SU1659058A1 - Organism detoxication method - Google Patents

Abstract

This invention relates to medicine. To increase the therapeutic effect, the patient's blood is taken and divided into plasma and shaped elements, the plasma is removed. A hemisphere is formed from formed elements at a pressure of 140-150 mm Hg, the deplassed cells are washed with a stream of physiological solution under the same pressure by affecting the surface layer of the hemisphere, and the mixture is re-filtered. The washed blood cells are mixed with the donor plasma or plasma-substituting liquid in a volume equal to the volume of the removed plasma, and return the mixture to the patient.

Description

The invention relates to medicine and can be used in the treatment of diseases accompanied by intoxication of the body.

The purpose of the invention is to increase the therapeutic effect.

The method is carried out as follows.

The extracorporeal circuit is filled with saline with a temperature of 37 ° C. Then, the radial artery and central vein of the patient can be cannulated. 150 units of heparin per 1 kg of patient weight were administered intravenously. The roller pump is switched on at a rate of 40-50 ml / min and the filling of the system with blood begins. When the filtration column is filled, the plasma filtration process begins. In this case, the transmembrane pressure should not exceed 100 mm Hg. Deplassed blood cells enter the container, at the base of which they form a hemisphere of deplassed cells with a volume of up to 30 ml.

When the top point of the hemisphere reached the level of the cannula, through which the saline solution is supplied, the second roller pump with a speed equal to the speed of the hemisphere, which depends on the blood flow rate, transmembrane pressure, hematocrit, and technical characteristics of the plasma filter, averaged 30-40 ml / min The upper layer of deplassed cells begins to deflate from the surface of the hemisphere at a pressure of 140-150 mm Hg. and, mixing with the physiological saline solution in the tank, enters the second filtration column, in which secondary filtration takes place and the excess saline is removed. Transmembrane pressure on the column should also not exceed 100 mm Hg.

The deplassed and washed blood cells enter the air trap, where they are mixed with the donor plasma, the volume of which must correspond to the volume of the plasma removed, and reinfused into the blood stream.

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nose of the patient. The pressure in the venous line should not exceed 150 mm Hg. The speed of the roller pump should be equal to the plasma filtration rate on the first filtration column. The total volume of plasma exchange is 1200-1500 ml. 200 ml of blood is extruded simultaneously. Plasma loss is compensated by the administration of reopolyglucine and hemodez. Compensation of plasma losses is completed by the introduction of an adequate amount of fresh frozen donor plasma and hyperimmune plasma of directional action in accordance with the nature of microflora seeded in this patient. Conduct 2-3 procedures with an interval of no more than 2 days.

Example. Sick B., 39 years old, diagnosis: trogenic stricture of hepaticocholedochus, mechanical jaundice,

In order to correct the patient's humoral homeostasis, the proposed method of detoxification of the organism has been applied. After plasmapheresis, the hemisphere of the de-plated cells is formed at a pressure of 150 mm Hg, the erythrocytes are washed by exposing the surface layer of the formed hemisphere of the deplassed cells with a stream of saline, and then the saline solution is washed and removed from the surface citov toxins.

Already during the first days after the procedure, the patient's condition improved significantly. After the session, blood bilirubin decreased from 192 µmol / L (direct 108 µmol / L) to 57 µmol / L (direct 23 µmol / L), i.e. 4.6 times. Concentration of Medium Molecular Toxins

decreased from 0.43 to 0.18 srv.ed., the partial pressure of oxygen increased to 160 mm Hg, the partial pressure of carbon dioxide decreased from 35 to 11 mm Hg, blood pH 7.34 and 7.33 before and after the session, respectively.

After preoperative preparation, the patient was operated on 02/29/88. During pararotomy, the trogenic stricture of the common duct was revealed. Plasticized hepaticoholedochus on the transhepatic drainage according to Praderi. The postoperative course is smooth. Was discharged in a satisfactory condition on 03.16.88.

The proposed method allows to increase the efficiency of detoxification of the body and reduce mortality from 47 to 23.7% of surgical patients.

F d p m u l a i z o b r e te n u

The method of detoxifying the body by taking the patient's blood, dividing it into plasma and uniform elements, removing the plasma, washing the formed elements with saline solution, mixing them with the donor plasma or plasma replacement fluid in a volume equal to the volume of the removed plasma, followed by reinfusing the mixture into the patient's organism, characterized in that, in order to increase the therapeutic effect, after the separation of blood, the hemisphere of deplassed cellular elements is formed at a pressure of MO- ISO mm Hg, they are washed with a stream of water ologicheskogo solution under the same pressure when exposed to the surface layer of the hemisphere, the mixture was refiltered and washed blood cells are returned to the patient.

Claims (1)

Claim A method of detoxifying the body by * taking the patient’s blood, separating it into plasma and shaped elements, removing the plasma, washing the shaped elements with physiological saline, mixing them with donor plasma or a plasma-replacing liquid in an amount equal to the volume of the removed plasma; followed by reinfusion of the mixture into the patient’s body, characterized in that, in order to increase the therapeutic effect, a hemisphere of depopulated cell elements is formed after blood separation at a pressure of 140-150 mm Hg, they are washed with a saline stream under the same pressure when exposed to the surface layer hemispheres, re-filter the mixture and washed blood cells are returned to the patient. Compiled by I. Ivanova Editor I. Casarda Tehred M. Morgenthal Corrector M. Maximishenets Order 1800 Circulation 395 Subscription VNIIIPI of the State Committee for Inventions and Discoveries at the State Committee for Science and Technology 113035, Moscow, Zh-35, Raushskaya nab., 4/5 Production and Publishing Combine Patent, Uzhgorod, 101 Gagarin St.