SU118557A1 - The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopentol) labeled by isotopic exchange - Google Patents
The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopentol) labeled by isotopic exchangeInfo
- Publication number
- SU118557A1 SU118557A1 SU598976A SU598976A SU118557A1 SU 118557 A1 SU118557 A1 SU 118557A1 SU 598976 A SU598976 A SU 598976A SU 598976 A SU598976 A SU 598976A SU 118557 A1 SU118557 A1 SU 118557A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- sodium
- labeled
- obtaining
- butyl
- ethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title description 3
- 239000011734 sodium Substances 0.000 title description 3
- 229910052708 sodium Inorganic materials 0.000 title description 3
- 159000000000 sodium salts Chemical class 0.000 title description 3
- 230000000155 isotopic effect Effects 0.000 title description 2
- PDXOPTFTOFXXSU-UHFFFAOYSA-N 1-sulfanylpentan-1-ol Chemical compound CCCCC(O)S PDXOPTFTOFXXSU-UHFFFAOYSA-N 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 5
- IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 229960003279 thiopental Drugs 0.000 description 4
- AWLILQARPMWUHA-UHFFFAOYSA-M thiopental sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC([S-])=NC1=O AWLILQARPMWUHA-UHFFFAOYSA-M 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Известный способ получени 5,5-этил-(1-метил-бутил)тиобарбитуровой кислоты и ее натриевой соли (тиопентала натри ) состоит из нескольких стадий и дает относительно невысокий выход продукта.A known method for producing 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopental) consists of several stages and gives a relatively low yield of the product.
Предлагаемый способ получени меченого тиопентала изотопного обмена, позвол ет упростить процесс получени препарата и увеличить его выход.The proposed method of obtaining labeled thiopental isotope metabolism allows to simplify the process of obtaining the drug and increase its yield.
Препарат получают путем изотопного обмена между элементарной серой и Sз тиопентала натри .The drug is produced by isotope exchange between elemental sulfur and S3 of sodium thiopental.
Пример. 0,0047 г серы, уд. акт. 7 мкюри/г, общ. акт. 33,2 мкюри раствор ют в 5 мл ксилола, приливают к раствору 1 г 87%-ного тиопентала натри в 100 мл изоамилового спирта и нагревают в течение 12 час. на глицериновой бане при 100-105°. После нагрева смесь обрабатывают дистиллированной водой 4-5 раз по 50 мл. Соединенные водные выт жки подкисл ют однонормальной сол ной кислотой, осаждают меченую тиопенталовую кислоту, тщательно промывают водой и сущат в вакууме.Example. 0,0047 g of sulfur, beats. Act. 7 mkuri / g, total Act. 33.2 muri are dissolved in 5 ml of xylene, poured into a solution of 1 g of 87% sodium thiopental in 100 ml of isoamyl alcohol and heated for 12 hours. on a glycerin bath at 100-105 °. After heating, the mixture is treated with distilled water 4-5 times 50 ml. The combined aqueous extracts are acidified with one-normal hydrochloric acid, the labeled thiopental acid is precipitated, thoroughly washed with water and taken up in vacuum.
Получают продукт весом 0,6 г; химическим выходом 72%; выходом по активности 65%; т. пл. 152-154°; уд. акт. 20 мкюри/г; общ. акт. 12 мкюри (с учетом распада).Get the product weight of 0.6 g; chemical yield 72%; 65% activity yield; m.p. 152-154 °; beats. Act. 20 μury / g; total Act. 12 mkury (taking into account disintegration).
Меченый S тиопентал натри получают прибавлением 2,86 мл однонормального спиртового раствора щелочи и высушиванием в вакууме-сушилке .Sodium thiopental labeled with S1 is prepared by adding 2.86 ml of a single-normal alcohol solution of alkali and drying it in a vacuum dryer.
Получают продукт весом 0,65 г; химическим выходом 74%; выходом по активности 65%; уд. акт. 20 мкюри/г; общ акт. 12 мкюри (с учетом распада).Get the product weight of 0.65 g; chemical yield 74%; 65% activity yield; beats. Act. 20 μury / g; general act. 12 mkury (taking into account disintegration).
