SU101898A1 - Method for producing technical morphine - Google Patents
Method for producing technical morphineInfo
- Publication number
- SU101898A1 SU101898A1 SU451043A SU451043A SU101898A1 SU 101898 A1 SU101898 A1 SU 101898A1 SU 451043 A SU451043 A SU 451043A SU 451043 A SU451043 A SU 451043A SU 101898 A1 SU101898 A1 SU 101898A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- morphine
- technical
- producing technical
- extract
- poppy plant
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title description 34
- 229960005181 morphine Drugs 0.000 title description 17
- 238000004519 manufacturing process Methods 0.000 title description 2
- 240000001090 Papaver somniferum Species 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000000284 extract Substances 0.000 description 4
- 238000003795 desorption Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000008753 Papaver somniferum Nutrition 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Предметом изобретени вл етс способ получени технического морфина методом ионгюобменной адсорбции и десорбции.The subject of the invention is a method for obtaining technical morphine by the method of ion-exchange adsorption and desorption.
Известный адсорбционный способ получени морфина из коробочек масличного мака не обеспечивает извлечени всего количества морфипа , которое может дать маковое растение .The known adsorption method for producing morphine from oilseed poppy boxes does not ensure extraction of the total amount of morphine that a poppy plant can produce.
Предлагае1МЫ1 1 способ уст)аи ет этот недостаток и увеличивает выход морфина.The proposed IIM1 1 method establishes this disadvantage and increases the yield of morphine.
Особенность способа заключаетс в том, что в качестве сырь примен ют водный экстракт из высушенного целого растени мака.A feature of the method is that an aqueous extract from a dried whole poppy plant is used as a raw material.
Способ осуществл етс следующим образом.The method is carried out as follows.
Высущенное маковое растение, скошенное до технической зрелости сем н, измельчаетс на соломорезке и подвергаетс экстракции водой, слабым раствором серной кислоты или известковой водой при нагревании в батарее из нескольких экстракторов по принципу противотока. Полученный экстракт, в случае необходимости , очищаетс известью, отфильтровываетс от выпавшего осадка и подкисл етс серпой кислотой до слабокислой реакции. Выпадающий осадок сульфата кальци отдел етс фильтрованием.A thickened poppy plant, slanting to technical maturity of seeds, is crushed on a straw cutter and subjected to extraction with water, a weak solution of sulfuric acid or lime water when heated in a battery of several extractors on the principle of countercurrent. The extract obtained, if necessary, is cleaned with lime, filtered from the precipitated sediment and acidified with sickle acid to a weakly acidic reaction. The precipitated calcium sulfate is separated by filtration.
Пиже приводитс пример получени технического морфина из водного экстракта целого макового растени .An example of obtaining technical morphine from an aqueous extract of a whole poppy plant is given below.
Вз то 140 кг измельченного макового растени , содержащего 420 г морфина-основани . После экстракции 1%-ным раствором серной кис .аоты получено 960 л экстракта, содержан;его 386 г морфина.Take 140 kg of crushed poppy plant containing 420 g of morphine base. After extraction with a 1% solution of sulfuric sour. Aota, 960 l of extract was obtained, containing 386 g of morphine.
В результате очистки окисью кальци получено 825 л экстракта той же концентрации, т. е. 380 г морфипа. При пропускании этого экстракта через адсорбционную батарею , запо щепную катионитом - эспатитом Ао 1, со скоростыо 700 л/час на 1 м насыщено 6500 г адсорбента. При десорбции морфина с адсорбента 1%-ным раствором аммиака в метиловом сппрте в десорбционной батарее нри скорости тока растворител 40 л/час на 1 м получено 48,5 л элюата, содержащего 315 г морфииа.As a result of purification with calcium oxide, 825 liters of extract of the same concentration were obtained, i.e., 380 g of morphine. When this extract is passed through an adsorption battery, which is supplied with a cation exchanger — Espatite Ao 1, at a speed of 700 l / h per 1 m, 6500 g of adsorbent is saturated. During desorption of morphine from the adsorbent with a 1% ammonia solution in a methyl concentrate in a desorption battery at a solvent flow rate of 40 l / h per 1 m, 48.5 l of eluate containing 315 g of morphine was obtained.
Выделение морфина производилось путем отгонки спирта из подкисленного элюата и осаждени морфина 25% аммиака из воды, насыщенной дихлорэтаном. При этом выделено 350 г технического продукта с 80% морфииа в нем (280 г 100%пого морфина). После промывки продукта гор чей водой получено j 101898 - -2 301,7 г морфина-основани технического , соответствующего техническим услови м (с 90%-ным содержанием морфина), или 271,5 г 100%-ного морфина. , „ , °Й 10оГкгй%7ф™/ . . 64.60/0 Расход ширта на I кг продукта . . 30 «г Расход эспатита (учитыва его Ю-кратную оборачиваемость)Ч кг Предмет изобретени Способ получени технического морфина методом поннообменнои адсорбции и десорбции, отлкчающийс тем,- что в качестве сырь примен ют ВОДНЫЙ экстракт ИЗ высушенного целого растени мака , скощенного ДО технической зреЛОСТИ сеМЯН.The morphine was isolated by distilling the alcohol from the acidified eluate and precipitating the morphine with 25% ammonia from water saturated with dichloroethane. At the same time, 350 g of a technical product with 80% of morphine in it (280 g of 100% of pogo morphine) was isolated. After washing the product with hot water, j 101898 - -2 301.7 g of morphine-base technical, corresponding to the technical conditions (with 90% morphine content), or 271.5 g of 100% morphine was obtained. , „, ° 10GS% 7f ™. . 64.60 / 0 Consumption of bread per I kg of product. . 30 "g Consumption of espatite (considering its U-fold turnover) H kg Subject of the invention .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU451043A SU101898A1 (en) | 1952-05-10 | 1952-05-10 | Method for producing technical morphine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU451043A SU101898A1 (en) | 1952-05-10 | 1952-05-10 | Method for producing technical morphine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU101898A1 true SU101898A1 (en) | 1954-11-30 |
Family
ID=48375674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU451043A SU101898A1 (en) | 1952-05-10 | 1952-05-10 | Method for producing technical morphine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU101898A1 (en) |
-
1952
- 1952-05-10 SU SU451043A patent/SU101898A1/en active
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