SK284813B6 - Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom - Google Patents

Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom Download PDF

Info

Publication number: SK284813B6
Authority: SK; Slovakia
Prior art keywords: itraconazole; coating; pellets; water; percent
Prior art date: 1997-03-26

Application number

SK544-99A

Other languages

English (en)

Slovak (sk)

Other versions

SK54499A3 (en

Inventor

Roger Petrus Gerebern Vandecruys

Cond� Valentin Florent Victor De

Paul Marie Victor Gilis

Jozef Peeters

Original Assignee

Janssen Pharmaceutica N. V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-26

Filing date

1998-03-18

Publication date

2005-12-01

1998-03-18 Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.

2000-01-18 Publication of SK54499A3 publication Critical patent/SK54499A3/sk

2005-12-01 Publication of SK284813B6 publication Critical patent/SK284813B6/sk

Links

239000008188 pellet Substances 0.000 title claims abstract description 67
229960004130 itraconazole Drugs 0.000 title claims abstract description 64
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 title claims abstract description 63
238000000034 method Methods 0.000 title claims abstract description 27
239000002552 dosage form Substances 0.000 title claims abstract description 25
238000002360 preparation method Methods 0.000 title abstract description 8
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 60
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
238000000576 coating method Methods 0.000 claims abstract description 42
239000011248 coating agent Substances 0.000 claims abstract description 30
229920003169 water-soluble polymer Polymers 0.000 claims abstract description 28
239000007921 spray Substances 0.000 claims abstract description 27
235000000346 sugar Nutrition 0.000 claims abstract description 16
229920001688 coating polymer Polymers 0.000 claims abstract description 14
238000001035 drying Methods 0.000 claims abstract description 14
238000005507 spraying Methods 0.000 claims abstract description 13
239000003960 organic solvent Substances 0.000 claims abstract description 7
239000003814 drug Substances 0.000 claims description 35
229940079593 drug Drugs 0.000 claims description 34
239000011162 core material Substances 0.000 claims description 33
239000011324 bead Substances 0.000 claims description 30
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 29
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 29
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 27
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 26
229920001223 polyethylene glycol Polymers 0.000 claims description 13
239000002202 Polyethylene glycol Substances 0.000 claims description 10
239000012530 fluid Substances 0.000 claims description 9
239000007903 gelatin capsule Substances 0.000 claims description 7
238000007789 sealing Methods 0.000 claims description 5
239000000565 sealant Substances 0.000 claims description 2
230000000843 anti-fungal effect Effects 0.000 abstract description 2
229940121375 antifungal agent Drugs 0.000 abstract 1
239000000243 solution Substances 0.000 description 26
239000000203 mixture Substances 0.000 description 20
239000002775 capsule Substances 0.000 description 17
238000004090 dissolution Methods 0.000 description 16
-1 itraconazole compound Chemical class 0.000 description 13
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
229920000642 polymer Polymers 0.000 description 12
239000000417 fungicide Substances 0.000 description 11
239000002904 solvent Substances 0.000 description 10
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
238000004519 manufacturing process Methods 0.000 description 9
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
239000011247 coating layer Substances 0.000 description 8
230000000855 fungicidal effect Effects 0.000 description 8
239000010410 layer Substances 0.000 description 8
239000000463 material Substances 0.000 description 8
239000000546 pharmaceutical excipient Substances 0.000 description 8
239000003086 colorant Substances 0.000 description 7
239000000314 lubricant Substances 0.000 description 7
HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 description 6
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 6
239000002253 acid Substances 0.000 description 6
239000000796 flavoring agent Substances 0.000 description 6
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
239000002245 particle Substances 0.000 description 6
239000004014 plasticizer Substances 0.000 description 6
229950005137 saperconazole Drugs 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
206010017533 Fungal infection Diseases 0.000 description 5
229920000168 Microcrystalline cellulose Polymers 0.000 description 5
208000031888 Mycoses Diseases 0.000 description 5
239000003085 diluting agent Substances 0.000 description 5
239000007884 disintegrant Substances 0.000 description 5
238000011049 filling Methods 0.000 description 5
239000007888 film coating Substances 0.000 description 5
238000009501 film coating Methods 0.000 description 5
229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 description 5
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 5
235000019813 microcrystalline cellulose Nutrition 0.000 description 5
239000008108 microcrystalline cellulose Substances 0.000 description 5
229940016286 microcrystalline cellulose Drugs 0.000 description 5
238000003756 stirring Methods 0.000 description 5
239000000126 substance Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
229920002472 Starch Polymers 0.000 description 4
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