Величину уд. акт. полученных соединений можно варьировать в довольно широких пределах в зависимости от уд. акт. исходной серы, соотношени органического соединени и элементарной серы.Magnitude beats. Act. The compounds obtained can be varied within fairly wide limits depending on the beats. Act. starting sulfur, the ratio of organic compound and elemental sulfur.
Предмет изобретени Subject invention
Способ получени 5,5-этил-(1-метил-бутил) тиобарбитуровой кислоты и ее натриевой соли (тиопентала иатри ), меченых методом изотопного обмена, отличающийс тем, что, с целью упрощени процесса и увеличени выхода продукта, препарат получают путем изотопного обмена между элементарной серой S и S тиопентала иатри .The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (thiopental and sodium), isotopically labeled, characterized in that, in order to simplify the process and increase the yield of the product, the preparation is obtained by isotopic exchange between elemental sulfur S and S of thiopental and sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU598976A SU118557A1 (en) | 1958-05-07 | 1958-05-07 | The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopentol) labeled by isotopic exchange |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU598976A SU118557A1 (en) | 1958-05-07 | 1958-05-07 | The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopentol) labeled by isotopic exchange |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU118557A1 true SU118557A1 (en) | 1959-01-01 |
Family
ID=36337492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU598976A SU118557A1 (en) | 1958-05-07 | 1958-05-07 | The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopentol) labeled by isotopic exchange |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU118557A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006041327A1 (en) * | 2004-10-11 | 2006-04-20 | Sergeev, Sergey Sergeevich | Self-contained device for product leakage testing |
-
1958
- 1958-05-07 SU SU598976A patent/SU118557A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006041327A1 (en) * | 2004-10-11 | 2006-04-20 | Sergeev, Sergey Sergeevich | Self-contained device for product leakage testing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU118557A1 (en) | The method of obtaining 5,5-ethyl- (1-methyl-butyl) thiobarbituric acid and its sodium salt (sodium thiopentol) labeled by isotopic exchange | |
| GB1055243A (en) | Improvements in or relating to electroplating | |
| SU112669A1 (en) | Method for preparing 2-nitroso-1-antrol-4-sulfonic acid and 2-nitro-1-antrol-4-sulfonic acid | |
| SU504441A1 (en) | The method of obtaining meta-or para-iodo derivatives of benzene, labeled with radioisotopes of iodine | |
| SU145597A1 (en) | The method of obtaining soil builders | |
| SU138611A1 (en) | The method of preparation of furyl-alpha and tinil-alpha-alkyl ketones | |
| GB1066812A (en) | Improvements in or relating to the manufacture of 2,6-dichlorobenzonitrile | |
| SU455952A1 (en) | The method of cleaning sulfonylamide drugs | |
| SU502896A1 (en) | The method of obtaining bis (priortilsilyl) sulfates | |
| SU374303A1 (en) | METHOD OF OBTAINING 2,4-DIPHENYL PERGYDROCHINOLINE | |
| SU106378A1 (en) | The method of obtaining 4-amino-5-formylamino-uracil | |
| SU145244A1 (en) | The method of obtaining esters of Kamenovo acid | |
| SU109979A1 (en) | Method for preparing P-phenylquinolini perchlorate | |
| SU437762A1 (en) | Method for preparing 3-phenylisopropylsidnonimine hydrochloride (sydnophene) | |
| SU148041A1 (en) | The method of obtaining 2-chlornaftoquinone-1,4 | |
| SU105803A1 (en) | Method for producing vinylphosphonic acid ethyl ester | |
| SU115946A1 (en) | Method for preparing fumagillin potassium salt | |
| SU396322A1 (en) | A METHOD FOR OBTAINING N-METHYLOLFORMAMIDE | |
| SU382613A1 (en) | ||
| SU459066A1 (en) | The method of obtaining 3-trifluoromethyldiphenylamine | |
| SU105423A1 (en) | Method for preparing dithiophosphoric acid mixed esters | |
| SU123534A1 (en) | Method for preparing 5,8-diketo-1,4,5,8,9,10-hexahydronaphthalene-1 carbinic acid | |
| SU334788A1 (en) | The method of obtaining the urea complex of copper pyrophosphate | |
| SU96305A1 (en) | The method of obtaining monomethyl-aminoantipyrin | |
| SU145243A1 (en) | Method for preparing 4- and 5-hydroxybenz-2,1,3-thiodiazoles |