SK772001A3 - Heterocyclic compounds as inhibitors of rotamase enzymes - Google Patents

Heterocyclic compounds as inhibitors of rotamase enzymes Download PDF

Info

Publication number: SK772001A3
Authority: SK; Slovakia
Prior art keywords: compound; formula; alkyl; group; benzoxazol
Prior art date: 1998-07-21

Application number

SK77-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Mark Ian Kemp

Michael John Palmer

Mark Allen Sanner

Martin James Wythes

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-21

Filing date

1999-06-28

Publication date

2001-12-03

1999-06-28 Application filed by Pfizer filed Critical Pfizer

2001-12-03 Publication of SK772001A3 publication Critical patent/SK772001A3/sk

Links

101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 title abstract description 10
239000003112 inhibitor Substances 0.000 title abstract description 6
102000004190 Enzymes Human genes 0.000 title abstract description 5
108090000790 Enzymes Proteins 0.000 title abstract description 5
101710103508 FK506-binding protein Proteins 0.000 title abstract description 4
101710104425 FK506-binding protein 2 Proteins 0.000 title abstract description 4
101710104423 FK506-binding protein 3 Proteins 0.000 title abstract description 4
101710104333 FK506-binding protein 4 Proteins 0.000 title abstract description 4
101710104342 FK506-binding protein 5 Proteins 0.000 title abstract description 4
101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 title abstract description 4
101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710114693 Outer membrane protein MIP Proteins 0.000 title abstract description 4
101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 title abstract description 4
101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 title abstract description 4
101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 title abstract description 4
101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 title abstract description 4
101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 title abstract description 4
101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 title abstract description 4
101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 title abstract description 4
101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 title abstract description 4
101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 title abstract description 4
101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 title abstract description 4
101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 title abstract description 4
101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 title abstract description 4
101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 title abstract description 4
101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 title abstract description 4
101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 title abstract description 4
101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 title abstract description 4
101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 title abstract description 4
101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 title abstract description 4
101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title abstract description 4
150000002391 heterocyclic compounds Chemical class 0.000 title description 2
102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 237
125000003118 aryl group Chemical group 0.000 claims abstract description 48
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125000001424 substituent group Chemical group 0.000 claims abstract description 31
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208000025966 Neurological disease Diseases 0.000 claims abstract description 21
229910052717 sulfur Inorganic materials 0.000 claims abstract description 21
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 19
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125000000217 alkyl group Chemical group 0.000 claims abstract description 13
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238000002360 preparation method Methods 0.000 claims description 101
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
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125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 14
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125000002393 azetidinyl group Chemical group 0.000 claims description 6
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206010028417 myasthenia gravis Diseases 0.000 claims description 6
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 6
125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims description 6
208000022670 retrobulbar neuritis Diseases 0.000 claims description 6
206010044652 trigeminal neuralgia Diseases 0.000 claims description 6
125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 5
206010041591 Spinal osteoarthritis Diseases 0.000 claims description 5
208000036319 cervical spondylosis Diseases 0.000 claims description 5
208000016354 hearing loss disease Diseases 0.000 claims description 5
HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims description 5
125000005936 piperidyl group Chemical group 0.000 claims description 5
125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 claims description 5
125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 claims description 5
208000005801 spondylosis Diseases 0.000 claims description 5
WSKQFWTWMRABMA-ICSRJNTNSA-N (2s)-1-(1,3-benzoxazol-2-yl)-n-[(3s)-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]piperidine-2-carboxamide Chemical compound C([C@@H](C1)NC(=O)[C@H]2N(CCCC2)C=2OC3=CC=CC=C3N=2)CN1CC1=CC=CC=N1 WSKQFWTWMRABMA-ICSRJNTNSA-N 0.000 claims description 4
JRLIAYYZWGPBRQ-FPOVZHCZSA-N (2s)-1-(1,3-benzoxazol-2-yl)-n-[(3s)-1-benzylpyrrolidin-3-yl]piperidine-2-carboxamide Chemical compound C([C@@H](C1)NC(=O)[C@H]2N(CCCC2)C=2OC3=CC=CC=C3N=2)CN1CC1=CC=CC=C1 JRLIAYYZWGPBRQ-FPOVZHCZSA-N 0.000 claims description 4
DBLZXAKIKCKPNV-FPOVZHCZSA-N (2s)-n-[(3s)-1-benzylpyrrolidin-3-yl]-1-(6-bromo-1,3-benzoxazol-2-yl)piperidine-2-carboxamide Chemical compound C([C@@H](C1)NC(=O)[C@@H]2CCCCN2C2=NC3=CC=C(C=C3O2)Br)CN1CC1=CC=CC=C1 DBLZXAKIKCKPNV-FPOVZHCZSA-N 0.000 claims description 4
MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 claims description 4
208000003618 Intervertebral Disc Displacement Diseases 0.000 claims description 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
208000024777 Prion disease Diseases 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 4
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 4
229960000860 dapsone Drugs 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 4
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
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238000006467 substitution reaction Methods 0.000 claims description 4
DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims description 3
125000002619 bicyclic group Chemical group 0.000 claims description 3
125000001246 bromo group Chemical group Br* 0.000 claims description 3
125000001309 chloro group Chemical group Cl* 0.000 claims description 3
125000000000 cycloalkoxy group Chemical group 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
125000001153 fluoro group Chemical group F* 0.000 claims description 3
125000005842 heteroatom Chemical group 0.000 claims description 3
125000002883 imidazolyl group Chemical group 0.000 claims description 3
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 3
125000002950 monocyclic group Chemical group 0.000 claims description 3
125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
125000004076 pyridyl group Chemical group 0.000 claims description 3
125000005493 quinolyl group Chemical group 0.000 claims description 3
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 3
125000001425 triazolyl group Chemical group 0.000 claims description 3
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MOQWZJNJXNUCQS-CVDCTZTESA-N (2s)-1-(1,3-benzoxazol-2-yl)-n-[(3s)-1-(quinoline-2-carbonyl)pyrrolidin-3-yl]piperidine-2-carboxamide Chemical compound C1=CC=C2OC(N3CCCC[C@H]3C(N[C@@H]3CN(CC3)C(=O)C=3N=C4C=CC=CC4=CC=3)=O)=NC2=C1 MOQWZJNJXNUCQS-CVDCTZTESA-N 0.000 claims description 2
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MTAODLNXWYIKSO-UHFFFAOYSA-N 2-fluoropyridine Chemical compound FC1=CC=CC=N1 MTAODLNXWYIKSO-UHFFFAOYSA-N 0.000 claims 1
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Classifications

