SMT201600365B - Polipeptidi chimerici e loro uso nella decolonizzazione batterica - Google Patents
Polipeptidi chimerici e loro uso nella decolonizzazione battericaInfo
- Publication number
- SMT201600365B SMT201600365B SM201600365T SM201600365T SMT201600365B SM T201600365 B SMT201600365 B SM T201600365B SM 201600365 T SM201600365 T SM 201600365T SM 201600365 T SM201600365 T SM 201600365T SM T201600365 B SMT201600365 B SM T201600365B
- Authority
- SM
- San Marino
- Prior art keywords
- decolonization
- bacterial
- chemical polypeptides
- polypeptides
- chemical
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24075—Lysostaphin (3.4.24.75)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09015998A EP2338916A1 (en) | 2009-12-23 | 2009-12-23 | Chimeric polypeptides and their use in bacterial decoloniation |
| PCT/EP2010/007941 WO2011076432A1 (en) | 2009-12-23 | 2010-12-23 | Chimeric polypeptides and their use in bacterial decolonization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600365B true SMT201600365B (it) | 2016-11-10 |
Family
ID=42153758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600365T SMT201600365B (it) | 2009-12-23 | 2016-10-12 | Polipeptidi chimerici e loro uso nella decolonizzazione batterica |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9057059B2 (it) |
| EP (2) | EP2338916A1 (it) |
| CY (1) | CY1118331T1 (it) |
| DK (1) | DK2516471T4 (it) |
| ES (1) | ES2597579T5 (it) |
| HR (1) | HRP20161320T4 (it) |
| HU (1) | HUE031164T2 (it) |
| LT (1) | LT2516471T (it) |
| PL (1) | PL2516471T5 (it) |
| PT (1) | PT2516471T (it) |
| RS (1) | RS55230B1 (it) |
| SI (1) | SI2516471T2 (it) |
| SM (1) | SMT201600365B (it) |
| WO (1) | WO2011076432A1 (it) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
| WO2013170022A1 (en) * | 2012-05-09 | 2013-11-14 | Contrafect Corporation | Biofilm prevention, disruption and treatment with bacteriophage lysin |
| WO2014078373A1 (en) * | 2012-11-13 | 2014-05-22 | Iogenetics, Llc | Antimicrobial compositions |
| CN103122347B (zh) * | 2013-02-01 | 2015-04-22 | 中国科学院武汉病毒研究所 | 一种杀灭葡萄球菌的裂解酶及其应用 |
| DK3019185T3 (da) * | 2013-07-11 | 2021-02-15 | Micreos Human Health Bv | Kombinationsbehandling for atopisk dermatitis |
| EP2904912A1 (en) | 2014-02-07 | 2015-08-12 | Hyglos Invest GmbH | Novel high pressure method with endolysin for processing of foods |
| CA2979873A1 (en) | 2015-03-12 | 2016-09-15 | Micreos Human Health B.V. | Combination of bactericidal agent with a lysosomotropic alkalinising agent for the treatment of a bacterial infection |
| CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
| KR20230164221A (ko) | 2016-11-18 | 2023-12-01 | 뤼산도 아게 | 스태필로코커스 아우레우스에 대한 신규한 항미생물제 |
| US10256592B1 (en) * | 2017-04-27 | 2019-04-09 | Lockheed Martin Corporation | Device, system and method with cascaded burst mode laser amplified pumping oscillator signal |
| EP3873917A4 (en) * | 2018-11-02 | 2022-08-17 | The Rockefeller University | COMPOSITIONS AND METHODS COMPRISING LYSOCINES AS BIOTECHNICAL ANTIMICROBIAL FOR USE IN TARGETING GRAM-NEGATIVE BACTERIA |
| BR112021022283A2 (pt) * | 2019-05-08 | 2021-12-28 | Phagomed Biopharma Gmbh | Novas endolisinas de gardnerella e usos das mesmas |
| GB201906653D0 (en) * | 2019-05-10 | 2019-06-26 | Cc Biotech Ltd | Polypeptides for treatment of bacterial infections |
| EP3771463A1 (en) | 2019-07-29 | 2021-02-03 | Ludwig-Maximilians-Universität München | Stabilizing therapeutic proteins with piperazin- or morpholine-containing zwitterionic buffering substances |
| WO2021185948A1 (en) | 2020-03-19 | 2021-09-23 | Micreos Human Health B.V. | A stabilized protein of interest |
| WO2024241070A1 (en) | 2023-05-22 | 2024-11-28 | L'oreal | Cosmetic composition comprising an endolysin and a polyvinyl alcohol |
| CN121358455A (zh) * | 2023-06-02 | 2026-01-16 | 莱雅公司 | 包含衍生自金黄色葡萄球菌噬菌体的内溶素和芳族醇的化妆品组合物 |
| FR3149207A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un composé de formule (I) |
| FR3149203A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane |
| FR3149202A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile. |
| FR3149209A1 (fr) * | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique |
| FR3149208A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane |
