TH98013B - Azacycloalkane derivatives As a stabilizing agent of stearyl-coenzyme A delta-9 decaturase. - Google Patents
Azacycloalkane derivatives As a stabilizing agent of stearyl-coenzyme A delta-9 decaturase.Info
- Publication number
- TH98013B TH98013B TH701006000A TH0701006000A TH98013B TH 98013 B TH98013 B TH 98013B TH 701006000 A TH701006000 A TH 701006000A TH 0701006000 A TH0701006000 A TH 0701006000A TH 98013 B TH98013 B TH 98013B
- Authority
- TH
- Thailand
- Prior art keywords
- decaturase
- coenzyme
- stearyl
- delta
- stabilizing agent
- Prior art date
Links
- SIARJEKBADXQJG-LFZQUHGESA-N stearoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCCCCCCCCCCCCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SIARJEKBADXQJG-LFZQUHGESA-N 0.000 title abstract 3
- 150000003976 azacycloalkanes Chemical class 0.000 title 1
- 239000003381 stabilizer Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Proteins 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000001732 sebaceous gland Anatomy 0.000 abstract 1
Abstract
อนุพันธ์ของอะซาไซโคลแอลเคนที่มีสูตรโครงสร้าง I จะเป็นสารยับยั้งที่เลือกสรรของ สเตียโรอิล-โคเอนไซม์ A เดลตา-9 ดีแซททูเรส (SCD1) เมื่อเทียบกับสเตียโรอิล-โคเอนไซม์ A ดีแซททูเรส ที่เป็นที่รู้จักชนิดอื่น สารประกอบของการประดิษฐ์นี้จะเป็นประโยชน์สำหรับ การป้องกัน และกานบำบัดรักษาของภาวะที่เกี่ยวของกับการสังเคราะห์ และเมทาโบลิซึมของไขมัน ที่ผิดปกติ ที่รวมถึงโรคหัวใจและหลอดเลือด เช่น โรคหลอดเลือดแข็งจัว ; โรคอ้วน ; โรคเบาหวาน ; โรคทางประสามวิทยา ; กลุ่มอาการเมทาโบลิก ; ภาวะดื้อซูลิน ; และโรคของต่อมไขมันที่ตับ Azacyclalkane derivatives with structural formula I will be selective inhibitors of Stearyl-coenzyme A delta-9 decaturase (SCD1) compared to other well-known stearyl-coenzyme A decaturase. The invention compound is useful for the prevention and treatment of synthetic-related conditions. And abnormal lipid metabolism, including cardiovascular disease, such as arteriosclerosis; Obesity; Diabetes; Endocrine diseases; Metabolic syndrome; Stubborn resistance; And diseases of the sebaceous glands of the liver
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH98013A TH98013A (en) | 2009-08-27 |
| TH98013B true TH98013B (en) | 2009-08-27 |
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