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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Organic Chemistry (AREA)
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Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
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Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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SK77-2001A 1998-07-21 1999-06-28 Heterocyclic compounds as inhibitors of rotamase enzymes SK772001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9815880.1A GB9815880D0 (en)	1998-07-21	1998-07-21	Heterocycles
PCT/IB1999/001211 WO2000005232A1 (en)	1998-07-21	1999-06-28	Heterocyclic compounds as inhibitors of rotamase enzymes

Publications (1)

Publication Number	Publication Date
SK772001A3 true SK772001A3 (en)	2001-12-03

Family

ID=10835920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK77-2001A SK772001A3 (en)	1998-07-21	1999-06-28	Heterocyclic compounds as inhibitors of rotamase enzymes

Country Status (45)

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US (2)	US6372736B1 (pt)
EP (1)	EP1100797B1 (pt)
JP (2)	JP3795329B2 (pt)
KR (2)	KR100450008B1 (pt)
CN (3)	CN1511837A (pt)
AP (1)	AP2001002046A0 (pt)
AR (1)	AR019427A1 (pt)
AT (1)	ATE233261T1 (pt)
AU (1)	AU765925B2 (pt)
BG (1)	BG105254A (pt)
BR (1)	BR9912330A (pt)
CA (1)	CA2338214C (pt)
CO (1)	CO5080782A1 (pt)
CR (1)	CR6073A (pt)
DE (1)	DE69905582T2 (pt)
DK (1)	DK1100797T3 (pt)
DZ (1)	DZ2851A1 (pt)
EA (1)	EA003513B1 (pt)
EE (1)	EE200100044A (pt)
ES (1)	ES2191484T3 (pt)
GB (1)	GB9815880D0 (pt)
GE (1)	GEP20033028B (pt)
GT (1)	GT199900115A (pt)
HK (1)	HK1039779A1 (pt)
HN (1)	HN1999000106A (pt)
HR (1)	HRP20010052A2 (pt)
HU (1)	HUP0103413A3 (pt)
ID (1)	ID26991A (pt)
IL (1)	IL140244A0 (pt)
IS (1)	IS5790A (pt)
MA (1)	MA24936A1 (pt)
MY (1)	MY118222A (pt)
NO (1)	NO20010322L (pt)
NZ (2)	NZ508838A (pt)
OA (1)	OA11585A (pt)
PA (1)	PA8478501A1 (pt)
PE (1)	PE20001037A1 (pt)
PL (1)	PL345734A1 (pt)
SI (1)	SI1100797T1 (pt)
SK (1)	SK772001A3 (pt)
SV (1)	SV1999000102A (pt)
TN (1)	TNSN99147A1 (pt)
TR (1)	TR200100135T2 (pt)
TW (1)	TWI229672B (pt)
WO (1)	WO2000005232A1 (pt)