150000007513 acids Chemical class 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
235000013355 food flavoring agent Nutrition 0.000 description 4
239000012729 immediate-release (IR) formulation Substances 0.000 description 4
239000003921 oil Substances 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
238000012545 processing Methods 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
229910001220 stainless steel Inorganic materials 0.000 description 4
239000010935 stainless steel Substances 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
238000006467 substitution reaction Methods 0.000 description 4
239000000341 volatile oil Substances 0.000 description 4
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229920001213 Polysorbate 20 Polymers 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
238000005054 agglomeration Methods 0.000 description 3
230000002776 aggregation Effects 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
239000001768 carboxy methyl cellulose Substances 0.000 description 3
235000010980 cellulose Nutrition 0.000 description 3
229920002678 cellulose Polymers 0.000 description 3
239000001913 cellulose Substances 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
239000012738 dissolution medium Substances 0.000 description 3
238000009826 distribution Methods 0.000 description 3
229940088679 drug related substance Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000000945 filler Substances 0.000 description 3
230000002496 gastric effect Effects 0.000 description 3
239000008172 hydrogenated vegetable oil Substances 0.000 description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
239000001863 hydroxypropyl cellulose Substances 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
239000006186 oral dosage form Substances 0.000 description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
239000000049 pigment Substances 0.000 description 3
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
229920001451 polypropylene glycol Polymers 0.000 description 3
229940068977 polysorbate 20 Drugs 0.000 description 3
239000001267 polyvinylpyrrolidone Substances 0.000 description 3
239000013557 residual solvent Substances 0.000 description 3
239000000377 silicon dioxide Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
235000010356 sorbitol Nutrition 0.000 description 3
239000000600 sorbitol Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
240000000560 Citrus x paradisi Species 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
239000004375 Dextrin Substances 0.000 description 2
229920001353 Dextrin Polymers 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000008186 active pharmaceutical agent Substances 0.000 description 2
239000000654 additive Substances 0.000 description 2
229910052783 alkali metal Inorganic materials 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008119 colloidal silica Substances 0.000 description 2
230000000536 complexating effect Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
230000007423 decrease Effects 0.000 description 2
235000019425 dextrin Nutrition 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
235000013399 edible fruits Nutrition 0.000 description 2
LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
239000012458 free base Substances 0.000 description 2
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
229960003511 macrogol Drugs 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
239000007962 solid dispersion Substances 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
238000013268 sustained release Methods 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
230000009747 swallowing Effects 0.000 description 2
239000000454 talc Substances 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
238000012360 testing method Methods 0.000 description 2
239000002562 thickening agent Substances 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
PWMWNFMRSKOCEY-UHFFFAOYSA-N 1-Phenyl-1,2-ethanediol Chemical compound OCC(O)C1=CC=CC=C1 PWMWNFMRSKOCEY-UHFFFAOYSA-N 0.000 description 1
HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 1
125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 description 1
ZFEKANLLFQEKED-UHFFFAOYSA-N 2-propan-2-yloxypropan-1-ol Chemical compound CC(C)OC(C)CO ZFEKANLLFQEKED-UHFFFAOYSA-N 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
244000144730 Amygdalus persica Species 0.000 description 1
244000099147 Ananas comosus Species 0.000 description 1
235000007119 Ananas comosus Nutrition 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
241000167854 Bourreria succulenta Species 0.000 description 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
MRABAEUHTLLEML-UHFFFAOYSA-N Butyl lactate Chemical compound CCCCOC(=O)C(C)O MRABAEUHTLLEML-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
229920002101 Chitin Polymers 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
244000223760 Cinnamomum zeylanicum Species 0.000 description 1
241000207199 Citrus Species 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
235000005979 Citrus limon Nutrition 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical group COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
244000004281 Eucalyptus maculata Species 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
235000016623 Fragaria vesca Nutrition 0.000 description 1
240000009088 Fragaria x ananassa Species 0.000 description 1
235000011363 Fragaria x ananassa Nutrition 0.000 description 1
229920000926 Galactomannan Polymers 0.000 description 1
239000001828 Gelatine Substances 0.000 description 1
241000206672 Gelidium Species 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
