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TN2009000182A1 - Compounds and methods for inhibiting the interaction of bcl proteins with binding partners - Google Patents

Compounds and methods for inhibiting the interaction of bcl proteins with binding partners

Info

Publication number
TN2009000182A1
TN2009000182A1 TNP2009000182A TN2009000182A TN2009000182A1 TN 2009000182 A1 TN2009000182 A1 TN 2009000182A1 TN P2009000182 A TNP2009000182 A TN P2009000182A TN 2009000182 A TN2009000182 A TN 2009000182A TN 2009000182 A1 TN2009000182 A1 TN 2009000182A1
Authority
TN
Tunisia
Prior art keywords
compounds
inhibiting
interaction
methods
binding partners
Prior art date
Application number
TNP2009000182A
Other languages
English (en)
Inventor
Alfredo C Castro
Edward B Holson
Brian T Hopkins
Nii O Koney
Daniel A Snyder
Thomas T Tibbitts
Original Assignee
Infinity Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Discovery Inc filed Critical Infinity Discovery Inc
Publication of TN2009000182A1 publication Critical patent/TN2009000182A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TNP2009000182A 2006-11-15 2009-05-08 Compounds and methods for inhibiting the interaction of bcl proteins with binding partners TN2009000182A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/600,332 US7842815B2 (en) 2004-06-17 2006-11-15 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
PCT/US2007/023941 WO2008060569A1 (fr) 2006-11-15 2007-11-14 Composés et procédés permettant d'inhiber l'interaction des protéines bcl avec des partenaires de liaison

Publications (1)

Publication Number Publication Date
TN2009000182A1 true TN2009000182A1 (en) 2010-10-18

Family

ID=39064388

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000182A TN2009000182A1 (en) 2006-11-15 2009-05-08 Compounds and methods for inhibiting the interaction of bcl proteins with binding partners

Country Status (20)

Country Link
US (2) US7842815B2 (fr)
EP (1) EP2094673B1 (fr)
JP (2) JP2010510214A (fr)
KR (1) KR101530721B1 (fr)
CN (1) CN101583606B (fr)
AU (1) AU2007319848B2 (fr)
BR (1) BRPI0718606A2 (fr)
CA (1) CA2669596C (fr)
EC (1) ECSP099398A (fr)
ES (1) ES2537762T3 (fr)
GT (1) GT200900123A (fr)
IL (1) IL198597A (fr)
MA (1) MA31067B1 (fr)
MX (1) MX2009005184A (fr)
MY (1) MY156754A (fr)
NO (1) NO20092306L (fr)
NZ (1) NZ577243A (fr)
RU (1) RU2449996C2 (fr)
TN (1) TN2009000182A1 (fr)
WO (1) WO2008060569A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008210434C8 (en) 2007-01-31 2014-03-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
US20090275519A1 (en) * 2008-02-08 2009-11-05 Aileron Therapeutics, Inc. Therapeutic peptidomimetic macrocycles
US8314250B2 (en) * 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
US8945853B2 (en) 2012-02-06 2015-02-03 Discoverx Corporation Detection of intracellular binding events by measuring protein abundance
CA2864120A1 (fr) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques reticules par triazole et par thioether
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CN103656642A (zh) * 2012-08-31 2014-03-26 中国科学院上海生命科学研究院 预防和治疗结直肠癌的方法和试剂
US20160068463A1 (en) 2012-11-14 2016-03-10 Metabolix, Inc. Production of salts of 4-hydroxybutyrate using biobased raw materials
WO2014138429A2 (fr) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leur utilisation dans la régulation de hif1alpha
EP3669881B1 (fr) 2014-01-28 2022-03-30 Buck Institute for Research on Aging Compositions pour leur utilisation pour traiter les maladies et les troubles oculaires associés à la sénescence
WO2015160975A2 (fr) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Polythérapies
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
KR102494039B1 (ko) 2016-03-28 2023-01-30 프레시지 바이오싸이언시스, 인크. 암 치료를 위한 제약학적 조합물
EP3454862B1 (fr) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Dégronimères spirocycliques pour la dégradation de protéines cibles
EP4491236A3 (fr) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Dégronimères hétérocycliques pour la dégradation de protéines cibles
WO2017197046A1 (fr) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Dégronimères de type glutarimide liés au carbone c3 pour la dégradation de protéines cibles
WO2017197051A1 (fr) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Dégronimères de c3-glutarimide liés à une amine pour la dégradation de protéines cibles
SG11201908603PA (en) * 2017-04-05 2019-10-30 Harvard College Macrocyclic compound and uses thereof
EP3641762A4 (fr) 2017-06-20 2021-03-10 C4 Therapeutics, Inc. Dégrons et dégronimères à liaison n/o pour la dégradation de protéines
CN113453679B (zh) 2018-12-20 2025-07-08 C4医药公司 靶向蛋白降解
WO2021233948A1 (fr) 2020-05-19 2021-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé de traitement d'une infection pulmonaire par un pathogène
EP4175644A1 (fr) 2020-07-06 2023-05-10 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combinaison d'antibiotiques anti néoplasiques et d'inhibiteurs de bcl-2 pour le traitement de la leucémie myéloïde aiguë (lma) entraînée par npm-1
WO2025087879A2 (fr) 2023-10-23 2025-05-01 Institut National de la Santé et de la Recherche Médicale Suppression de la voie de signalisation pi3kgamma/akt pour le traitement de leucémie myéloïde aiguë

