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SV1995000048A - Compuestos ariltios - Google Patents

Compuestos ariltios

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Publication number
SV1995000048A
SV1995000048A SV1995000048A SV1995000048A SV1995000048A SV 1995000048 A SV1995000048 A SV 1995000048A SV 1995000048 A SV1995000048 A SV 1995000048A SV 1995000048 A SV1995000048 A SV 1995000048A SV 1995000048 A SV1995000048 A SV 1995000048A
Authority
SV
El Salvador
Prior art keywords
compounds
useful
htlv
hiv
aryltium
Prior art date
Application number
SV1995000048A
Other languages
English (en)
Inventor
John Michael Domagala
Edward Faith Elslager
Rocco Dean Gogliotti
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/286,816 external-priority patent/US5463122A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of SV1995000048A publication Critical patent/SV1995000048A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cereal-Derived Products (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS CARACTERIZADOS COMO DERIVADOS ARILTIO, Y MAS ESPECIALMENTE, COMO ARILTIOLES Y ARIL DISULFURO. LOS COMPUESTOS SON UTILES COMO AGENTES ANTIBACTERIANOS Y ANTIVIRALES. LOS COMPUESTOS SON ESPECIALMENTE UTILES PARA INHIBIR EL CRECIMIENTO O REPRODUCCION DE RETROVIRUS COMO POR EJEMPLO EL VIRUS DE INMUNODEFICIENCIA HUMANA 1 Y 2 (HIV 1 Y HIV 2), EL VIRUS DE INMUNODEFICIENCIA SIMIA (SIV), EL VIRUS ROUS SARCOMA, Y LOS VIRUS T-LINFOTROPICOS HUMANOS 1 Y 2 (HTLV 1 Y HTLV 2). LOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS Y LAS INFECCIONES VIRALES.
SV1995000048A 1994-08-05 1995-08-07 Compuestos ariltios SV1995000048A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/286,816 US5463122A (en) 1994-08-05 1994-08-05 Arylthio compounds
US08/446,917 US5734081A (en) 1994-08-05 1995-06-01 Arylthio compounds

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CA2193845A1 (en) 1996-02-15
EP0775110A1 (en) 1997-05-28
FI970417A7 (fi) 1997-01-31
KR20040004371A (ko) 2004-01-13
AU710806B2 (en) 1999-09-30
WO1996004242A1 (en) 1996-02-15
FI970417L (fi) 1997-01-31
OA10467A (en) 2002-04-05
NO970495D0 (no) 1997-02-04
JPH10504292A (ja) 1998-04-28
RO119193B1 (ro) 2004-05-28
BG63301B1 (bg) 2001-09-28
MX9700249A (es) 1997-05-31
DE69534502D1 (de) 2006-02-16
PL181425B1 (pl) 2001-07-31
FI970417A0 (fi) 1997-01-31
IS1806B (is) 2002-03-08
NO308656B1 (no) 2000-10-09
CZ26297A3 (cs) 1998-06-17
US5929114A (en) 1999-07-27
RU2156236C2 (ru) 2000-09-20
EP0775110B1 (en) 2005-10-05
HUT77653A (hu) 1998-07-28
PL318540A1 (en) 1997-06-23
AU3008795A (en) 1996-03-04
TW313565B (es) 1997-08-21
SK15497A3 (en) 1998-01-14
IS4425A (is) 1997-02-03
HRP950429A2 (en) 1997-04-30
UA52588C2 (uk) 2003-01-15
NO970495L (no) 1997-04-02
BG101189A (bg) 1998-03-31
US5734081A (en) 1998-03-31
ATE305923T1 (de) 2005-10-15
NZ300073A (en) 1999-07-29
MY113732A (en) 2002-05-31
US5668291A (en) 1997-09-16

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