SU971337A1 - Method of treating patients ill with alcoholism - Google Patents

Description

(5) METHOD OF TREATMENT OF GREATER AHOHOLISM

one

 The invention relates to the field of medicine, namely narcology, and can be used in the vitamin therapy of alcoholics.

- A known method of treating patients with alcoholism by administering vitamin preparations, PP C However, the known method does not provide a stable therapeutic effect, the administration of large doses at the same time can cause complications, and the period of relief of the hangover syndrome lasts up to 3-5 days.

The aim of the invention is to reduce the time to stop a hangover syndrome.

The goal is achieved by the fact that, when implementing the method of treating patients with alcoholism by administering vitamin preparations, the PP is distinguished by the fact that ... additionally administered the drug pantoin (pantethine - Daiichi) in an amount of 120-250 mg per day for 7- 10 days.

The treatment is carried out according to the following scheme: ripenarat pantosin (pantetin-Daiichi) at a dose of 120 mg 1 to 2 times B day 710 days peros or intramuscularly; 6% thiamine bromide solution, 3 ml once a day intramuscularly 5-6 days; riboflavin solution 1%

0 1 ml intramuscularly 1 time per day for 10 days; nicotinic acid 100 mg 2 times a day in powders - 10 days.

This drug complex was administered to patients in parallel with other

Claims (1)