235000017858 Laurus nobilis Nutrition 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
241000220225 Malus Species 0.000 description 1
235000011430 Malus pumila Nutrition 0.000 description 1
235000015103 Malus silvestris Nutrition 0.000 description 1
240000003183 Manihot esculenta Species 0.000 description 1
235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
229920003091 Methocel™ Polymers 0.000 description 1
240000005561 Musa balbisiana Species 0.000 description 1
235000018290 Musa x paradisiaca Nutrition 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
235000009827 Prunus armeniaca Nutrition 0.000 description 1
244000018633 Prunus armeniaca Species 0.000 description 1
235000006040 Prunus persica var persica Nutrition 0.000 description 1
235000014443 Pyrus communis Nutrition 0.000 description 1
240000001987 Pyrus communis Species 0.000 description 1
240000007651 Rubus glaucus Species 0.000 description 1
235000011034 Rubus glaucus Nutrition 0.000 description 1
235000009122 Rubus idaeus Nutrition 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
244000125380 Terminalia tomentosa Species 0.000 description 1
235000005212 Terminalia tomentosa Nutrition 0.000 description 1
235000007303 Thymus vulgaris Nutrition 0.000 description 1
240000002657 Thymus vulgaris Species 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
244000098338 Triticum aestivum Species 0.000 description 1
235000009499 Vanilla fragrans Nutrition 0.000 description 1
244000263375 Vanilla tahitensis Species 0.000 description 1
235000012036 Vanilla tahitensis Nutrition 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229920013820 alkyl cellulose Polymers 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
229960004977 anhydrous lactose Drugs 0.000 description 1
239000010617 anise oil Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
238000000889 atomisation Methods 0.000 description 1
239000002585 base Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
239000001191 butyl (2R)-2-hydroxypropanoate Substances 0.000 description 1
229960005069 calcium Drugs 0.000 description 1
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
229940062672 calcium dihydrogen phosphate Drugs 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
239000007963 capsule composition Substances 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229950008138 carmellose Drugs 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000019693 cherries Nutrition 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
229960000913 crospovidone Drugs 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
229940097362 cyclodextrins Drugs 0.000 description 1
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000002242 deionisation method Methods 0.000 description 1
239000000645 desinfectant Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
238000000113 differential scanning calorimetry Methods 0.000 description 1
230000029087 digestion Effects 0.000 description 1
239000011363 dried mixture Substances 0.000 description 1
238000009507 drug disintegration testing Methods 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
239000000686 essence Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
ZANNOFHADGWOLI-UHFFFAOYSA-N ethyl 2-hydroxyacetate Chemical compound CCOC(=O)CO ZANNOFHADGWOLI-UHFFFAOYSA-N 0.000 description 1
229940116333 ethyl lactate Drugs 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000005243 fluidization Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
230000037406 food intake Effects 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
230000035876 healing Effects 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
239000010514 hydrogenated cottonseed oil Substances 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229910052588 hydroxylapatite Inorganic materials 0.000 description 1
229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
229960003943 hypromellose Drugs 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000009434 installation Methods 0.000 description 1
JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
VHVPQPYKVGDNFY-ZPGVKDDISA-N itraconazole Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-ZPGVKDDISA-N 0.000 description 1
229940079302 itraconazole 200 mg Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
229960001021 lactose monohydrate Drugs 0.000 description 1
239000004571 lime Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
235000012054 meals Nutrition 0.000 description 1
239000002609 medium Substances 0.000 description 1
FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
235000019691 monocalcium phosphate Nutrition 0.000 description 1
238000000465 moulding Methods 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
229920005606 polypropylene copolymer Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Chemical class 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
238000007873 sieving Methods 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000006104 solid solution Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
229940063138 sporanox Drugs 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000001585 thymus vulgaris Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
238000009736 wetting Methods 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SK544-99A 1997-03-26 1998-03-18 Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom SK284813B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97200914		1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en)	1997-03-26	1998-03-18	Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number	Publication Date
SK54499A3 SK54499A3 (en)	2000-01-18
SK284813B6 true SK284813B6 (sk)	2005-12-01