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS55133364A (en) 1979-04-03 1980-10-17 Mitsubishi Petrochem Co Ltd Preparation of isoxazolidine derivative
DE3643012A1 (de) 1986-12-17 1988-06-30 Hoechst Ag 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
EP0527736B1 (fr) 1990-05-18 1997-04-16 Hoechst Aktiengesellschaft Amides d'acide carboxylique-4 d'isoxazol et cyanamides acetiques d'hydroxyalkylidene, medicaments contenant ces composes et leur application
US5294617A (en) 1993-04-23 1994-03-15 American Cyanamid Company Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
ES2134870T3 (es) * 1993-05-01 1999-10-16 Merck Patent Gmbh Antagonistas del receptor de adhesion.
ATE198748T1 (de) 1993-11-24 2001-02-15 Du Pont Pharm Co Isoxazoline und isoxazole derivate als fibrinogen rezeptor antagonisten
CA2185019C (fr) 1994-03-09 2000-08-08 Pfizer Limited Isoxazolines, inhibiteurs de la liberation du fnt
US5514505A (en) 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
DE19539638A1 (de) 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
US6221865B1 (en) 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
CA2262117A1 (fr) 1996-08-16 1998-02-19 The Dupont Merck Pharmaceutical Company Amidinophenyl-pyrrolidines, -pyrrolines et -isoxazolidines et leurs derives
WO1998016830A2 (fr) 1996-10-16 1998-04-23 The President And Fellows Of Harvard College Systeme de criblage par gouttelettes
AR015649A1 (es) 1997-05-07 2001-05-16 Univ Pittsburgh Inhibidores de isoprenil-transferasas proteicas, composiciones que los comprenden y el uso de los mismos para la fabricacion de un medicamento
WO2001016115A1 (fr) 1999-09-01 2001-03-08 Chemrx Advanced Technologies, Inc. Procede relatif a la synthese d'isoxazolidines
KR100399361B1 (ko) 1999-11-04 2003-09-26 주식회사 엘지생명과학 캐스파제 억제제 함유 치료제 조성물
ES2349349T3 (es) 2001-05-30 2010-12-30 The Regents Of The University Of Michigan Asociacion sinergica de (-)-gosipol con docetaxel o paclitaxel para el tratamiento de cancer.
FR2840807B1 (fr) 2002-06-12 2005-03-11 Composition cosmetique de soin et/ou de maquillage, structuree par des polymeres silicones et des organogelateurs, sous forme rigide
WO2006009907A2 (fr) * 2004-06-17 2006-01-26 Infinity Pharmaceuticals, Inc. Traitement d'infections bacteriennes au moyen de composes d'isoxazolidine
EP1768966B1 (fr) 2004-06-17 2012-03-07 Infinity Discovery, Inc. Composes et procedes pour l'inhibition de l'interaction de proteines bcl avec des partenaires de liaison
TWI403320B (zh) * 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法

Also Published As

Publication number Publication date
US20080306127A9 (en) 2008-12-11
EP2094673B1 (fr) 2015-04-08
MY156754A (en) 2016-03-31
US8461191B2 (en) 2013-06-11
MA31067B1 (fr) 2010-01-04
US7842815B2 (en) 2010-11-30
CA2669596A1 (fr) 2008-05-22
HK1130057A1 (en) 2009-12-18
CN101583606B (zh) 2015-04-08
ES2537762T3 (es) 2015-06-11
JP2010510214A (ja) 2010-04-02
RU2449996C2 (ru) 2012-05-10
KR20090082284A (ko) 2009-07-29
AU2007319848B2 (en) 2012-05-03
MX2009005184A (es) 2009-10-12
US20110160259A1 (en) 2011-06-30
EP2094673A1 (fr) 2009-09-02
KR101530721B1 (ko) 2015-06-22
WO2008060569A1 (fr) 2008-05-22
JP2014055156A (ja) 2014-03-27
RU2009121808A (ru) 2010-12-20
IL198597A (en) 2014-03-31
CN101583606A (zh) 2009-11-18
IL198597A0 (en) 2010-02-17
BRPI0718606A2 (pt) 2013-12-17
NO20092306L (no) 2009-08-17
US20070161690A1 (en) 2007-07-12
ECSP099398A (es) 2009-07-31
CA2669596C (fr) 2014-09-30
NZ577243A (en) 2011-12-22
AU2007319848A1 (en) 2008-05-22
GT200900123A (es) 2011-09-02

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