| FR3149206A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique aqueuse comprenant une endolysine et du tréhalose |
| FR3152395A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone |
| FR3149205A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un agent de charge organique |
| FR3149204A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate |
| FR3152393A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale |
| FR3152396A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane |
| FR3152394A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe |
| WO2025093666A1 (en) | 2023-11-01 | 2025-05-08 | University Of Copenhagen | Treatment of lymphoma |
| PL449073A1 (pl) * | 2024-06-29 | 2026-01-05 | Instytut Medycyny Doświadczalnej I Klinicznej Im. M. Mossakowskiego Polskiej Akademii Nauk | Rekombinowane białko o właściwościach przeciwbakteryjnych zawierające aktywną domenę katalityczną CHAP, kompozycje je zawierające, zastosowania oraz sposoby je wykorzystujące |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2255561B (en) | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US7572602B1 (en) * | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| ES2536852T3 (es) | 2006-05-05 | 2015-05-28 | Gangagen, Inc. | Actividades antimicrobianas derivadas de fagos |
| IE20060488A1 (en) | 2006-06-29 | 2008-01-09 | Teagasc Agric Food Dev Authori | Recombinant staphylococcal phage lysin as an antibacterial agent |
| US20090130082A1 (en) * | 2007-10-18 | 2009-05-21 | Kaplan Jeffrey B | Compositions and methods for the treatment and prevention of infections caused by staphylococcus aureus bacteria |
| WO2010011960A2 (en) † | 2008-07-24 | 2010-01-28 | The United State Of America, As Represented By The Secretary Of Agriculture | Triple acting antimicrobials that are refractory to resistance development |
| US8383102B2 (en) * | 2009-05-21 | 2013-02-26 | The United States Of America As Represented By The Secretary Of Agriculture | Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens |
-
2009
- 2009-12-23 EP EP09015998A patent/EP2338916A1/en not_active Ceased
-
2010
- 2010-12-23 DK DK10798274.6T patent/DK2516471T4/da active
- 2010-12-23 ES ES10798274T patent/ES2597579T5/es active Active
- 2010-12-23 HU HUE10798274A patent/HUE031164T2/en unknown
- 2010-12-23 LT LTEP10798274.6T patent/LT2516471T/lt unknown
- 2010-12-23 US US13/519,095 patent/US9057059B2/en active Active
- 2010-12-23 WO PCT/EP2010/007941 patent/WO2011076432A1/en not_active Ceased
- 2010-12-23 PL PL10798274T patent/PL2516471T5/pl unknown
- 2010-12-23 RS RS20160853A patent/RS55230B1/sr unknown
- 2010-12-23 HR HRP20161320TT patent/HRP20161320T4/hr unknown
- 2010-12-23 PT PT107982746T patent/PT2516471T/pt unknown
- 2010-12-23 EP EP10798274.6A patent/EP2516471B9/en active Active
- 2010-12-23 SI SI201031300T patent/SI2516471T2/sl unknown
-
2015
- 2015-05-11 US US14/709,118 patent/US10022430B2/en active Active
-
2016
- 2016-10-12 CY CY20161101015T patent/CY1118331T1/el unknown
- 2016-10-12 SM SM201600365T patent/SMT201600365B/it unknown
-
2018
- 2018-06-15 US US16/009,321 patent/US10342857B2/en active Active
-
2019
- 2019-06-27 US US16/454,196 patent/US11116824B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SI2516471T1 (sl) | 2016-11-30 |
| ES2597579T5 (es) | 2021-03-18 |
| US20190381151A1 (en) | 2019-12-19 |
| DK2516471T3 (en) | 2016-10-17 |
| EP2516471A1 (en) | 2012-10-31 |
| US9057059B2 (en) | 2015-06-16 |
| EP2516471B2 (en) | 2020-05-27 |
| US10022430B2 (en) | 2018-07-17 |
| US10342857B2 (en) | 2019-07-09 |
| RS55230B1 (sr) | 2017-02-28 |
| CY1118331T1 (el) | 2017-06-28 |
| US20130004476A1 (en) | 2013-01-03 |
| HUE031164T2 (en) | 2017-06-28 |
| SI2516471T2 (sl) | 2020-07-31 |
| EP2516471B9 (en) | 2020-10-28 |
| PT2516471T (pt) | 2016-10-20 |
| US20150238577A1 (en) | 2015-08-27 |
| US11116824B2 (en) | 2021-09-14 |
| HRP20161320T1 (hr) | 2016-12-16 |
| ES2597579T3 (es) | 2017-01-19 |
| PL2516471T5 (pl) | 2020-10-19 |
| LT2516471T (lt) | 2016-10-25 |
| EP2338916A1 (en) | 2011-06-29 |
| EP2516471B1 (en) | 2016-07-13 |
| PL2516471T3 (pl) | 2017-01-31 |
| US20180333471A1 (en) | 2018-11-22 |
| WO2011076432A1 (en) | 2011-06-30 |
| DK2516471T4 (da) | 2020-08-03 |
| HRP20161320T4 (hr) | 2020-07-10 |
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