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GB0905664D0 (en) *	2009-04-02	2009-05-13	Summit Corp Plc	Compounds for treatment of duchenne muscular dystrophy
CA2905340C (en)	2013-03-12	2022-05-31	Celtaxsys, Inc.	Low dose oral formulations of acebilustat
BR112015022864A8 (pt)	2013-03-14	2019-11-26	Celtaxsys Inc	composto, composição farmacêutica e uso dos mesmos
RU2696559C2 (ru)	2013-03-14	2019-08-05	Селтакссис, Инк.	Ингибиторы лейкотриен а4-гидролазы
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1998
- 1998-07-21 GB GBGB9815880.1A patent/GB9815880D0/en not_active Ceased
1999
- 1999-06-28 ID IDW20010155A patent/ID26991A/id unknown
- 1999-06-28 JP JP2000561188A patent/JP3795329B2/ja not_active Expired - Fee Related
- 1999-06-28 HU HU0103413A patent/HUP0103413A3/hu unknown
- 1999-06-28 ES ES99963123T patent/ES2191484T3/es not_active Expired - Lifetime
- 1999-06-28 NZ NZ508838A patent/NZ508838A/xx unknown
- 1999-06-28 KR KR10-2001-7000927A patent/KR100450008B1/ko not_active Expired - Fee Related
- 1999-06-28 CN CNA2003101239079A patent/CN1511837A/zh active Pending
- 1999-06-28 NZ NZ522270A patent/NZ522270A/en unknown
- 1999-06-28 DK DK99963123T patent/DK1100797T3/da active
- 1999-06-28 EE EEP200100044A patent/EE200100044A/xx unknown
- 1999-06-28 AP APAP/P/2001/002046A patent/AP2001002046A0/en unknown
- 1999-06-28 EP EP99963123A patent/EP1100797B1/en not_active Expired - Lifetime
- 1999-06-28 TR TR2001/00135T patent/TR200100135T2/xx unknown
- 1999-06-28 SK SK77-2001A patent/SK772001A3/sk unknown
- 1999-06-28 EA EA200100052A patent/EA003513B1/ru not_active IP Right Cessation
- 1999-06-28 CN CNA2004100399747A patent/CN1611499A/zh active Pending
- 1999-06-28 KR KR10-2004-7007852A patent/KR100468185B1/ko not_active Expired - Fee Related
- 1999-06-28 BR BR9912330-4A patent/BR9912330A/pt not_active Application Discontinuation
- 1999-06-28 HR HR20010052A patent/HRP20010052A2/hr not_active Application Discontinuation
- 1999-06-28 PL PL99345734A patent/PL345734A1/xx not_active Application Discontinuation
- 1999-06-28 HK HK02100933.8A patent/HK1039779A1/zh unknown
- 1999-06-28 AT AT99963123T patent/ATE233261T1/de not_active IP Right Cessation
- 1999-06-28 CA CA002338214A patent/CA2338214C/en not_active Expired - Fee Related
- 1999-06-28 AU AU42858/99A patent/AU765925B2/en not_active Ceased
- 1999-06-28 WO PCT/IB1999/001211 patent/WO2000005232A1/en not_active Ceased
- 1999-06-28 SI SI9930246T patent/SI1100797T1/xx unknown
- 1999-06-28 IL IL14024499A patent/IL140244A0/xx unknown
- 1999-06-28 DE DE69905582T patent/DE69905582T2/de not_active Expired - Fee Related
- 1999-06-28 OA OA1200100023A patent/OA11585A/en unknown
- 1999-06-28 CN CNB998089974A patent/CN1174978C/zh not_active Expired - Fee Related
- 1999-06-28 GE GEAP19995715A patent/GEP20033028B/en unknown
- 1999-07-07 HN HN1999000106A patent/HN1999000106A/es unknown
- 1999-07-13 TW TW088111868A patent/TWI229672B/zh not_active IP Right Cessation
- 1999-07-19 CO CO99045677A patent/CO5080782A1/es unknown
- 1999-07-19 AR ARP990103544A patent/AR019427A1/es unknown
- 1999-07-20 DZ DZ990151A patent/DZ2851A1/xx active
- 1999-07-20 PE PE1999000727A patent/PE20001037A1/es not_active Application Discontinuation
- 1999-07-20 CR CR6073A patent/CR6073A/es not_active Application Discontinuation
- 1999-07-20 TN TNTNSN99147A patent/TNSN99147A1/fr unknown
- 1999-07-20 PA PA19998478501A patent/PA8478501A1/es unknown
- 1999-07-20 MY MYPI99003048A patent/MY118222A/en unknown
- 1999-07-20 SV SV1999000102A patent/SV1999000102A/es not_active Application Discontinuation
- 1999-07-20 MA MA25691A patent/MA24936A1/fr unknown
- 1999-07-20 GT GT199900115A patent/GT199900115A/es unknown
- 1999-07-21 US US09/358,107 patent/US6372736B1/en not_active Expired - Fee Related
2000
- 2000-12-22 IS IS5790A patent/IS5790A/is unknown
2001
- 2001-01-19 NO NO20010322A patent/NO20010322L/no not_active Application Discontinuation
- 2001-02-14 BG BG105254A patent/BG105254A/xx unknown
2002
- 2002-01-23 US US10/056,901 patent/US6562964B1/en not_active Expired - Fee Related
2003
- 2003-04-09 JP JP2003105099A patent/JP2004002374A/ja active Pending