15 detoxification measures taken on the grounds of individual indications (intravenous injections of glucose with vitamin C, unitiol or magnesia sulfuric acid intramuscularly, oxygen subcutaneously, lipoic acid intramuscularly, etc.). ; The proposed method is applied to patients with alcoholism. Among the patients examined, 9 were women and ST of men aged 20 to 58 years. As for alcoholism, a Stage of Persons was observed, and Stage III - 9 people. By the age of illness, patients were divided into the following groups: up to 10 years - 2b people, up to 15 years - 16 people, and over 15 years of alcohol abuse for drinks - 3 people. Before admission to the hospital, hard drinking continued for up to 7 days for 20 people, from 7 to 15 days for 10 people, up to 30 days for 10 patients and 5 people for drinking. wore a permanent character. In 32 patients, there were no acute psychopathological symptoms and severe neurological disorders, 13 people were stunned with acute alcoholic psychosis (delirium, hallucinosis); all the sick were in a state of hangover. The hangover syndrome was manifested in general unwellness, well-being, difficulty, general tremor and tremor of the extremities, desire to get sick, and vegetative-vascular disorders. On the part of the internal organs, 7 people had ischemic heart disease, 23 had hypertonic disease or symptomatic hypertension, 12 had chronic hepatitis, 5 had cirrhosis of the liver, 5 had chronic gastroduodenitis and cholecystitis, 8 had chronic pyelbnephritis and 1 patient had diabetes. On the mental side, 3 patients had the appearance of cerebral atherosclerosis, 6 people in premor bidet are psychopathic personalities. All patients had a treatment for alcoholism. In order to assess the availability of vitamine BSs to people who did not abuse alcohol compared to patients, CoA levels and pantothenic acid levels in leukocytes and urine were studied in 20 healthy people. Upon admission to the hospital, all patients determined the level of CoA in lecocytes, the content of pantothenic acid in leukocytes and daily urine, as well as general clinical and biochemical studies were performed (general blood and urine anaLysis, according to indications, blood cholesterol, bilirubin. and aminotransferase activity of glucose, residual nitrogen, CSFR, concentration of pyruvic and lactic acid). The results of biochemical and microbiological determination of vitamin BZ (CoA level in leukocytes and pantothenic acid content in leukocytes and urine) in patients suggests that when alcohol is abused, there is a significant decrease in the level of all pantothenic acid — an average of 80% in leukocytes. Hypovitaminosis 83 with a general decrease in all forms of pantothenic acid in the urine is accompanied by a predominant excretion of the bound form. Thus, the above data suggests that alcoholism causes metabolic disorders in the system of active CoA. The use of the drug pantosin (pantethine-Doyche) in combination with other detoxification measures showed a high therapeutic effect, which is expressed in the following. On the 2nd day of treatment, most patients began to experience symptoms of a hangover syndrome, alcohol disappeared, tremor of the arms and legs, anxiety, irritability decreased, temper, in the mouth, improved appetite and sleep, increased arterial blood pressure decreased, and from 7-8 One day marked a decrease in inflammatory events with sto-. In the liver, there was an improvement and normalization of indicators of the general urine analysis in patients admitted for treatment with the effects of chronic pyelonephritis. As a result of treatment, all patients experienced a recovery of the normal level of CoA in leukocytes and pantothenic acid content in leukocytes and urine. Example. Patient V. Nahodils is hospitalized in a psychoneurological hospital with a diagnosis of stage II alcoholism in the form of a drunken drink, pronounced hangover SYNDROME. Duration of alcohol abuse since the year, drinks by brew for 3–10 days, prefers vodka, sober. After the first glass notes the craving for alcohol, loses control over the amount of alcohol consumed. The treatment for alcoholism comes 2 times, previously treated in 1976. After treatment, after a short time, I began to drink. At the service - a conflict situation due to the patient's nicks. Drinks up to 1.5 liters of vodka over the course of the day, drinking is not slow, constantly sobering up, in the morning there is a depressed mood, apati, fatigue, poor appetite. Drunken - 8 days. Alcohol use of substitutes is denied. I came to the treatment myself, as I felt some kind of anxiety, pain in my heart. When admitted to the hospital, he correctly answered the questions, during the conversation he was verbose, articulate, undisguised. He talks in detail about conflicts in the service and at home, he does not consider himself an alcoholic. Delusional expressions (vanities and hallucinatory experiences are absent. Low mood. Upon admission to hospital: hangover is pronounced, feels anxiety, does not sleep at night, notes craving for alcoholic beverages. Patient in l, apathetic, notes increased thirst, no appetite. U the patient has hyperemia of the skin, increased sweating, hyperthermia, alternating with chills, hand tremor, convulsive muscle twitching, blood pressure 130/90. Consulted by a neurologist - currently symptoms no organ damage of the central nervous system was detected; the oculist showed that the anterior segment of the eyes and the fundus of the eye were normal.It wascermichesky heart disease was detected from the internal organs. General blood and urine tests without significant abnormalities. Blood content, mg%: cholesterol 305 , glucose - 103, pyruvic acid, 1.23, lactic acid, 11.3, residual nitrogen, Zb, blood KSCHR: pH - 7.21, BE (-9), pCOj 32. CoA level in 1 million leukocytes 13, 0 ng Pantothenic acid content in 1 million, leukocytes, ng: total 15.3, 13.6 associated, free 1.7. The level of pantothenic acid in daily urine, mg: total 3.50, associated 2.05, free 1.5. The patient was prescribed detoxification therapy: pantosin (pantetin-Daiichi), 120 mg once a day, intramuscularly for 10 days; 6% solution of thiamine bromide, 3.0 ml 1 time a day intramuscularly - 5 days; 1% riboflavin solution 1 ML1 once a day intramuscularly - 10 days; nicotinic acid 100 mg 2 times a day in powder for 10 days; About th glucose solution 20 ml 1 time per day intravenously for 10 days, Elenium 100 mg intramuscularly 2 times for 3 days. As a result of the treatment, the patient's condition improved. From the second day, the effects of the hangover syndrome began to take place: alcohol disappeared, hand tremor, anxiety; irritability, iridescence, decreased, appetin and sleep improved, blood pressure returned to normal. By the time of the examination on the 10th day of detoxification therapy, the patient had no health complaints. The results of laboratory studies. Blood levels, mg%: cholesterol 230, glucose 90, pyruvic and lactic acid, respectively, 0.1 and 13.2, residual nitrogen 30, blood CRP: pH 7.31, BE (-3), pCO 39. CoA level in 1 million leukocytes 6k, 6 ng. The content of pantothenic acid in 1 million leukocytes, ng: total 7-0.5, associated 7.7, free 2.8. The content of pantothenic acid in daily urine, mg: total 6.08, associated 3.16, free 2.92. After a course of detoxification therapy, the patient was prescribed anti-alcohol therapy. The proposed method of treating people with alcoholism makes it possible to buy a hangover syndrome for 23 days (versus 3-5 days) and shorten the detoxification therapy in general to days (as opposed to 1 day), at the same time providing a stable therapeutic effect. The invention of the method of treating patients with alcoholism through the introduction of vitamin preparations, PP, o tl and h and y with the fact that, in order to reduce 79713378 timing of hangover syndication, Sources of information, Roma additionally introduced drugs into account in the examination 1 1andosin (pantetin-Daiichi) in the coli-I .. Les v-itamines B eer Wort 120-250 mg per day for g e Je eeng carejnce eiUeMZindicatiowe 7-10 days. 5 fct e reipeMtig ne5.Pam, i069, p.346 (npbToTMn).