[go: up one dir, main page]

TN2010000107A1 - Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3 - Google Patents

Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3

Info

Publication number
TN2010000107A1
TN2010000107A1 TNP2010000107A TN2010000107A TN2010000107A1 TN 2010000107 A1 TN2010000107 A1 TN 2010000107A1 TN P2010000107 A TNP2010000107 A TN P2010000107A TN 2010000107 A TN2010000107 A TN 2010000107A TN 2010000107 A1 TN2010000107 A1 TN 2010000107A1
Authority
TN
Tunisia
Prior art keywords
azacyclylisoquinolinone
receptor antagonists
histamine receptor
isoindolinone derivatives
isoindolinone
Prior art date
Application number
TNP2010000107A
Other languages
English (en)
Inventor
Dahui Zhou
Jonathan Laird Gross
Albert Jean Robichaud
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of TN2010000107A1 publication Critical patent/TN2010000107A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un composé représenté par la formule (I) et son utilisation pour le traitement d'un trouble du système nerveux central en rapport avec ou influencé par le récepteur de l'histamine-3.
TNP2010000107A 2007-09-12 2010-03-11 Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3 TN2010000107A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99355407P 2007-09-12 2007-09-12
PCT/US2008/075942 WO2009036117A1 (fr) 2007-09-12 2008-09-11 Dérivés d'azacyclylisoquinolinone et d'isoindolinone convenant comme antagonistes de l'histamine-3

Publications (1)

Publication Number Publication Date
TN2010000107A1 true TN2010000107A1 (fr) 2011-09-26

Family

ID=40261508

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000107A TN2010000107A1 (fr) 2007-09-12 2010-03-11 Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3

Country Status (23)

Country Link
US (1) US20090069370A1 (fr)
EP (1) EP2200998A1 (fr)
JP (1) JP2010539178A (fr)
KR (1) KR20100054852A (fr)
CN (1) CN101842366A (fr)
AP (1) AP2010005199A0 (fr)
AU (1) AU2008298983A1 (fr)
BR (1) BRPI0816806A2 (fr)
CA (1) CA2699383A1 (fr)
CL (1) CL2008002708A1 (fr)
CO (1) CO6300951A2 (fr)
CR (1) CR11309A (fr)
DO (1) DOP2010000078A (fr)
EA (1) EA201000319A1 (fr)
EC (1) ECSP10010032A (fr)
MA (1) MA31700B1 (fr)
MX (1) MX2010002899A (fr)
NI (1) NI201000035A (fr)
PA (1) PA8795601A1 (fr)
PE (1) PE20090679A1 (fr)
TN (1) TN2010000107A1 (fr)
TW (1) TW200918062A (fr)
WO (1) WO2009036117A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
JP2011213700A (ja) * 2010-04-02 2011-10-27 Nishizaki Soyaku Kenkyusho:Kk 認知症改善用組成物
WO2011143150A1 (fr) 2010-05-11 2011-11-17 Sanofi Spirolactames et amides de phénylcycloalkylpyrrolidine (pipéridine) substitués, leur préparation et leur utilisation thérapeutique
AR081383A1 (es) 2010-05-11 2012-08-29 Sanofi Aventis N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central.
JP5766278B2 (ja) 2010-05-11 2015-08-19 サノフイ 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用
TW201206910A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
JP5784110B2 (ja) 2010-05-11 2015-09-24 サノフイ 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用
TW201202251A (en) 2010-05-11 2012-01-16 Sanofi Aventis Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
EP2535062A1 (fr) 2011-06-13 2012-12-19 Dentsply IH AB Article revêtu de collagène
US9295531B2 (en) 2011-06-13 2016-03-29 Dentsply International Inc. Collagen coated article
PT2785695T (pt) * 2011-11-30 2020-08-20 Hoffmann La Roche Novos derivados bicíclicos de dihidroisoquinolina-1-ona
JO3442B1 (ar) 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
LT3063139T (lt) 2013-10-29 2019-02-25 Takeda Pharmaceutical Company Limited Heterociklinis junginys
CN112209876B (zh) * 2020-10-15 2022-08-26 华侨大学 一种3-三氟甲基异喹啉酮衍生物的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933829A (en) * 1974-08-22 1976-01-20 John Wyeth & Brother Limited 4-Aminoquinoline derivatives
US4166853A (en) * 1978-05-05 1979-09-04 The Upjohn Company Antihypertensive 7-trifluoromethyl-4-aminoquinolones
US4159331A (en) * 1978-05-05 1979-06-26 The Upjohn Company Antihypertensive 4-aminoquinolines
SE7907121L (sv) * 1979-08-27 1981-02-28 Astra Laekemedel Ab Ftalimidinderivat
US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
AU4319797A (en) * 1996-09-25 1998-04-17 Yamanouchi Pharmaceutical Co., Ltd. 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof
WO1998048800A1 (fr) * 1997-05-01 1998-11-05 Eli Lilly And Company Agents antithrombotiques
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US7572784B2 (en) * 2004-05-14 2009-08-11 Millennium Pharmaceuticals, Inc. Compounds and methods for inhibiting mitotic progression
US20060014733A1 (en) * 2004-07-19 2006-01-19 Pfizer Inc Histamine-3 agonists and antagonists
SE0401970D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Novel compounds
US7381732B2 (en) * 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
MX2007008843A (es) * 2005-01-21 2007-08-22 Schering Corp Derivados de imidazol y bencimidazol utiles como antagonistas de histamina h3.
US20070032475A1 (en) * 2005-04-15 2007-02-08 Ye Xiaocong M Novel compounds useful for bradykinin B1 receptor antagonism
US8143284B2 (en) * 2006-10-05 2012-03-27 Abbott Laboratories Poly(ADP-ribose)polymerase inhibitors
US7799806B2 (en) * 2007-04-04 2010-09-21 Hoffmann-La Roche Inc. Substituted n-benzyl piperidines as somatostatin receptor modulators

