES2931537T3 (es) 2017-10-18 2022-12-30 Blueprint Medicines Corp Pirrolopiridinas sustituidas como inhibidores de la quinasa similar al receptor de activina
BR112020012651A2 (pt) * 2017-12-22 2020-12-01 Ravenna Pharmaceuticals, Inc. compostos derivados de aril-bipiridina amina como inibidores da fosfatidilinositol fosfato quinase, composição farmacêutica compreendendo os mesmos e usos terapêuticos dos ditos compostos
CN111867632B (zh) * 2018-03-23 2024-08-16 赛途公司 骨骼肌肥大诱导剂的alk5抑制剂
PT3813800T (pt) 2018-06-29 2025-06-06 Incyte Corp Formulações de um inibidor de axl/mer
US20200247812A1 (en) * 2018-07-10 2020-08-06 Integral Biosciences Private Limited Heterocyclic compounds and methods of use
CN111018858B (zh) * 2018-10-10 2022-11-18 复旦大学 杂环类衍生物及其制备方法和用途
TW202415643A (zh) * 2018-12-12 2024-04-16 加拿大商愛彼特生物製藥公司 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法
EP3898609A1 (fr) 2018-12-19 2021-10-27 Shy Therapeutics LLC Composés interagissant avec la superfamille ras pour le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladie fibrotique
KR20200105246A (ko) * 2019-02-28 2020-09-07 한미약품 주식회사 아데노신 수용체 길항제로서 신규 화합물 및 이를 포함하는 약학 조성물
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
EP4122927A4 (fr) * 2020-03-16 2024-07-03 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Dérivé de pyrimidine amine ou de pyridine amine substituée, composition et utilisation médicale associées
CN113698395B (zh) * 2020-05-22 2023-12-08 赛诺哈勃药业（成都）有限公司 转化生长因子受体拮抗剂、其制备方法和应用
AU2021282596A1 (en) 2020-06-05 2023-01-19 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
MX2023000519A (es) 2020-07-15 2023-02-13 Chiesi Farm Spa Derivados de pirido-oxazina-amino como inhibidores de alk5.
WO2022013307A1 (fr) 2020-07-15 2022-01-20 Chiesi Farmaceutici S.P.A. Dérivés d'amino pyridazinyle utilisés en tant qu'inhibiteurs d'alk5
EP4182322B1 (fr) 2020-07-15 2024-04-24 Chiesi Farmaceutici S.p.A. Dérivés de pyrido-oxazine en tant qu'inhibiteurs d'alk5
WO2022136221A1 (fr) 2020-12-23 2022-06-30 Chiesi Farmaceutici S.P.A. Dérivés de pyrido-oxazine utilisés comme inhibiteurs d'alk5
CA3232178A1 (fr) 2021-09-21 2023-03-30 Daniela PIZZIRANI Derives d'amino pyridazinyle en tant qu'inhibiteurs d'alk5
WO2023208986A1 (fr) 2022-04-27 2023-11-02 Chiesi Farmaceutici S.P.A. Dérivés d'imidazole en tant qu'inhibiteurs d'alk5
CN118126036A (zh) * 2022-12-01 2024-06-04 复旦大学 7-氮杂吲哚类化合物及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020078A1 (fr) 1992-04-03 1993-10-14 The Upjohn Company Amines bicycliques-heterocycliques efficaces pharmaceutiquement
US6686366B1 (en) * 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
WO2000058307A2 (fr) * 1999-03-11 2000-10-05 Neurogen Corporation Pyridines 2,4-disubstituees fusionnees avec un aryle: ligands du recepteur nk-3
US7160890B2 (en) * 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en) * 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
WO2001039777A1 (fr) 1999-12-02 2001-06-07 Osi Pharmaceuticals, Inc. Composes specifiques aux recepteurs a1, a2a et a3 de l'adenosine et leurs utilisations
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
IL155962A0 (en) 2000-12-01 2003-12-23 Osi Pharm Inc Compounds specific to adenosine a1, a2a, and a3 receptors and uses thereof
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
ATE446298T1 (de) 2001-11-30 2009-11-15 Osi Pharm Inc Verbindungen, die für adenosin a1 und a3 rezeptoren spezifisch sind, und deren anwendungen
US20030139427A1 (en) * 2002-08-23 2003-07-24 Osi Pharmaceuticals Inc. Bicyclic pyrimidinyl derivatives and methods of use thereof
WO2004065392A1 (fr) * 2003-01-24 2004-08-05 Smithkline Beecham Corporation Pyridines et pyrimidines condensees et leur utilisation en tant que ligands du recepteur alk-5
ATE398125T1 (de) * 2003-03-12 2008-07-15 Millennium Pharm Inc Chinazolin-derivate als tgf-beta-inhibitoren
US20050205625A1 (en) * 2004-03-16 2005-09-22 House Arthur G Container support device, system, and method
CA2596922A1 (fr) 2005-02-18 2006-08-24 Solvay Pharmaceuticals Gmbh Compositions pharmaceutiques comprenant des inhibiteurs de l'endopeptidase neutre (epn), des inhibiteurs du systeme de production de l'endotheline endogene ainsi que des diuretiques
US20060205625A1 (en) 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
US20070014956A1 (en) * 2005-07-14 2007-01-18 Mccarthy Dillon P Adhesive tape device
MX2008008320A (es) * 2005-12-23 2008-09-03 Smithkline Beecham Corp Inhibidores de azaindol de aurora cinasas.

