SK412001A3 - Diacylhydrazine derivatives as integrin inhibitors - Google Patents

Diacylhydrazine derivatives as integrin inhibitors Download PDF

Info

Publication number: SK412001A3
Authority: SK; Slovakia
Prior art keywords: formula; compound; group; acid; groups
Prior art date: 1998-07-15

Application number

SK41-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Gunter Holzemann

Simon Goodman

Horst Kessler

Christoph Gibson

Jorg Simon Schmitt

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-15

Filing date

1999-07-06

Publication date

2001-08-06

1999-07-06 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2001-08-06 Publication of SK412001A3 publication Critical patent/SK412001A3/sk

Links

108010044426 integrins Proteins 0.000 title claims abstract description 12
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239000003112 inhibitor Substances 0.000 title claims abstract description 7
125000005077 diacylhydrazine group Chemical group 0.000 title claims description 9
150000001875 compounds Chemical class 0.000 claims abstract description 80
150000003839 salts Chemical class 0.000 claims abstract description 24
238000011282 treatment Methods 0.000 claims abstract description 12
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
206010028980 Neoplasm Diseases 0.000 claims abstract description 8
206010003210 Arteriosclerosis Diseases 0.000 claims abstract description 6
208000007536 Thrombosis Diseases 0.000 claims abstract description 6
208000011775 arteriosclerosis disease Diseases 0.000 claims abstract description 6
230000033115 angiogenesis Effects 0.000 claims abstract description 5
239000012453 solvate Substances 0.000 claims abstract description 5
208000037273 Pathologic Processes Diseases 0.000 claims abstract description 4
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230000009054 pathological process Effects 0.000 claims abstract description 4
-1 COOA Chemical group 0.000 claims description 80
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Classifications

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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

SK41-2001A 1998-07-15 1999-07-06 Diacylhydrazine derivatives as integrin inhibitors SK412001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19831710A DE19831710A1 (de)	1998-07-15	1998-07-15	Diacylhydrazinderivate
PCT/EP1999/004673 WO2000003973A1 (fr)	1998-07-15	1999-07-06	Derives de diacylhydrazine utilises comme inhibiteurs de l'integrine

Publications (1)

Publication Number	Publication Date
SK412001A3 true SK412001A3 (en)	2001-08-06

Family

ID=7874107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK41-2001A SK412001A3 (en)	1998-07-15	1999-07-06	Diacylhydrazine derivatives as integrin inhibitors

Country Status (22)

Country	Link
US (1)	US6326403B1 (fr)
EP (1)	EP1097127B1 (fr)
JP (1)	JP2002520382A (fr)
KR (1)	KR20010079520A (fr)
CN (1)	CN1309633A (fr)
AR (1)	AR019777A1 (fr)
AT (1)	ATE234276T1 (fr)
AU (1)	AU753333B2 (fr)
BR (1)	BR9912072A (fr)
CA (1)	CA2337305A1 (fr)
DE (2)	DE19831710A1 (fr)
DK (1)	DK1097127T3 (fr)
ES (1)	ES2194486T3 (fr)
HU (1)	HUP0102602A3 (fr)
ID (1)	ID27168A (fr)
NO (1)	NO20010203L (fr)
PL (1)	PL345398A1 (fr)
PT (1)	PT1097127E (fr)
SK (1)	SK412001A3 (fr)
TW (1)	TW448145B (fr)
WO (1)	WO2000003973A1 (fr)
ZA (1)	ZA200101267B (fr)

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US20020002152A1 (en)	2000-04-14	2002-01-03	Craig Richard A.	Hydrazide and alkoxyamide angiogenesis inhibitors
AR028537A1 (es) *	2000-04-14	2003-05-14	Abbott Lab	Hidrazidas y alcoxiamidas inhibidoras de la angiogénesis
DE10040105A1 (de)	2000-08-17	2002-02-28	Merck Patent Gmbh	Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
DE10040103A1 (de)	2000-08-17	2002-02-28	Merck Patent Gmbh	Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II
DZ3415A1 (fr) *	2000-08-31	2002-03-07	Chiron Corp	Guanidinobenzamides comme mc4-r agonistes.
DK1385823T3 (da)	2001-04-09	2007-03-26	Novartis Vaccines & Diagnostic	Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister
HUP0402250A3 (en)	2001-04-13	2007-06-28	Biogen Idec Inc	Antibodies to vla-1
WO2003099818A1 (fr)	2002-05-23	2003-12-04	Chiron Corporation	Composes de quinazolinone substitues
US7226577B2 (en)	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
US7304161B2 (en) *	2003-02-10	2007-12-04	Intrexon Corporation	Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en)	2003-02-28	2008-11-25	Intrexon Corporation	Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
AU2004249120B2 (en)	2003-05-23	2008-07-24	Glaxosmithkline	Guanidino-substituted quinazolinone compounds as MC4-R agonists
DE10325049A1 (de) *	2003-06-02	2004-12-23	Merck Patent Gmbh	Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III
MXPA06005736A (es)	2003-11-19	2006-12-14	Chiron Corp	Compuestos de quinazolinona con bioacumulacion reducida.
JP4943324B2 (ja)	2004-06-04	2012-05-30	ザスクリプスリサーチインスティチュート	新生血管病の治療のための組成物および方法
JP4745175B2 (ja) *	2005-12-28	2011-08-10	本田技研工業株式会社	自動二輪車
JP5496658B2 (ja)	2006-05-25	2014-05-21	バイオジェン・アイデック・エムエイ・インコーポレイテッド	脳卒中を処置する方法
WO2008153801A1 (fr) *	2007-05-29	2008-12-18	Intrexon Corporation	Ligands diacylhydrazine chiraux destinés à moduler l'expression de gènes exogènes par le biais d'un complexe récepteur de l'ecdysone
CA2864539C (fr)	2012-02-16	2022-06-07	Santarus, Inc.	Formulations d'anticorps
ES2683329T3 (es)	2013-03-15	2018-09-26	Intrexon Corporation	Diacilhidrazinas que contienen boro
BR112016027778A2 (pt)	2014-05-30	2017-08-15	Pfizer	Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica
CN104027805B (zh) *	2014-06-18	2017-02-15	北京大学	抑制整合素α5的物质在制备预防内皮细胞激活和/或动脉粥样硬化的产品中的新用途
CA2961738A1 (fr)	2014-09-17	2016-03-24	Intrexon Corporation	Composes diacylhydrazine contenant du bore
SG11202002967SA (en)	2017-11-01	2020-05-28	Arrowhead Pharmaceuticals Inc	Integrin ligands and uses thereof
BR112023020626A2 (pt)	2021-04-08	2023-12-19	Arrowhead Pharmaceuticals Inc	Agentes de rnai para inibir a expressão do receptor para produtos finais de glicação avançada, composições dos mesmos e métodos de uso
WO2023275715A1 (fr)	2021-06-30	2023-01-05	Pfizer Inc.	Métabolites de modulateurs sélectifs du récepteur des androgènes