Also Published As

Publication number	Publication date
JP2002521382A (ja)	2002-07-16
HUP0103413A3 (en)	2002-10-28
IS5790A (is)	2000-12-22
GB9815880D0 (en)	1998-09-16
AP2001002046A0 (en)	2001-03-31
NZ522270A (en)	2004-03-26
DE69905582T2 (de)	2003-09-04
EA200100052A1 (ru)	2001-06-25
EP1100797B1 (en)	2003-02-26
IL140244A0 (en)	2002-02-10
NZ508838A (en)	2002-12-20
GT199900115A (es)	2001-01-10
CR6073A (es)	2004-04-29
SI1100797T1 (en)	2003-06-30
PL345734A1 (en)	2002-01-02
CO5080782A1 (es)	2001-09-25
AU4285899A (en)	2000-02-14
WO2000005232A1 (en)	2000-02-03
CN1310718A (zh)	2001-08-29
SV1999000102A (es)	2000-07-06
CN1611499A (zh)	2005-05-04
DE69905582D1 (de)	2003-04-03
TR200100135T2 (tr)	2001-06-21
HN1999000106A (es)	1999-11-11
EP1100797A1 (en)	2001-05-23
EA003513B1 (ru)	2003-06-26
JP2004002374A (ja)	2004-01-08
PE20001037A1 (es)	2000-10-11
CA2338214A1 (en)	2000-02-03
HUP0103413A2 (hu)	2002-05-29
AU765925B2 (en)	2003-10-02
US6372736B1 (en)	2002-04-16
EE200100044A (et)	2002-06-17
JP3795329B2 (ja)	2006-07-12
BG105254A (en)	2001-10-31
ES2191484T3 (es)	2003-09-01
CA2338214C (en)	2006-08-01
TNSN99147A1 (fr)	2005-11-10
CN1511837A (zh)	2004-07-14
CN1174978C (zh)	2004-11-10
OA11585A (en)	2004-07-26
HRP20010052A2 (en)	2001-12-31
MA24936A1 (fr)	2000-04-01
DZ2851A1 (fr)	2004-02-04
PA8478501A1 (es)	2000-05-24
AR019427A1 (es)	2002-02-20
KR20040062640A (ko)	2004-07-07
DK1100797T3 (da)	2003-04-22
KR100450008B1 (ko)	2004-09-24
KR100468185B1 (ko)	2005-01-26
HK1039779A1 (zh)	2002-05-10
TWI229672B (en)	2005-03-21
NO20010322D0 (no)	2001-01-19
US6562964B1 (en)	2003-05-13
BR9912330A (pt)	2001-04-17
MY118222A (en)	2004-09-30
ID26991A (id)	2001-02-22
KR20010071013A (ko)	2001-07-28
NO20010322L (no)	2001-03-15
ATE233261T1 (de)	2003-03-15
GEP20033028B (en)	2003-07-25

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AU2006255944B2 (en)	2010-03-04	Heterocyclic compound
US6610707B1 (en)	2003-08-26	Heterocyclic compounds as inhibitors of rotomase enzymes
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WO2002006234A1 (en)	2002-01-24	Sulfone derivatives, process for their production and use thereof
JP2001302633A (ja)	2001-10-31	環状アミン化合物、その製造法および用途
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SG175718A1 (en)	2011-12-29	Derivatives of n-acyl-n'-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
JP2010523530A (ja)	2010-07-15	タンパク質キナーゼ阻害剤として有益な［２，６］ナフチリジン
EP1098894B1 (en)	2002-10-02	Fkbp inhibitors
CZ2001236A3 (cs)	2001-06-13	Heterocyklické sloučeniny jako inhibitory rotamasy