Family

ID=8228147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK544-99A SK284813B6 (sk)	1997-03-26	1998-03-18	Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom

Country Status (30)

Country	Link
EP (1)	EP0969821B1 (xx)
JP (1)	JP3608800B2 (xx)
KR (1)	KR100520936B1 (xx)
CN (1)	CN1206984C (xx)
AP (1)	AP1227A (xx)
AT (1)	ATE241969T1 (xx)
AU (1)	AU734248B2 (xx)
BG (1)	BG64434B1 (xx)
BR (1)	BR9806174A (xx)
CA (1)	CA2269501C (xx)
CY (1)	CY2384B1 (xx)
CZ (1)	CZ295502B6 (xx)
DE (1)	DE69815316T2 (xx)
DK (1)	DK0969821T3 (xx)
EE (1)	EE03904B1 (xx)
ES (1)	ES2201485T3 (xx)
HU (1)	HU224217B1 (xx)
ID (1)	ID21477A (xx)
IL (1)	IL129575A (xx)
NO (1)	NO325102B1 (xx)
NZ (1)	NZ335364A (xx)
OA (1)	OA11162A (xx)
PL (1)	PL190566B1 (xx)
PT (1)	PT969821E (xx)
RU (1)	RU2218153C2 (xx)
SI (1)	SI0969821T1 (xx)
SK (1)	SK284813B6 (xx)
TR (1)	TR199900990T2 (xx)
UA (1)	UA60318C2 (xx)
WO (1)	WO1998042318A1 (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ505245A (en)	1998-07-17	2001-12-21	Janssen Pharmaceutica Nv	Pharmaceutical compositions of itraconazole and a water-soluble polymer to treat fungal infection
ES2157731B1 (es) *	1998-07-21	2002-05-01	Liconsa Liberacion Controlada	Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ATE307808T1 (de)	1999-03-24	2005-11-15	Scherer Technologies Inc R P	Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
KR100432949B1 (ko) *	2000-06-13	2004-05-31	코오롱제약주식회사	생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) *	2001-02-06	2003-12-16	Dsm Ip Assets B.V.	Oral itraconazole formulations and methods of making the same
PT1370543E (pt)	2001-02-14	2007-02-28	Tibotec Pharm Ltd	Inibidores de protease de vih 2-(amino-substituída)-benzotiazol-sulfonamida de largo espectro
MXPA03009179A (es)	2001-04-09	2004-11-22	Tibotec Pharm Ltd	2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa.
EA009590B1 (ru)	2001-05-11	2008-02-28	Тиботек Фармасьютикалз Лтд.	2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
WO2002100407A1 (en) *	2001-06-12	2002-12-19	Smartrix Technologies Inc.	Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en)	2001-08-20	2011-12-06	Stiefel Laboratories, Inc.	Oral dosage forms of water insoluble drugs and methods of making the same
MXPA04006201A (es)	2001-12-21	2004-12-06	Tibotec Pharm Ltd	Sulfonamidas que contienen fenilo sustituido con grupos heterociclicos, inhibidores de la proteasa del vih de amplio espectro.
MY142238A (en)	2002-03-12	2010-11-15	Tibotec Pharm Ltd	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
SI1517899T1 (sl)	2002-05-17	2008-02-29	Tibotec Pharm Ltd	Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
KR100994759B1 (ko)	2002-08-14	2010-11-16	티보텍 파마슈티컬즈	광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제
KR100557680B1 (ko) *	2002-11-23	2006-03-07	한국유나이티드제약 주식회사	이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
DE60312636T3 (de) *	2003-01-14	2014-12-24	Acino Pharma Ag	Bioaequivalente Zusammensetzung in der Form einer festen Dispersion enthaltend Itraconazol und ein hydrophiles Polymer
ES2283724T5 (es) *	2003-01-14	2013-04-09	Acino Pharma Ag	Composición de itraconazol dispersada en un polímero hidrófilo con biodisponibilidad potenciada
