SV1998000003A - Proceso para producir eters de oxima (z)-azabiciclo en un unico recipiente - Google Patents
Proceso para producir eters de oxima (z)-azabiciclo en un unico recipienteInfo
- Publication number
- SV1998000003A SV1998000003A SV1998000003A SV1998000003A SV1998000003A SV 1998000003 A SV1998000003 A SV 1998000003A SV 1998000003 A SV1998000003 A SV 1998000003A SV 1998000003 A SV1998000003 A SV 1998000003A SV 1998000003 A SV1998000003 A SV 1998000003A
- Authority
- SV
- El Salvador
- Prior art keywords
- separation
- isomer
- oxima
- azabicycle
- eters
- Prior art date
Links
- 238000000926 separation method Methods 0.000 abstract 3
- -1 O-SUBSTITUTED HYDROXYLAMINE Chemical class 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Abstract
ES POSIBLE AISLAR EN FORMA LAS OXIMAS AZABICICLO O-SUBSTITUIDAS BIOLOGICAMENTE ACTIVAS QUE POSEEN LA CONFIGURACION Z, SIN NECESIDAD DE EFECTUAR UNA SEPARACION POR CROMATOGRAFICA, Y OBTENER ALTOS RENDIMIENTOS Y PUREZA E/Z MEDIANTE LA UNION DE UN 1-AZABICICLO-3-UNO CON UNA HIDROXILAMINA O-SUBSTITUIDA EN SOLUCION ACUOSA ACIDICA. DEL MISMO MODO, SE PUEDE EFECTUAR LA CONVERSION DE UN ISOMERO CONFIGURADO E A UN ISOMERO Z SIN NECESIDAD DE REALIZAR UNA PURIFICACION O SEPARCION. LA NEUTRALIZACION Y LA SUBSIGUIENTE AISLACION DE LA BASE LIBRE, SEGUIDA POR LA PRECIPITACION DE LA SAL, PERMITE LA SEPARACION DEL ISOMERO Z CON ALTA PUREZA Z/E.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3597797P | 1997-01-27 | 1997-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV1998000003A true SV1998000003A (es) | 1998-08-13 |
Family
ID=21885887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV1998000003A SV1998000003A (es) | 1997-01-27 | 1998-01-14 | Proceso para producir eters de oxima (z)-azabiciclo en un unico recipiente |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6121459A (es) |
| EP (1) | EP1021446A1 (es) |
| JP (1) | JP2001511127A (es) |
| KR (1) | KR20000070464A (es) |
| AR (1) | AR011775A1 (es) |
| AU (1) | AU741566B2 (es) |
| BR (1) | BR9714469A (es) |
| CA (1) | CA2270884A1 (es) |
| CO (1) | CO5011092A1 (es) |
| GT (1) | GT199800019A (es) |
| HR (1) | HRP980040B1 (es) |
| IL (1) | IL129793A (es) |
| MY (1) | MY132840A (es) |
| NZ (1) | NZ335784A (es) |
| PA (1) | PA8445601A1 (es) |
| PE (1) | PE75499A1 (es) |
| SV (1) | SV1998000003A (es) |
| TW (1) | TW533215B (es) |
| UY (1) | UY24857A1 (es) |
| WO (1) | WO1998032758A1 (es) |
| ZA (1) | ZA98618B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ｉｄｏ阻害剤 |
| FR2938534B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Procede de preparation de l'hemifumarate d'eplivanserine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158015A (en) * | 1978-08-16 | 1979-06-12 | Mobil Oil Corporation | Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes |
| IL97266A0 (en) * | 1990-03-06 | 1992-05-25 | Warner Lambert Co | Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them |
| US5306718A (en) * | 1990-03-06 | 1994-04-26 | Warner-Lambert Company | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
| US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
| AU2782792A (en) * | 1991-10-15 | 1993-05-21 | Warner-Lambert Company | Azabicyclo oxime and amine cholinergic agents and methods of treatment |
| DE4203170A1 (de) * | 1992-02-05 | 1993-08-12 | Basf Ag | Verfahren zur herstellung von e-oximethern von phenylglyoxylsaeureestern |
| IL107881A0 (en) * | 1992-12-05 | 1994-04-12 | Fisons Corp | Furanone derivatives and pharmaceutical compositions containing them |
| US5514812A (en) * | 1994-06-10 | 1996-05-07 | Warner-Lambert Company | Preparation of stereochemically pure oximes with muscarinic activity |
-
1997
- 1997-12-29 EP EP97954232A patent/EP1021446A1/en not_active Withdrawn
- 1997-12-29 WO PCT/US1997/023872 patent/WO1998032758A1/en not_active Ceased
- 1997-12-29 BR BR9714469-0A patent/BR9714469A/pt not_active IP Right Cessation
- 1997-12-29 NZ NZ335784A patent/NZ335784A/xx unknown
- 1997-12-29 JP JP53198098A patent/JP2001511127A/ja active Pending
- 1997-12-29 KR KR1019997006702A patent/KR20000070464A/ko not_active Ceased
- 1997-12-29 CA CA002270884A patent/CA2270884A1/en not_active Abandoned
- 1997-12-29 IL IL12979397A patent/IL129793A/xx active IP Right Grant
