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SV2016005318A - Pirazolopiridinas y pirazolopirimidinas - Google Patents

Pirazolopiridinas y pirazolopirimidinas

Info

Publication number
SV2016005318A
SV2016005318A SV2016005318A SV2016005318A SV2016005318A SV 2016005318 A SV2016005318 A SV 2016005318A SV 2016005318 A SV2016005318 A SV 2016005318A SV 2016005318 A SV2016005318 A SV 2016005318A SV 2016005318 A SV2016005318 A SV 2016005318A
Authority
SV
El Salvador
Prior art keywords
rent
phenyl
independently
replaced
naftilo
Prior art date
Application number
SV2016005318A
Other languages
English (en)
Inventor
Jotham Wadsworth Coe
Christoph Martin Dehnhardt
Peter Jones
Yogesh Anil Sabnis
Joseph Walter Strohbach
Florian Michel Wakenhut
Gavin Alistair Whitlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53264695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2016005318(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of SV2016005318A publication Critical patent/SV2016005318A/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Child & Adolescent Psychology (AREA)

Abstract

UN COMPUESTO QUE TIENE LA ESTRUCTURA: (VER FORMULA); O UNA DE SUS SALES FARMACÉUTICAMENTE ACEPTABLES O UN SOLVATO FARMACÉUTICAMENTE ACEPTABLE DE DICHO COMPUESTO O SAL FARMACÉUTICAMENTE ACEPTABLE, EN DONDE A Y A' SON, DE MODO INDEPENDIENTE, C O N, DONDE O PUEDE NO ESTAR SUSTITUIDO O PUEDE ESTAR SUSTITUIDO CON HALO O ALQUILO C1-C6; R Y R0 SE SELECCIONAN, DE MODO INDEPENDIENTE, DEL GRUPO QUE CONSISTE EN H, ALQUILO C1-C6, HIDROXI(ALQUILO C1-C6), FENIL(ALQUILO C1-C6) Y -(CH2)N-W, DONDE W ES CICLOALQUILO C3-C8, FENILO, NAFTILO, HETEROARILO DE 5 Ó 6 MIEMBROS O HETEROC�CLICO QUE CONTIENE 1-3 �TOMOS DE N, S Y/U O, -S02-R', -NHSO2-R', -NR"502-R' Y SR', DONDE R' Y R" SON, DE MODO INDEPENDIENTE, ALQUILO 01-06 0 CICLOALQUILO C3-C8, ETC.; EN DONDE CADA UNO DE DICHOS ALQUILO, CICLOALQUILO, HETEROC�CLICO, FENILO, NAFTILO O HETEROARILO PUEDE NO ESTAR SUSTITUIDO O PUEDE ESTAR SUSTITUIDO CON FENILO, HETEROARILO, ETC.; O R Y R0 Y EL �TOMO DE N AL QUE EST�N UNIDOS FORMAN UN ANILLO HETEROC�CLICO MONOC�CLICO O BIC�CLICO QUE PUEDE NO ESTAR SUSTITUIDO O PUEDE ESTAR SUSTITUIDO CON (A) HALO, HIDROXI, HETEROARILO, ALQUILO C1-C8, ALCOXI C1-C6, ETC. O (B) -(CH2)N-W, DONDE W ES CICLOALQUILO C3-C8, FENILO, ETC.; R1 ES H, HALO O CIANO; R2 Y R2' SON, DE MODO INDEPENDIENTE, H, ALQUILO C1-C6, CIANO, ALCOXI C1-C6, ALQUIL C1-C6-TIO O CICLOALQUILO C3-C8, DONDE ALQUILO, ALCOXI O CICLOALQUILO EST� OPCIONALMENTE SUSTITUIDO CON UNO O VARIOS �TOMOS DE FLÚOR; X ES UN ENLACE, -CO-, -CONH-, -SO2-, -SONH- O -(CH2)M--; R3 ES H, ALQUILO C1-C4, FENILO, NAFTILO, HETEROARILO DE 5 Ó 6 MIEMBROS O HETEROC�CLICO QUE CONTIENE 1-3 �TOMOS DE N, UN HETEROARILO DE 5 MIEMBROS O HETEROC�CLICO, ETC. O (C) 2 �TOMOS DE O O S Y 0-2 �TOMOS DE N; EN DONDE CADA UNO DE DICHOS FENILO, NAFTILO, HETEROARILO O 25 HETEROC�CLICO EST� OPCIONALMENTE SUSTITUIDO CON ALQUILO, 1 SUSTITUYENTE -Y-R4 Y/O 1-4 SUSTITUYENTES SELECCIONADOS CADA UNO, DE MODO INDEPENDIENTE, DE R5; SIEMPRE QUE, CUANDO X ES -CO- O -SO2-, R3 NO SEA H; Y ES UN ENLACE, -(CH2)M- U -O-; R4 ES (A) H, ALQUILO C1-C6, CICLOALQUILO C3-C8, HALO, OXO, -CR6, -NR7R8, -SR6, -SOR9, -SO2R9, -COR6, -OCOR6, -COOR6, -NR6COR6, -CONR7R8, ETC.; (B) FENILO O NAFTILO, ESTANDO DICHO FENILO Y NAFTILO OPCIONALMENTE SUSTITUIDOS CON 1-5 SUSTITUYENTES SELECCIONADOS DE ALQUILO C1-C6, CICLOALQUILO C3-C8, HALO, CIANO, -CR6, -NR7R8, ETC.; O (C) UN HETEROARILO MONOC�CLICO SATURADO O PARCIALMENTE INSATURADO DE 3 A 8 MIEMBROS, ETC.; R6 ES H, ALQUILO C1-C6 O CICLOALQUILO C3-C8, ETC.; R7 Y R8 SON CADA UNO, DE MODO INDEPENDIENTE, H, ALQUILO C1-C6 O CICLOALQUILO C3-C8 O SE TOMAN JUNTO CON EL �TOMO DE NITRÓGENO AL QUE EST�N UNIDOS PARA FORMAR UN ANILLO HETEROC�CLICO SATURADO DE 4, 5 Ó 6 MIEMBROS QUE CONTIENE 1-2 5 �TOMOS DE NITRÓGENO O 1 �TOMO DE NITRÓGENO Y 1 �TOMO DE OX�GENO, DICHO ALQUILO C1-C6 EST� OPCIONALMENTE SUSTITUIDO CON CICLOALQUILO C3-C8, HALO, ETC. Y ESTANDO DICHO ANILLO HETEROC�CLICO OPCIONALMENTE SUSTITUIDO CON UNO O VARIOS GRUPOS ALQUILO C1-C6 0 CICLOALQUILO C3-C8; R9 ES ALQUILO C1-C6 O CICLOALQUILO C3-C8; Y, M Y N SON, DE MODO INDEPENDIENTE, 0, 1, 2 Ó 3. LA INVENCIÓN TAMBIÉN SE REFIERE A SALES FARMACÉUTICAMENTE ACEPTABLES DE ESTOS COMPUESTOS Y SOLVATOS FARMACÉUTICAMENTE ACEPTABLES; A COMPOSICIONES QUE CONTIENEN TALES COMPUESTOS; Y A LOS USOS DE TALES COMPUESTOS EN EL TRATAMIENTO DE DIVERSAS ENFERMEDADES, EN PARTICULAR ASMA Y EPOC
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