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SV2016005230A - Derivados de acido heteroaril butanoico como inhibidores de lta4h - Google Patents

Derivados de acido heteroaril butanoico como inhibidores de lta4h

Info

Publication number
SV2016005230A
SV2016005230A SV2016005230A SV2016005230A SV2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A SV 2016005230 A SV2016005230 A SV 2016005230A
Authority
SV
El Salvador
Prior art keywords
heteroaril
butanoic
derivatives
acid
lta4h
Prior art date
Application number
SV2016005230A
Other languages
English (en)
Inventor
Birgit Bollbuck
Cristian Markert
Wofgang Miltz
Till Roehn
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SV2016005230A publication Critical patent/SV2016005230A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCIÓN DESCRIBE DERIVADOS NOVEDOSOS DE ÁCIDO HETEROARIL BUTANOICO QUE SON BUENOS CANDIDATOS A FÁRMACOS ESPECIALMENTE, EN RELACIÓN CON LA LEUCOTRIENO A4 HIDRO LASA (LTA4H). LA PRESENTE INVENCIÓN TAMBIÉN SE RELACIONA CON COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS DERIVADOS NOVEDOSOS DE ÁCIDO HETEROARIL BUTANOICO, MÉTODOS DE USO DE DICHOS COMPUESTOS EN EL TRATAMIENTO DE VARIAS ENFERMEDADES Y TRASTORNOS Y PROCESOS PARA LA PREPARACIÓN DE TALES COMPUESTOS NOVEDOSOS
SV2016005230A 2013-12-20 2016-06-20 Derivados de acido heteroaril butanoico como inhibidores de lta4h SV2016005230A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13199138 2013-12-20
EP14181155 2014-08-15

Publications (1)

Publication Number Publication Date
SV2016005230A true SV2016005230A (es) 2016-11-21

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US (4) US9981926B2 (es)
EP (1) EP3083564B1 (es)
JP (1) JP6500024B2 (es)
KR (2) KR102368958B1 (es)
CN (1) CN105829286B (es)
AP (1) AP2016009301A0 (es)
AU (1) AU2014369180B2 (es)
BR (1) BR112016011170B1 (es)
CA (1) CA2927564C (es)
CL (1) CL2016001255A1 (es)
CR (1) CR20160279A (es)
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EC (1) ECSP16062173A (es)
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GT (1) GT201600132A (es)
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PH (1) PH12016500814B1 (es)
PL (1) PL3083564T3 (es)
PT (1) PT3083564T (es)
RS (1) RS57642B1 (es)
SG (1) SG11201602787YA (es)
SI (1) SI3083564T1 (es)
SV (1) SV2016005230A (es)
TN (1) TN2016000127A1 (es)
UA (1) UA117498C2 (es)
UY (1) UY36178A (es)
WO (1) WO2015092740A1 (es)
ZA (1) ZA201602445B (es)

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DK3083564T3 (en) 2013-12-20 2018-10-22 Novartis Ag Heteroberl butyric acid derivatives as LTA4H inhibitors
WO2017175185A1 (en) 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
BR112020023001A2 (pt) 2018-05-15 2021-02-02 Alkahest, Inc. tratamento de doença associada ao envelhecimento com moduladores da leucotrieno a4 hidrolase
CN112424207B (zh) 2018-07-25 2024-03-19 诺华股份有限公司 Nlrp3炎性小体抑制剂
EP4389125A3 (en) * 2018-07-31 2024-09-11 Novartis AG Crystalline forms of a lta4h inhibitor
KR20250119653A (ko) 2018-11-07 2025-08-07 추가이 세이야쿠 가부시키가이샤 O-치환 세린 유도체의 제조 방법
AU2020207638B2 (en) * 2019-01-11 2023-04-13 Novartis Ag LTA4H inhibitors for the treatment of Hidradenitis Suppurativa
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
WO2021044351A1 (en) 2019-09-06 2021-03-11 Novartis Ag Methods of treating liver disease using lta4h inhibitors
BR112023002031A2 (pt) 2020-08-14 2023-03-07 Novartis Ag Derivados de espiropiperidinila substituídos por heteroarila e usos farmacêuticos dos mesmos
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
JP2024542963A (ja) 2021-11-01 2024-11-19 アルカヘスト，インコーポレイテッド 加齢関連疾患の予防及び治療のためのロイコトリエンａ４加水分解酵素（ｌｔａ４ｈ）のベンゾジオキサン調節剤
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3

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