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CR20160525A - Pirazolopiridinas y pirazolopirimidinas - Google Patents

Pirazolopiridinas y pirazolopirimidinas

Info

Publication number
CR20160525A
CR20160525A CR20160525A CR20160525A CR20160525A CR 20160525 A CR20160525 A CR 20160525A CR 20160525 A CR20160525 A CR 20160525A CR 20160525 A CR20160525 A CR 20160525A CR 20160525 A CR20160525 A CR 20160525A
Authority
CR
Costa Rica
Prior art keywords
alkyl
pharmaceutically acceptable
pirazolopirimidinas
pirazolopiridinas
phenyl
Prior art date
Application number
CR20160525A
Other languages
English (en)
Inventor
Peter Jones
Gavin Alistair Whitlock
Yogesh Anil Sabnis
Jotham Wadsworth Coe
Florian Michel Wakenhut
Christoph Martin Dehnhardt
Joseph Walter Strohbach
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53264695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20160525(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CR20160525A publication Critical patent/CR20160525A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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Abstract

Un compuesto que tiene la estructura, o una de sus sales farmacéuticamente aceptables o un solvato farmacéuticamente aceptable de dicho compuesto o sal farmacéuticamente aceptable, en donde A y A¿ son, de modo independiente, C o N, donde C puede no estar sustituido o puede estar sustituido con halo o alquilo C1-C6; R y R0 se seleccionan, de modo independiente, del grupo que consiste en H, alquilo C1-C6, hidroxi(alquilo C1-C6), fenil(alquilo C1-C6) y -(CH2)n-W, donde W es cicloalquilo C3-C8, fenilo, naftilo, heteroarilo de 5 ó 6 miembros o heterocíclico que contiene 1-3 átomos de N, S y/u O, -SO2-R¿, -NHSO2-R¿, -NR¿SO2-R¿ y SR¿.
CR20160525A 2014-05-14 2015-04-30 Pirazolopiridinas y pirazolopirimidinas CR20160525A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461993138P 2014-05-14 2014-05-14
PCT/IB2015/053174 WO2015173683A1 (en) 2014-05-14 2015-04-30 Pyrazolopyridines and pyrazolopyrimidines

Publications (1)

Publication Number Publication Date
CR20160525A true CR20160525A (es) 2016-12-20

Family

ID=53264695

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160525A CR20160525A (es) 2014-05-14 2015-04-30 Pirazolopiridinas y pirazolopirimidinas

Country Status (29)

Country Link
US (2) US9518052B2 (es)
EP (1) EP3143021B1 (es)
JP (1) JP6663857B2 (es)
KR (1) KR20170002623A (es)
CN (1) CN106459048A (es)
AP (1) AP2016009562A0 (es)
AR (1) AR100438A1 (es)
AU (1) AU2015260905A1 (es)
CA (1) CA2948587C (es)
CL (1) CL2016002888A1 (es)
CR (1) CR20160525A (es)
CU (1) CU20160167A7 (es)
DO (1) DOP2016000298A (es)
EA (1) EA201650029A1 (es)
EC (1) ECSP16087271A (es)
ES (1) ES2737696T3 (es)
GE (2) GEP20186921B (es)
IL (1) IL248970A0 (es)
MD (1) MD20160121A2 (es)
MX (1) MX2016014878A (es)
NI (1) NI201600170A (es)
PE (1) PE20161475A1 (es)
PH (1) PH12016502228A1 (es)
SG (1) SG11201609139WA (es)
SV (1) SV2016005318A (es)
TN (1) TN2016000503A1 (es)
TW (1) TWI591067B (es)
UY (1) UY36121A (es)
WO (1) WO2015173683A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20160525A (es) 2014-05-14 2016-12-20 Pfizer Pirazolopiridinas y pirazolopirimidinas
US9403810B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
UA123633C2 (uk) 2015-11-03 2021-05-05 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі Сполуки інгібітору jak-кінази для лікування респіраторного захворювання
ES2864035T3 (es) 2015-11-03 2021-10-13 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina y 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inhibidores de la quinasa janus
US10556901B2 (en) 2015-11-03 2020-02-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors
TWI754019B (zh) 2017-03-09 2022-02-01 美商施萬生物製藥研發 Ip有限責任公司 含有4員雜環醯胺之jak抑制劑
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
CA3059785A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
SG11201909376TA (en) 2017-05-01 2019-11-28 Theravance Biopharma R&D Ip Llc Crystalline forms of a jak inhibitor compound
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