BRPI0413353A (pt)	2003-08-06	2006-10-10	Nirmal Mulye	composição farmacêutica contendo droga solúvel em água
US8268885B2 (en)	2003-09-11	2012-09-18	Janssen R&D Ireland	Entry inhibitors of the HIV virus
EP1568369A1 (en)	2004-02-23	2005-08-31	Boehringer Ingelheim Vetmedica Gmbh	Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es)	2004-05-04	2006-05-10	Tibotec Pharm Ltd	Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
AU2005244121B2 (en)	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
JP4879889B2 (ja)	2004-05-17	2012-02-22	テイボテク・フアーマシユーチカルズ・リミテツド	４−置換−１，５−ジヒドロ−ピリド［３，２−ｂ］インドール−２−オン
TW200607503A (en)	2004-05-17	2006-03-01	Tibotec Pharm Ltd	1-heterocyclyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones
ATE481403T1 (de)	2004-05-17	2010-10-15	Tibotec Pharm Ltd	Substituierte 1-phenyl-1,5-dihydro-pyridoä3,2- büindol-2-on-derivate verwendbar als pharmazeutische antiinfektiva
US7994187B2 (en)	2006-04-03	2011-08-09	Tibotec Pharmaceuticals Ltd.	HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones
RU2420268C2 (ru) *	2006-09-04	2011-06-10	Панацея Биотек Лимитед	Способ программируемой плавучей доставки
KR100809903B1 (ko) *	2006-09-05	2008-03-06	주식회사유한양행	안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) *	2007-04-12	2010-05-26	永胜药品工业股份有限公司	高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) *	2007-05-08	2008-11-20	Everest Pharm Industrial Co Ltd	生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en)	2007-11-05	2012-11-20	Allergan, Inc.	Soft prosthesis shell texturing method
EP2224923A4 (en)	2007-11-28	2013-05-15	Sequoia Pharmaceuticals Inc	COMPOSITIONS AND METHOD FOR INHIBITING ZYTOCHROM P450 2D6
EP2257160B1 (en)	2008-02-21	2017-07-05	Sequoia Pharmaceuticals, Inc.	Diamide inhibitors of cytochrome p450
US9050184B2 (en)	2008-08-13	2015-06-09	Allergan, Inc.	Dual plane breast implant
US8877822B2 (en)	2010-09-28	2014-11-04	Allergan, Inc.	Porogen compositions, methods of making and uses
US9138309B2 (en)	2010-02-05	2015-09-22	Allergan, Inc.	Porous materials, methods of making and uses
US9205577B2 (en)	2010-02-05	2015-12-08	Allergan, Inc.	Porogen compositions, methods of making and uses
SG174658A1 (en)	2010-04-01	2011-10-28	Theravida Inc	Pharmaceutical formulations for the treatment of overactive bladder
US11202853B2 (en)	2010-05-11	2021-12-21	Allergan, Inc.	Porogen compositions, methods of making and uses
DK2569021T3 (en) *	2010-05-11	2017-04-10	Allergan Inc	POROGENE COMPOSITIONS, PROCEDURES FOR MANUFACTURING AND APPLICATIONS
US8679279B2 (en)	2010-11-16	2014-03-25	Allergan, Inc.	Methods for creating foam-like texture
CN102100678B (zh) *	2011-02-18	2012-10-17	天津力生制药股份有限公司	伊曲康唑硫酸盐微丸及其制备方法
WO2014093669A1 (en)	2012-12-13	2014-06-19	Allergan, Inc.	Device and method for making a variable surface breast implant
US10092392B2 (en)	2014-05-16	2018-10-09	Allergan, Inc.	Textured breast implant and methods of making same
DK3405191T3 (da)	2016-01-20	2025-05-19	Theravida Inc	Sammensætninger til anvendelse ved behandling af hyperhidrose
WO2019204193A1 (en) *	2018-04-16	2019-10-24	Bristol-Myers Squibb Company	Apixaban formulations
CN114767636B (zh) *	2022-04-11	2023-11-07	苏州中化药品工业有限公司	伊曲康唑微丸、制备方法及伊曲康唑微丸胶囊