Also Published As

Publication number Publication date
ECSP10010032A (es) 2010-08-31
MX2010002899A (es) 2010-04-09
NI201000035A (es) 2010-07-15
BRPI0816806A2 (pt) 2015-03-10
CL2008002708A1 (es) 2008-10-10
PE20090679A1 (es) 2009-05-28
DOP2010000078A (es) 2010-04-15
CO6300951A2 (es) 2011-07-21
CA2699383A1 (fr) 2009-03-19
PA8795601A1 (es) 2009-05-15
EA201000319A1 (ru) 2010-10-29
TW200918062A (en) 2009-05-01
JP2010539178A (ja) 2010-12-16
MA31700B1 (fr) 2010-09-01
WO2009036117A1 (fr) 2009-03-19
EP2200998A1 (fr) 2010-06-30
AP2010005199A0 (en) 2010-04-30
AU2008298983A1 (en) 2009-03-19
KR20100054852A (ko) 2010-05-25
CR11309A (es) 2010-04-07
US20090069370A1 (en) 2009-03-12
CN101842366A (zh) 2010-09-22

Similar Documents

Publication Publication Date Title
TN2010000107A1 (fr) Derives d'azacyclylisoquinolinone et isoindolinone servant d'antagonistes du recepteur d'histamine -3
TN2010000105A1 (fr) Derives d'isoquinolinyle et d'isoindolinyle servant d'antagonistes du recepteur d'histamine -3
WO2007108936A3 (fr) Azacyclylamines avec substitution n en tant qu'antagonistes de l'histamine-3
MA34361B1 (fr) Dérivés de tétrahydro-pyrido-pyrimidine
MA31910B1 (fr) Antagonistes des recepteurs non steroidiens des mineralocorticoides derives de la 6h-dibenzo[b,e]oxepine
MA29772B1 (fr) Benzimidazoles substitues et procedes de preparation
WO2007136668A3 (fr) N-benzoyle et n-benzylpyrrolidin-3-ylamines comme antagonistes de l'histamine-3
MA34509B1 (fr) Composé hétérocyclique et son utilisation
WO2008056259A3 (fr) Dérivés d'oxazole utilisés en tant que modulateurs allostériques positifs des récepteurs métabotropiques du glutamate
MA33559B1 (fr) Composes bicycliques 5,6- heteroaryle contenant l'uree comme inhibiteurs de kinase.
MY155212A (en) Quaternary ammonium salt compounds
TW200718692A (en) Dihydrobenzofuran derivatives and uses thereof
MA30991B1 (fr) Utilisation de dérivés du benzamide comme agonistes des récepteurs ep4
UA100695C2 (ru) 2,3-дигидробензо[1,4] диоксин-2-илметиловые производные как альфа2с антагонисты для применения в лечении заболеваний периферической и центральной нервной системы
ECSP055536A (es) Derivados de 1-heterociclilalquil-3-sulfonilindol o indazol como ligandos de 5-hidroxitriptamina-6
WO2007142905A3 (fr) Dérivés de 1-sulfonylindazolylamine et de 1-sulfonylindazolylamide en tant que ligands de la 5-hydroxytryptamine-6
MA39152A1 (fr) Cyclopentanes substitués en 1,2 utilisés comme antagonistes du récepteur d'orexine
MX2009003645A (es) Azaciclilaminas n-sustituidas como antagonistas de histamina-3.
UA106873C2 (uk) Сполуки заміщених діазепанів як антагоністи орексинових рецепторів
EA200900783A1 (ru) Соединения и композиции в качестве ингибиторов киназы
GT200600030A (es) 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2
SG163564A1 (en) Kinin antagonists for treating bladder dysfunction
MA39315A1 (fr) Dérivés de pyridazine à utiliser dans la prévention ou le traitement d'un trouble ataxique
ATE486058T1 (de) Prolinamidderivate als nk3-antagonisten
TN2015000490A1 (fr) Dérivés d'imidazo-triazine servant d' inhibiteurs de pde10