TH137164A - Utilization of a combination of sinus node If current inhibitor and angiotensin-converting enzyme inhibitor. (angiotensin-converting enzyme inhibitor) in the treatment of heart failure. - Google Patents
Utilization of a combination of sinus node If current inhibitor and angiotensin-converting enzyme inhibitor. (angiotensin-converting enzyme inhibitor) in the treatment of heart failure.Info
- Publication number
- TH137164A TH137164A TH1101000776A TH1101000776A TH137164A TH 137164 A TH137164 A TH 137164A TH 1101000776 A TH1101000776 A TH 1101000776A TH 1101000776 A TH1101000776 A TH 1101000776A TH 137164 A TH137164 A TH 137164A
- Authority
- TH
- Thailand
- Prior art keywords
- angiotensin
- converting enzyme
- inhibitor
- enzyme inhibitor
- heart failure
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 210000001013 sinoatrial node Anatomy 0.000 title abstract 3
- 239000005541 ACE inhibitor Substances 0.000 title 2
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 title 2
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 title 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title 2
- 229960003825 ivabradine Drugs 0.000 claims abstract 4
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
DC60 (13/07/54) การใช้ประโยชน์ของการร่วมกันของสารยับยั้งกระแสไซนัสโหนด If ชนิดเลือกจำเพาะ และเฉพาะเจาะจง (selective and specific sinus node If current inhibitor), โดยเฉพาะ อิวาบราดีน (ivabradine) หรือ N-{[(7S)-3,4- ไดเมทธอกซีไบไซโคล [4.2.0]ออคตะ-1,3,5-ไตรอีน-7-อิล]-เมทธิล}-3- (7,8-ไดเมทธอกซี-1,2,4,5-เตตระไฮโดร-3H-3-เบนซาซีพิน-3-อิล)-N-เมทธิล-3-ออกโซ-1-โพรเพนเอมีน (N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-y1]methy1}-3-(7,8-dimethoxy-1,2,4,5- tetrahydro-3H-3-benzazepin-3-y1)-N-methy1-3-oxo-1-propanamine) และสารที่ยับยั้งเอนไซม์ซึ่งเปลี่ยน ผันแองจิโอเทนซิน (angiotensin-converting enzyme) เพื่อให้ได้มาซึ่งเวชภัณฑ์ซึ่งมุ่งหมายสำหรับ การบำบัดภาวะหัวใจล้มเหลว, โดยเฉพาะอย่างยิ่ง ภาวะหัวใจล้มเหลวที่หัวใจมีการทำงานบีบตัวคงเดิม สิทธิบัตรยา DC60 (13/07/54) Common utilization of selective sinus node If inhibitors And specific (selective and specific sinus node If current inhibitor), especially ivabradine (ivabradine) or N - (((7S) -3,4-dimethoxybycloid) [4.2.0] Octa -1,3,5-triene-7-il] -methyl} -3- (7,8-dimethoxy -1,2,4,5 - Tetrahydro-3H-3benzazipine-3-il) -N-methyl-3-oxo-1-propaneamine (N - {(7S) -3,4-dimethoxybicyclo [4.2.0] octa-1,3,5-trien-7-y1] methy1) -3- (7,8-dimethoxy-1,2,4 , 5- tetrahydro-3H-3-benzazepin-3-y1) -N-methy1-3-oxo-1-propanamine) and enzyme inhibitors that change Panangiotensin (angiotensin-converting enzyme) to obtain pharmaceuticals intended for Heart failure therapy, in particular Congestive heart failure in the heart
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH137164A true TH137164A (en) | 2014-10-08 |
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