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3346123A1 (de) *	1983-12-21	1985-06-27	Janssen Pharmaceutica, N.V., Beerse	Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
GB8506792D0 (en) *	1985-03-15	1985-04-17	Janssen Pharmaceutica Nv	Derivatives of y-cyclodextrin
USH672H (en) *	1986-12-31	1989-09-05	E. R. Squibb & Sons, Inc.	Stable antifungal capsule formulation
ES2051968T3 (es) *	1988-12-22	1994-07-01	American Cyanamid Co	Metodo para el tratamiento de enfermedad periodontal mediante la liberacion continua de un agente terapeutico a la bolsa periodontal; composicion de materia del mismo y aparato para su administracion.
PH30929A (en) *	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
EP0914100A1 (en) *	1996-06-28	1999-05-12	Schering Corporation	Oral composition comprising a triazole antifungal compound

1998
- 1998-03-18 AP APAP/P/1999/001516A patent/AP1227A/en active
- 1998-03-18 NZ NZ335364A patent/NZ335364A/xx not_active IP Right Cessation
- 1998-03-18 TR TR1999/00990T patent/TR199900990T2/xx unknown
- 1998-03-18 SK SK544-99A patent/SK284813B6/sk not_active IP Right Cessation
- 1998-03-18 EP EP98919155A patent/EP0969821B1/en not_active Expired - Lifetime
- 1998-03-18 IL IL12957598A patent/IL129575A/en not_active IP Right Cessation
- 1998-03-18 UA UA99042468A patent/UA60318C2/uk unknown
- 1998-03-18 CZ CZ19991398A patent/CZ295502B6/cs not_active IP Right Cessation
- 1998-03-18 CN CNB988020181A patent/CN1206984C/zh not_active Expired - Lifetime
- 1998-03-18 ID IDW990316A patent/ID21477A/id unknown
- 1998-03-18 SI SI9830489T patent/SI0969821T1/xx unknown
- 1998-03-18 DK DK98919155T patent/DK0969821T3/da active
- 1998-03-18 AU AU72107/98A patent/AU734248B2/en not_active Expired
- 1998-03-18 ES ES98919155T patent/ES2201485T3/es not_active Expired - Lifetime
- 1998-03-18 JP JP54490198A patent/JP3608800B2/ja not_active Expired - Lifetime
- 1998-03-18 KR KR10-1999-7003848A patent/KR100520936B1/ko not_active Expired - Lifetime
- 1998-03-18 PT PT98919155T patent/PT969821E/pt unknown
- 1998-03-18 HU HU0002056A patent/HU224217B1/hu active IP Right Grant
- 1998-03-18 AT AT98919155T patent/ATE241969T1/de active
- 1998-03-18 PL PL98335542A patent/PL190566B1/pl unknown
- 1998-03-18 CA CA002269501A patent/CA2269501C/en not_active Expired - Lifetime
- 1998-03-18 WO PCT/EP1998/001773 patent/WO1998042318A1/en not_active Ceased
- 1998-03-18 DE DE69815316T patent/DE69815316T2/de not_active Expired - Lifetime
- 1998-03-18 EE EEP199900453A patent/EE03904B1/xx unknown
- 1998-03-18 RU RU99112123/15A patent/RU2218153C2/ru active
- 1998-03-18 BR BR9806174-7A patent/BR9806174A/pt not_active Application Discontinuation
1999
- 1999-04-23 BG BG103356A patent/BG64434B1/bg unknown
- 1999-04-30 NO NO19992114A patent/NO325102B1/no not_active IP Right Cessation
- 1999-09-24 OA OA9900215A patent/OA11162A/en unknown
2003
- 2003-11-04 CY CY0300079A patent/CY2384B1/xx unknown

