SU31013A1 - The method of obtaining compounds of bismuth with tartaric or citric acid - Google Patents
The method of obtaining compounds of bismuth with tartaric or citric acidInfo
- Publication number
- SU31013A1 SU31013A1 SU118600A SU118600A SU31013A1 SU 31013 A1 SU31013 A1 SU 31013A1 SU 118600 A SU118600 A SU 118600A SU 118600 A SU118600 A SU 118600A SU 31013 A1 SU31013 A1 SU 31013A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- bismuth
- tartaric
- citric acid
- obtaining compounds
- acid
- Prior art date
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title description 15
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 title description 12
- 229910052797 bismuth Inorganic materials 0.000 title description 11
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title description 11
- 239000011975 tartaric acid Substances 0.000 title description 8
- 235000002906 tartaric acid Nutrition 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 title description 3
- 238000000034 method Methods 0.000 title description 3
- 239000002244 precipitate Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- 229910000416 bismuth oxide Inorganic materials 0.000 description 4
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- TVQVQBIJZJIIFO-UHFFFAOYSA-N acetic acid;bismuth Chemical compound [Bi].CC(O)=O TVQVQBIJZJIIFO-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001622 bismuth compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940079905 intestinal adsorbents bismuth preparations Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- QGWDKKHSDXWPET-UHFFFAOYSA-E pentabismuth;oxygen(2-);nonahydroxide;tetranitrate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[O-2].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O QGWDKKHSDXWPET-UHFFFAOYSA-E 0.000 description 1
- 239000008237 rinsing water Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Обычные способы приготовлени свободных от азотной кислоты препаратов висмута представл ют в технике большие затруднени , вследствие трудности отмывки водой соединений висмута и требуют расхода такого ценного продукта , как глицерин (см. патент № 14468 В. А, Измаильского и В. К. Даниева). Conventional methods for preparing nitric acid-free bismuth preparations are very difficult in the art due to the difficulty of washing the bismuth compounds with water and require the consumption of such a valuable product as glycerin (see patent No. 14468 V. A, Izmailsky and V. K. Daniyev).
В предлагаемом способе получени соединений Висмута с винной или лимонной кислотой к молочноуксуснокислому раствору висмута добавл ют растворIn the proposed method of producing compounds of bismuth with tartaric or citric acid, a solution of bismuth is added to the lactobutyric acid solution of bismuth.
- винной или лимонн.ой кислоты при нагревании до 80° и отдел ют выпавший осадок.- tartaric or citric acid when heated to 80 ° and the precipitated precipitate is separated.
Пример. 366 г (1,2 моли) основного азотнокислого висмута перемешивают до полного отсутстви азотной кислоты в осадке с 1,5 литрами 5%-го едкого натра. Осадок отсасывают и промывают водой до отсутстви азотной кислоты в фильтрате .Example. 366 g (1.2 moles) of basic bismuth nitrate are mixed until no nitric acid is present in the sediment with 1.5 liters of 5% caustic soda. The precipitate is filtered off with suction and washed with water until no nitric acid is in the filtrate.
Полученную окись висмута постепенно внос т в перемешиваемую и нагретую до 35-40° смесь из 1,64 моли молочной и 7 молей уксусной кислоты, разбавленную водой до объема 1,750 литра. Раствор отфильтровывают от незначительной мути и определ ют в нем содержание висмута.The resulting bismuth oxide is gradually introduced into a mixture of 1.64 moles of lactic and 7 moles of acetic acid, diluted with water and heated to 35-40 °, diluted with water to a volume of 1.750 liters. The solution is filtered from a slight turbidity and the content of bismuth in it is determined.
150 .150
Раствор уксусномолочнокислого висмута нагревают до 50-60° и при хорошем перемешивании добавл ют концентрированный раствор виннокаменной кислоты с таким расчетом, чтобы на/1 моль висмута приходилось 0,4 моли виннокаменной кислоты. Температуру повышают до 80° и перемешивают 3 часа. Осадок отсасывают, промывают гор чей водой и спиртом. Осадок содержит 1 молекулу св занной уксусной кислоты, котора уходит при сушке в вакууме при 80-90. Фильтрат (без промывных .вод), содержащий висмут, вз тый в избытке, идет на новое растворрние окиси висмута, который беретс соответственно меньше дл следующей операции.A solution of bismuth-acetic acid is heated to 50-60 ° and with good stirring a concentrated solution of tartaric acid is added in such a way that 0.4 mol of tartaric acid is found per / 1 mole of bismuth. The temperature is raised to 80 ° and stirred for 3 hours. The precipitate is sucked off, washed with hot water and alcohol. The precipitate contains 1 bound acetic acid molecule, which leaves when dried under vacuum at 80-90. The filtrate (without rinsing water) containing bismuth, taken in excess, goes to a new solution of bismuth oxide, which is taken correspondingly less for the next operation.
Выход на вошедший в реакцию висмут превышает 90% от теории. Полученный продукт содержит около 750/в окиси висмута , что соответствует формуле:The yield on the reacted bismuth exceeds 90% of theory. The resulting product contains about 750 / in bismuth oxide, which corresponds to the formula:
соо.Soo
I BiOHI BiOH
сно/ снонsno
COO-Bi(OH),COO-Bi (OH),
т.-е. препарату, выпускаемому под названием „висмувероль.those. The drug, marketed under the name „Bismysuverol.
При действии при тех же услови х на 1 моль висмута в молочно-уксусном растворе 0,4 моли лимонной вместо 0,4 . моли виннокаменной кислоты, получаетс Under the action under the same conditions, per mole of bismuth in a milky acetic solution of 0.4 moles citric instead of 0.4. moth tartaric acid, get
СООSoo
Предмет изобретени .The subject matter of the invention.
Способ получени соединени висмута с винной или лимонной кислотой, отли«The method of obtaining compounds of bismuth with tartaric or citric acid, cast "
осадок лимоннокислого висмута, содержащий после отмывани и сушки в вакууме около 72% висмута, что соответствует формуле:bismuth citrate precipitate, containing after washing and drying in vacuum about 72% bismuth, which corresponds to the formula:
ВЮНWyun
чающийс тем, что к молочноуксуснокислому раствору окиси висмута добавл ют раствор винной или лимонной кислоты и выпавший осадок отдел ют.It is added by adding tartaric or citric acid solution to the lactic acid solution of bismuth oxide and the precipitated precipitate is separated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU118600A SU31013A1 (en) | 1932-11-15 | 1932-11-15 | The method of obtaining compounds of bismuth with tartaric or citric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU118600A SU31013A1 (en) | 1932-11-15 | 1932-11-15 | The method of obtaining compounds of bismuth with tartaric or citric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU31013A1 true SU31013A1 (en) | 1933-07-31 |
Family
ID=48348371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU118600A SU31013A1 (en) | 1932-11-15 | 1932-11-15 | The method of obtaining compounds of bismuth with tartaric or citric acid |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU31013A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2701013C1 (en) * | 2019-05-24 | 2019-09-24 | Общество с ограниченной ответственностью "Брайт Вэй" | Method of producing bismuth citrate |
-
1932
- 1932-11-15 SU SU118600A patent/SU31013A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2701013C1 (en) * | 2019-05-24 | 2019-09-24 | Общество с ограниченной ответственностью "Брайт Вэй" | Method of producing bismuth citrate |
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