Also Published As

Publication number Publication date
CN101970435B (zh) 2014-07-02
WO2009087225A2 (fr) 2009-07-16
MA31952B1 (fr) 2010-12-01
AU2009203694B2 (en) 2012-04-26
EP2242756A2 (fr) 2010-10-27
EA201001126A1 (ru) 2011-02-28
AR070127A1 (es) 2010-03-17
US20090181941A1 (en) 2009-07-16
CA2711845A1 (fr) 2009-07-16
ZA201004602B (en) 2011-03-30
CN101970435A (zh) 2011-02-09
ECSP10010335A (es) 2010-08-31
JP5643110B2 (ja) 2014-12-17
WO2009087225A3 (fr) 2009-11-05
CL2009000028A1 (es) 2009-07-17
CR11554A (es) 2010-08-11
CO6331340A2 (es) 2011-10-20
MX2010007605A (es) 2010-08-02
TW200934781A (en) 2009-08-16
PE20091306A1 (es) 2009-09-24
IL206819A0 (en) 2010-12-30
JP2011509279A (ja) 2011-03-24
US8314112B2 (en) 2012-11-20
BRPI0907231A2 (pt) 2019-09-24
AU2009203694A1 (en) 2009-07-16
KR20100116606A (ko) 2010-11-01

Similar Documents

Publication Publication Date Title
TN2010000305A1 (en) Pyrrolopyrimidines and pyrrolopyridines
ZA201000079B (en) Organic compounds
TN2010000167A1 (en) Organic compounds
EA201001687A1 (ru) Производные имидазопиридина в качестве ингибиторов активиноподобной рецепторной киназы ( alk-4 или alk-5 )
MY150059A (en) Pyrrolo [2,3-d] pyrimidin derivatives as protein kinase b inhibitors
PH12013501754A1 (en) Triazolopyridine compounds as pim kinase inhibitors
MX2009004715A (es) Compuestos heterociclicos como agentes antiinflamatorios.
MX2009010728A (es) Compuestos de imidazo[1,2-a]piridina como inhibidores de la tirosina-cinasa repectora.
WO2010111406A3 (fr) Composés et leurs utilisations thérapeutiques
IN2012DN02577A (fr)
MX2013010898A (es) Novedoso derivados de la pirimidina.
MX2012013274A (es) Novedosos derivados de la pirimidina.
PH12012500278A1 (en) Substituted xanthine derivatives
TW200637863A (en) Organic compounds
IN2012DN01642A (fr)
MX2012002327A (es) Inhibidores de cinasa, formas de profarmaco de los mismos y su uso en terapia.
TW200630366A (en) Organic compounds
EA201101604A1 (ru) [1,2,4]триазоло[4,3-b]пиридазины в качестве лигандов андрогенового рецептора
PH12013502524A1 (en) Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
WO2007068473A3 (fr) Composés organiques
CU20100147A7 (es) Pirrolo-pirimidinas y pirrolo-piridinas
UA100390C2 (en) Pyrrolo[2,3-d]pyrimidin derivatives as protein kinase b inhibitors
HK1173146A (en) Kinase inhibitors, prodrug forms thereof and their use in therapy