Also Published As

Publication number	Publication date
TR199900990T2 (xx)	1999-10-21
RU2218153C2 (ru)	2003-12-10
CA2269501C (en)	2005-11-08
JP2001520663A (ja)	2001-10-30
EP0969821B1 (en)	2003-06-04
EE9900453A (et)	2000-04-17
NZ335364A (en)	2000-08-25
DE69815316D1 (de)	2003-07-10
IL129575A (en)	2004-06-20
JP3608800B2 (ja)	2005-01-12
CN1206984C (zh)	2005-06-22
WO1998042318A1 (en)	1998-10-01
KR20000052971A (ko)	2000-08-25
DK0969821T3 (da)	2003-09-15
SI0969821T1 (en)	2003-10-31
BR9806174A (pt)	1999-10-19
CA2269501A1 (en)	1998-10-01
IL129575A0 (en)	2000-02-29
PL335542A1 (en)	2000-04-25
PT969821E (pt)	2003-10-31
CN1244796A (zh)	2000-02-16
CZ295502B6 (cs)	2005-08-17
SK54499A3 (en)	2000-01-18
KR100520936B1 (ko)	2005-10-17
DE69815316T2 (de)	2004-04-29
AP9901516A0 (en)	1999-06-30
BG64434B1 (en)	2005-02-28
ATE241969T1 (de)	2003-06-15
HUP0002056A2 (hu)	2000-12-28
EE03904B1 (et)	2002-12-16
PL190566B1 (pl)	2005-12-30
UA60318C2 (uk)	2003-10-15
NO992114L (no)	1999-08-26
AP1227A (en)	2003-11-24
HK1022840A1 (en)	2000-08-25
CZ139899A3 (cs)	1999-10-13
AU734248B2 (en)	2001-06-07
NO325102B1 (no)	2008-02-04
OA11162A (en)	2003-04-16
BG103356A (en)	2000-03-31
AU7210798A (en)	1998-10-20
NO992114D0 (no)	1999-04-30
ES2201485T3 (es)	2004-03-16
EP0969821A1 (en)	2000-01-12
CY2384B1 (en)	2004-06-04
ID21477A (id)	1999-06-17
HUP0002056A3 (en)	2001-01-29
HU224217B1 (hu)	2005-06-28

Publication	Publication Date	Title
SK284813B6 (sk)	2005-12-01	Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom
RU2219909C2 (ru)	2003-12-27	Гранулы, имеющие ядро, покрытое противогрибковым препаратом и полимером
CZ293841B6 (cs)	2004-08-18	Částice s obsahem itrakonazolu
HU220614B1 (hu)	2002-03-28	Gombaellenes szerrel és polimerrel bevont magot tartalmazó mikrorészecskék, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
SK15252000A3 (sk)	2001-10-08	Peleta, ktorej jadro je obalené činidlom znižujúcim lipidy a polymérom
MXPA99004411A (en)	1999-09-01	Pellets having a core coated with an antifungal and a polymer
HK1022840B (en)	2003-09-05	Pellets having a core coated with an antifungal and a polymer
MXPA00008322A (en)	2001-07-09	Pellets having a core coated with an antifungal and a polymer
US7314641B1 (en)	2008-01-01	High-bioavailability particle coated with fungicide and polymer
MXPA00010649A (en)	2001-07-31	Pellets having a core coated with a lipid lowering agent and a polymer
CZ20003753A3 (cs)	2001-01-17	Peleta, jejíž jádro je potaženo činidlem snižujícím lipidy a polymerem

Legal Events

Date	Code	Title	Description
2018-05-02	MK4A	Expiry of patent	Expiry date: 20180318