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EP0570507A4 (en) *	1991-02-05	1994-09-21	Smithkline Beecham Corp	Anti-aggregatory peptides containing an aromatic ester or amide
US5530028A (en) *	1992-11-23	1996-06-25	Rohm And Haas Company	Insecticidal N'-substituted-N,N'-diacylhydrazines
EP0677043A1 (fr) *	1992-12-29	1995-10-18	Smithkline Beecham Corporation	Composes inhibant l'aggregation des plaquettes
DE69528829T2 (de)	1994-05-27	2003-08-07	Merck & Co., Inc.	Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption
US5482962A (en) *	1994-07-22	1996-01-09	Rohm And Haas Company	Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines
CA2242877A1 (fr) *	1996-01-16	1997-07-24	Merck & Co., Inc.	Antagonistes du recepteur integrine

1998
- 1998-07-15 DE DE19831710A patent/DE19831710A1/de not_active Withdrawn
1999
- 1999-07-06 BR BR9912072-0A patent/BR9912072A/pt not_active IP Right Cessation
- 1999-07-06 JP JP2000560082A patent/JP2002520382A/ja active Pending
- 1999-07-06 SK SK41-2001A patent/SK412001A3/sk unknown
- 1999-07-06 PT PT99934576T patent/PT1097127E/pt unknown
- 1999-07-06 CN CN99808610A patent/CN1309633A/zh active Pending
- 1999-07-06 EP EP99934576A patent/EP1097127B1/fr not_active Expired - Lifetime
- 1999-07-06 DK DK99934576T patent/DK1097127T3/da active
- 1999-07-06 WO PCT/EP1999/004673 patent/WO2000003973A1/fr not_active Ceased
- 1999-07-06 US US09/743,605 patent/US6326403B1/en not_active Expired - Fee Related
- 1999-07-06 AU AU50313/99A patent/AU753333B2/en not_active Ceased
- 1999-07-06 KR KR1020017000359A patent/KR20010079520A/ko not_active Withdrawn
- 1999-07-06 ID IDW20010206A patent/ID27168A/id unknown
- 1999-07-06 HU HU0102602A patent/HUP0102602A3/hu unknown
- 1999-07-06 ES ES99934576T patent/ES2194486T3/es not_active Expired - Lifetime
- 1999-07-06 PL PL99345398A patent/PL345398A1/xx unknown
- 1999-07-06 DE DE59904547T patent/DE59904547D1/de not_active Expired - Fee Related
- 1999-07-06 AT AT99934576T patent/ATE234276T1/de not_active IP Right Cessation
- 1999-07-06 CA CA002337305A patent/CA2337305A1/fr not_active Abandoned
- 1999-07-13 TW TW088111860A patent/TW448145B/zh active
- 1999-07-14 AR ARP990103436A patent/AR019777A1/es not_active Application Discontinuation
2001
- 2001-01-12 NO NO20010203A patent/NO20010203L/no not_active Application Discontinuation
- 2001-02-14 ZA ZA200101267A patent/ZA200101267B/en unknown

Also Published As

Publication number	Publication date
AU5031399A (en)	2000-02-07
HUP0102602A3 (en)	2002-02-28
DE19831710A1 (de)	2000-01-20
NO20010203D0 (no)	2001-01-12
BR9912072A (pt)	2001-09-25
HUP0102602A2 (hu)	2002-01-28
PT1097127E (pt)	2003-07-31
ES2194486T3 (es)	2003-11-16
AR019777A1 (es)	2002-03-13
JP2002520382A (ja)	2002-07-09
PL345398A1 (en)	2001-12-17
DE59904547D1 (de)	2003-04-17
WO2000003973A1 (fr)	2000-01-27
DK1097127T3 (da)	2003-06-10
CA2337305A1 (fr)	2000-01-27
EP1097127B1 (fr)	2003-03-12
AU753333B2 (en)	2002-10-17
EP1097127A1 (fr)	2001-05-09
US6326403B1 (en)	2001-12-04
NO20010203L (no)	2001-01-12
KR20010079520A (ko)	2001-08-22
ZA200101267B (en)	2002-10-04
CN1309633A (zh)	2001-08-22
ID27168A (id)	2001-03-08
ATE234276T1 (de)	2003-03-15
TW448145B (en)	2001-08-01

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