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SV2002000301A - Composicion farmaceutica ref. z-1032 - Google Patents

Composicion farmaceutica ref. z-1032

Info

Publication number
SV2002000301A
SV2002000301A SV2001000301A SV2001000301A SV2002000301A SV 2002000301 A SV2002000301 A SV 2002000301A SV 2001000301 A SV2001000301 A SV 2001000301A SV 2001000301 A SV2001000301 A SV 2001000301A SV 2002000301 A SV2002000301 A SV 2002000301A
Authority
SV
El Salvador
Prior art keywords
pharmaceutical composition
composition ref
ref
monotioglycerol
cistein
Prior art date
Application number
SV2001000301A
Other languages
English (en)
Inventor
Bernd Ulrich Riebesehl
Jens Kemken
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0002691A external-priority patent/GB2358799A/en
Priority claimed from GB0019599A external-priority patent/GB2365768A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2002000301A publication Critical patent/SV2002000301A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UNA COMPOSICION FARMACEUTICA QUE COMPRENDE PEMETREXED, POR LO MENOS UN ANTIOXIDANTE SELECCIONADO DEL GRUPO QUE CONSISTE EN MONOTIOGLICEROL,CISTEINA-L Y ACIDO TIOGLICOLICO, Y UN EXCIPIENTE ACEPTABLE FARMACEUTICAMENTE. LA FORMULACION FARMACEUTICA ES ADECUADA PARA SU ADMINISTRACION PARENTERAL LIQUIDA
SV2001000301A 2000-02-04 2001-02-02 Composicion farmaceutica ref. z-1032 SV2002000301A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0002691A GB2358799A (en) 2000-02-04 2000-02-04 A pharmaceutical composition comprising pemetrexed and an antioxidant
GB0019599A GB2365768A (en) 2000-08-09 2000-08-09 Stable liquid composition containing pemetrexed

Publications (1)

Publication Number Publication Date
SV2002000301A true SV2002000301A (es) 2002-06-07

Family

ID=26243579

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000301A SV2002000301A (es) 2000-02-04 2001-02-02 Composicion farmaceutica ref. z-1032

Country Status (30)

Country Link
EP (1) EP1265612B1 (es)
JP (1) JP2003521518A (es)
KR (1) KR20020081293A (es)
CN (1) CN1396828A (es)
AR (1) AR027360A1 (es)
AT (1) ATE267601T1 (es)
AU (1) AU3442201A (es)
BR (1) BR0107958A (es)
CA (1) CA2399124A1 (es)
CO (1) CO5280222A1 (es)
CZ (1) CZ20022654A3 (es)
DE (1) DE60103512T2 (es)
DK (1) DK1265612T3 (es)
DZ (1) DZ3269A1 (es)
EA (1) EA004708B1 (es)
ES (1) ES2220716T3 (es)
HR (1) HRP20020636A2 (es)
HU (1) HUP0300709A3 (es)
IL (1) IL150475A0 (es)
MX (1) MXPA02007191A (es)
MY (1) MY129450A (es)
NO (1) NO20023379L (es)
NZ (1) NZ519727A (es)
PE (1) PE20011223A1 (es)
PL (1) PL356705A1 (es)
PT (1) PT1265612E (es)
SK (1) SK10982002A3 (es)
SV (1) SV2002000301A (es)
TR (1) TR200401436T4 (es)
WO (1) WO2001056575A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042280A1 (en) * 2001-12-28 2005-02-24 Rogers Tracey L. Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
KR20130122065A (ko) * 2012-04-30 2013-11-07 씨제이제일제당 (주) 페메트렉시드를 함유하는 안정화된 주사용 액상 제제
EP2666463A1 (en) 2012-05-21 2013-11-27 Synthon BV Stabilized liquid composition comprising pemetrexed
DE102012010774A1 (de) 2012-05-31 2013-12-05 Stada Arzneimittel Ag Pharmazeutische Pemetrexed-Lösung
KR101260636B1 (ko) 2012-11-29 2013-05-13 씨제이제일제당 (주) 안정화된 페메트렉시드 제제
KR101485243B1 (ko) * 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
JP6094388B2 (ja) * 2013-06-07 2017-03-15 ニプロ株式会社 ペメトレキセドを含む注射用組成物
CN103340826B (zh) * 2013-07-05 2015-09-09 浙江震元制药有限公司 美他多辛注射用组合物及其制备方法
WO2015050230A1 (ja) 2013-10-03 2015-04-09 富士フイルム株式会社 注射液製剤及びその製造方法
KR101703980B1 (ko) 2013-12-30 2017-02-08 주식회사 삼양바이오팜 항산화제를 함유하지 않는 약학 조성물 및 그의 제조방법
EP3124026B1 (en) * 2014-03-28 2018-07-25 Fujifilm Corporation Injection preparation and method for producing same
WO2016024369A1 (ja) * 2014-08-13 2016-02-18 テバ製薬株式会社 がん治療用医薬組成物
LT3206666T (lt) 2014-10-16 2020-03-10 Synthon B.V. Skysta farmacinė kompozicija, apimanti pemetreksedą
KR101770605B1 (ko) * 2014-11-17 2017-08-23 동아에스티 주식회사 페메트렉시드 또는 그것의 약제학적으로 허용가능 한 염을 함유하는 안정한 약제학적 조성물
KR101919436B1 (ko) * 2015-05-28 2018-11-16 주식회사 삼양바이오팜 안정화된 약학 조성물 및 그의 제조방법
KR101693675B1 (ko) 2015-12-14 2017-01-06 주식회사 종근당 페메트렉시드 또는 그의 약제학적으로 허용가능한 염을 함유하는 안정화된 약학조성물
US20170239250A1 (en) 2016-02-19 2017-08-24 Eagle Pharmaceuticals, Inc. Pemetrexed formulations
JP2019094284A (ja) * 2017-11-21 2019-06-20 日本化薬株式会社 ペメトレキセドを含有する注射用溶液製剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체

Also Published As

Publication number Publication date
NZ519727A (en) 2004-04-30
CA2399124A1 (en) 2001-08-09
PT1265612E (pt) 2004-08-31
ES2220716T3 (es) 2004-12-16
EP1265612B1 (en) 2004-05-26
ATE267601T1 (de) 2004-06-15
MXPA02007191A (es) 2002-12-09
EP1265612A1 (en) 2002-12-18
AU3442201A (en) 2001-08-14
HUP0300709A3 (en) 2005-04-28
IL150475A0 (en) 2002-12-01
EA200200831A1 (ru) 2003-02-27
DK1265612T3 (da) 2004-08-09
WO2001056575A1 (en) 2001-08-09
NO20023379D0 (no) 2002-07-12
CO5280222A1 (es) 2003-05-30
TR200401436T4 (tr) 2004-07-21
DZ3269A1 (fr) 2001-08-09
HRP20020636A2 (en) 2003-10-31
MY129450A (en) 2007-04-30
PE20011223A1 (es) 2001-12-20
PL356705A1 (en) 2004-06-28
JP2003521518A (ja) 2003-07-15
DE60103512T2 (de) 2005-06-02
HK1052461A1 (en) 2003-09-19
SK10982002A3 (sk) 2003-03-04
DE60103512D1 (de) 2004-07-01
AR027360A1 (es) 2003-03-26
HUP0300709A2 (hu) 2003-07-28
CZ20022654A3 (cs) 2003-01-15
NO20023379L (no) 2002-09-30
EA004708B1 (ru) 2004-06-24
BR0107958A (pt) 2002-10-29
KR20020081293A (ko) 2002-10-26
CN1396828A (zh) 2003-02-12

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