- 1997-12-29 US US09/355,227 patent/US6121459A/en not_active Expired - Fee Related
- 1997-12-29 AU AU58065/98A patent/AU741566B2/en not_active Ceased
-
1998
- 1998-01-12 MY MYPI98000130A patent/MY132840A/en unknown
- 1998-01-14 SV SV1998000003A patent/SV1998000003A/es active IP Right Grant
- 1998-01-26 UY UY24857A patent/UY24857A1/es not_active IP Right Cessation
- 1998-01-26 PA PA19988445601A patent/PA8445601A1/es unknown
- 1998-01-26 CO CO98003337A patent/CO5011092A1/es unknown
- 1998-01-26 GT GT199800019A patent/GT199800019A/es unknown
- 1998-01-26 AR ARP980100342A patent/AR011775A1/es not_active Application Discontinuation
- 1998-01-26 ZA ZA98618A patent/ZA98618B/xx unknown
- 1998-01-26 PE PE1998000052A patent/PE75499A1/es not_active Application Discontinuation
- 1998-01-27 HR HR980040A patent/HRP980040B1/xx not_active IP Right Cessation
- 1998-02-17 TW TW087101120A patent/TW533215B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001511127A (ja) | 2001-08-07 |
| US6121459A (en) | 2000-09-19 |
| AU5806598A (en) | 1998-08-18 |
| HRP980040A2 (en) | 1998-10-31 |
| MY132840A (en) | 2007-10-31 |
| CA2270884A1 (en) | 1998-07-30 |
| IL129793A (en) | 2003-01-12 |
| NZ335784A (en) | 2000-12-22 |
| PA8445601A1 (es) | 2000-05-24 |
| CO5011092A1 (es) | 2001-02-28 |
| GT199800019A (es) | 1999-07-20 |
| TW533215B (en) | 2003-05-21 |
| IL129793A0 (en) | 2000-02-29 |
| AU741566B2 (en) | 2001-12-06 |
| BR9714469A (pt) | 2000-05-16 |
| AR011775A1 (es) | 2000-09-13 |
| ZA98618B (en) | 1998-07-30 |
| WO1998032758A1 (en) | 1998-07-30 |
| PE75499A1 (es) | 1999-08-20 |
| UY24857A1 (es) | 1998-06-25 |
| HRP980040B1 (en) | 2002-10-31 |
| KR20000070464A (ko) | 2000-11-25 |
| EP1021446A1 (en) | 2000-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2088425T3 (es) | Metodo de produccion de xilitol a partir de mezclas que contienen xilosa. | |
| MX9302432A (es) | Mejoras en una membrana de pelicula delgada compuesta en su proceso. | |
| HN1997000110A (es) | Derivados del acido arilsulfoonilamino hidroxamico | |
| PT83958B (pt) | Processo de preparacao de mono-hidrato do hidrocloreto de n,n-dimetil-1-{1-(4-clorofenil)ciclobutil}-3-metilbutilamina | |
| FI862916A7 (fi) | Matalapaineinen elohopeahöyrypurkauslamppu. | |
| MX169089B (es) | Metodo para convertir almidon en un producto hidrolizado | |
| IT7904834A0 (it) | Procedimento per la desalinizzazione di soluzioni con applicazione della osmosi invertita. | |
| ES2180194T3 (es) | Procedimiento para la obtencion de una solucion acuosa de hidroxilamina libre. | |
| ES2098485T3 (es) | Complejo que contiene el factor de coagulacion ix. | |
| MX9302279A (es) | Metodo para la produccion del factor viii presenteen el plasma, altamente purificado. | |
| AR220434A1 (es) | Conjunto para generar ozono,por medio de la aplicacion de tubos generadores | |
| ES2167419T3 (es) | Procedimiento de fabricacion de un epoxido. | |
| SV1998000003A (es) | Proceso para producir eters de oxima (z)-azabiciclo en un unico recipiente | |
| ES2088877T3 (es) | Procedimiento de preparacion del 3-pirrolidinol. | |
| MX9200977A (es) | Proceso para producir l-lisina por fermentacion. | |
| ES2183860T3 (es) | Procedimiento para producir n-terc butil-2-pirazincarboxamida y n-ter-butil-2-piperazincarboxamida. | |
| ES2090432T3 (es) | Preparaciones farmaceuticas con una modificacion cristalina especial del ester isopropil-(2-metoxietilico) del acido 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridincarboxilico. | |
| KR930016096A (ko) | 상처 치유 촉진용 조성물 | |
| ES2046437T3 (es) | Procedimiento para la separacion de cobre de unas soluciones acuosas de reaccion basica. | |
| ES547371A0 (es) | Un procedimiento para eliminar impurezas,que comprenden ami-das,a partir de una solucion que comprende nitrilos y dichasimpurezas | |
| GB932167A (en) | Improvements in or relating to low pressure mercury vapour fluorescent electric discharge lamps | |
| IT8723088A0 (it) | Dispositivo per la ricerca del capo di filo spezzato su una spola in formazione. | |
| ECSP931002A (es) | Medicamentos | |
| TH1384S1 (th) | ขวด | |
| RU2000105080A (ru) | Препарат для лечения гриппа |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant |